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1. 发明申请

US20180330936A1 IMAGING MASS SPECTROMETER 审中-公开
公开(公告)号：US20180330936A1
公开(公告)日：2018-11-15
申请号：US15776585
申请日：2016-11-16
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： John Brian Hoyes , Anatoly Verenchikov , Mikhail Yavor , Keith Richardson , Jason Wildgoose
IPC分类号： H01J49/40 , H01J49/10 , H01J49/00 , H01J49/06
CPC分类号： H01J49/405 , H01J49/0004 , H01J49/062 , H01J49/067 , H01J49/10 , H01J49/406
摘要： A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.

2. 发明授权

US09728391B2 Orthogonal acceleration coaxial cylinder time of flight mass analyser 有权
公开(公告)号：US09728391B2
公开(公告)日：2017-08-08
申请号：US14401683
申请日：2013-05-16
申请人： Micromass UK Limited
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/00
CPC分类号： H01J49/401 , G01N2223/506 , H01J49/0031 , H01J49/405 , H01J49/406 , H01J49/408
摘要： A Time of Flight mass analyzer is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. An ion detector is disposed within the annular ion guide. Ions are orthogonally accelerated in a first axial direction from the first annular ion guide section into the second annular ion guide section. An axial DC potential is maintained along at least a portion of the second annular ion guide section so that the ions are reflected in a second axial direction which is substantially opposed to the first axial direction. The ions undergo multiple axial passes through the second annular ion guide section before being detected by the ion detector.

3. 发明授权

US09564307B2 Constraining arcuate divergence in an ion mirror mass analyser 有权
标题翻译：在离子镜质量分析仪中限制弓形散度
公开(公告)号：US09564307B2
公开(公告)日：2017-02-07
申请号：US14945305
申请日：2015-11-18
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander A. Makarov
IPC分类号： H01J49/40 , H01J49/42
CPC分类号： H01J49/405 , H01J49/4245 , H01J49/425 , H01J49/427
摘要： A charged particle analyzer apparatus comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner, whereby when the electrode systems are electrically biased the mirrors create an electrical field comprising opposing electrical fields along z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer while the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces. A mass spectrometer system comprising a plurality of the charged particle analyzers arranged as a parallel array.
摘要翻译：一种带电粒子分析仪装置，包括两个相对的离子镜，每个反射镜包括沿着轴线z延伸的内部和外部场限定电极系统，外部系统围绕内部，由此当电极系统被电偏置时，反射镜产生电场，包括相对 z电场; 以及至少一个弧形聚焦透镜，用于约束分束器内的带电粒子束的弓形发散，同时光束围绕轴线z运动，分析器还包括具有至少部分跨越内外两者之间的空间的两个面的圆盘场定义电极系统并且位于垂直于轴线z的平面中，该盘在两个面上具有电阻涂层。一种质谱仪系统，包括多个被布置成平行阵列的带电粒子分析器。

4. 发明申请

US20160365233A1 REFLECTRONS AND METHODS OF PRODUCING AND USING THEM 审中-公开
公开(公告)号：US20160365233A1
公开(公告)日：2016-12-15
申请号：US15155034
申请日：2016-05-15
申请人： PERKINELMER HEALTH SCIENCES, INC.
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/06 , H01J49/40
CPC分类号： H01J49/067 , H01J49/405
摘要： Certain embodiments described herein are directed to reflectron assemblies and methods of producing them. In some configurations, a reflectron comprising a plurality of lenses each comprising a planar body and comprising a plurality of separate and individual conductors spanning a central aperture from a first side to a second side of a first surface of the planar body is described. In some instances, the plurality of conductors are each substantially parallel to each other and are positioned in the same plane.

5. 发明授权

US09384954B2 Time of flight tubes and methods of using them 有权
标题翻译：飞行时间管和使用它们的方法
公开(公告)号：US09384954B2
公开(公告)日：2016-07-05
申请号：US14291417
申请日：2014-05-30
申请人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/40 , H01J49/02 , H01J49/24
CPC分类号： H01J49/405 , H01J49/02 , H01J49/24 , H01J49/40
摘要： Certain embodiments described herein are directed to time of flight tubes comprising a cylindrical tube comprising an inner surface and an outer surface, the cylindrical tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the cylindrical tube. In some configurations, the cylindrical tube further comprises a conductive material disposed on the inner surface of the cylindrical tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged.
摘要翻译：本文描述的某些实施例涉及包括包括内表面和外表面的圆柱形管的飞行管的时间，圆柱形管包括有效厚度，并且其尺寸和布置成联接到圆柱形管内部并支撑反射器组件。在一些构造中，圆柱形管还包括设置在圆柱形管的内表面上的导电材料，导电材料以有效的量存在，以便在导电材料充电时为离子提供无场区域。

