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1. 发明申请

US20180118706A1 Synthetic Route To Anhydroryanodol, Ryanodol And Structural Analogues 审中-公开
公开(公告)号：US20180118706A1
公开(公告)日：2018-05-03
申请号：US15848686
申请日：2017-12-20
申请人： California Institute of Technology
发明人： Sarah Reisman , Kangway V. Chuang , Chen Xu
IPC分类号： C07D309/30 , C07C49/753 , C07D309/32 , C07C43/23 , C07C49/743 , C07C49/577 , C07C43/315
CPC分类号： C07D309/30 , C07C43/23 , C07C43/315 , C07C49/577 , C07C49/743 , C07C49/753 , C07D309/32
摘要： This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogues thereof and novel compounds prepared thereby.

2. 发明申请

US20130123367A1 VINYLOGOUS CHALCONE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：乙酰胆碱衍生物及其医学用途
公开(公告)号：US20130123367A1
公开(公告)日：2013-05-16
申请号：US13811739
申请日：2011-07-27
申请人： Thomas Erker , Gerda Brunhofer , Ulrich Jäger , Katrina Vanura , Verena Dirsch , Elke Heiss
发明人： Thomas Erker , Gerda Brunhofer , Ulrich Jäger , Katrina Vanura , Verena Dirsch , Elke Heiss
IPC分类号： C07C49/255 , C07C49/577 , C07C323/22
CPC分类号： C07C49/255 , A61K31/121 , A61K45/06 , C07C49/577 , C07C49/755 , C07C49/84 , C07C323/22 , C07C2602/08 , C07F17/02 , A61K2300/00
摘要： The present invention relates to vinylogous chalcone derivatives, in particular the compounds of formula (I) as described and defined herein, pharmaceutical compositions comprising these compounds, and their medical use, including their use in the treatment or prevention of cancer, in particular malignant hematological diseases/disorders.
摘要翻译：本发明涉及野生型查耳酮衍生物，特别是本文所述和定义的式（I）化合物，包含这些化合物的药物组合物及其医学用途，包括其在治疗或预防癌症中的用途，特别是恶性血液学疾病/病症。

3. 发明申请

US20100179061A1 PLANT GROWTH PROMOTER 审中-公开
标题翻译：植物生长促进剂
公开(公告)号：US20100179061A1
公开(公告)日：2010-07-15
申请号：US12602047
申请日：2008-05-29
申请人： Yutaka Saito
发明人： Yutaka Saito
IPC分类号： A01N35/06 , C07C49/577 , A01P21/00
CPC分类号： C05F11/10 , A01N31/16 , A01N49/00 , A01N2300/00
摘要： A plant-growth-promoting agent is provided, which is lower in environmental pollution, highly safe and harmless to human bodies, and which exhibits an excellent plant growth-promoting action even under wide temperature conditions from low temperatures to high temperatures. A plant growth-promoting agent is also provided, which has an ability to store ubiquinone, as an active ingredient of the plant-growth-promoting agent, in a stable state and can be dispersed and stably present in a medium such as a soil or an aqueous liquid which supplies nutrition to the plant, especially in an initial stage in which a plant body is grown after germination.
摘要翻译：提供了一种植物生长促进剂，其环境污染较低，对人体而言是安全无害的，并且即使在从低温到高温的宽温度条件下也表现出优异的植物生长促进作用。还提供了一种植物生长促进剂，其具有以稳定状态存储作为植物生长促进剂的活性成分的泛醌的能力，并且可以分散稳定地存在于介质如土壤或向植物提供营养的水性液体，特别是在发芽后植物体生长的初始阶段。

