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1. 发明授权

US09981997B2 Chemical reagents for attaching affinity molecules on surfaces 有权
公开(公告)号：US09981997B2
公开(公告)日：2018-05-29
申请号：US15033004
申请日：2014-10-28
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： Peiming Zhang , Subhadip Senapati , Saikat Manna
IPC分类号： C07C317/00 , C07C247/04 , C07F7/18 , C07F7/10 , C07C315/00 , C07C317/28 , C07F7/04 , C07K5/12 , C12N15/115 , G01Q70/18 , G01Q60/42
CPC分类号： C07F7/1804 , C07C315/00 , C07C317/28 , C07F7/045 , C07F7/10 , C07F7/1876 , C07K5/126 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2310/3517 , G01Q60/42 , G01Q70/18
摘要： Chemical linkage reagents, methods of making and method of using the same are provided. Chemical linkage reagents according to at least some of the embodiments of the present disclosure may be incorporated into or operatively-linked with affinity molecules for attachment to silicon oxide surfaces to, for example, measure interactions between an affinity molecule and its targeting biomolecules.

2. 发明授权

US09725410B2 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 有权
公开(公告)号：US09725410B2
公开(公告)日：2017-08-08
申请号：US15286145
申请日：2016-10-05
申请人： Cardioxyl Pharmaceuticals, Inc. , The Johns Hopkins University
发明人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
IPC分类号： C07C311/00 , C07C317/00 , C07C323/00 , C07D213/74 , C07D231/00 , C07D261/00 , A61K31/00 , C07C311/48 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D333/62 , C07C317/14 , C07C323/67 , C07D309/12 , C07D317/14 , C07D231/18 , C07D333/34
CPC分类号： C07C311/48 , C07C317/14 , C07C323/67 , C07D213/74 , C07D231/18 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D309/12 , C07D317/14 , C07D333/34 , C07D333/62
摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

3. 发明授权

US09365471B2 Substituted phenylsulfur trifluoride and other like fluorinating agents 有权
公开(公告)号：US09365471B2
公开(公告)日：2016-06-14
申请号：US14213494
申请日：2014-03-14
申请人： UBE INDUSTRIES, LTD.
发明人： Teruo Umemoto
IPC分类号： C07C315/00 , C07C319/00 , C07C317/00 , C07C331/00 , C07C381/00 , C07C321/00 , C07C323/00 , C09B49/00 , C09B59/00 , C07C17/18 , C07B39/00 , C07C319/14 , C07C319/20 , C07C323/19 , C07C17/093 , C07C17/16 , C07C17/361 , C07C45/65 , C07C51/60
CPC分类号： C07C17/18 , C07B39/00 , C07C17/093 , C07C17/16 , C07C17/361 , C07C45/65 , C07C51/60 , C07C319/14 , C07C319/20 , C07C323/19 , C07C381/00 , C07C2601/14 , C07C19/08 , C07C22/08 , C07C23/10 , C07C323/03 , C07C63/10 , C07C63/04
摘要： Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.

4. 发明授权

US08748445B2 Methods for treating glioma 失效
标题翻译：治疗胶质瘤的方法
公开(公告)号：US08748445B2
公开(公告)日：2014-06-10
申请号：US11791588
申请日：2005-10-27
申请人： W. Joon Chung , Harald Sontheimer
发明人： W. Joon Chung , Harald Sontheimer
IPC分类号： A01N43/54 , A61K31/505 , A01N43/40 , A61K31/44 , A01N41/10 , A61K31/10 , C07D239/02 , C07D213/72 , C07D211/72 , C07D211/84 , C07C315/00 , C07C317/00
CPC分类号： G01N33/566 , A61K31/00 , A61K31/63
摘要： The present disclosure provides for method of treatment and/or prevention of disease states that require cystine for maintenance or progression of the disease state. In addition, methods for screening and identifying novel therapeutic agents useful in the treatment of such disease states are described. In one embodiment, the disease state is a cancer, such as, but not limited to, glioma. In this embodiment, methods for the treatment and prevention of glioma by inhibiting cystine uptake or decreasing intracellular cystine concentrations are provided. The present disclosure teaches that glioma cells are dependent on system Xc for cystine uptake. Pharmacological inhibition of system Xc causes a rapid depletion of intracellular glutathione, resulting in decreased cell growth. In contrast, non-malignant astrocytes and cortical neurons remain viable in the presence of Xc inhibitors and continue to take up cystine via alternate amino acid transporters.
摘要翻译：本公开提供了治疗和/或预防需要胱氨酸以维持或发展疾病状态的疾病状态的方法。此外，描述了筛选和鉴定用于治疗这种疾病状态的新型治疗剂的方法。在一个实施方案中，疾病状态是癌症，例如但不限于神经胶质瘤。在该实施方案中，提供了通过抑制胱氨酸摄取或减少细胞内胱氨酸浓度来治疗和预防神经胶质瘤的方法。本公开内容教导了神经胶质瘤细胞依赖于系统Xc用于胱氨酸摄取。系统Xc的药理学抑制导致细胞内谷胱甘肽的快速消耗，导致细胞生长减少。相比之下，非恶性星形胶质细胞和皮层神经元在Xc抑制剂存在下保持存活，并通过替代氨基酸转运体继续摄取胱氨酸。

