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1. 发明授权

US09701607B2 Method for synthesising cyclohexenones and the use of same in the perfume industry 有权
公开(公告)号：US09701607B2
公开(公告)日：2017-07-11
申请号：US14432549
申请日：2013-09-24
申请人： V. MANE FILS
发明人： Jean-Jacques Chanot , Caroline Plessis
IPC分类号： A61K8/00 , A61K8/18 , C07C45/61 , C07C29/40 , C07C67/08 , C07C35/18 , C07C35/21 , C07C69/145 , C07C69/157 , C07C45/62 , C07C45/68 , C07C45/74 , C07C49/403 , C11B9/00 , C07C29/143 , C07C41/16 , C07C43/188 , C07C49/603 , C07C49/613 , C07C49/653
CPC分类号： C07C45/61 , C07C29/143 , C07C29/40 , C07C35/18 , C07C35/21 , C07C41/16 , C07C43/188 , C07C45/62 , C07C45/68 , C07C45/74 , C07C49/403 , C07C49/603 , C07C49/613 , C07C49/653 , C07C67/08 , C07C69/145 , C07C69/157 , C07C2101/08 , C07C2101/10 , C07C2101/14 , C07C2101/16 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C11B9/0034 , C07C49/683 , C07C49/647 , C07C35/08 , C07C69/14
摘要： The present invention concerns a method for synthesizing cyclohexenone and cyclohexenol compounds having specific fragrances and remanence properties, said method consisting in condensing a ketone on an α-methylene-aldehyde in order to obtain, by means of a domino reaction, compounds of formula (I).

2. 发明授权

US09409931B1 3-O-acyl-ingenol analogues 有权
标题翻译： 3-O-酰基 - 烯醇类似物
公开(公告)号：US09409931B1
公开(公告)日：2016-08-09
申请号：US14739731
申请日：2015-06-15
申请人： LEO LABORATORIES LIMITED
发明人： Phillippe S. Baran , Jakob Felding , Yehua Jin , Chien-Hung Yeh
IPC分类号： C07C69/75 , A61K31/215 , A61K31/695 , C07F7/08
CPC分类号： A61K31/695 , A61K45/06 , C07C49/653 , C07C49/727 , C07C69/75 , C07C2601/14 , C07C2603/86 , C07F7/1804
摘要： The present invention relates to a compound according to formula I wherein R1 represents hydrogen, R2 represents hydroxyl and R3 represents hydroxyl; or R1 represents methyl, R2 represents hydroxyl and R3 represents hydrogen; or R1 represents methyl, R2 represents hydrogen and R3 represents hydroxyl; or R1 represents methyl, R2 represents hydrogen and R3 represents hydrogen; or pharmaceutically acceptable hydrates or solvates thereof. The invention further relates to said compounds for use as a medicament, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds and to intermediates for the preparation of said compounds.
摘要翻译：本发明涉及式Ⅰ化合物，其中R1代表氢，R2代表羟基，R3代表羟基; 或R 1表示甲基，R 2表示羟基，R 3表示氢; 或R 1表示甲基，R 2表示氢，R 3表示羟基; 或R 1表示甲基，R 2表示氢，R 3表示氢; 或其药学上可接受的水合物或溶剂化物。本发明还涉及用作药物的所述化合物，包含所述化合物的药物组合物，所述化合物治疗疾病的方法和用于制备所述化合物的中间体。

3. 发明授权

US09359277B2 Compositions and processes of preparing and using the same 有权
标题翻译：组合物及其制备和使用过程
公开(公告)号：US09359277B2
公开(公告)日：2016-06-07
申请号：US14006386
申请日：2012-03-22
申请人： David A. Colby , Mark V. Riofski , Changho Han
发明人： David A. Colby , Mark V. Riofski , Changho Han
IPC分类号： C07C45/00 , C07C49/83 , C07C49/173 , C07C29/38 , C07D317/54 , C07C41/30 , C07C303/40 , C07C201/12 , C07B37/04 , C07C45/45 , C07C45/67 , C07C45/72 , C07C49/24 , C07C49/82 , C07D317/46 , C07D487/04
CPC分类号： C07C45/008 , C07B37/04 , C07C29/38 , C07C41/30 , C07C45/455 , C07C45/673 , C07C45/72 , C07C49/173 , C07C49/24 , C07C49/82 , C07C49/83 , C07C201/12 , C07C303/40 , C07C2601/14 , C07C2602/18 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D317/46 , C07D317/54 , C07D487/04 , C07C49/573 , C07C49/835 , C07C49/84 , C07C43/23 , C07C33/46 , C07C35/52 , C07C49/794 , C07C49/807 , C07C49/796 , C07C49/653 , C07C49/333 , C07C49/697 , C07C49/693 , C07C49/687 , C07C49/557 , C07C49/683 , C07C49/647 , C07C205/45 , C07C311/16
摘要： The present invention relates to compositions, for example, the DBU/Hexafluoroacetone hydrate salt, and processes of preparing and using the same for the modification of chemical compounds via the release of trifluoroacetate. The DBU/Hexafluoroacetone hydrate salt can perform trifluoromethylation reactions on chemical compounds, such as carbonyl group-containing compounds.
摘要翻译：本发明涉及组合物，例如DBU /六氟丙酮水合物盐，以及通过三氟乙酸盐的释放制备和使用它们来改性化合物的方法。 DBU /六氟丙酮水合物盐可以对化学化合物，如含羰基化合物进行三氯甲基化反应。

