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    • 1. 发明申请
    • Process for manufacture of a 4-bromo-2-oxyimino butyric acid and its derivatives
    • 制备4-溴-2-氧亚氨基丁酸及其衍生物的方法
    • US20040054224A1
    • 2004-03-18
    • US10465926
    • 2003-06-26
    • Vinod Kumar KansalDnyandeo Ragho RaneSanjay DeshmukhSantosh Kumar SinghSantosh RichariaSusan Ajay Abraham
    • C07C251/36
    • C07C249/12C07C251/36
    • A process for producing 4-bromo-2-oxyimino butyric acid, predominantly as the (Z)-isomer of formula (I), 1 wherein R is hydrogen; a linear or branched C1-4 alkyl group; a linear or branched C1-4 alkyl group substituted by a carboxylic acid or an aryl group; a substituted or unsubstituted cyclic alkyl group of 3-6 carbon atoms or a substituted or unsubstituted aryl group. The product is produced by reacting bromine with a 2-(oxyimino)-3-oxo butyric acid derivative of formula (II) 2 wherein R is as defined above and R1 is a tert-butyl group in presence of an organic solvent and in presence of a C1-4 alcohol and acetyl bromide at a temperature ranging from about null15null C. to about null15null C. Bromine is used in a proportion of about 0.90 to about 1.35 moles per mole of compound (II), preferably 0.90 to 1.10 moles. The acetyl bromide is used in molar proportions of 0.9 to 2 moles per mole of compound (II), preferably 0.9 to 1.5 moles.
    • 主要用作式(I)的(Z) - 异构体的4-溴-2-氧亚氨基丁酸的制备方法,其中R是氢; 直链或支链C 1-4烷基; 被羧酸或芳基取代的直链或支链C 1-4烷基; 取代或未取代的3-6个碳原子的环状烷基或取代或未取代的芳基。 该产物通过使溴与式(II)的2-(氧亚氨基)-3-氧代丁酸衍生物反应制备,其中R如上定义,R 1在有机溶剂存在下为叔丁基, 在约-15℃至约+ 15℃的温度下,在C 1-4醇和乙酰溴的存在下进行。溴以每摩尔化合物(II)约0.90至约1.35摩尔的比例使用, 优选为0.90〜1.10摩尔。 乙酰溴的摩尔比为0.9〜2摩尔/摩尔化合物(II),优选为0.9〜1.5摩尔。