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1. 发明授权

US09950273B2 Method of separation 有权
公开(公告)号：US09950273B2
公开(公告)日：2018-04-24
申请号：US13821658
申请日：2012-03-30
申请人： Masaaki Shinohata , Nobuhisa Miyake
发明人： Masaaki Shinohata , Nobuhisa Miyake
IPC分类号： B01D3/00 , C07C263/20 , C07C269/08 , C07C331/30
CPC分类号： B01D3/009 , C07C37/74 , C07C41/42 , C07C263/20 , C07C269/08 , C07C331/30 , C07C2601/14 , Y02P20/127 , C07C265/14 , C07C271/12 , C07C271/44
摘要： The present invention provides a separation method of separating (A) and (B), comprising: a step of separating at least either an active hydrogen-containing compound (A) or a compound (B) that reversibly reacts with (A) from a mixture containing (A) and (B) by distillation in a multistage distillation column; and a step of supplying the mixture to an inactive region formed within the multistage distillation column.

2. 发明申请

US20120214742A1 GABA RELEASE-REGULATING AGENT IN CEREBELLUM 有权
标题翻译： GABA释放调节剂在CEREBELLUM
公开(公告)号：US20120214742A1
公开(公告)日：2012-08-23
申请号：US13389981
申请日：2010-08-24
申请人： Changjoon Justin Lee , Soo-Jung Lee , Bo-Eun Yoon
发明人： Changjoon Justin Lee , Soo-Jung Lee , Bo-Eun Yoon
IPC分类号： A61K38/08 , A61K31/7105 , C07H21/04 , A61K48/00 , A61K38/17 , C07D213/80 , A61K31/44 , C07C229/66 , A61K31/196 , C07C331/30 , A61K31/26 , C07K7/18 , A61P25/28 , A61P25/08 , A61P25/00 , A61P25/32 , B01L3/00 , G01R27/28 , C07H21/02
CPC分类号： A61K31/00 , A61K31/185 , A61K31/196 , A61K31/455 , A61K31/7105 , A61K31/713 , A61K38/043 , A61K38/08 , G01N33/9426 , G01N2500/10
摘要： A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1(Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.
摘要翻译：小脑中的GABA（γ-氨基丁酸）释放抑制剂和用于治疗由小脑中的GABA过度释放引起的病理学症状的组合物，每种包含Bestrophin 1（Best1）通道抑制剂作为活性成分; 小脑中的GABA释放促进剂和用于治疗由小脑中的GABA缺乏引起的病理学症状的组合物，每种包含Best1通道激活剂作为活性成分; 并提供了使用Best1通道作为靶标筛选小脑中的GABA释放调节剂的方法。

3. 发明授权

US6120699A Storage stable methylene bis(phenylisocyanate) compositions 失效
公开(公告)号：US6120699A
公开(公告)日：2000-09-19
申请号：US157876
申请日：1998-09-21
申请人： Thirumurti Narayan , Anthony Lunato , Jon S. Speier , David D. Peters , Cynthia Loop , Filip Nevejans
发明人： Thirumurti Narayan , Anthony Lunato , Jon S. Speier , David D. Peters , Cynthia Loop , Filip Nevejans
IPC分类号： C08G18/76 , C07C265/14 , C07C331/30 , C08G18/10 , C08G18/72 , C08G18/79 , C08G18/14
CPC分类号： C08G18/797 , C07C265/14 , C08G18/10 , C08G18/725
摘要： The present invention provides a liquid methylene bis(phenylisocyanate) composition including a high concentration of methylene bis(phenylisocyanate) which has an improved storage stability. The invention further provides a method of making the liquid methylene bis(phenylisocyanate) compositions of the present invention.

4. 发明授权

US5494932A Sulfonic stilbene derivatives in the treatment of viral disease 失效
标题翻译：磺基苯乙烯衍生物治疗病毒性疾病
公开(公告)号：US5494932A
公开(公告)日：1996-02-27
申请号：US248851
申请日：1994-05-25
申请人： Alan D. Cardin , A. Stanley Tyms
发明人： Alan D. Cardin , A. Stanley Tyms
IPC分类号： A61K31/165 , A61K31/16 , A61K31/185 , A61K31/255 , A61K31/26 , A61K31/275 , A61P31/12 , A61P31/18 , A61P31/22 , C07C331/28 , C07C331/30 , A61K31/21
CPC分类号： C07C331/30 , A61K31/185 , A61K31/26 , A61K31/275 , C07C331/28
摘要： Sulfonic acid stilbenes block the infection of cells by HSV, and CMV and these compounds can be used to treat viral infection.
摘要翻译：磺酸二苯乙烯通过HSV阻断细胞感染，CMV和这些化合物可用于治疗病毒感染。

