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1. 发明授权

US09528963B2 Buffer composition 有权
标题翻译：缓冲液组成
公开(公告)号：US09528963B2
公开(公告)日：2016-12-27
申请号：US14792694
申请日：2015-07-07
申请人： ARKRAY, Inc.
发明人： Naotsugu Onuma , Miho Fukuda
IPC分类号： G01N27/447 , B01L3/00 , B01D15/16
CPC分类号： G01N27/44791 , B01D15/166 , B01L3/50273 , B01L2400/0421 , G01N27/44747 , Y10T436/108331
摘要： Provided is a buffer composition capable of suppressing temperature dependency of the pH of a buffer solution, and a specimen analysis method and a specimen analysis system using the buffer composition, wherein the buffer composition contains a buffer substance A showing a positive correlation between temperature and pH and a buffer substance B showing a negative correlation between temperature and pH.
摘要翻译：提供了能够抑制缓冲溶液的pH的温度依赖性的缓冲组合物，以及使用缓冲组合物的样本分析方法和样本分析系统，其中缓冲组合物含有温度与pH之间呈正相关的缓冲物质A 以及温度与pH之间呈负相关的缓冲物质B。

2. 发明申请

US20160263141A1 ORGAN ARREST, PROTECTION AND PRESERVATION 审中-公开
标题翻译：组织防御，保护和保护
公开(公告)号：US20160263141A1
公开(公告)日：2016-09-15
申请号：US15074471
申请日：2016-03-18
申请人： HIBERNATION THERAPEUTICS, A KF, LLC
发明人： Geoffrey Phillip Dobson
IPC分类号： A61K31/7076 , A01N1/02 , A61K31/167
CPC分类号： A61K31/7076 , A01N1/02 , A01N1/0226 , A61K31/167 , A61K31/245 , A61K31/4184 , A61K31/445 , A61K31/455 , A61K31/551 , A61K31/554 , A61K38/17 , A61K45/06 , Y10T436/108331 , A61K2300/00
摘要： The present invention relates to a method for arresting, protecting and/or preserving an organ which includes administering effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) local anaesthetic to a subject in need thereof.The present invention also relates to a method for arresting, protecting and/or preserving an organ which comprises adding a composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic to the organ.The present invention further provides a pharmaceutical or veterinary composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic.
摘要翻译：本发明还提供了一种药物或兽药组合物，其包含有效量的（i）钾通道开放剂或激动剂和/或腺苷受体激动剂和（ii）局部麻醉剂。

3. 发明授权

US09410144B2 Blood cell sorting methods and systems 有权
标题翻译：血细胞分选方法和系统
公开(公告)号：US09410144B2
公开(公告)日：2016-08-09
申请号：US14806112
申请日：2015-07-22
申请人： The General Hospital Corporation
发明人： Denise L. Faustman , Douglas E. Burger
IPC分类号： C12N13/00 , G01N1/18 , G01N33/48 , C12N5/078 , C12N5/00 , G01N33/49
CPC分类号： C12N13/00 , C12N5/0087 , C12N5/0634 , G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： The invention relates to methods of isolating white blood cells (WBCs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to WBCs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to WBC isolation, agitating the sample at specified frequencies, and/or using a sample container arranged such that all of the sample is placed in close proximity (e.g., within 5, 2, 1, or 0.5 mm) to the source of the magnetic field. The new methods provide for isolation of WBC preparations with high yield, purity, and viability. The methods are designed for compatibility with automation protocols for rapid processing of multiple samples.
摘要翻译：本发明涉及使用特异性结合WBC的磁性颗粒和一系列特定步骤和条件从样品例如全血分离白细胞（WBC）的方法。所述方法可以包括以下一种或多种：在WBC分离之前降低样品的粘度，以特定频率搅拌样品，和/或使用样品容器排列成使得所有样品都放置在非常接近的位置，2,1或0.5mm）到磁场源。新方法提供了高产率，纯度和生存能力的WBC制剂的分离。这些方法旨在与自动化协议的兼容性快速处理多个样品。