4. 发明申请

US20150097146A1 Oxocarbon-, Pseudooxocarbon- and Radialene Compounds and Their Use 有权
标题翻译：氧化碳，假氧化碳和镭二烯化合物及其用途
公开(公告)号：US20150097146A1
公开(公告)日：2015-04-09
申请号：US14570443
申请日：2014-12-15
申请人： Novaled AG
发明人： Horst Hartmann , Olaf Zeika , Andrea Lux , Steffen Willmann
IPC分类号： H01L51/00
CPC分类号： H01L51/005 , C07C13/04 , C07C13/06 , C07C13/11 , C07C13/19 , C07C49/39 , C07C49/395 , C07C49/653 , C07C255/31 , C07C255/40 , C07C255/51 , C07C261/04 , C07C325/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D213/53 , C07D333/24 , C09B11/02 , C09B47/04 , C09B57/00 , C09B57/008 , H01L51/002 , H01L51/0051 , H01L51/0067 , H01L51/0068 , Y02E10/549 , Y02P70/521
摘要： The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
摘要翻译：本发明涉及氧化碳 - 假氧化碳 - 和枞酸化合物，以及它们作为掺杂剂用作掺杂有机半导体基质材料作为阻挡剂材料，作为电荷注入层，作为电极材料以及有机半导体的用途，以及作为电子元件和使用它们的有机半导体材料。

5. 发明授权

US08642815B2 Fragrance and methods for production of 5-epi-β-vetivone, 2-isopropyl-6, 10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6, 10-dimethyl-spiro[4.5]deca-1, 6-dien-8-one 有权
标题翻译：用于制备5-epi-β-vetivone，2-异丙基-6,10-二甲基 - 螺[4.5]十-2,6-二烯-8-酮和2-异丙基-6,10-二甲基的香料和方法螺[4.5]癸-1,6-二烯-8-酮
公开(公告)号：US08642815B2
公开(公告)日：2014-02-04
申请号：US13694597
申请日：2012-12-13
申请人： Bryan N. Julien , David M. Wallace
发明人： Bryan N. Julien , David M. Wallace
IPC分类号： C07C49/00 , C07C2/76 , C12P5/00
CPC分类号： C07C45/28 , A61Q5/02 , A61Q19/10 , C07C45/62 , C07C45/67 , C07C49/637 , C07C49/653 , C07C2602/50 , C12P7/26
摘要： The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethylspiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. Provided are methods for production of premnaspirodiene from a terpene substrate, methods for production of 5-epi-β-vetivone from premnaspirodiene as starting material, and methods for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one from premnaspirodiene as starting material.
摘要翻译：本发明涉及5-外消旋体，2-异丙基-6,10-二甲基 - 螺[4.5]癸-2,6-二烯-8-酮和2-异丙基-6 ，10-二甲基螺[4.5]癸-1,6-二烯-8-酮，其用于其香味。提供了从萜烯底物生产前芪二烯的方法，用作为起始原料的前体萘二甲酸生产5-外-β-螺旋体的方法，以及2-异丙基-6,10-二甲基 - 螺[4.5]十 - 2,6-二烯-8-酮和2-异丙基-6,10-二甲基 - 螺[4.5]癸-1,6-二烯-8-酮作为起始原料。

6. 发明授权

US08362309B2 Fragrance and methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one 有权
标题翻译： 2-异丙基-6,10-二甲基螺[4.5]癸-2,6-二烯-8-酮和2-异丙基-6,10-二烯-6-酮的香料和生产方法，二甲基螺[4.5]癸-1,6-二烯-8-酮
公开(公告)号：US08362309B2
公开(公告)日：2013-01-29
申请号：US13385059
申请日：2012-01-30
申请人： Bryan N. Julien , David M. Wallace
发明人： Bryan N. Julien , David M. Wallace
IPC分类号： C07C2/76 , C12P5/00
CPC分类号： C07C45/28 , A61Q5/02 , A61Q19/10 , C07C45/62 , C07C45/67 , C07C49/637 , C07C49/653 , C07C2602/50 , C12P7/26
摘要： The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethylspiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. Provided are methods for production of premnaspirodiene from a terpene substrate, methods for production of 5-epi-β-vetivone from premnaspirodiene as starting material, and methods for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one from premnaspirodiene as starting material.
摘要翻译：本发明涉及5-表面活性剂，2-异丙基-6,10-二甲基 - 螺[4.5]十-2,6-二烯-8-酮和2-异丙基 - 6,10-二甲基螺[4.5]十-1,6-二烯-8-酮，其用于其香味。提供了从萜烯底物生产前芪二烯的方法，从前体萘二甲酸作为起始原料生产5-表 - 乙酸的方法，以及2-异丙基-6,10-二甲基 - 螺[4.5]十氢化萘的生产方法 -2,6-二烯-8-酮和2-异丙基-6,10-二甲基 - 螺[4.5]癸-1,6-二烯-8-酮作为起始原料。

