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1. 发明授权

US10676427B2 Diazomethylation reagent and process for using it 有权
公开(公告)号：US10676427B2
公开(公告)日：2020-06-09
申请号：US16482966
申请日：2018-02-08
申请人： FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ)
发明人： Marcos García Suero , Zhaofeng Wang
IPC分类号： C07C271/26 , C07C245/18 , C07C251/00 , C07D347/00 , C07B47/00
摘要： The present invention relates compounds useful as reagents for the diazomethylation reaction, their preparation and the use thereof as reagents in a method for the diazomethylation reaction of aromatic substrates. It relates in particular to a compound of formula (I) wherein E is an electron withdrawing group.

2. 发明授权

US08871520B2 Uracil-specific fluorescence detection reaction and method for examining dihydropyrimidine dehydrogenase deficiency 有权
标题翻译：尿嘧啶特异性荧光检测反应及二氢嘧啶脱氢酶缺陷检测方法
公开(公告)号：US08871520B2
公开(公告)日：2014-10-28
申请号：US13582356
申请日：2011-03-01
申请人： Masaaki Kai , Takayuki Shibata
发明人： Masaaki Kai , Takayuki Shibata
IPC分类号： G01N21/64 , G01N21/00 , C07C251/00 , C09K11/06 , G01N33/533 , C12Q1/32
CPC分类号： G01N21/6428 , C09K11/06 , C09K2211/1074 , C12Q1/32 , G01N33/533 , G01N2333/90206 , Y10T436/14 , Y10T436/145555 , Y10T436/147777
摘要： The invention provides a method of detecting uracil. The method comprises reacting uracil with a compound represented by the formula (I) in the presence of an oxidant and a base to produce a fluorescent compound represented by the formula (II).
摘要翻译：本发明提供一种检测尿嘧啶的方法。所述方法包括在氧化剂和碱的存在下使尿嘧啶与由式（I）表示的化合物反应以产生由式（II）表示的荧光化合物。

3. 发明授权

US08440779B2 Carbodiimide compound and compositions for rendering substrates oil and water repellent 有权
标题翻译：碳化二亚胺化合物和用于使基材油和憎水剂的组合物
公开(公告)号：US08440779B2
公开(公告)日：2013-05-14
申请号：US10982107
申请日：2004-11-04
申请人： Frans A. Audenaert , Chetan P. Jariwala
发明人： Frans A. Audenaert , Chetan P. Jariwala
IPC分类号： C08G18/10 , C07C251/00
CPC分类号： C07C267/00 , C08G18/095 , C08G18/2825 , C08G18/6229
摘要： The invention relates to a carbodiimide compound or mixture of carbodiimide compounds derived from a carbodiimidization reaction of at least one oligomer having at least one isocyanate group and comprising at least two repeating units deriving from one or more ethylenically unsaturated monomers.
摘要翻译：本发明涉及一种碳二亚胺化合物或衍生自至少一种具有至少一个异氰酸酯基的低聚物的碳二亚胺化反应的碳二亚胺化合物的混合物，并且包含至少两个衍生自一种或多种烯属不饱和单体的重复单元。

4. 发明授权

US08227496B2 Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis 有权
标题翻译：使用4 - [（4-噻唑基）苯氧基]烷氧基 - 苄脒衍生物治疗骨质疏松症
公开(公告)号：US08227496B2
公开(公告)日：2012-07-24
申请号：US12689878
申请日：2010-01-19
申请人： Hong-Suk Suh , Jin Soo Lee , Pan-Soo Kim , Yun-Ha Hwang , Jei Man Ryu , Yong-Ho Chung , Eun-Joo Kim , Do-Hui Kim , Yong-Youp Park
发明人： Hong-Suk Suh , Jin Soo Lee , Pan-Soo Kim , Yun-Ha Hwang , Jei Man Ryu , Yong-Ho Chung , Eun-Joo Kim , Do-Hui Kim , Yong-Youp Park
IPC分类号： A01N43/78 , A01N37/52 , A61K31/425 , A61K31/155 , C07D277/60 , C07D416/00 , C07C249/00 , C07C251/00 , C07C259/00 , C07C291/00
CPC分类号： A61K31/426 , Y10S514/878
摘要： A method of treating osteoporosis comprising administering to a subject a composition comprising a compound, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine or a salt thereof, is described. A method of inhibiting osteoclast activity and stimulating osteoblast activity in a subject also is described.
摘要翻译：一种治疗骨质疏松症的方法，包括向受试者施用包含化合物4- {5- [4-（5-异丙基-2-甲基-1,3-噻唑-4-基）苯氧基]戊氧基} - 苄脒或其盐。还描述了抑制破骨细胞活性并刺激受试者成骨细胞活性的方法。

5. 发明授权

US08153758B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08153758B2
公开(公告)日：2012-04-10
申请号：US11925740
申请日：2007-10-26
申请人： Zhenwei Miao , Junjie Liu , Thea Norman
发明人： Zhenwei Miao , Junjie Liu , Thea Norman
IPC分类号： C07K2/00 , C07K4/00 , C07K14/50 , C07C251/00
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

6. 发明授权

US08048988B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
公开(公告)号：US08048988B2
公开(公告)日：2011-11-01
申请号：US11952975
申请日：2007-12-07
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K2/00 , C07K4/00 , C07K14/52 , C07C251/00 , C07C251/32
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

