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1. 发明授权

US11531031B2 Single use tubing set for making genetically modified donor cells for reinfusion into a patient 有权
公开(公告)号：US11531031B2
公开(公告)日：2022-12-20
申请号：US17725509
申请日：2022-04-20
申请人： MILTENYI BIOTEC B.V. & CO. KG
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

2. 发明申请

US20210276019A1 MAGNETIC DRUM SEPARATOR 有权
公开(公告)号：US20210276019A1
公开(公告)日：2021-09-09
申请号：US16900239
申请日：2020-06-12
申请人： Shujun ZHANG
发明人： Shujun ZHANG
IPC分类号： B03C1/247 , B03C1/03 , B03C1/032 , B03C1/034
摘要： A magnetic drum separator comprises a drum rotatable about an axis, the drum comprising an internal chamber and an opening at an end of the drum providing access into the internal chamber. The magnetic drum separator also comprises an inlet for supplying a liquid or granular substance into the internal chamber through the opening, a magnet outside of the drum for attracting magnetic material in the liquid or granular substance towards an internal sidewall of the internal chamber, a collection device for recovering magnetic material attracted to the internal sidewall and an annular seal member attached to the end of the drum that rotates with the drum in use. A baffle that bears against the annular seal member partially seals the opening. A plurality of cavities formed in the annular seal member receive fluid leaking into a boundary between the annular seal member and the baffle.

3. 发明授权

US10788503B2 Methods and apparatus for bead manipulation in a tip of a liquid handler 有权
公开(公告)号：US10788503B2
公开(公告)日：2020-09-29
申请号：US15463432
申请日：2017-03-20
申请人： Andrew Alliance S.A.
发明人： Giorgio Horak
IPC分类号： G01N35/00 , B01L3/02 , B03C1/28 , B03C1/30 , B03C1/01 , B03C1/03 , C12N15/10 , G01N35/10 , B03C1/032 , B03C1/033
摘要： The present invention is directed towards an apparatus and methods for a precise, fast and easy to use manipulation of beads. This method is particularly useful to carry out separation between the beads and the remaining supernants present in the fluid, maximizing the collection and purification efficiencies in tips for liquid handling.

4. 发明授权

US10370271B2 Column thickener and a process thereof for dewatering of iron ore slurry 有权
公开(公告)号：US10370271B2
公开(公告)日：2019-08-06
申请号：US15552641
申请日：2016-02-23
申请人： Council of Scientific and Industrial Research
发明人： Alok Tripathy , Surendra Kumar Biswal , Ashok Kumar Sahu
IPC分类号： B03C1/01 , B03C1/28 , B03C1/32 , C02F1/48 , C02F1/52 , C22B1/00 , B03C1/032 , B03C1/033 , C02F11/12 , C02F11/14 , C02F101/20 , C02F103/10
摘要： The present invention is related to a high aspect ratio column thickener and a process thereof useful for dewatering of iron ore tailings. The column thickener has been developed with multiple feed inlet points and an auxiliary inlet point for water to clear the jam of high concentration slurry, if required. The column also consists of a conical portion at the bottom. Magnetic field has been applied using induced magnetic coil just above the conical portion of column thickener. Iron ore tailings slurry is fed into the column thickener and particles are allowed to settle in axial direction with and without the application of magnetic field.

5. 发明授权

US10046334B2 Magnetic separation of electrochemical cell materials 有权
公开(公告)号：US10046334B2
公开(公告)日：2018-08-14
申请号：US14879238
申请日：2015-10-09
申请人： RSR Technologies, Inc.
发明人： Timothy W. Ellis , Joshua A. Montenegro
IPC分类号： B03C1/00 , B03C1/28 , B07B1/46 , B03C1/32 , H01M10/54 , B03C1/032 , B03C1/033 , B03C1/034
CPC分类号： B03C1/286 , B03C1/032 , B03C1/0335 , B03C1/034 , B03C1/32 , B03C2201/18 , B07B1/46 , B07B1/4609 , B07B1/4645 , H01M10/54 , Y02W30/84
摘要： A process and system for the separation of materials from electrochemical cells is disclosed. Electrode materials are removed from electrochemical cells and separated into constituent active materials using magnetic separation.

6. 发明授权

US09649639B2 Separation apparatus and methods of separating magnetic material 有权
公开(公告)号：US09649639B2
公开(公告)日：2017-05-16
申请号：US13754139
申请日：2013-01-30
申请人： Bassam El-Fahmawi
发明人： Bassam El-Fahmawi
IPC分类号： B03B9/00 , B03C1/02 , B03C1/032 , B03C1/28 , B01L9/00
CPC分类号： B03C1/02 , B01L9/50 , B01L9/52 , B03C1/032 , B03C1/286 , B03C2201/18 , E05Y2600/502
摘要： A separation apparatus comprises a base defining a mounting surface with a length and a width. The separation apparatus further includes a pair of clamps configured for toolless operation. The pair of clamps are spaced apart from one another along the length of the mounting surface and configured to inhibit a movement of the sample plate relative to the mounting surface. In further examples, methods of separating a magnetic material within containment areas of a sample plate are provided including the step of clamping a first edge portion of the sample plate with the spring clip and clamping a second edge portion of the sample plate with a jaw mechanism. The method further includes the step of inverting the base together with the sample plate such that liquid drains from the containment areas while magnetic material remains in the containment areas under the influence of respective magnets.