6. 发明授权

US09196469B2 Constraining arcuate divergence in an ion mirror mass analyser 有权
公开(公告)号：US09196469B2
公开(公告)日：2015-11-24
申请号：US13989697
申请日：2011-11-24
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/34 , H01J49/40 , H01J49/42
CPC分类号： H01J49/405 , H01J49/4245 , H01J49/425 , H01J49/427
摘要： A method of selecting ions of interest from a beam of ions using an analyzer, the method comprising: (i) providing an analyzer comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an analyzer axis z, each system comprising one or more electrodes, the outer system surrounding the inner; (ii) causing the beam of ions to fly through the analyzer along a main flight path in the presence of an analyzer field so as to undergo within the analyzer at least one full oscillation in the direction of the analyzer axis while orbiting about or oscillating between one or more electrodes of the inner field defining electrode system; (iii) providing one or more sets of electrodes adjacent the main flight path; (iv) constraining the arcuate divergence from the main flight path of ions of interest by applying one set of voltages to one or more of the sets of electrodes adjacent the main flight path when the ions of interest are in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path and applying one or more different sets of voltages to the said one or more sets of electrodes adjacent the main flight path when the ions of interest are not in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path; and: (v) ejecting the ions of interest from the analyzer. Also provided is a charged particle analyzer comprising the two opposing ion mirrors comprising inner and outer field-defining electrode systems elongated along an analyzer axis z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer while the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces.

7. 发明申请

US20150294849A1 Multireflection Time-of-flight Mass Spectrometer 有权
标题翻译：多反射飞行时间质谱仪
公开(公告)号：US20150294849A1
公开(公告)日：2015-10-15
申请号：US14748582
申请日：2015-06-24
申请人： Alexander A. MAKAROV , Dmitry E. GRINFELD , Mikhail A. MONASTYRSKIY
发明人： Alexander A. MAKAROV , Dmitry E. GRINFELD , Mikhail A. MONASTYRSKIY
IPC分类号： H01J49/40 , H01J49/06
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.
摘要翻译：公开了一种在多反射飞行时间质谱仪中反射离子的方法。该方法包括将离子导向具有多个电极的离子反射镜，并向离子镜电极施加电压以产生电场，使得离子的平均轨迹与离子反射镜的对称平面相交并离开离子反射镜，其中离子由反射镜在空间上聚焦到第一位置并且在时间上聚焦到与第一位置不同的第二位置。还公开了用于执行该方法的装置。

8. 发明申请

US20150270115A1 TIME-OF-FLIGHT MASS SPECTROMETER 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US20150270115A1
公开(公告)日：2015-09-24
申请号：US14434596
申请日：2013-09-18
申请人： Shimadzu Corporation
发明人： Osamu Furuhashi
IPC分类号： H01J49/40
CPC分类号： H01J49/405
摘要： In an ion reflector (4) configured from a plurality of electrodes, electrodes 42 disposed in a second stage region (S2) for reflecting ions after deceleration are formed thinner than electrodes (41) disposed in a first stage region (S1) for decelerating the ions.The thin electrodes suppress unevenness of potential, in particular, in a path away from the center axis of the reflector, which results in improvement of isochronism of an ion packet passing on the path. The thick electrodes (41, 43) disposed in the first stage region (S1) prevents stretching of the grid electrodes (G1, G2) from being affected, and unevenness of potential in the first stage region (S1) hardly affects isochronism of the ions. By appropriately adjusting thicknesses and a pitch of the electrodes (41, 42, 43, 44) adjacent to one another so as to align intervals between the electrodes (41, 42, 43, 44), it is possible to use spacers having the same size in common. Since the number of electrodes in the first stage region (S1) can be reduced, an increase in costs is suppressed. Consequently, it is possible to bring an electric field of an ion reflection region closer to an ideal state and improve mass-resolving power while suppressing costs.
摘要翻译：在由多个电极构成的离子反射体（4）中，比设置在第一阶段区域（S1）中的电极（41）更薄地设置在第二阶段区域（S2）中用于反射减速后的离子的电极42，离子。薄电极抑制电位的不均匀性，特别是在远离反射器的中心轴的路径中，这导致通过路径的离子包的等时性的改善。设置在第一级区域（S1）中的厚电极（41,43）防止栅电极（G1，G2）的拉伸受到影响，第一级区域（S1）的电位不均匀性几乎不影响离子的等时性。通过适当地调整彼此相邻的电极（41,42,43,44）的厚度和间距以便对准电极（41,42,43,44）之间的间隔，可以使用具有相同的间隔物大小相同由于可以减少第一级区域（S1）中的电极的数量，因此抑制了成本的增加。因此，可以使离子反射区域的电场更接近理想状态，并且能够在抑制成本的同时提高质量分辨能力。