5. 发明授权

US08741956B2 Treatment of pain with topical diclofenac 有权
标题翻译：用局部双氯芬酸治疗疼痛
公开(公告)号：US08741956B2
公开(公告)日：2014-06-03
申请号：US13668061
申请日：2012-11-02
申请人： Nuvo Research Inc.
发明人： Jagat Singh , Joseph Zev Shainhouse , Bradley S. Galer , Robert Dominic King-Smith , Lisa Marie Grierson , Maria Burian , Jonathan Wilkin , Edward Kisak , John M. Newsam
IPC分类号： A01N37/10 , A61K31/19 , A01N41/10 , C07C63/04 , C07C315/00 , C07C317/00
CPC分类号： A61K31/196 , A61K8/35 , A61K8/36 , A61K8/361 , A61K8/42 , A61K9/0014 , A61K31/10 , A61K45/06 , A61K47/10 , A61K47/20 , A61K47/38 , A61Q17/02 , A61Q17/04 , A61K2300/00
摘要： The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.
摘要翻译：该领域涉及可用于缓解疼痛的组合物，包括双氯芬酸溶液和凝胶制剂，特别是其使用方法，制品和试剂盒，其向用户提供临床前，临床和其他信息。

6. 发明授权

US08614357B2 Oligomeric derivatives of spirobifluorene, their preparation and use 有权
标题翻译：螺二芴的低聚衍生物，其制备和用途
公开(公告)号：US08614357B2
公开(公告)日：2013-12-24
申请号：US11632337
申请日：2005-07-15
申请人： Liliana Bagala'Rampazzo , Giulia Fioravanti , Leonardo Mattiello
发明人： Liliana Bagala'Rampazzo , Giulia Fioravanti , Leonardo Mattiello
IPC分类号： C07C49/00 , C07C315/00 , C07C317/00 , C07C319/00 , C07C331/00 , C07C381/00 , H01L29/08 , H01L35/24 , H01L51/00
CPC分类号： C07C13/72 , C07C13/62 , C07C2603/18 , C09B5/62 , C09B23/105 , C09B57/00 , C09B69/109 , C09K11/06 , C09K2211/1011 , H01L51/0058 , H01L51/5012 , H01L51/5016 , H01L51/5048 , H05B33/14 , Y02E10/549 , Y10S428/917
摘要： SBF derivatives, represented with the following formula: SBF-X wherein: with m=0, 1, 2 or 3; p=positive integer,; n=positive integer; L: is the same or different and independently represents C, PR, AsR, SbR, BiR, S, Se, Te, S═Y, Se═Y or Te═Y; Y: is the same or different and independently represents O, S, Se or Te; K: is the same or different and independently represents a chemical bond or a group selected from O, S, BR(2−p), N, NR(2−p), R(2−p)P═O, B3O3, (PR)3N3, CR(3−p), CR(3−p)(C6H4)(p+1), SiR(3−p)(C6H4)(p+1) alkyne, substituted alkyne, alkyne, substituted alkyne, aromatic or R substituted aromatic, heteroaromatic-or a combination of two, three or four of the above mentioned groups; SBF: spiro-compound of formula (I): R, A, B, C, D: is the same or different and independently represents H, deuterium, F, Cl, Br, I, CN, a linear, branched or cyclic alkyl, alkoxy or thioalkoxy chain, or a combination from two, three or four of these systems; two or more substituents R can form a further monocyclic or polycyclic aliphatic or aromatic ring system with each other.
摘要翻译： SBF衍生物，用下式表示：SBF-X其中：m = 0,1,2或3; p =正整数 n =正整数; L：相同或不同，独立地表示C，PR，AsR，SbR，BiR，S，Se，Te，S = Y，Se = Y或Te = Y; Y：相同或不同，独立地表示O，S，Se或Te; K：相同或不同，独立地表示化学键或选自O，S，BR（2-p），N，NR（2-p），R（2-p）P = O，（PR）3N3，CR（3-p），CR（3-p）（C6H4）（p + 1），SiR（3-p）（C6H4）（p + 1）炔，取代炔，炔，取代炔，芳族或R取代的芳族，杂芳族或两个，三个或四个上述基团的组合; SBF：式（I）的螺 - 化合物：R，A，B，C，D：相同或不同，独立地表示H，氘，F，Cl，Br，I，CN，直链，支链或环状烷基，烷氧基或硫代烷氧基链，或这些系统中的两个，三个或四个的组合; 两个或更多个取代基R可以彼此形成另外的单环或多环脂族或芳环体系。

