专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09994527B2 Modified amino acids 有权
公开(公告)号：US09994527B2
公开(公告)日：2018-06-12
申请号：US15604106
申请日：2017-05-24
申请人： Sutro Biopharma, Inc.
发明人： Ryan Stafford , Christopher D. Thanos , Wenjin Yang
IPC分类号： C07C271/20 , C07D213/55 , C07C275/14 , C07K14/00 , C07C247/00 , C07K16/00 , C07C247/04
CPC分类号： C07D213/55 , C07C247/04 , C07C271/20 , C07C275/14 , C07K14/00 , C07K16/00
摘要： Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.

2. 发明授权

US09347948B2 Phenyl glyoxal probes 有权
标题翻译：苯乙二醛探针
公开(公告)号：US09347948B2
公开(公告)日：2016-05-24
申请号：US14405467
申请日：2013-06-04
申请人： The Scripps Research Institute
发明人： Paul R. Thompson , Kevin L. Bicker , Venkataraman Subramanian
IPC分类号： C07C45/00 , C07C49/00 , C07C247/00 , C07D311/00 , C07D495/00 , C07B59/00 , G01N33/68 , C12Q1/34 , G01N33/532 , C07C49/86 , C07C247/04 , C07C45/61 , C07D311/86 , C07D311/90 , C07D495/04 , G01N33/58 , G01N33/92
CPC分类号： G01N33/581 , C07B59/00 , C07B2200/05 , C07C45/61 , C07C49/86 , C07C247/04 , C07D311/86 , C07D311/90 , C07D493/10 , C07D495/04 , C12Q1/34 , G01N33/532 , G01N33/582 , G01N33/583 , G01N33/68 , G01N33/6803 , G01N33/6893 , G01N33/92 , G01N2333/775 , G01N2333/978 , G01N2440/18 , G01N2458/15 , G01N2500/00 , G01N2570/00
摘要： Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described.
摘要翻译：提供了新的苯基乙二醛基抗瓜氨酸探针和合成方法。使用方法，例如开发用于随时间监测底物瓜氨酸化的方法; 用于鉴定来自细胞的瓜氨酸化蛋白质。

3. 发明授权

US08946302B2 Selective sigma-1 receptor ligands 有权
标题翻译：选择性σ-1受体配体
公开(公告)号：US08946302B2
公开(公告)日：2015-02-03
申请号：US13707418
申请日：2012-12-06
申请人： Wisconsin Alumni Research Foundation
发明人： Arnold E. Ruoho , Abdol R. Hajipour , Uyen B. Chu , Dominique A. Fontanilla
IPC分类号： A01N33/02 , A61K31/135 , A01N33/26 , A61K31/655 , C07C247/00 , C07J41/00 , C07C211/00 , C12N5/00 , C12N5/02 , C07C247/16 , C07C211/27 , C07C211/29 , C07C211/49
CPC分类号： C07C247/16 , C07C211/27 , C07C211/29 , C07C211/49
摘要： The invention provides compounds of the formulas described herein and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.
摘要翻译：本发明提供了本文所述的化合物及其组合物。本发明还提供了使用化合物和组合物的方法。本发明的化合物可以提供与哺乳动物中σ-1受体的高亲和力结合。该化合物可显示σ-2受体超过σ-2受体的选择性。本发明的化合物和组合物还可用于治疗涉及σ-1受体的病症，例如成瘾，心血管病症和癌症，例如乳腺癌，肺癌，前列腺癌，卵巢癌，结肠直肠癌或中枢神经系统

4. 发明授权

US08669367B2 Method for producing 2-azaadamantane 有权
标题翻译： 2-氮杂金刚烷的制备方法
公开(公告)号：US08669367B2
公开(公告)日：2014-03-11
申请号：US13585592
申请日：2012-08-14
申请人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
发明人： Toshimasa Hamada , Noriaki Nagahama , Masami Kozawa , Yoshiharu Iwabuchi , Masatoshi Shibuya , Masaki Tomizawa , Yusuke Sasano
IPC分类号： C07D451/14 , C07C61/29 , C07C211/41 , C07C247/00 , C07C271/24
CPC分类号： C07D451/14
摘要： To provide a method whereby a 2-azaadamantane can easily be obtained in good yield.A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound represented by the following formula (2) in the presence of an acid.
摘要翻译：提供可以容易地以良好的产率获得2-氮杂金刚烷的方法。一种制备由式（1）表示的2-氮杂金刚烷的方法，其包括在酸存在下环化下式（2）表示的化合物。