4. 发明申请

US20090186900A1 COMPOUND 审中-公开
标题翻译：复合
公开(公告)号：US20090186900A1
公开(公告)日：2009-07-23
申请号：US12199364
申请日：2008-08-27
申请人： Nigel VICKER , Gillian Margaret ALLAN , Harshani Rithma Ruchiranani LAWRENCE , Joanna Mary DAY , Atul PUROHIT , Michael John REED , Barry Victor Lloyd POTTER
发明人： Nigel VICKER , Gillian Margaret ALLAN , Harshani Rithma Ruchiranani LAWRENCE , Joanna Mary DAY , Atul PUROHIT , Michael John REED , Barry Victor Lloyd POTTER
IPC分类号： A61K31/4965 , C07C49/577 , A61K31/122 , C07D213/56 , A61K31/4406 , C07D241/12
CPC分类号： C07C323/22 , C07C37/62 , C07C45/00 , C07C45/46 , C07C45/673 , C07C45/68 , C07C45/71 , C07C49/747 , C07C49/753 , C07C49/755 , C07C49/757 , C07C49/83 , C07C49/84 , C07C49/86 , C07C59/90 , C07C69/712 , C07C69/738 , C07C235/74 , C07C235/78 , C07C235/84 , C07C255/40 , C07C2602/08 , C07C2602/10 , C07D213/40 , C07D213/75 , C07D231/12 , C07D231/38 , C07D241/12 , C07D261/08 , C07D277/40 , C07D317/54 , C07D401/12 , C07C39/367
摘要： There is provided a compound of Formula I wherein the various symbols are as defined in the description, and a method of manufacturing a medicament for use in the therapy of a condition or disease associated with 17β-hydroxysteroid dehydrogenase (17β-HSD), comprising a compound of Formula I.
摘要翻译：提供式I化合物，其中各种符号如说明书中所定义，以及制备用于治疗与17β-羟类固醇脱氢酶（17β-HSD）相关的病症或疾病的药物的方法，其包含式Ⅰ化合物。

5. 发明申请

US20080119565A1 NOVEL COMPOUNDS FROM ANTRODIA CAMPHORATA 有权
标题翻译：来自ANTRODIA CAMPHORATA的新化合物
公开(公告)号：US20080119565A1
公开(公告)日：2008-05-22
申请号：US12021584
申请日：2008-01-29
申请人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
发明人： Sheng-Yun Liu , Mao-Tien Kuo , Wu-Che Wen
IPC分类号： A61K31/12 , C07C49/577
CPC分类号： C07C403/10 , C07C403/08 , C07C2601/16
摘要： The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells. The compounds from Antrodia camphorata are first reported, which can be applied not only in inhibiting growth of breast cancer, lung cancer, hepatic cancer and prostate cancer, but also in anti-cancer medicinal compositions for the abovementioned cancer cells.
摘要翻译：本发明涉及一种新颖的化合物及其用途，特别是可以有效抑制癌细胞生长的Antrodia樟脑提取物中分离的Antroquinonol B和Antroquinonol C。首先报道了来自樟芝的化合物，其不仅可用于抑制乳腺癌，肺癌，肝癌和前列腺癌的生长，而且可用于上述癌细胞的抗癌药物组合物。