4. 发明申请

US20150369805A1 ANALYTE SENSORS, METHODS FOR PREPARING AND USING SUCH SENSORS, AND METHODS OF DETECTING ANALYTE ACTIVITY 有权
公开(公告)号：US20150369805A1
公开(公告)日：2015-12-24
申请号：US14797870
申请日：2015-07-13
申请人： Georgia State University Research Foundation, Inc.
发明人： Jenny Jie Yang , Shen Tang
IPC分类号： G01N33/569 , A61B5/1455
CPC分类号： G01N33/56966 , A61B5/14556 , C07K14/43595 , G01N33/542 , G01N33/582 , G01N33/84 , Y10T436/108331
摘要： Analyte sensors, methods for producing and using analyte sensors, methods of detecting and/or measuring analyte activity, detecting pH change, and/or, controlling the concentration of an analyte in a system, are disclosed. Embodiments of the analyte sensors according to the disclosure can provide an accurate and convenient method for characterizing analyte activity, detecting pH change, controlling the concentration of an analyte in a system, and the like, in both in vivo and in vitro environments, in particular in living cell imaging.

5. 发明授权

US09164087B2 Rapid diagnostic device, assay and multifunctional buffer 有权
标题翻译：快速诊断装置，测定和多功能缓冲液
公开(公告)号：US09164087B2
公开(公告)日：2015-10-20
申请号：US14064486
申请日：2013-10-28
申请人： MedMira Inc.
发明人： Hermes K. W. Chan
IPC分类号： G01N33/00 , G01N33/53 , G01N33/543
CPC分类号： G01N33/5302 , G01N33/54366 , G01N33/54386 , Y10T436/10 , Y10T436/108331
摘要： An improved rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit capable of receiving the fluid sample and multifunctional buffer, respectively. The test unit comprises a reaction zone containing immobilized capture reagent that can specifically bind to the target analyte, an absorbent zone supporting the reaction zone, and optionally, a blood separation zone in lateral fluid communication with the reaction zone. The dried indicator reagent delivery unit comprises a label zone permeated with a dried indicator reagent which is capable of being placed in transient fluid communication with the reaction zone of the test unit during the assay procedure. The rapid diagnostic assay system reduces the number of assay reagents, method steps and time required for performance compared to other conventional assays.
摘要翻译：提供改进的快速诊断装置，测定和多功能缓冲剂用于检测流体测试样品中的目标分析物。两步测定使用双组分流通装置，其包括分别能够接收流体样品和多功能缓冲液的测试单元和干燥的指示剂试剂递送单元。测试单元包括含有可特异性结合靶分析物的固定化捕获试剂的反应区，支持反应区的吸收区，以及任选地与反应区侧向流体连通的血液分离区。干燥的指示剂递送单元包括渗透有干燥的指示剂试剂的标签区，其能够在测定程序期间与测试单元的反应区域暂时流体连通。与其他常规测定相比，快速诊断测定系统减少了测定试剂的数量，方法步骤和所需的时间。

6. 发明授权

US09081023B2 Analyte sensors, methods for preparing and using such sensors, and methods of detecting analyte activity 有权
标题翻译：分析物传感器，制备和使用这些传感器的方法以及检测分析物活性的方法
公开(公告)号：US09081023B2
公开(公告)日：2015-07-14
申请号：US14465070
申请日：2014-08-21
申请人： Georgia State University Research Foundation, Inc.
发明人： Jenny Jie Yang , Shen Tang
IPC分类号： G01N33/84 , C07K14/435 , G01N33/58
CPC分类号： G01N33/56966 , A61B5/14556 , C07K14/43595 , G01N33/542 , G01N33/582 , G01N33/84 , Y10T436/108331
摘要： Analyte sensors, methods for producing and using analyte sensors, methods of detecting and/or measuring analyte activity, detecting pH change, and/or, controlling the concentration of an analyte in a system, are disclosed. Embodiments of the analyte sensors according to the disclosure can provide an accurate and convenient method for characterizing analyte activity, detecting pH change, controlling the concentration of an analyte in a system, and the like, in both in vivo and in vitro environments, in particular in living cell imaging.
摘要翻译：公开了分析物传感器，用于生产和使用分析物传感器的方法，检测和/或测量分析物活性的方法，检测pH变化和/或控制系统中分析物的浓度。根据本公开的分析物传感器的实施方案可以提供用于表征分析物活性，检测pH变化，在体内和体外环境中检测pH变化，控制系统中分析物的浓度等的方法，特别是在活细胞成像中。

