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1. 发明申请

WO2008092011A2 BIOFILM-INHIBITING MEDICAL PRODUCTS 审中-公开
标题翻译：生物膜抑制医疗产品
公开(公告)号：WO2008092011A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/051924
申请日：2008-01-24
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , BATES, Brian, L. , HILES, Michael, C. , JOHNSON, Chad, E.
发明人： BATES, Brian, L. , HILES, Michael, C. , JOHNSON, Chad, E.
IPC分类号： A61L26/00
CPC分类号： A61L15/44 , A61L15/40 , A61L26/0057 , A61L26/0066 , A61L31/005 , A61L31/16 , A61L2300/216 , A61L2300/404
摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
摘要翻译：生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

2. 发明申请

WO9933515A3 APPARATUS FOR SUPPLYING RADIOACTIVE GAS TO A DELIVERY DEVICE 审中-公开
标题翻译：将放射性气体供应给送货装置的装置
公开(公告)号：WO9933515A3
公开(公告)日：1999-09-16
申请号：PCT/US9825129
申请日：1998-12-01
申请人： COOK INC , MED INST INC , APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
IPC分类号： A61M36/04 , A61F2/958 , A61M36/12 , A61N5/10 , A61M36/06
CPC分类号： A61M25/10182 , A61M25/10185 , A61N5/1002 , A61N2005/1021
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).
摘要翻译：公开了一种填充有诸如惰性放射性气体的辐射载体材料用于治疗血管成形术后的再狭窄的导管装置和恶性肿瘤。膨胀的导管包括单个单元或者可替换地，用于运输放射性载体材料的多个离散室，并且血液可以在用规定的辐射治疗期间继续流动。当放射性载体是诸如氙133的气体时，可以使用注射装置（1400），其允许使用可装载到放射源小瓶外壳或室（1403）中的标准放射性气体源小瓶（1401）。用于封闭小瓶（1404）的装置还可以用作推动机构（1442），以将源小瓶（1401）推向一个或多个允许将放射性气体输送到导管的刺穿套管（1406,1454）。在一系列实施例中，放射性气体通过诸如多位置阀的选择器装置（1409）被抽出到诸如注射器的气密可变容积腔室（1411）中，然后将其放置以将气体输送到导管。在处理之后，将气体取出到注射器中并返回到源小瓶（1401）。在另一系列实施例中，使用填充有液体的注射器将气体直接置换到输送导管（1422）中，或者进入将气体注射到输送导管（1422）的第二注射器中。

3. 发明申请

WO2010025379A1 VENA CAVA FILTER HAVING PLURALITY OF HOOKS 审中-公开
标题翻译： VENA CAVA过滤器具有多样的HOOKS
公开(公告)号：WO2010025379A1
公开(公告)日：2010-03-04
申请号：PCT/US2009/055381
申请日：2009-08-28
申请人： COOK INCORPORATED , BATES, Brian, L.
发明人： BATES, Brian, L.
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： A removable filter for capturing thrombi in a body vessel is disclosed. The filter comprises a plurality of primary struts comprising proximal and distal portions. Each proximal portion has a first end, wherein the first ends are attached together along a longitudinal axis. Each primary strut extends arcuately along the longitudinal axis and linearly radially. The distal portions of the primary struts are configured to expand in the body vessel, engaging the distal hooks with the body vessel. Each distal portion integrally extends from the proximal portion to a plurality of distal hooks. The distal hooks are substantially equal in size relative to each other.
摘要翻译：公开了一种用于在身体血管中捕获血栓的可移除过滤器。过滤器包括多个主支柱，其包括近端部分和远端部分。每个近端部分具有第一端，其中第一端部沿着纵向轴线附接在一起。每个主支柱沿着纵向轴线弧线延伸并且线性地径向延伸。主支柱的远端部分构造成在身体容器中膨胀，将远端钩与身体血管接合。每个远侧部分从近端部分整体地延伸到多个远端钩。远端钩相对于彼此大小相等。

4. 发明申请

WO2008092011A3 BIOFILM-INHIBITING MEDICAL PRODUCTS 审中-公开
标题翻译：生物膜抑制医疗产品
公开(公告)号：WO2008092011A3
公开(公告)日：2009-08-13
申请号：PCT/US2008051924
申请日：2008-01-24
申请人： COOK INC , COOK BIOTECH INC , BATES BRIAN L , HILES MICHAEL C , JOHNSON CHAD E
发明人： BATES BRIAN L , HILES MICHAEL C , JOHNSON CHAD E
IPC分类号： A61L15/40 , A61L15/44 , A61L26/00 , A61L31/00 , A61L31/16
CPC分类号： A61L15/44 , A61L15/40 , A61L26/0057 , A61L26/0066 , A61L31/005 , A61L31/16 , A61L2300/216 , A61L2300/404
摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
摘要翻译：生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

