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1. 发明授权

US11085047B2 Synthetic cannabinoid compounds for treatment of substance addiction and other disorders 有权
公开(公告)号：US11085047B2
公开(公告)日：2021-08-10
申请号：US16612472
申请日：2019-02-11
申请人： MyMD Pharmaceuticals (Florida), Inc.
发明人： Jonnie R. Williams
IPC分类号： C07C39/23 , C07D311/00 , A61K31/00 , C12N15/00 , C12N15/82 , A61K31/352 , A61K36/185
摘要： A method of increasing the cannabinoid levels in a genetically modified Cannabis sativa plant includes genetically modifying the plant to induce the overexpression of the gene that controls the expression of tetrahydrocannabinolic acid (THCA) synthase and/or cannabidiolic acid (CBDA) synthase. The overexpression of THCA synthase and CBDA synthase catalyzes an increased synthesis of cannabigerolic acid to tetrahydrocannabinolic acid and cannabidiolic acid, as well as the cannabinoids (3aR)-2,4,4-trimethyl-7-pentyl-3,3a,4,9b-tetrahydrocyclopenta[c]chromen-9-ol and 2-((1R,5R)-3-methyl-5-(prop-1-en-2-yl)cyclopent-2-en-1-yl)-5-pentylbenzene-1,3-diol. Pharmaceutical compositions comprising the modified cannabinoids produced by the transgenic Cannabis sativa plant or prepared synthetically are used to treat various diseases and conditions.

2. 发明申请

US20200159115A1 NOVEL SALT COMPOUND, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND PATTERNING PROCESS 审中-公开
公开(公告)号：US20200159115A1
公开(公告)日：2020-05-21
申请号：US16669780
申请日：2019-10-31
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Emiko Ono , Masayoshi Sagehashi , Masahiro Fukushima , Yuki Kera
IPC分类号： G03F7/004 , G03F7/039 , G03F7/038 , C07D307/77 , C07C381/12 , C07C309/12 , C07D311/00 , C07D333/76 , C07D333/08 , C07D327/06 , C08F220/18
摘要： A novel salt having an amide bond in its anion structure is provided. A chemically amplified resist composition comprising the salt has advantages including minimal defects and improved values of sensitivity, LWR, MEF and CDU, when processed by lithography using high-energy radiation such as KrF excimer laser, ArF excimer laser, EB or EUV.

3. 发明授权

US10512856B1 Method of extracting one or more chemical extracts from a plant product 有权
公开(公告)号：US10512856B1
公开(公告)日：2019-12-24
申请号：US16246256
申请日：2019-01-11
申请人： Gildrien Farm, LLC
发明人： Andrew Peter Jackson , Jeremy Adam Gildrien
IPC分类号： C07D311/00 , C11B1/00 , B01D11/00 , B01D11/04 , C11B1/10 , C07D311/80 , C11C1/00
摘要： Disclosed is a method for extracting one or more chemical extracts from a plant product. The chemical extracts are purified and extracted by first separating at least a phytochemical bearing part of a plant product from one or more other portions of the plant product. A carrier oil is then heated at a target temperature to be used as the vehicle for extraction and then mixed with the at least a phytochemical bearing part while the target temperature is maintained. The process may be streamlined by having heating and mixing occur in a press device. The mixed carrier oil and the at least a phytochemical bearing part are then passed through the press device to produce an oil mixture. At least a chemical extract may be extracted from the oil mixture, and in some cases may be further purified by evaporation and/or centrifugation.

4. 发明授权

US10029971B2 Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols 有权
公开(公告)号：US10029971B2
公开(公告)日：2018-07-24
申请号：US15411861
申请日：2017-01-20
申请人： BioElectron Technology Corporation
发明人： Paul Mollard
IPC分类号： C07C46/06 , C07C403/00 , C07D311/00
摘要： A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans.