7. 发明申请

US20150111276A1 BLOOD CELL SORTING METHODS AND SYSTEMS 审中-公开
标题翻译：血细胞分选方法和系统
公开(公告)号：US20150111276A1
公开(公告)日：2015-04-23
申请号：US14291313
申请日：2014-05-30
申请人： The General Hospital Corporation
发明人： Denise L. Faustman , Douglas E. Burger
IPC分类号： C12N13/00 , C12N5/078
CPC分类号： C12N13/00 , C12N5/0087 , C12N5/0634 , G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/108331 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： The invention relates to methods of isolating white blood cells (WBCs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to WBCs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to WBC isolation, agitating the sample at specified frequencies, and/or using a sample container arranged such that all of the sample is placed in close proximity (e.g., within 5, 2, 1, or 0.5 mm) to the source of the magnetic field. The new methods provide for isolation of WBC preparations with high yield, purity, and viability. The methods are designed for compatibility with automation protocols for rapid processing of multiple samples.
摘要翻译：本发明涉及使用特异性结合WBC的磁性颗粒和一系列特定步骤和条件从样品例如全血分离白细胞（WBC）的方法。所述方法可以包括以下一种或多种：在WBC分离之前降低样品的粘度，以特定频率搅拌样品，和/或使用样品容器来排列，使得所有样品都放置在非常接近的位置，2,1或0.5mm）到磁场源。新方法提供了高产率，纯度和生存能力的WBC制剂的分离。这些方法旨在与自动化协议的兼容性快速处理多个样品。

8. 发明授权

US08945928B2 Microarray system with improved sequence specificity 有权
标题翻译：具有改善序列特异性的微阵列系统
公开(公告)号：US08945928B2
公开(公告)日：2015-02-03
申请号：US13911971
申请日：2013-06-06
申请人： Kerry B Gunning , Mark Aaron Behlke
发明人： Kerry B Gunning , Mark Aaron Behlke
IPC分类号： G01N31/00 , C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/0059 , B01J2219/00608 , B01J2219/00626 , B01J2219/00722 , C12P19/34 , C12Q1/6806 , Y10T436/108331 , C12Q2525/125 , C12Q2533/101 , C12Q2521/319
摘要： The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple SNPs (where the variation occurs at a fixed position and is of limited allelic number) to more complex sequence variation patterns (such as with multigene families or multiple genetic strains of an organism where the sequence variation between the individual members is neither fixed nor consistent). The array is comprised of short, synthetic oligonucleotide probes attached to a solid surface which are hybridized to single-stranded targets. Single stranded targets can be produced using a method that employs primers modified on the 5′ end to prohibit degradation by a 5′-exonuclease that is introduced to degrade the unprotected strand. The invention further provides for printing buffers/solutions for the immobilization of oligonucleotide probes to an array surface. The invention also provides hybridization and wash buffers and conditions to maximize hybridization specificity and signal intensity, and reduce hybridization times.
摘要翻译：本发明提供了一种用于核酸序列检测的新型阵列方法，其具有改进的特异性，其允许从简单SNP（其中在固定位置发生并且具有有限等位基数的变体）检测遗传变异与更复杂的序列变异模式（例如与多基因家族或生物体的多种遗传菌株一样，其中各个成员之间的序列变异既不固定也不一致）。阵列由连接到固体表面的短合成寡核苷酸探针组成，其与单链靶标杂交。可以使用使用在5'端修饰的引物来防止引入降解未保护链的5'-外切核酸酶降解的方法来产生单链靶标。本发明还提供用于将寡核苷酸探针固定到阵列表面的印刷缓冲液/溶液。本发明还提供杂交和洗涤缓冲液和条件以使杂交特异性和信号强度最大化，并减少杂交时间。