7. 发明授权

US08212084B2 Method for the production of 4,4′-[1-trifluoromethyl)alkylidene]-bis-(2,6-diphenylphenols) 有权
标题翻译：制备4,4' - [1-三氟甲基）亚烷基] - 双（2,6-二苯基苯酚）
公开(公告)号：US08212084B2
公开(公告)日：2012-07-03
申请号：US12808865
申请日：2008-12-17
申请人： Gabriele Gralla , Gunnar Heydrich , Klaus Ebel , Wolfgang Krause
发明人： Gabriele Gralla , Gunnar Heydrich , Klaus Ebel , Wolfgang Krause
IPC分类号： C07C39/16 , C07C39/12
CPC分类号： C07C45/74 , C07C37/07 , C07C37/20 , C07C37/62 , C07C49/613 , C07C49/653 , C07C39/15 , C07C39/367
摘要： The present invention relates to a process for preparing 4,4′-[1-(trifluoromethyl)alkylidene]bis(2,6-diphenylphenols), in particular for preparing 4,4′-[1-(trifluoromethyl)ethylidene]bis(2,6-diphenylphenol), which comprises the self-condensation of cyclohexanone in the presence of a basic catalyst to form tricyclic condensation products, dehydrogenation of the resulting tricyclic condensation products in the presence of a supported transition metal catalyst in the condensed phase to form 2,6-diphenylphenol and reaction of the 2,6-diphenylphenol with a trifluoromethyl ketone. The invention further provides an improved process for preparing 2,6-diphenylphenol by aldol self-condensation of cyclohexanone.
摘要翻译：本发明涉及一种制备4,4' - [1-（三氟甲基）亚烷基]双（2,6-二苯基苯酚）的方法，特别是制备4,4' - [1-（三氟甲基）亚乙基]双（ 2,6-二苯基苯酚），其包括环己酮在碱性催化剂存在下的自缩合以形成三环缩合产物，所得三环缩合产物在冷凝相中负载的过渡金属催化剂存在下脱氢形成 2,6-二苯基苯酚和2,6-二苯基苯酚与三氟甲基酮的反应。本发明还提供了通过环己酮的醛醇自缩合制备2,6-二苯基苯酚的改进方法。

8. 发明授权

US07968734B2 Organocatalysts and methods of use in chemical synthesis 有权
标题翻译：有机催化剂和化学合成中使用的方法
公开(公告)号：US07968734B2
公开(公告)日：2011-06-28
申请号：US11628818
申请日：2005-06-30
申请人： Wei Wang , Jian Wang , Hao Li
发明人： Wei Wang , Jian Wang , Hao Li
IPC分类号： C07D207/16 , C07D207/04
CPC分类号： C07D207/09 , C07B2200/07 , C07C45/511 , C07C45/54 , C07C45/72 , C07C45/74 , C07C47/56 , C07C49/203 , C07C49/21 , C07C49/235 , C07C49/647 , C07C49/653 , C07C49/683 , C07C49/697 , C07C49/753 , C07C49/86 , C07C67/343 , C07C201/12 , C07C205/44 , C07C205/45 , C07C213/02 , C07C215/42 , C07C227/32 , C07C239/20 , C07C253/30 , C07C319/14 , C07C391/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07D309/30 , C07D317/72 , C07D333/22 , C07C49/258 , C07C49/245 , C07C69/76 , C07C323/22 , C07C255/56 , C07C229/22 , C07C229/28 , C07C229/30 , C07C229/36
摘要： The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.
摘要翻译：本发明通常涉及促进立体选择性反应的有机催化剂及其合成和使用方法的组合物。特别地，本发明涉及促进立体选择性反应的无金属有机催化剂及其合成和使用方法。