5. 发明授权

US08076496B2 Chemoselective ligation 有权
公开(公告)号：US08076496B2
公开(公告)日：2011-12-13
申请号：US13043274
申请日：2011-03-08
申请人： Eliana Saxon , Carolyn Ruth Bertozzi
发明人： Eliana Saxon , Carolyn Ruth Bertozzi
IPC分类号： C07C247/00 , C07C233/00 , G01N33/53
CPC分类号： C07K1/1077 , C07F9/5022 , C07F9/6506 , C07F9/65522 , C07F9/6561 , C07H7/02 , C07H13/00 , C07H15/203 , C07H15/26 , C07K1/023 , C07K1/04 , C07K1/1075
摘要： The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

6. 发明授权

US06861456B2 Photosensitive compound, photosensitive resin, and photosensitive composition 有权
标题翻译：感光性化合物，感光性树脂和感光性组合物
公开(公告)号：US06861456B2
公开(公告)日：2005-03-01
申请号：US10400844
申请日：2003-03-27
申请人： Toru Shibuya , Masanori Kurihara , Mineko Takeda , Kazuo Yamada
发明人： Toru Shibuya , Masanori Kurihara , Mineko Takeda , Kazuo Yamada
IPC分类号： C07C247/18 , C07D213/40 , C07D213/56 , C07D233/61 , C08F2/46 , C08F8/00 , C08F8/30 , G03F7/00 , G03F7/008 , G03F7/012 , C07C247/00
CPC分类号： G03F7/012 , C07C247/18 , C08F8/30 , C08F8/48 , G03F7/0007 , G03F7/008 , C08F16/06
摘要： The present invention provides a novel photosensitive compound having an azido group suitable for exposure to light of a short wavelength; a photosensitive resin containing the photosensitive compound; and a photosensitive composition containing the photosensitive compound or photosensitive resin. The photosensitive compound containing a photosensitive unit represented by formula (1): wherein R is selected from among the following groups, R: X is selected from among the following groups, X: and each of Y and Z represents a hydrogen atom, an alkyl group, an acetal-group-containing alkyl group, an aryl group, an aralkyl group, or a substituent containing a base-forming nitrogen atom, wherein at least one of R and X contains an azido group.
摘要翻译：本发明提供了具有适合暴露于短波长的光的叠氮基的新型光敏化合物; 含有感光性化合物的感光性树脂; 和含有感光性化合物或感光性树脂的感光性组合物。含有式（1）表示的光敏单元的光敏化合物：其中R选自下列基团，R：X选自下列基团X：Y和Z各自表示氢原子，烷基基团，含缩醛基的烷基，芳基，芳烷基或含有形成碱的氮原子的取代基，其中R和X中的至少一个含有叠氮基。

7. 发明授权

US08816001B2 Genetically encoded initiator for polymer growth from proteins 有权
标题翻译：用于聚合物从蛋白质生长的基因编码引发剂
公开(公告)号：US08816001B2
公开(公告)日：2014-08-26
申请号：US13788710
申请日：2013-03-07
申请人： Franklin and Marshall College
发明人： Ryan A. Mehl , Krzysztof Matyjaszewski , Saadyah Averick
IPC分类号： A61K47/48 , C07C229/00 , C07C69/00 , C07C69/63 , C07C247/00 , C07K1/00
CPC分类号： C12P21/00 , C07C229/36 , C07C231/14 , C07C233/54 , C07C233/81 , C07C247/10 , C07C247/12 , C07K14/001 , C07K14/43595 , C08F289/00 , C08F2438/01 , C12P21/02
摘要： This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2′-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1). Purified GFP-1 was then used as an initiator under standard ATRP conditions with oligo(ethylene oxide)monomethyl ether methacrylate, efficiently producing a polymer-GFP bioconjugate wherein the polymer is connected at a specifically selected site on GFP.
摘要翻译：本发明涉及用于制备在限定位点含有聚合物引发剂的均质重组蛋白的方法。设计并合成式1的非天然氨基酸4-（2'-溴异丁酰胺基）苯丙氨酸作为包含进一步包含原子转移自由基聚合引发剂（“ATRP”）的官能团的分子，其另外将提供蛋白质与生长聚合物之间的稳定连接。我们进化了一种甲烷球菌（Mj）酪氨酰-tRNA合成酶/ tRNACUA对以响应于琥珀密码子遗传编码该非天然氨基酸。为了证明这种功能性氨基酸的实用性，我们用表面特异性引入（GFP-1）的式1的非天然氨基酸引发剂制备了绿色荧光蛋白。然后将纯化的GFP-1用作标准ATRP条件下的引发剂，用寡聚（环氧乙烷）单甲醚甲基丙烯酸酯作为引发剂，有效生产聚合物-GFP生物缀合物，其中聚合物连接在GFP的特定选择位点。