5. 发明授权

US3322810A Hindered isothiocyanates, and the method of preparing the same 失效
标题翻译：受阻异硫氰酸酯及其制备方法
公开(公告)号：US3322810A
公开(公告)日：1967-05-30
申请号：US31012163
申请日：1963-09-19
申请人： MONSANTO CO
发明人： OLIN JOHN F
IPC分类号： C07C331/30
CPC分类号： C07C331/30

6. 发明授权

US09586907B2 Isothiocyanate compounds, pharmaceutical compositions, and uses thereof 有权
标题翻译：异硫氰酸酯化合物，药物组合物及其用途
公开(公告)号：US09586907B2
公开(公告)日：2017-03-07
申请号：US14512884
申请日：2014-10-13
申请人： Rutgers, The State University of New Jersey
发明人： Arkady Mustaev , Natalia Kurepina
IPC分类号： A61K31/26 , C07C331/00 , A61K31/21 , C07D233/64 , C07C331/20 , C07C331/22 , C07C331/30 , C07C331/28 , C07D209/14 , C07D213/24
CPC分类号： C07D233/64 , C07C331/20 , C07C331/22 , C07C331/28 , C07C331/30 , C07C2603/20 , C07C2603/50 , C07C2603/74 , C07D209/14 , C07D213/24
摘要： Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.
摘要翻译：本文提供了用于抑制各种微生物病原体（包括细菌，真菌，原生动物和病毒病原体）的生长的物质及其药物组合物的组合物。本文还提供了用组合物治疗微生物疾病/感染和癌症的方法。通过抑制微生物生长，组合物另外可用于木材保存和食品保存。

7. 发明申请

US20150344613A1 POLYTHIOUREA COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：多羟基化合物的组合物和使用方法
公开(公告)号：US20150344613A1
公开(公告)日：2015-12-03
申请号：US14291124
申请日：2014-05-30
申请人： EMPIRE TECHNOLOGY DEVELOPMENT LLC
发明人： William Brenden CARLSON , Gregory D. PHELAN
IPC分类号： C08G18/76 , C07C331/30 , C08G18/18 , C08G18/08 , C09D175/02 , C08G18/38
CPC分类号： C08G18/14 , C07C331/30 , C07C335/08 , C07C335/14 , C07C335/16 , C07C2601/14 , C08G18/3228 , C08G18/3234 , C09D175/04
摘要： Disclosed herein are compositions and methods of making polythiourea and polythiourethane foams and coatings. In one embodiment, a method of preparing a polythiourea composition involves combining at least one polyamine compound, at least one polyisothiocyanate compound, and at least one catalyst to form a reaction mixture, and mixing the reaction mixture to form the polythiourea composition. In some embodiments, the polyamine compound may have an amine functionality of two or more, and is present in an amount of about 14 wt % to about 40 wt % of the reaction mixture. In some embodiments, the polyisothiocyanate compound may have a functionality of two or more, and is present in an amount of about 60 wt % to about 86 wt % of the reaction mixture. In some embodiments, the catalyst may be present in an amount of about 0 wt % to about 5 wt % of the reaction mixture.
摘要翻译：本文公开了制备聚硫脲和聚硫氨酯泡沫和涂料的组合物和方法。在一个实施方案中，制备聚硫脲组合物的方法包括将至少一种多胺化合物，至少一种多异硫氰酸酯化合物和至少一种催化剂混合以形成反应混合物，并将该反应混合物混合以形成聚硫脲组合物。在一些实施方案中，多胺化合物可以具有两个或更多个胺官能度，并且以反应混合物的约14重量％至约40重量％的量存在。在一些实施方案中，多异硫氰酸酯化合物可以具有两个或更多个的官能度，并且以反应混合物的约60重量％至约86重量％的量存在。在一些实施方案中，催化剂可以以反应混合物的约0重量％至约5重量％的量存在。

