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    • 5. 发明授权
    • Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
    • 富勒烯(C60)为基础的X线造影剂进行诊断成像
    • US06660248B2
    • 2003-12-09
    • US10038075
    • 2001-11-09
    • Lon J. WilsonJohn T. WhartonUri Sagman
    • Lon J. WilsonJohn T. WhartonUri Sagman
    • A61K5100
    • B82Y15/00A61K47/6949A61K49/0447B82Y5/00Y10S516/901Y10S977/835Y10S977/928
    • An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamide, hydroxyl, and 1,3-diol. The fullerene scaffold may comprise an empty fullerene or an endohedral fullerene. A method for making the agent includes a) synthesizing iodinating moieties, b) protecting serinols, forming protected serinols, c) attaching the protected serinols to the iodinated moieties, forming iodinated serinols, d) attaching the iodinated serinols to the fullerene scaffold, and, optionally, d) de-protecting the serinols. Also disclosed are a method for providing diagnostic treatment to a patient comprising administering to said patient a radiopaque effective amount of a contrast agent comprising a fullerene scaffold and an iodinated moiety, a method of making a blood pool agent.
    • 用于治疗或诊断治疗的造影剂包括富勒烯支架和结合到支架的碘化部分。 该试剂还可以包含结合到支架上的水溶性部分,其可以是丝氨醇壬二酰胺,羟基和1,3-二醇。 富勒烯支架可以包括空的富勒烯或内嵌的富勒烯。 制备该试剂的方法包括:a)合成碘化部分,b)保护丝氨醇,形成受保护的丝氨醇,c)将被保护的丝氨醇连接到碘化部分,形成碘化丝氨醇,d)将碘化丝氨醇连接到富勒烯支架上, 任选地,d)脱保护丝氨醇。 还公开了一种向患者提供诊断治疗的方法,包括向所述患者施用不透射线的有效量的包含富勒烯支架和碘化部分的造影剂,制备血液池剂的方法。
    • 10. 发明授权
    • Coating compositions for electronic components and other metal surfaces, and methods for making and using the compositions
    • 电子部件和其他金属表面的涂料组合物,以及制备和使用组合物的方法
    • US06455100B1
    • 2002-09-24
    • US09549119
    • 2000-04-13
    • Robert L. HeimannWilliam L. Dalton
    • Robert L. HeimannWilliam L. Dalton
    • B05D512
    • H01F27/022B22D19/0054C23C2/02C23C6/00C23C26/02C23C30/00H02K15/0012Y10S977/725Y10S977/773Y10S977/777Y10S977/835Y10S977/89
    • A method is disclosed for providing inorganic and/or organic coating compositions onto rotor cores to eliminate soldering during aluminum injection. These coatings can also be applied upon electric motor rotors and/or stators laminates as well as other electronic components such as transformers. The disclosed method provides at least one film or layer of a coating composition within channels or bar slots defined by the rotor of the electric motor core/rotor (depending upon the design of the motor the slots can be defined within the rotor or open ended along the longitudinal axis of the rotor). The coating composition is also typically applied upon all exposed surfaces of the rotor, e.g., within the channels and exterior surfaces of the rotor. The coated rotor is then contacted with a molten metal. The coating composition functions to isolate the laminates (e.g., steel) of the rotor from a molten metal (e.g., aluminum and its alloys), which surrounds the rotor and fills the channels thereby embedding the rotor, and prevents the metal from forming an undesirable conductive path typically termed soldering among the individual laminates.
    • 公开了一种将无机和/或有机涂层组合物提供到转子芯上以消除铝注入期间的焊接的方法。 这些涂层也可以应用于电动机转子和/或定子层压板以及其他电子部件,例如变压器。 所公开的方法提供了由电动机芯/转子的转子限定的通道或条槽内的至少一层涂层组合物(取决于电动机的设计,槽可以在转子内限定或沿开放端 转子的纵轴)。 涂层组合物也通常施加在转子的所有暴露表面上,例如在转子的通道和外表面内。 然后将涂覆的转子与熔融金属接触。 涂料组合物用于将转子的层压板(例如钢)与熔融金属(例如,铝及其合金)隔离,该熔融金属(例如,铝及其合金)围绕转子并填充通道,从而嵌入转子,并防止金属形成不期望的 导电路径通常称为各个层压板之间的焊接。