7. 发明授权

US09227198B2 Method and apparatus for removing metal cuttings from an oil well drilling mud stream 有权
标题翻译：从油井钻井泥浆流中去除金属切屑的方法和装置
公开(公告)号：US09227198B2
公开(公告)日：2016-01-05
申请号：US14172121
申请日：2014-02-04
申请人： PETROLEUM SPECIALTY RENTAL, LLC
发明人： James A. Branch
IPC分类号： B03C1/02 , B03C1/032 , B03C1/28 , B03C1/30 , B01D35/06 , E21B21/06 , B03C3/74
CPC分类号： B03C1/02 , B01D35/06 , B03C1/032 , B03C1/286 , B03C1/30 , B03C3/743 , B03C2201/28 , E21B21/065
摘要： An improved method and apparatus for removing metal cuttings from an oil well drilling mud stream provides a magnetic body or “ditch magnet” having end plates that extend radially and circumferentially from the magnetic body, the plates being positioned at end portions of the magnetic body. A third plate in the form of a wiper is used to dislodge metal cuttings and other metallic material from the magnetic body after the magnetic body has accumulated such metallic parts. One of the end plates can be removable to facilitate a complete scraping or wiping of the metallic parts from the metallic body by the wiper plate.
摘要翻译：一种用于从油井钻井泥浆流中去除金属切屑的改进方法和装置提供了具有从磁体径向和周向延伸的端板的磁体或“沟槽磁体”，所述板位于磁体的端部。在磁体累积了这种金属部件之后，使用擦拭器形式的第三板用于将金属切屑和其它金属材料从磁性体中移出。其中一个端板可以是可去除的，以便于通过擦拭板从金属体完全刮擦或擦拭金属部件。

8. 发明授权

US5972721A Immunomagnetic assay system for clinical diagnosis and other purposes 失效
标题翻译：免疫磁性检测系统用于临床诊断等目的
公开(公告)号：US5972721A
公开(公告)日：1999-10-26
申请号：US816429
申请日：1997-03-14
申请人： John G. Bruno , Johnathan L. Kiel , John P. Kilian
发明人： John G. Bruno , Johnathan L. Kiel , John P. Kilian
IPC分类号： B03C1/01 , B03C1/032 , B03C1/033 , B03C1/034 , G01N33/533 , B03C1/00
CPC分类号： B03C1/032 , B03C1/01 , B03C1/0332 , B03C1/034 , Y10S436/824
摘要： An apparatus and method for immunomagnetic separation and concentration of target biological materials is disclosed. The immunomagnetic separation is performed by a magnetic flow cell, or filter block, as part of an automated mostly continuous immunomagnetic assay system. The magnetic flow cell has two bundles of ferromagnetic rods or pins positioned inside an internal chamber so that a fluid sample flowing through the flow cell passes through the pins. A pair of cobalt magnets flank the flow cell so that the pins concentrate and sufficiently increase the magnetic fields so that even nanometer size magnetic beads can be captured. The overall system combines a reaction subsystem for reacting coated magnetic beads with a sample, a collection subsystem for capturing magnetic beads, a rinsing subsystem for removing debris and a filtering subsystem for removing captured magnetic beads from the collection subsystem. The new magnetic flow filter is the key component for the collection and filtering subsystems.
摘要翻译：公开了一种用于免疫磁性分离和靶向生物材料浓缩的装置和方法。免疫磁性分离由磁流量池或过滤块进行，作为自动化大多数连续的免疫磁性测定系统的一部分。磁流量计具有两束位于内部室内的铁磁棒或销，使得流过流动池的流体样品通过销。在流动池侧面的一对钴磁体，使得引脚集中并充分增加磁场，使得可以捕获甚至纳米尺寸的磁珠。整个系统结合了用于使涂覆的磁珠与样品反应的反应子系统，用于捕获磁珠的收集子系统，用于去除碎屑的冲洗子系统和用于从收集子系统中去除捕获的磁珠的过滤子系统。新的磁流过滤器是收集和过滤子系统的关键组件。