9. 发明申请

US20150204827A1 GAS ANALYSIS SYSTEM COMPRISING A GAS SPECTROMETER EQUIPPED WITH A MICRO-REFLECTRON 有权
标题翻译：气体分析系统，包含配有微电子的气体光谱仪
公开(公告)号：US20150204827A1
公开(公告)日：2015-07-23
申请号：US14419108
申请日：2013-08-05
申请人： Commissariat a L'Energie Atomique et aux Energies Alternatives , Analytical Pixels Technology-Apix Technology
发明人： Laurent Duraffourg , Philippe Andreucci , Charles-Marie Tassetti , Eric Colinet , Pierre Puget , Joshua Whiting , Peter Thomas Stevens , Mélanie Petitjean
IPC分类号： G01N30/72 , H01J49/00 , H01J49/40
CPC分类号： G01N30/7206 , G01N2030/025 , H01J49/0018 , H01J49/405
摘要： The invention relates to a gas analysis system comprising, from upstream to downstream: a module (SEP) for separating at least a portion of the species contained in the gas to be analysed, comprising at least one microcapillary column (GC) for gas phase chromatography, and a time-of-flight mass spectrometer (TOFMS) coupled to said separation module, said spectrometer comprising a ion source (MS1, MS2) adapted to ionise at least a portion of said species and to emit a ion beam, and a free-flight zone (MS4) for said ions, said mass spectrometer (TOFMS) being arranged in the volume of at least one substrate and comprising a micro-reflectron (R) arranged between the source (MS1, MS2) and the free-flight zone (MS4), a wall (R1) of said micro-reflectron comprising a layer made from a resistive material designed to be polarised between at least two regions so as to create a continuous electrostatic field gradient in said reflectron.
摘要翻译：本发明涉及一种气体分析系统，包括从上游到下游：用于分离包含在待分析气体中的物质的至少一部分的模块（SEP），其包括用于气相色谱的至少一个微毛细管柱（GC），以及耦合到所述分离模块的飞行时间质谱仪（TOFMS），所述光谱仪包括适于离子化所述物质的至少一部分并且发射离子束的离子源（MS1，MS2）（MS4），所述质谱仪（TOFMS）布置在至少一个衬底的体积中，并且包括布置在源（MS1，MS2）和自由飞行区之间的微反射器（R）（MS4），所述微反射器的壁（R1）包括由电阻材料制成的层，其被设计为在至少两个区域之间极化，以便在所述反射器中产生连续的静电场梯度。

10. 发明授权

US08552367B2 Micro-reflectron for time-of-flight mass spectrometer 有权
标题翻译：微反射仪用于飞行时间质谱仪
公开(公告)号：US08552367B2
公开(公告)日：2013-10-08
申请号：US13366701
申请日：2012-02-06
申请人： Jean-Sebastien Danel , Laurent Duraffourg , Frederic Progent , Charles-Marie Tassetti
发明人： Jean-Sebastien Danel , Laurent Duraffourg , Frederic Progent , Charles-Marie Tassetti
IPC分类号： H01J49/00
CPC分类号： H01J49/405 , B05D3/10 , B81C1/00119 , B81C2201/0133 , B81C2203/031 , H01J49/0018
摘要： A micro-reflectron for a time-of-flight mass spectrometer including a substrate and integrated with the volume of the substrate, means for application of a potential gradient in a volume suitable for constituting a flight zone of the ions. The means of application includes at least two polarization electrodes and a wall of at least one resistive material that can be polarized between these electrodes so as to generate a continuous potential gradient, itself providing the function of reflectron, this flight zone, these electrodes and this wall being obtained by the technology of microelectromechanical systems (MEMS) and this micro-reflectron having a thickness of less than 5 millimeters while its other dimensions are less than 10 times this thickness.
摘要翻译：用于包括衬底并与衬底的体积整合的飞行时间质谱仪的微反射器是在适于构成离子的飞行区域的体积中施加电位梯度的装置。施加装置包括至少两个极化电极和至少一个电阻材料的壁，其可以在这些电极之间极化，以便产生连续的电势梯度，其本身提供反射器的功能，该飞行区域，这些电极和这些电极通过微机电系统（MEMS）的技术获得壁，该微反射器的厚度小于5毫米，而其它尺寸小于该厚度的10倍。

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