7. 发明授权

US08546450B1 Treatment of pain with topical diclofenac compounds 有权
公开(公告)号：US08546450B1
公开(公告)日：2013-10-01
申请号：US12459998
申请日：2009-07-10
申请人： Jagat Singh , Joseph Zev Shainhouse , Bradley S. Galer , Robert Dominic King-Smith , Lisa Marie Grierson , Maria Burian , Jonathan Wilkin , Edward T. Kisak , John M. Newsam
发明人： Jagat Singh , Joseph Zev Shainhouse , Bradley S. Galer , Robert Dominic King-Smith , Lisa Marie Grierson , Maria Burian , Jonathan Wilkin , Edward T. Kisak , John M. Newsam
IPC分类号： A01N37/10 , A01N41/10 , A61K31/19 , A61K31/10 , C07C63/04 , C07C315/00 , C07C317/00
CPC分类号： A61K31/196 , A61K45/06 , A61K2300/00
摘要： The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.

8. 发明授权

US08334410B2 Method for producing 3-mercaptoaniline compound 有权
标题翻译： 3-巯基苯胺化合物的制备方法
公开(公告)号：US08334410B2
公开(公告)日：2012-12-18
申请号：US12743389
申请日：2008-11-28
申请人： Kentaro Kawazoe
发明人： Kentaro Kawazoe
IPC分类号： C07C209/00 , C07C323/00 , C07C317/00
CPC分类号： C07C319/02 , C07C303/22 , C07C309/86 , C07C323/34
摘要： A method for producing a 3-mercaptoaniline compound, which is a known intermediate for a 3-(1H-1,2,4-triazol-1-yl)phenylsulfide derivative, useful as a pesticide, and a method for producing a compound which can be used as a starting material in producing the 3-mercaptoaniline compound are disclosed. In one embodiment the nitro group and the chlorosulfonyl group of a 3-nitrobenzenesulfonyl chloride compound represented by general formula (1): are reduced in the presence of an acid catalyst to produce a compound of general formula (2): In the above general formulas (1) and (2), R represents an alkyl group or a cyclic alkyl group, and X represents a halogen atom.
摘要翻译：作为可用作农药的3-（1H-1,2,4-三唑-1-基）苯硫醚衍生物的已知中间体的3-巯基苯胺化合物的制造方法及其制造方法可以用作生产3-巯基苯胺化合物的原料。在一个实施方案中，通式（1）表示的3-硝基苯磺酰氯化合物的硝基和氯磺酰基在酸催化剂的存在下还原，得到通式（2）的化合物：在上述通式（1）和（2）中，R表示烷基或环状烷基，X表示卤素原子。

9. 发明授权

US08017656B2 Organic sulfur compounds and use thereof 有权
标题翻译：有机硫化合物及其用途
公开(公告)号：US08017656B2
公开(公告)日：2011-09-13
申请号：US12094255
申请日：2006-11-01
申请人： Hiroyuki Miyazaki
发明人： Hiroyuki Miyazaki
IPC分类号： C07C325/00 , C07C315/00 , C07C317/00 , C07C331/00 , C07C17/00 , C09B49/00 , C09B59/00 , A01N33/08 , A01N37/18 , A61K31/13
CPC分类号： C07C317/44 , A01N37/36 , A01N41/10 , C07C323/52 , C07C323/60 , C07C327/42
摘要： A compound given by the formula (I): has an excellent controlling activity against noxious arthropods.
摘要翻译：由式（I）给出的化合物：对有害节肢动物具有优异的控制活性。

10. 发明授权

US07947831B2 Sulfoxides or sulfones grafted onto polymers 失效
标题翻译：接枝到聚合物上的亚砜或砜
公开(公告)号：US07947831B2
公开(公告)日：2011-05-24
申请号：US11523441
申请日：2006-09-19
申请人： Hans-Rudolf Meier , Gerrit Knobloch , Pierre Rota-Graziosi , Samuel Evans , Paul Dubs , Michèle Gerster
发明人： Hans-Rudolf Meier , Gerrit Knobloch , Pierre Rota-Graziosi , Samuel Evans , Paul Dubs , Michèle Gerster
IPC分类号： C07C317/00 , C07C317/04 , C07C317/06 , C07C317/10 , C07C317/18 , C07C317/44
CPC分类号： C07D303/22 , C07C317/04 , C07C317/10 , C07C317/18 , C07C317/44 , C07C323/12 , C07C323/25 , C07C323/52 , C07C323/65 , C07C2601/14 , C07D303/16 , C07D405/12 , C07F7/1804 , C08C19/20 , C08C19/22 , C08K5/36
摘要： Polymers grafted with a compound of formula I, wherein the general symbols are as defined within, have outstanding stability against oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation.
摘要翻译：用式I化合物接枝的聚合物，其中通式如上所定义，具有优异的抗氧化，热，动态，光诱导和/或臭氧诱导的降解的稳定性。

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