5. 发明授权

US09921225B2 Phenyl glyoxal probes 有权
公开(公告)号：US09921225B2
公开(公告)日：2018-03-20
申请号：US15160079
申请日：2016-05-20
申请人： The Scripps Research Institute
发明人： Paul R. Thompson , Kevin L. Bicker , Venkataraman Subramanian
IPC分类号： C07C45/00 , C07C49/00 , C07D311/00 , C07B59/00 , G01N33/58 , C12Q1/34 , G01N33/532 , G01N33/68 , C07C49/86 , C07C247/04 , C07C45/61 , C07D311/86 , C07D311/90 , C07D495/04 , G01N33/92 , C07D493/10
CPC分类号： G01N33/581 , C07B59/00 , C07B2200/05 , C07C45/61 , C07C49/86 , C07C247/04 , C07D311/86 , C07D311/90 , C07D493/10 , C07D495/04 , C12Q1/34 , G01N33/532 , G01N33/582 , G01N33/583 , G01N33/68 , G01N33/6803 , G01N33/6893 , G01N33/92 , G01N2333/775 , G01N2333/978 , G01N2440/18 , G01N2458/15 , G01N2500/00 , G01N2570/00
摘要： Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described.

6. 发明授权

US09567279B2 Methods for oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols 有权
标题翻译：在非α-生育三烯酚存在下氧化α-生育三烯酚的方法
公开(公告)号：US09567279B2
公开(公告)日：2017-02-14
申请号：US14850855
申请日：2015-09-10
申请人： Edison Pharmaceuticals, Inc.
发明人： Paul Mollard
IPC分类号： C07C46/00 , C07C403/00 , C07D311/00 , C07C46/06 , C07D311/72 , C07C403/08
CPC分类号： C07C46/06 , C07C403/08 , C07C2601/16 , C07D311/72 , C07C50/28
摘要： A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-to-cotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans.
摘要翻译：一种生产α-生育三烯酚醌或其立体异构体的方法，所述方法包括通过用金属盐氧化剂氧化α-对三烯酚，在非α-生育三烯酚染料色素存在下选择性地将α-生育三烯酚苯并二氢吡喃酮打开至α-生育三烯酚醌，其中金属盐氧化剂/α-生育三烯酚的化学计量比为至少4:1，并且其中所述金属氧化剂按顺序加入添加，以减少任何量的非α-生育三烯酚染色剂的氧化，这可能已经被存在于起始α-生育三烯酚色满物质中。该方法使用有利于α-生育三烯酚色度酮与非α-生育三烯酚染料色素的氧化速率的条件。

7. 发明授权

US09522932B2 Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production 有权
标题翻译：可用作用于治疗病毒感染的药物组合物中的活性成分的膦酸核苷和用于其生产的中间体
公开(公告)号：US09522932B2
公开(公告)日：2016-12-20
申请号：US14867208
申请日：2015-09-28
申请人： K.U. Leuven Research & Development
发明人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De Clercq
IPC分类号： C07H23/00 , C07H19/04 , C07H19/20 , C07H19/10 , C07H3/00 , C07H11/00 , C07H15/00 , C07H17/00 , C07D311/00 , C07D493/00 , C07D305/00 , C07D309/00 , C07H19/00 , C07H19/06 , C07H19/16 , C07H1/00 , C07F7/08 , C07H15/04 , C07H17/02 , C07D313/00 , C07D319/00 , C07D321/00 , C07D323/00 , C07D325/00 , C07D407/00 , C07D323/04 , C07F7/02
CPC分类号： C07H19/20 , C07F7/0812 , C07H1/00 , C07H15/04 , C07H17/02 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： The invention is directed to a process for the preparation of substituted threonolactone and substituted threose compounds which are intermediates in the synthesis of phosphonate nucleosides being useful antiviral agents.
摘要翻译：本发明涉及一种制备取代的苏氨酸内酯和取代的苏糖化合物的方法，其是合成膦酸酯核苷的中间体是有用的抗病毒剂。