8. 发明授权

US08367315B2 Inactivation of reverse transcriptases by azido-diarylpyrimidines 有权
标题翻译：通过叠氮基 - 二芳基嘧啶灭活逆转录酶
公开(公告)号：US08367315B2
公开(公告)日：2013-02-05
申请号：US12718726
申请日：2010-03-05
申请人： Adan Rios
发明人： Adan Rios
IPC分类号： A61K39/21 , C07C247/00 , C07J41/00
CPC分类号： A61K31/505 , A61K9/0019 , A61K41/0019 , C07D239/48
摘要： Azido-diarylpyrimidine (azido-DAPY) compounds, and compositions containing such compounds, are provided. In addition, methods of using azido-diarylpyrimidines to inactivate reverse transcriptases, prepare inactivated viruses, and treat or prevent viral infections are also provided.
摘要翻译：提供叠氮基 - 二芳基嘧啶（叠氮基-DAPY）化合物和含有这些化合物的组合物。此外，还提供了使用叠氮基 - 二芳基嘧啶灭活逆转录酶，制备灭活病毒以及治疗或预防病毒感染的方法。

9. 发明授权

US08163943B2 Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing α-keto amide compound using them 失效
标题翻译：环氧甲酰胺化合物，叠氮化合物和氨基醇化合物，以及使用它们制备α-酮酰胺化合物的方法
公开(公告)号：US08163943B2
公开(公告)日：2012-04-24
申请号：US11981120
申请日：2007-10-31
申请人： Nobuo Kobayashi , Tsuneo Koji , Takashi Fujita , Tomofumi Nishimura , Akihiko Hosoda
发明人： Nobuo Kobayashi , Tsuneo Koji , Takashi Fujita , Tomofumi Nishimura , Akihiko Hosoda
IPC分类号： C07C247/00 , C07C261/00 , C07C69/00 , C07D317/44 , C07D223/12 , C07D223/04
CPC分类号： C07D295/215 , C07C231/12 , C07C231/16 , C07C237/22 , C07C247/12 , C07C271/22 , C07C2601/14 , C07D207/16 , C07D295/18 , C07D303/46 , C07D303/48 , C07D317/66 , C07D405/12 , C07D407/12 , C07D413/12
摘要： The present invention is to provide manufacturing intermediates which can be led to useful α-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: wherein R1 and R2 each represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R3 represents alkyl group, alkenyl group, aromatic hydrocarbon group, heterocyclic group, R6—O— or R7—N(R8)—; where R6 represents alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group; R7 and R8 each represents hydrogen atom, alkyl group, alkenyl group, aromatic hydrocarbon group or heterocyclic group, and, R4 and R5 represent the same groups as R7 and R8, respectively, and R4 and R5 optionally form a ring together; and X represents —O— or —N(R9)—, where R9 represents hydrogen atom or alkyl group, and X optionally forms a ring together with R4 or R5, and processes for preparing α-keto amide compound using the same.
摘要翻译：本发明提供制造中间体，其可以经济地和立体选择性地引入具有蛋白酶抑制活性的有用的α-酮酰胺化合物，并提供由下式表示的环氧羧酰胺化合物，叠氮化合物和氨基醇化合物：其中R1和R2 各自表示烷基，烯基，芳族烃基或杂环基; R3代表烷基，烯基，芳族烃基，杂环基，R6-O-或R7-N（R8） - ; 其中R 6表示烷基，烯基，芳族烃基或杂环基; R 7和R 8各自表示氢原子，烷基，烯基，芳族烃基或杂环基，R 4和R 5分别表示与R 7和R 8相同的基团，R 4和R 5任选地形成环; 并且X表示-O-或-N（R 9） - ，其中R 9表示氢原子或烷基，X任选地与R 4或R 5一起形成环，以及使用其制备α-酮酰胺化合物的方法。

10. 发明申请

US20070249014A1 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS 审中-公开
标题翻译：翻译后检测翻译后修饰蛋白
公开(公告)号：US20070249014A1
公开(公告)日：2007-10-25
申请号：US11674140
申请日：2007-02-12
申请人： Brian AGNEW , Kyle GEE , Tamara NYBERG
发明人： Brian AGNEW , Kyle GEE , Tamara NYBERG
IPC分类号： C12P21/00 , C07C247/00 , C07K14/435 , G01N33/68 , C12N9/10
CPC分类号： C12P21/005 , A61K47/549 , C07K1/13 , C07K14/47 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12Y302/01096 , G01N33/5005 , G01N33/5008 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/581 , G01N33/582 , G01N33/583 , Y10T436/17
摘要： Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.
摘要翻译：在某些实施方案中提供了形成报道分子，载体分子或固体支持物的叠氮基改性的生物分子缀合物的新方法。在其它实施方案中提供了用叠氮化物基团对生物分子进行酶标记的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式