6. 发明授权

US5292771A Substituted .beta.-diketones and their use 失效
标题翻译：取代的β-二酮及其用途
公开(公告)号：US5292771A
公开(公告)日：1994-03-08
申请号：US958487
申请日：1992-10-08
申请人： Reijo J. Backstrom , Erkki J. Honkanen , Jarmo J. Pystynen , Anne M. Luiro , Paivi A. Aho , Inge-Britt Y. Linden , Erkki A. O. Nissinen , Pentti Pohto
发明人： Reijo J. Backstrom , Erkki J. Honkanen , Jarmo J. Pystynen , Anne M. Luiro , Paivi A. Aho , Inge-Britt Y. Linden , Erkki A. O. Nissinen , Pentti Pohto
IPC分类号： A61K31/00 , A61K31/06 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/345 , C07C49/217 , C07C49/235 , C07C49/248 , C07C49/255 , C07C49/258 , C07C49/567 , C07C49/577 , C07C65/36 , C07C65/40 , C07C205/45 , C07C233/31 , C07C235/84 , C07C255/56 , C07C317/24 , A61K31/38 , A61K31/44 , A61K31/47
CPC分类号： C07C205/45 , A61K31/00 , A61K31/06 , A61K31/12 , A61K31/165 , A61K31/275 , A61K31/345 , C07C233/31 , C07C235/84 , C07C255/56 , C07C317/24 , C07C49/217 , C07C49/235 , C07C49/248 , C07C49/255 , C07C49/258 , C07C49/567 , C07C49/577 , C07C65/36 , C07C65/40 , C07C2101/02
摘要： Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.
摘要翻译：式（Ⅰ）化合物其中n为0或1，R 1和R 2独立地为甲基，乙基或环丙基，R为任选取代的苯基或杂芳基或其盐或酯可用于治疗炎症性肠病。

7. 发明授权

US5086074A 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes 失效
标题翻译： 1-氨基甲基-1,2,3,4-四氢萘
公开(公告)号：US5086074A
公开(公告)日：1992-02-04
申请号：US499232
申请日：1990-03-26
申请人： John F. DeBernardis , Robert E. Zelle , Fatima Z. Basha
发明人： John F. DeBernardis , Robert E. Zelle , Fatima Z. Basha
IPC分类号： C07C45/00 , C07C45/46 , C07C45/63 , C07C45/71 , C07C49/577 , C07C49/697 , C07C49/747 , C07C49/753 , C07C62/32 , C07C62/34 , C07C211/30 , C07C215/50 , C07C217/74 , C07C229/50 , C07C233/18 , C07C255/47 , C07C259/08 , C07C323/22 , C07D207/06 , C07D207/08 , C07D207/32 , C07D207/335 , C07D213/38 , C07D307/52 , C07D317/70 , C07D319/20 , C07D319/22 , C07D333/20 , C07D333/24 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14
CPC分类号： C07D207/08 , C07C211/30 , C07C215/50 , C07C217/74 , C07C229/50 , C07C233/18 , C07C255/47 , C07C259/08 , C07C323/22 , C07C45/004 , C07C45/46 , C07C45/63 , C07C45/71 , C07C49/577 , C07C49/697 , C07C49/747 , C07C49/753 , C07C62/32 , C07C62/34 , C07D207/06 , C07D207/335 , C07D213/38 , C07D307/52 , C07D317/70 , C07D319/20 , C07D319/22 , C07D333/20 , C07D333/24 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07C2101/08 , C07C2102/10
摘要： Compounds of the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sup.2 is selected from hydroxy and lower alkoxy, R.sup.5 is lower alkyl, and R.sup.11 and R.sup.12 are independently selected from hydrogen, halo, hydroxy, methoxy, and lower alkyl, are selective .alpha..sub.2 adrenergic receptor antagonists useful in the treatment of glaucoma.
摘要翻译：下式化合物及其药学上可接受的盐，其中R2选自羟基和低级烷氧基，R5是低级烷基，R11和R12独立地选自氢，卤素，羟基，甲氧基和低级烷基，是选择性的可用于治疗青光眼的α2肾上腺素能受体拮抗剂。

