专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4220720A Manufacture of fatty acids having straight and long carbon chains using a microorganism 失效
标题翻译：使用微生物制造具有直链和长碳链的脂肪酸
公开(公告)号：US4220720A
公开(公告)日：1980-09-02
申请号：US968607
申请日：1978-12-11
申请人： Akira Taoka , Seiichi Uchida
发明人： Akira Taoka , Seiichi Uchida
IPC分类号： C12P7/40 , C12P7/44 , C12P7/64 , C12D1/02
CPC分类号： C12P7/6409 , C12P7/40 , C12P7/44 , Y10S435/911
摘要： A method for the oxidation of hydrocarbons to monocarboxylic acids and thence to dicarboxylic acids by the aerobic resting cell reaction of the organism Debaryomyces phaffii ATCC 20499.
摘要翻译：一种通过生物体巴马假单孢菌ATCC 20499的有氧休止细胞反应将烃氧化成单羧酸，从而进行二羧酸的方法。

2. 发明授权

US4088536A Method for preparing prostaglandins 失效
标题翻译：前列腺素的制备方法
公开(公告)号：US4088536A
公开(公告)日：1978-05-09
申请号：US772019
申请日：1977-02-25
申请人： Charles J. Sih
发明人： Charles J. Sih
IPC分类号： C07C405/00 , C07D303/32 , C07D309/12 , C07F1/02 , C07F1/08 , C07F5/06 , C12D1/02
CPC分类号： C07F1/02 , C07C405/00 , C07D303/32 , C07D309/12 , C07F1/08 , C07F5/066 , Y10S435/913 , Y10S435/933
摘要： Racemic 15-deoxo, 11,15-deoxy and other prostaglandins and methods for preparing the same. The initial reactant is lithium cyclopentadiene which is reacted with ethyl-7-bromoheptanoate to give the alkylated diene which in turn is oxygenated to a mixture of hydroxycyclopentenones. 2-(6'-carboethoxyhexyl)-4-hydroxy-cyclopenten-1-one is chromatographically recovered from the mixture and reacted with dihydropyran to give the tetrahydropyranyl ether which is then reacted with 1-lithium-1-trans-octene in the presence of tri-n-butylphosphine-copper iodide to produce racemic 15-deoxy-prostaglandin E.sub.1 ethyl ester which is chromatographically recovered. The ester is converted to the corresponding prostaglandin by the action of an esterase-producing microorganism.
摘要翻译：外消旋15-脱氧，11,15-脱氧等前列腺素及其制备方法。初始反应物是环戊二烯锂，其与7-溴庚酸乙酯反应，得到烷基化二烯，其又被氧化成羟基环戊烯酮的混合物。将2-（6'-羰乙氧基己基）-4-羟基 - 环戊烯-1-酮从混合物中色谱回收并与二氢吡喃反应，得到四氢吡喃基醚，然后在存在下与1-锂-1-反式 - 辛烯反应的三正丁基膦 - 碘化铜，制备色谱回收的外消旋15-脱氧 - 前列腺素E1乙酯。通过产酯酶微生物的作用将酯转变成相应的前列腺素。

3. 发明授权

US3922195A Process for preparing L-Malic acid 失效
标题翻译： L-苹果酸的制备方法
公开(公告)号：US3922195A
公开(公告)日：1975-11-25
申请号：US51568974
申请日：1974-10-17
申请人： TANABE SEIYAKU CO
发明人： CHIBATA ICHIRO , TOSA TETSUYA , SATO TADASHI , YAMAMOTO KOZO
IPC分类号： C07C51/367 , C07F3/00 , C12N9/88 , C12N11/04 , C12P7/46 , C12D1/02
CPC分类号： C12P7/46 , C07C51/367 , C07F3/003 , C12N9/88 , C12N11/04 , Y10S435/822 , Y10S435/84 , Y10S435/843 , Y10S435/849 , Y10S435/873 , Y10S435/938 , C07C59/245
摘要： At least one acryloyl monomer is polymerized in an aqueous suspension containing a fumarase-producing microorganism. The acryloyl monomers employed in the present invention include acryloylamide, N,N''-lower alkylene-bis-acryloylamide, bis(acryloylamidomethyl)ether and N,N''-di-acryloyl-ethyleneurea. The resultant immobilized fumarase-producing microorganism is subjected to enzymatic reaction with fumaric acid or a salt thereof. L-Malic acid is produced.
摘要翻译：至少一种丙烯酰基单体在含有产生富马酸酶的微生物的水性悬浮液中聚合。用于本发明的丙烯酰基单体包括丙烯酰胺，N，N'-低级亚烷基 - 双丙烯酰胺，双（丙烯酰氨基甲基）醚和N，N'-二丙烯酰基亚乙基脲。所得到的固定化富马酸生成微生物与富马酸或其盐进行酶反应。产生L-苹果酸。