7. 发明授权

US08008456B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08008456B2
公开(公告)日：2011-08-30
申请号：US11952960
申请日：2007-12-07
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K2/00 , C07K4/00 , C07K14/50 , C07C251/00 , C07C251/32
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Non-natural amino acids and polypeptides with non-natural amino acids are disclosed. Further, polypeptides with non-natural amino acids that are subject to post-translational modification are disclosed. Additionally, methods of making, purifying, and using non-natural amino acids and polypeptides with non-natural amino acids are disclosed. The non-natural amino acids, by themselves or as part of a polypeptide, can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Uses for the non-natural amino acids and polypeptides with non-natural amino acids include diagnostic, therapeutic, and various biotechnology uses.
摘要翻译：公开了非天然氨基酸和具有非天然氨基酸的多肽。此外，公开了具有经翻译后修饰的非天然氨基酸的多肽。另外，公开了制备，纯化和使用非天然氨基酸和多肽与非天然氨基酸的方法。非天然氨基酸本身或作为多肽的一部分可以包括多种可能的功能，但通常具有至少一个肟，羰基，二羰基和/或羟胺基团。用于非天然氨基酸和具有非天然氨基酸的多肽包括诊断，治疗和各种生物技术用途。

8. 发明授权

US07985881B2 Aromatic imine compounds for use as sulfide scavengers 有权
标题翻译：用作硫化物清除剂的芳香族亚胺化合物
公开(公告)号：US07985881B2
公开(公告)日：2011-07-26
申请号：US11854069
申请日：2007-09-12
申请人： Gary Westlund , David Weller
发明人： Gary Westlund , David Weller
IPC分类号： C07C251/00 , C07C251/02 , C07C251/10 , C07C251/16
CPC分类号： B01D53/1468 , B01D53/1493 , C02F1/683 , C02F2101/101 , C02F2303/02 , C02F2303/08 , C07C249/02 , C07C251/24
摘要： Compositions and methods relating to aromatic imine compounds and methods of their use are described. The compounds are formed from aromatic aldehydes and amino or amino derivatives. The compounds and their derivatives are useful, for example, as hydrogen sulfide and mercaptan scavengers for use in both water and petroleum products.
摘要翻译：描述了与芳族亚胺化合物有关的组合物和方法及其使用方法。化合物由芳族醛和氨基或氨基衍生物形成。化合物及其衍生物可用作例如用于水和石油产品的硫化氢和硫醇清除剂。

9. 发明申请

US20110084230A1 Process for Synthesizing Organoelemental Compounds 审中-公开
标题翻译：合成有机化合物的方法
公开(公告)号：US20110084230A1
公开(公告)日：2011-04-14
申请号：US12225647
申请日：2007-04-03
申请人： Paul Knochel , Andrei Gavryushin , Vladimir Malakhov , Arkady Krasovskiy
发明人： Paul Knochel , Andrei Gavryushin , Vladimir Malakhov , Arkady Krasovskiy
IPC分类号： C07F3/06 , C07C69/76 , C07C255/50 , C07C49/303 , C07C251/00 , C07C15/02 , C07D307/02 , C07D307/34 , C07C1/32 , C09K3/00
CPC分类号： C07F3/06 , C07F13/00
摘要： The present application discloses a process for preparing a compound of the general formula R1-M1-Ad.zLiX (I) by reacting a compound R1-A (III) with an element M1 in the presence of lithium salts. The application also discloses a process for preparing a compound of the general formula R1m-M3-Tm.zLiX (II) by reacting a compound R1-A (III) with an M3-containing compound in the presence of lithium salts and in the presence of an elemental metal M2. The metal M3 may be selected from Al, Mn, Cu, Zn, Sn, Ti, In, La, Ce, Nd, Y, Li, Sm, Bi, Mg, B, Si and S.
摘要翻译：本申请公开了通过在锂盐存在下使化合物R1-A（III）与元素M1反应来制备通式为R 1 -M1-Ad.zLiX（I）的化合物的方法。本申请还公开了在锂盐存在下使化合物R1-A（III）与含M3化合物反应制备通式为R1m-M3-Tm.zLiX（II）的化合物的方法，的元素金属M2。金属M3可以选自Al，Mn，Cu，Zn，Sn，Ti，In，La，Ce，Nd，Y，Li，Sm，Bi，Mg，B，Si和S.

10. 发明授权

US07820861B2 2-methoxymethylphenylhydrazine 有权
标题翻译： 2-甲氧基甲基苯肼
公开(公告)号：US07820861B2
公开(公告)日：2010-10-26
申请号：US11790940
申请日：2007-04-30
申请人： Hidetaka Hiyoshi , Mahito Ogawa
发明人： Hidetaka Hiyoshi , Mahito Ogawa
IPC分类号： C07C241/00 , C07C243/00 , C07C249/00 , C07C251/00 , C07D239/02
CPC分类号： C07D403/04 , C07C243/22 , C07D239/30 , C07D239/42 , C07D239/52
摘要： A substitute aniline compound represented by the following formula (6): wherein, R1, R2 and R3 are each independently an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group, an alkyl-carboxamide group, a nitro group, an aryl group, an arylalkyl group, an aryloxy group, a halogen atom or a hydrogen atom; and X and Y are each independently a hydrogen atom, an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl group, a carboxyl group, an alkoxycarbonyl group or halogen. A process for producing the compound formula (6) is also discussed.
摘要翻译：由下式（6）表示的替代苯胺化合物：其中，R1，R2和R3各自独立地为烷基，烷氧基，烷氧基烷基，卤代烷基，羧基，烷氧基羰基，烷基 - 甲酰胺基，硝基，芳基，芳烷基，芳氧基，卤素原子或氢原子; X和Y各自独立地为氢原子，烷基，烷氧基，烷氧基烷基，卤代烷基，羧基，烷氧基羰基或卤素。还讨论了制备化合物式（6）的方法。

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