8. 发明申请

US20100312000A1 METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND HAVING CARBOXYL GROUP 有权
标题翻译：生产具有羧基的异硫氰酸酯化合物的方法
公开(公告)号：US20100312000A1
公开(公告)日：2010-12-09
申请号：US12867339
申请日：2009-02-27
申请人： Satoshi Nakano , Daisuke Saito
发明人： Satoshi Nakano , Daisuke Saito
IPC分类号： C07C331/30 , C07C331/28 , C07C331/24 , C07C331/20
CPC分类号： C07C331/20 , C07C331/24 , C07C331/28 , C07C331/30 , C07C2601/14
摘要： To provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) from the corresponding amino compound having a carboxyl group(s).A method for producing an isothiocyanate compound which has a carboxyl group(s) and is represented by the formula (2). And the method comprises reacting an amino compound which has a carboxyl group(s) and is represented by the formula (1) (wherein A is e.g. a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group, and B is e.g. a single bond, a C6-14 aromatic hydrocarbon group or a C1-12 saturated hydrocarbon group), in a solvent, with carbon disulfide (CS2) and then with a halogen as a simple substance.
摘要翻译：提供从具有羧基的相应氨基化合物制备具有羧基的异硫氰酸酯化合物的新方法。一种具有羧基并由式（2）表示的异硫氰酸酯化合物的制备方法。该方法包括使具有羧基的氨基化合物与由式（1）表示的氨基化合物反应（其中A为例如C 6-14芳族烃基或C 1-12饱和烃基，B为例如单键，C6-14芳族烃基或C1-12饱和烃基）在溶剂中与二硫化碳（CS2）反应，然后以卤素作为单一物质。

9. 发明授权

US4863940A N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof 失效
标题翻译： N-丙酮酰取代的酰胺及其植物病原性杀真菌用途
公开(公告)号：US4863940A
公开(公告)日：1989-09-05
申请号：US634917
申请日：1984-07-26
申请人： Ashok K. Sharma
发明人： Ashok K. Sharma
IPC分类号： A01N37/30 , A01N37/20 , A01N37/38 , A01N39/02 , A01N39/04 , A01N43/08 , A01N43/10 , A01N43/40 , A01N43/80 , C07C67/00 , C07C233/31 , C07C235/06 , C07C235/20 , C07C235/48 , C07C239/00 , C07C253/00 , C07C255/29 , C07C271/00 , C07C271/12 , C07C313/00 , C07C323/41 , C07C323/42 , C07C323/60 , C07C325/00 , C07C331/12 , C07C331/20 , C07C331/30 , C07C333/20 , C07D207/32 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D217/26 , C07D231/14 , C07D233/60 , C07D239/26 , C07D239/28 , C07D261/10 , C07D261/18 , C07D263/34 , C07D277/20 , C07D277/56 , C07D307/68 , C07D333/38 , C07D521/00
CPC分类号： C07D207/325 , A01N37/20 , A01N39/02 , A01N39/04 , A01N43/08 , A01N43/10 , A01N43/40 , A01N43/80 , C07D213/81 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/12 , C07D233/56 , C07D239/28 , C07D249/08 , C07D261/18 , C07D263/34 , C07D307/68 , C07D333/38
摘要： Certain N-acetonyl-substituted-amides of the formula: ##STR1## wherein A is a heterocycle, a phenylalkyl, a phenylalkoxy, naphthyl, cycloalkyl, alkoxyalkyl, alkyl, haloalkyl or alkenyl group; X, Y and Z are selected from the group consisting of hydrogen, halo, cyano, thiocyano, isothiocyano, methylsulfonyloxy, thio(C.sub.1 -C.sub.2) alkyl, (C.sub.1 -C.sub.2)alkoxy, carbamoyloxy, thiocarbamoylthio, hydroxy, azide, trifluoromethylcarboxy, (C.sub.1 -C.sub.4)alkylcarbonyloxy, phenylcarbonyloxy, phenoxy, thiophenyl, imidazolyl or triazolyl group as described herein; R.sup.1 and R.sup.2 are each independently a hydrogen atom or a (C.sub.1 -C.sub.6)alkyl group; and compositions containing these amides are fungicidally active, particularly against phytopathogenic fungi.
摘要翻译：某些具有下式的N-丙酰基取代的酰胺：其中A是杂环，苯基烷基，苯基烷氧基，萘基，环烷基，烷氧基烷基，烷基，卤代烷基或烯基; X，Y和Z选自氢，卤素，氰基，硫氰基，异硫氰基，甲基磺酰氧基，硫代（C1-C2）烷基，（C1-C2）烷氧基，氨基甲酰氧基，硫代氨基甲酰硫基，羟基，叠氮化物，三氟甲基羧基，（ C 1 -C 4）烷基羰基氧基，苯基羰基氧基，苯氧基，噻吩基，咪唑基或三唑基; R1和R2各自独立地为氢原子或（C1-C6）烷基; 并且含有这些酰胺的组合物是杀真菌活性的，特别是针对植物病原真菌。

10. 发明授权

US2263386A Isothiocyanates of aromatic ethers 失效
标题翻译：芳香醚的异硫氰酸酯
公开(公告)号：US2263386A
公开(公告)日：1941-11-18
申请号：US32604640
申请日：1940-03-26
申请人： ROHM & HAAS
发明人： HESTER WILLIAM F
IPC分类号： C07C331/28 , C07C331/30
CPC分类号： C07C331/30 , C07C331/28

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