4. 发明授权

US3850750A Preparation of d-({31 ) pantoic acid and/or d-({31 ) pantoyl lactone 失效
标题翻译： D-（{31）苯甲酸和/或D - （{31）PANTOYL LACTONE的制备
公开(公告)号：US3850750A
公开(公告)日：1974-11-26
申请号：US36629673
申请日：1973-06-04
申请人： SYNTEX CORP
发明人： LANZIOLOTTA R
IPC分类号： C12P7/42 , C12P17/04 , C12D1/02
CPC分类号： C12P17/04 , C12P7/42 , C12R1/645 , Y10S435/911
摘要： Stereoselective microbiological processes for preparing D-(-) pantoic acid and/or D-(-) pantoyl lactone. The processes are characterized by stereoselectively reducing Alpha -ketopantoic acid and/or Alpha -ketopantoyl lactone via contact with the fungus Byssochlamys, an ascomycete in the family Endomycetaceae in the order Endomycetales. The resulting D-(-) pantoic acid and/or D-(-) pantoyl lactone have utility as intermediates for pantothenic acid which is a well known member of the Vitamin B complex family.
摘要翻译：用于制备D - [ - ] pantoic酸和/或D - [ - ]泛酰基内酯的立体选择性微生物过程。这些方法的特征在于通过与真菌Byssochlamys接触立体选择性还原α-酮戊酸和/或α-酮戊酰基内酯，其是依照Endomycetales的Eniconycetaceae家族中的子囊菌。所得的D - [ - ]泛酸和/或D - [ - ]泛酰基内酯可作为维生素B复合家族众所周知的泛酸中间体。

5. 发明授权

US3687811A Microbiological reduction of 15-keto prostaglandin derivatives 失效
标题翻译： 15-KETO PROSTAGLANDIN衍生物的微生物学减少
公开(公告)号：US3687811A
公开(公告)日：1972-08-29
申请号：US3687811D
申请日：1970-12-18
申请人： SEARLE & CO
发明人： COLTON FRANK B , MARSHECK WILLIAM J , MIYANO MASATERU
IPC分类号： C07C405/00 , C12P31/00 , C12D1/02
CPC分类号： C07C405/00 , C12P31/00 , Y10S435/83 , Y10S435/85 , Y10S435/866 , Y10S435/872 , Y10S435/874
摘要： SELECTIVE REDUCTION OF THE 15-KETO GROUP OF 9,15-DIKETO PROSTAGLANDIN DERIVATIVES IS ACHIEVED BY FERMENTATION WITH A BACTERIUM OF THE GENERA ARTHROBACTER, PSEUDOMONAS, NOCARDIA, CORYNEBACTERIUM, MYCOBACTERIUM OR FLAVOBACTERIUM OR WITH A YEAST BELONGING TO THE CLASS CONSISTING OF RHODOTORULA AND SACCHAROMYCES. THE RESULTING 9-KETO-15-HYDROXY COMPOUNDS DISPLAY USEFUL PHARMACOLOGICAL PROPERTIES, E.G. ANTI-ULCEROGENIC, HYPOTENSIVE AND SMOOTH MUSCLE STIMULATING PROPERTIES.

6. 发明授权

US3616228A Beta-substituted propionic acids and method of making the same 失效
标题翻译： β-取代的酸性酸及其制备方法
公开(公告)号：US3616228A
公开(公告)日：1971-10-26
申请号：US3616228D
申请日：1969-03-12
申请人： KURT SCHUBERT , KARL HEINZ ADAND BOHME , CLARE HORHOLD
发明人： SCHUBERT KURT , BOHME KARL-HEINZ ADAND , HORHOLD CLARE
IPC分类号： C07D311/74 , C12P7/40 , C12P7/42 , C12P7/62 , C12P17/04 , C12P17/06 , C12P17/10 , C12P17/12 , C12P33/00 , C12D1/02
CPC分类号： C12R1/365 , C07D311/74 , C12P7/40 , C12P7/42 , C12P7/62 , C12P17/04 , C12P17/06 , C12P17/10 , C12P17/12 , C12P33/00 , Y10S435/872
摘要： A Beta -substituted propionic acid of the general formula

WHEREIN W is CH2, O or NH and wherein X and Y may be the same or different and are H, OH, O, OAc, lower alkyl, hydroxy- or oxosubstituted lower alkyl, and wherein X and Y may be interconnected. The acids are made by dissolving 3-keto-steroids in an organic water-soluble solvent and fermenting it with an aerobic culture of Nocardia SPEC and recovering the product from the fermentation medium.