9. 发明授权

US5876593A Magnetic immobilization and manipulation of biological entities 失效
标题翻译：磁固定和操纵生物实体
公开(公告)号：US5876593A
公开(公告)日：1999-03-02
申请号：US931067
申请日：1997-09-15
申请人： Paul A. Liberti , Yuzhou Wang
发明人： Paul A. Liberti , Yuzhou Wang
IPC分类号： B01D35/06 , B03C1/00 , B03C1/01 , B03C1/025 , B03C1/032 , B03C1/033 , B03C1/034 , B03C1/035 , B03C1/28 , C12M3/00 , G01N33/483 , G01N33/543 , G01N33/569 , G01N35/00 , G01N35/02
CPC分类号： B03C1/002 , B03C1/01 , B03C1/025 , B03C1/032 , B03C1/0332 , B03C1/034 , B03C1/035 , C12M47/04 , G01N33/54326 , G01N33/56972 , G01N35/026 , G01N2333/70589 , G01N35/0098 , Y10T436/108331 , Y10T436/25375
摘要： Biological entities such as cells, microbes, or components thereof are labeled with a magnetic colloid containing microscopic magnetic particles. The magnetic particles have a coating capable of biospecific or non-specific binding with the entities. An immobilization apparatus includes a non-magnetic vessel having a ferromagnetic collection structure for attracting the entities toward a collection surface upon which the magnetically labeled entities are immobilized subsequent to placement of the vessel on a support between two magnets. The ferromagnetic collection structure preferably has a sharp edge or high curvature for intensifying the magnetic field and for collecting the entities in a monolayer. The vessel includes an un-obstructed observation path so that immobilized entities may be observed and/or manipulated. The ferromagnetic collection structure may be arranged in various two dimensional patterns to provide a desired collection configuration. The apparatus may further have inlet and outlet ports for allowing a flow of liquid reagent through the vessel for washing or straining the immobilized entities. The support can be translated so that a shoulder on the collection structure concentrates the collected entities by movement of the shoulder in a transverse direction relative to the magnetic field.
摘要翻译： PCT No.PCT / US93 / 11087 Sec。 371日期1995年04月24日 102（e）1995年4月24日PCT PCT 1997年9月15日PCT公布。公开号WO94 / 11078 日期1994年5月26日生物实体如细胞，微生物或其组分用含有微观磁性颗粒的磁性胶体标记。磁性颗粒具有能够与实体进行生物特异性或非特异性结合的涂层。固定装置包括具有铁磁收集结构的非磁性容器，用于在将容器放置在两个磁体之间的支撑件上时，将实体吸引到收集表面，在该收集表面上磁性标记的实体被固定。铁磁收集结构优选地具有尖锐的边缘或高曲率，用于增强磁场和用于在单层中收集实体。容器包括未阻挡的观察路径，使得可以观察和/或操纵固定的实体。铁磁收集结构可以以各种二维图案布置以提供期望的收集配置。该装置还可以具有用于允许液体试剂流过容器的入口和出口，用于洗涤或使固定的实体变窄。支撑件可以平移，使得收集结构上的肩部通过肩部相对于磁场的横向方向的移动来集中收集的实体。

10. 发明授权

US4784758A Process for removing magnetic particles from a suspension of solids in a liquid 失效
标题翻译：从液体中的固体悬浮液中除去磁性颗粒的方法
公开(公告)号：US4784758A
公开(公告)日：1988-11-15
申请号：US900666
申请日：1986-08-27
申请人： Mitchell J. Willis
发明人： Mitchell J. Willis
IPC分类号： B03C1/00 , B01D35/06 , B03C1/025 , B03C1/032 , B03C1/02
CPC分类号： B03C1/032
摘要： A process which is especially useful for effecting magnetic separation of magnetically attractable impurities from an aqueous clay slurry or suspension includes passing the suspension through a porous, ferromagnetic matrix while applying a magnetic field to the matrix, on which impurities are collected, and thereafter regenerating the matrix by flushing collected impurities therefrom with a flush liquid, e.g., water. The improvement comprises, after discontinuing the passage of the suspension through the matrix, but before passing flush liquid therethrough, admitting a pressurized gas, e.g., compressed air, into the separator to displace suspension retained therein, and recovering the displaced suspension. In addition, flush liquid retained in the matrix after the flushing step may be displaced therefrom by the compressed air. By displacing the retained suspension from the matrix with, e.g., compressed air, instead of a flush liquid, e.g., water, the retained suspension is not diluted by flush water and is recovered instead of sewered as in the prior art processes.
摘要翻译：特别可用于从含水粘土浆液或悬浮液中磁性吸引杂质的磁分离的方法包括使悬浮液通过多孔铁磁性基质，同时向收集杂质的基质施加磁场，然后再生通过用冲洗液（例如水）冲洗其中收集的杂质，从而形成基质。改进之处在于，在使悬浮液通过基质之后，但在使冲洗液体从其中通过之前，将加压气体例如压缩空气导入分离器中以置换保留在其中的悬浮液，并回收所述置换的悬浮液。此外，在冲洗步骤之后保留在基体中的冲洗液体可能被压缩空气从其中移位。通过用例如压缩空气将保留的悬浮液从基质中置换而不是冲洗液体例如水，保留的悬浮液不会被冲洗水稀释，并且如现有技术方法那样被回收而不是下水。

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