8. 发明授权

US5032313A Trifluorobenzene derivative and liquid crystal composition containing the same 失效
标题翻译：三氟苯衍生物和含有它们的液晶组合物
公开(公告)号：US5032313A
公开(公告)日：1991-07-16
申请号：US490706
申请日：1990-03-07
申请人： Yasuyuki Goto , Kisei Kitano
发明人： Yasuyuki Goto , Kisei Kitano
IPC分类号： G02F1/13 , C07C17/00 , C07C25/18 , C07C43/192 , C07C43/225 , C07C49/233 , C07C49/255 , C07C49/567 , C07C49/577 , C07C49/697 , C07C49/753 , C07C69/75 , C07C69/753 , C07C69/773 , C07D239/26 , C07D317/16 , C07D319/06 , C09K19/12 , C09K19/30 , C09K19/34 , C09K19/42 , C09K19/54
CPC分类号： C07D239/26 , C07D317/16 , C09K19/12 , C09K19/3003 , C09K19/3028 , C09K19/3068 , C09K19/3402 , C09K19/3458 , C09K2019/3422
摘要： A trifluorobenzene derivative having a superior stability and a large positive dielectric anisotropy value and a liquid crystal composition containing the derivative are provided, which derivative is expressed by the formula ##STR1## wherein R is 1-10C alkyl and one --CH.sub.2 -- group or two not-adjacent --CH.sub.2 -- groups in the alkyl may be replaced by O and/or --CO-- and/or --COO-- and/or --CH.dbd.CH--, --A-- and --B-- are 1,4-cyclohexylene, 1,4-phenylene, pyrimidine-2,5-diyl or 1,3-dioxane-2,5-diyl, l and m each are 0, 1 or 2 and l+m.gtoreq.1, and Z.sup.1 and Z.sup.2 each are --COO--, --OCO--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O--, --CH.dbd.CH-- or single bond and may be same or different.

9. 发明授权

US4829091A Process for the preparation of ketones and novel insecticides produced therefrom 失效
标题翻译：用于制备由其制备的酮和新型杀虫剂的方法
公开(公告)号：US4829091A
公开(公告)日：1989-05-09
申请号：US55265
申请日：1987-05-27
申请人： Frank D. Mills , Richard T. Brown , Giles D. Mills, Jr
发明人： Frank D. Mills , Richard T. Brown , Giles D. Mills, Jr
IPC分类号： A01N35/02 , A01N43/08 , C07C45/67 , C07C49/577 , C07D307/42
CPC分类号： C07C45/676 , A01N35/02 , A01N43/08 , C07C49/577 , C07D307/42
摘要： An improved method for the decarbalkoxylation of alkylated .beta.-keto esters to obtain high yields of ketones. In accordane with the method, decarbalkoxylation of alkylated .beta.-keto esters is accomplished by heating the esters in the presence of dilute aqueous alkali and an effective amount of a phase-transfer agent. The method produces commercially practical yields of ketone in a manner which is facile, economical and environmentally safe. Novel methylene-linked pyrethroid ketones produced from the improved method exhibit insecticidal activity against various agricultural pests.
摘要翻译：烷基化β-酮酯的脱烷基氧化的改进方法，以获得高产率的酮。根据该方法，烷基化β-酮酯的脱烷基氧化通过在稀碱水溶液和有效量的相转移剂的存在下加热酯来实现。该方法以便利，经济和环境安全的方式产生商业上实用的酮产率。由改进的方法生产的新型亚甲基联结的拟除虫菊酯对各种农业害虫具有杀虫活性。

10. 发明授权

US4189500A Aryl substituted diketones 失效
标题翻译：芳基取代二酮
公开(公告)号：US4189500A
公开(公告)日：1980-02-19
申请号：US885353
申请日：1978-03-13
申请人： Joseph C. Collins
发明人： Joseph C. Collins
IPC分类号： C07C33/34 , C07C33/50 , C07C45/68 , C07C45/74 , C07C49/213 , C07C49/215 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/245 , C07C49/255 , C07C49/567 , C07C49/573 , C07C49/577 , C07D317/54 , C07D317/60 , C07C49/84 , A01N9/24
CPC分类号： C07D317/60 , C07C33/34 , C07C33/50 , C07C45/68 , C07C45/74 , C07D317/54
摘要： Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester.
摘要翻译：通过使芳基烷基或芳基烯基碘与适当的二酮或酮酯的金属盐反应来制备用作抗病毒剂和杀虫剂的芳基取代的二酮和酮酯。

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