7. 发明授权

US3579425A Preparation of prostaglandins 失效
标题翻译： PROSTAGLANDINS的制备
公开(公告)号：US3579425A
公开(公告)日：1971-05-18
申请号：US3579425D
申请日：1969-08-29
申请人： UNILEVER NV
发明人： DORP DAVID ADRIAAN VAN , BEERTHUIS ROELOF KAREL , NUGTEREN DIEDERIK HENDRIK , VONKEMAN HENDRIK
IPC分类号： C07C405/00 , C12P31/00 , C12D1/02
CPC分类号： C07C405/00 , C12P31/00
摘要： THE SPECIFICATION DISCLOSES A PROCESS FOR PREPARING PROSTAGLANDINS WHICH COMPRISES INCUBATING, UNDER AEROBIC CONDITIONS, A MIXTURE COMPRISING A PROSTAGLANDIN-SYNTHESIZING ENZYME SYSTEM PREPARED FROM ANIMAL TISSUE, GLUTHAHIONE, AND AN ALL-CIS POLYUNSATURATED CARBOXYLIC ACID OF THE FORMULA

CH3(CH2)N(CH=CHCH2)P(CH2)QCOOH

WHEREIN N IS A NUMBER FROM 0 TO 5, P IS A NUMBER FROM 3 TO 5, AND Q IS A NUMBER FROM 0 TO 8, WITH THE PROVISO THAT THE SUM OF N+3P+Q IS FROM 16 TO 20 AND THAT WHEN P IS 3 THEN N IS A NUMBER FROM 3 TO 5. THE ENZYME SYSTEM IS OBTAINED FROM LIVING ANIMAL ORGAN CELLS, E.G., THYMUS, IRIS, GENITAL GLANDS AND THE LIKE.

8. 发明授权

US3486980A Process for producing 5'-inosinic acid 失效
标题翻译：生产5'-肌苷酸的方法
公开(公告)号：US3486980A
公开(公告)日：1969-12-30
申请号：US3486980D
申请日：1966-08-24
申请人： KYOWA HAKKO KOGYO KK
发明人： TANAKA KATSUNOBU , KIMURA KAZUO , INUZUKA KEIICHI , TOKORO YOH
IPC分类号： C12P19/30 , C12P19/32 , C12R1/13 , C12D1/02 , C12B1/00
CPC分类号： C12P19/32 , C12P19/30 , Y10S435/84 , Y10S435/843 , Y10S435/861

9. 发明授权

US3455785A Microbiological process 失效
标题翻译：微生物学过程
公开(公告)号：US3455785A
公开(公告)日：1969-07-15
申请号：US3455785D
申请日：1966-04-19
申请人： LEVER BROTHERS LTD
发明人： BUTT WALTER DION
IPC分类号： C11C3/12 , C12P7/64 , C12D1/02
CPC分类号： C12P7/6427 , C11C3/12 , C12P7/6472 , Y10S435/842 , Y10S435/853

10. 发明授权

US4436725A Physiologically active novel substance mutastein and process for its production 失效
标题翻译：生理活性的新型物质mutastin及其生产工艺
公开(公告)号：US4436725A
公开(公告)日：1984-03-13
申请号：US352069
申请日：1982-02-24
申请人： Akira Endo
发明人： Akira Endo
IPC分类号： A61K36/06 , A61P1/02 , C07G99/00 , C12P1/02 , C12R1/66 , A61K35/00 , A61K7/16 , C12D1/02
CPC分类号： C12R1/66 , C12P1/02
摘要： A physiologically active novel substance designated as Mutastein is disclosed, which has the following specific physiological properties:(1) it has a molecular weight of at least 200,000, and when subjected to gel-filtration with Sephadex G-100 and Sephallose 6B, it will be eluted in the void volume;(2) its ultraviolet spectrum: FIG. 1;(3) its infrared spectrum: FIG. 2;(4) it has a proteinous nature and contains about 10% of saccharide;(5) it is soluble in water and a saline solution, but it will be salted out from a saturated solution containing about 30% of ammonium salfate; and it is insoluble in acetone, ethanol, ethylacetate and benzene,(6) it dissolves in a buffer solution having a pH 7 or over, but it precipitates at a pH of from 3 to 3.5,(7) it is stable when heat-treated at pH 9, at 100.degree. C. for 10 minutes,(8) its elementary analysis: C: about 44%, H: about 7%, and N: about 12%,(9) its color reactions: Phenol-surfuric acid color reaction (orange), and Folin's color reaction (blue). This substance can be prepared by culturing the Mutastein-producing strain belonging to the genus Aspergillus, and isolating the Mutastein from the culture medium.
摘要翻译：公开了一种命名为Mutastein的生理活性新物质，其具有以下具体的生理特性：（1）其分子量至少为20万，当用Sephadex G-100和Sephallose 6B进行凝胶过滤时，将会是在空隙体积中洗脱; （2）其紫外光谱： 1; （3）其红外光谱： 2; （4）具有蛋白质性质，含有约10％的糖类; （5）它可溶于水和盐水溶液，但会从含有约30％硫酸铵的饱和溶液中脱盐; 它不溶于丙酮，乙醇，乙酸乙酯和苯，（6）溶于pH7或以上的缓冲溶液中，但在3〜3.5的pH下析出，（7）在pH 9，100℃下处理10分钟，（8）其元素分析：C：约44％，H：约7％，N：约12％，（9）其显色反应：苯酚 - 酸性反应（橙色）和Folin的颜色反应（蓝色）。该物质可以通过培养属于曲霉属的产生Mutaminin的菌株并从培养基中分离出Mutastein来制备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式