8. 发明授权

US09422259B2 Synthetic transtaganolide and basiliolide products, derivatives thereof, and synthesis methods thereof 有权
标题翻译：合成的转铁蛋白和巴利内酯产物及其衍生物及其合成方法
公开(公告)号：US09422259B2
公开(公告)日：2016-08-23
申请号：US14529911
申请日：2014-10-31
申请人： California Institute of Technology
发明人： Hosea Nelson , Kei Murakami , Scott C. Virgil , Brian M. Stoltz , Jonathan R. Gordon
IPC分类号： C07D313/06 , C07D311/00 , C07D493/08 , C07D493/18 , C07D493/16
CPC分类号： C07D311/00 , C07D493/08 , C07D493/16 , C07D493/18
摘要： Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.
摘要翻译：提供由式I表示的化合物，其包括合成的经斯曲肽内酯和巴利内酯产物。还提供了这些化合物的衍生物和合成方法。

9. 发明授权

US09139551B2 Preparation of a new class of water-soluble ammonium 2,3-dihydroxy-5-((2R,3R)-3,5,7-trihydroxy-4-oxochroman-2-yl) phenolates and their biological activity of alcohol elimination 有权
标题翻译：制备新一类水溶性2,3-二羟基-5 - （（2R，3R）-3,5,7-三羟基-4-氧代色满-2-基）苯酚盐及其消除醇的生物学活性
公开(公告)号：US09139551B2
公开(公告)日：2015-09-22
申请号：US14159588
申请日：2014-01-21
申请人： Xianxing Jiang , Dekui Zhang , Cheng Jin
发明人： Xianxing Jiang , Dekui Zhang , Cheng Jin
IPC分类号： A61K31/445 , A61K31/35 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00 , C07D311/00 , C07D311/62
CPC分类号： C07D311/62
摘要： A new class of high water-soluble compound based upon the Hovenia plant, or its herbal extract form known as DHM, and the methods for synthesizing same, to produce anti-alcohol intoxication treatment to alleviate the symptoms of hangover and other over-drinking, binge-drinking related ailments. Such compounds, known as TDHM and PDHM, can reduce the alcohol concentration in the blood, lengthen the waking time, and shorten the period of drowsiness induced after drinking alcohol; they also are proved to have high water solubility and thus are suitable for immediate protection and treatment to persons with alcohol intoxication or hangover and over-drinking.
摘要翻译：一种新型的基于禾本科植物的高水溶性化合物或其称为DHM的草药提取物及其合成方法，用于产生抗酒精中毒治疗以缓解宿醉和过度饮酒的症状，饮酒有关的疾病。称为TDHM和PDHM的化合物可以降低血液中的酒精浓度，延长醒来时间，并缩短饮酒后诱发的睡意期; 它们也被证明具有高水溶性，因此适用于立即对酒精中毒或宿醉和过度饮酒的人进行保护和治疗。

10. 发明授权

US09018249B2 SGLT inhibitors 有权
标题翻译： SGLT抑制剂
公开(公告)号：US09018249B2
公开(公告)日：2015-04-28
申请号：US14344628
申请日：2012-09-12
申请人： Rajesh Jain , Sanjay Trehan , Jagattaran Das , Gurmeet Kaur Nanda , Sastry V. R. S. Thungathurthi , Nishan Singh , Sudhir Kumar Sharma
发明人： Rajesh Jain , Sanjay Trehan , Jagattaran Das , Gurmeet Kaur Nanda , Sastry V. R. S. Thungathurthi , Nishan Singh , Sudhir Kumar Sharma
IPC分类号： A61K31/352 , C07D311/00 , C07D309/10 , C07D493/08
CPC分类号： C07D309/10 , C07D493/08 , C07H7/04
摘要： The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).
摘要翻译：本发明涉及式I的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂化物。本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构形式，异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。本发明还提供包含式I的新化合物和治疗或预防一种或多种可通过抑制葡萄糖转运蛋白-2（SGLT-2）调节或归一化的病症或疾病的药物组合物。

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