9. 发明授权

US08921113B2 Buffer kit and method of generating a linear pH gradient 有权
标题翻译：缓冲试剂盒和产生线性pH梯度的方法
公开(公告)号：US08921113B2
公开(公告)日：2014-12-30
申请号：US13724873
申请日：2012-12-21
申请人： Shanhua Lin , Christopher A. Pohl
发明人： Shanhua Lin , Christopher A. Pohl
IPC分类号： G01N30/34 , G01N30/02 , G01N33/68 , B01D15/16 , C09K15/30 , B01D15/36
CPC分类号： C09K15/30 , B01D15/168 , B01D15/362 , G01N30/34 , Y10T436/10 , Y10T436/108331 , Y10T436/173845 , Y10T436/18
摘要： A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The second eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The first eluent solution has a first pH and the second eluent solution has a second pH where the first pH and second pH are different values. The buffer kit provides a linear pH gradient that forms an approximately straight line from at least the first pH to the second pH.
摘要翻译：缓冲试剂盒包括第一洗脱液和第二洗脱液。第一洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是一价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。第二洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是单价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。第一洗脱溶液具有第一pH，第二洗脱液具有第二pH，其中第一pH和第二pH是不同的值。缓冲试剂盒提供线性pH梯度，其从至少第一pH至第二pH形成近似的直线。

10. 发明授权

US08877505B2 Composition and method for stabilizing fluorescent particles 有权
标题翻译：用于稳定荧光颗粒的组合物和方法
公开(公告)号：US08877505B2
公开(公告)日：2014-11-04
申请号：US13382509
申请日：2011-02-01
申请人： Eric May , Alexandra Nagy , Jerome Kosmeder
发明人： Eric May , Alexandra Nagy , Jerome Kosmeder
IPC分类号： G01N21/64 , C12Q1/68 , G01N33/533 , C09K11/02 , G01N33/58 , B82Y15/00
CPC分类号： C09K11/025 , B82Y15/00 , C09K11/883 , G01N33/533 , G01N33/588 , Y10S977/774 , Y10S977/902 , Y10T436/108331
摘要： Embodiments of a composition for stabilizing fluorescent signal of nanoparticles and methods for its use are disclosed. In some embodiments, the composition has a pH from 7 to 10 and includes borate, protein and/or protein hydrolysate, an amine, a preservative, and a nonionic surfactant. In particular embodiments, the amine is an N-ethanol substituted amine, such as ethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, N,N-dimethylethanolamine, or a combination thereof. In some embodiments, a fluorescent particle solution, such as a quantum dot solution or quantum dot conjugate solution, is diluted in the composition and stored at 4° C. In certain embodiments, the fluorescence intensity of the diluted fluorescent particle remains substantially the same when stored at 4° C. for at least one month or at least three months. In particular embodiments, a diluted quantum dot conjugate is used to detect a hybridized probe or a protein antigen.
摘要翻译：公开了用于稳定纳米颗粒的荧光信号的组合物的实施方案及其使用方法。在一些实施方案中，组合物具有7至10的pH，并且包括硼酸盐，蛋白质和/或蛋白质水解产物，胺，防腐剂和非离子表面活性剂。在具体实施方案中，胺是N-乙醇取代的胺，例如乙醇胺，二乙醇胺，三乙醇胺，N-甲基二乙醇胺，N，N-二甲基乙醇胺或其组合。在一些实施方案中，将荧光颗粒溶液（例如量子点溶液或量子点共轭物溶液）在组合物中稀释并在4℃下储存。在某些实施方案中，稀释的荧光颗粒的荧光强度保持基本相同，当在4℃下储存至少一个月或至少三个月。在具体实施方案中，使用稀释的量子点缀合物来检测杂交的探针或蛋白质抗原。

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