9. 发明授权

US07622614B2 Methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro [4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one 有权
标题翻译：制备5-表-β-螺旋体，2-异丙基-6,10-二甲基 - 螺[4.5]十-2,6-二烯-8-酮和2-异丙基-6,10-二甲基 - 螺 [4.5]十氢-1,6-二烯-8-酮
公开(公告)号：US07622614B2
公开(公告)日：2009-11-24
申请号：US12052464
申请日：2008-03-20
申请人： Bryan N. Julien , David M. Wallace
发明人： Bryan N. Julien , David M. Wallace
IPC分类号： C07C49/00 , C07C45/00 , C12P7/26
CPC分类号： C12P7/26 , C07C45/34 , C07C45/67 , C07C49/637 , C07C49/653 , C07C2602/50
摘要： The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. In one embodiment the present invention describes a method for production of 5-epi-β-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes a method for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one by the use of premnaspirodiene as starting material. In yet another embodiment the present invention describes a novel method for production of premnaspirodiene from a terpene substrate.
摘要翻译：本发明涉及5-外消旋体，2-异丙基-6,10-二甲基 - 螺[4.5]癸-2,6-二烯-8-酮和2-异丙基-6 ，10-二甲基 - 螺[4.5]十-1,6-二烯-8-酮，其用于其香味。在一个实施方案中，本发明描述了通过使用前脑嘧啶二酮作为起始原料来生产5-外β-v-叶维酮的方法。在另一个实施方案中，本发明描述了制备2-异丙基-6,10-二甲基 - 螺[4.5]十-2,6-二烯-8-酮和2-异丙基-6,10-二甲基 - 螺[ 4.5]十一-1,6-二烯-8-酮，通过使用前二硬脂基二烯作为起始原料。在另一个实施方案中，本发明描述了一种用于从萜烯底物生产前体二萜烯的新方法。

10. 发明授权

US07183440B2 Pharmaceutically useful compounds 有权
标题翻译：药用有用化合物
公开(公告)号：US07183440B2
公开(公告)日：2007-02-27
申请号：US11059086
申请日：2005-02-07
申请人： Stanley Michael Roberts , Maria Gabriella Santoro , Vasudev Jadhav , Alan Michael Happe , Jérôme Dauvergne
发明人： Stanley Michael Roberts , Maria Gabriella Santoro , Vasudev Jadhav , Alan Michael Happe , Jérôme Dauvergne
IPC分类号： C07C315/00 , C07C49/00 , A61K31/12 , A61K31/095
CPC分类号： C07C323/59 , C07C45/673 , C07C49/647 , C07C49/653 , C07C49/657 , C07C49/753 , C07C205/45 , C07C225/20 , C07C233/32 , C07C233/76 , C07C271/24 , C07C271/36 , C07C271/56 , C07C271/66 , C07C311/20 , C07C311/53 , C07C323/43 , C07C2601/08 , C07C2601/10
摘要： A compound of formula (I) or (II): wherein A is hydrogen or CR1R2; Y and Z are each, independently, hydrogen or a halogen; X is —NR4R5, or R7; R1 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1–4 carbon atoms; when X is —NR4R5, R2 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; when X is R7, R2 is an unsubstituted alkyl, alkenyl or alkynyl group, or a substituted or unsubstituted aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; R3 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; R4 is hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms, —COOR8, or —COR8; R5 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1–5 carbon atoms; R7 is an unsubstituted alkyl, alkenyl, or alkynyl group, that contains 1–4 carbon atoms; and, R8 is an unsubstituted or halo-substituted alkyl, aryl, or aralkyl group, that contains 1–12 carbon atoms
摘要翻译：式（I）或（II）的化合物：其中A是氢或CR 1 R 2; Y和Z各自独立地为氢或卤素; X是-NR 4 R 5或R 7; R 1是氢或含有1-4个碳原子的取代或未取代的烷基或链烯基; 当X是-NR 4 R 5时，R 2是取代或未取代的烷基，烯基，炔基，芳基，芳烷基芳烯基或芳炔基基团，其任选地在其碳骨架中包含至少一个杂原子并且含有1-12个碳原子; 当X是R 7时，R 2是未取代的烷基，烯基或炔基，或取代或未取代的芳基，芳烷基芳烯基或芳炔基，其任选地包括在其碳骨架中至少有一个杂原子，含有1-12个碳原子; R 3是取代或未取代的烷基，烯基，炔基，芳基，芳烷基芳烯基或芳炔基，其任选地在其碳骨架中包含至少一个杂原子并含有1-12个碳原子; R 4是氢，取代或未取代的烷基，烯基，炔基，芳基，芳烷基芳烯基或芳炔基，其任选地在其碳骨架中包含至少一个杂原子并含有1-12个碳原子， -COOR 8或-COR 8; R 5是氢或含有1-5个碳原子的取代或未取代的烷基或链烯基; R 7是含有1-4个碳原子的未取代的烷基，烯基或炔基; 并且R 8是含有1-12个碳原子的未取代或卤素取代的烷基，芳基或芳烷基

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