5. 发明申请

WO2007041131A3 COATED VASO-OCCLUSION DEVICE 审中-公开
标题翻译：涂层血管闭塞装置
公开(公告)号：WO2007041131A3
公开(公告)日：2007-09-20
申请号：PCT/US2006037595
申请日：2006-09-28
申请人： COOK INC , BATES BRIAN L
发明人： BATES BRIAN L
IPC分类号： A61B17/12 , A61B17/00 , A61B19/00 , A61L27/40 , A61L31/16
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1215 , A61B17/12181 , A61B90/39 , A61B2017/00004 , A61B2017/00893 , A61B2090/374 , A61B2090/3954 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/418 , A61L2300/42 , A61L2430/36 , C08L75/04
摘要： Compositions and methods for occluding a vessel in a subject are provided in which a vaso-occlusion device includes an occluding element having a polymeric material containing a plurality of holes at least partially filled with one or more bioactive agents, the vaso-occlusion device configured to occlude a vessel in the subject.
摘要翻译：提供了用于封闭受试者中的血管的组合物和方法，其中血管阻塞装置包括阻塞元件，该阻塞元件具有包含至少部分地填充有一种或多种生物活性剂的多个孔的聚合物材料，血管阻塞装置被配置为在受试者中阻塞血管。

6. 发明申请

WO2007041131A2 COATED VASO-OCCLUSION DEVICE 审中-公开
标题翻译：涂层VASO-OCCLUSION设备
公开(公告)号：WO2007041131A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/037595
申请日：2006-09-28
申请人： COOK INCORPORATED , BATES, Brian, L.
发明人： BATES, Brian, L.
IPC分类号： A61B17/12 , A61L31/16
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1215 , A61B17/12181 , A61B90/39 , A61B2017/00004 , A61B2017/00893 , A61B2090/374 , A61B2090/3954 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/418 , A61L2300/42 , A61L2430/36 , C08L75/04
摘要： Compositions and methods for occluding a vessel in a subject are provided in which a vaso-occlusion device includes an occluding element having a polymeric material containing a plurality of holes at least partially filled with one or more bioactive agents, the vaso-occlusion device configured to occlude a vessel in the subject.
摘要翻译：提供了一种用于闭塞受试者中的血管的组合物和方法，其中血管闭塞装置包括具有至少部分填充有一种或多种生物活性剂的多个孔的聚合材料的阻塞元件，所述血管闭塞装置被配置为封闭受试者的血管。

7. 发明申请

WO2007002260A3 IMPLANTABLE GRAFT TO CLOSE A FISTULA 审中-公开
公开(公告)号：WO2007002260A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/024260
申请日：2006-06-21
申请人： COOK INCORPORATED , COOK BIOTECH, INC. , ARMSTRONG, David, N. , BATES, Brian, L. , BLEYER, Mark, W. , OBERMILLER, F., Joseph , PATEL, Umesh, H.
发明人： ARMSTRONG, David, N. , BATES, Brian, L. , BLEYER, Mark, W. , OBERMILLER, F., Joseph , PATEL, Umesh, H.
IPC分类号： A61B17/00
摘要： An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.

8. 发明申请

WO2004100836A1 STENT GRAFT 审中-公开
公开(公告)号：WO2004100836A1
公开(公告)日：2004-11-25
申请号：PCT/US2004/014689
申请日：2004-05-12
申请人： COOK INCORPORATED , COOK BIOTECH INCORPORATED , FETTE, Clay, D. , BATES, Brian, L. , PAUL, Ram, H., Jr. , AMARANT, Paul, D.
发明人： FETTE, Clay, D. , BATES, Brian, L. , PAUL, Ram, H., Jr. , AMARANT, Paul, D.
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/0644 , A61B2017/00252 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61F2/064 , A61F2/848 , A61F2/86 , A61F2/89 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2230/005
摘要： An anastomosis device (12) for advantageously bridging an artery and a vein. The anastomosis device includes a tubular graft (15) with first and second ends (47 and 48) and a longitudinal passageway extending longitudinally through the graft. The device further includes a first stent (10) disposed about the first end of the tubular graft and a second stent (10) disposed about the second end of the tubular graft. Each of the first and second stents has a plurality of hooks or barbs (11) pointed or releasable to the point toward the other end of the graft.
摘要翻译：一种用于有利地桥接动脉和静脉的吻合装置（12）。吻合装置包括具有第一和第二端（47和48）的管状移植物（15）和纵向延伸穿过移植物的纵向通道。该装置还包括围绕管状移植物的第一端设置的第一支架（10）和围绕管状移植物的第二端设置的第二支架（10）。第一和第二支架中的每一个具有多个钩或倒钩（11），所述钩或倒钩可指向或可释放到朝向移植物另一端的点。

9. 发明申请

WO2011109288A1 THERMO-CHEMICAL MEDICAL DEVICE FOR MANIPULATION OF TISSUE 审中-公开
标题翻译：用于操作组织的热化学医疗装置
公开(公告)号：WO2011109288A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026460
申请日：2011-02-28
申请人： COOK MEDICAL TECHNOLOGIES, LLC , BATES, Brian L. , MELSHEIMER, Jeffry S.
发明人： BATES, Brian L. , MELSHEIMER, Jeffry S.
IPC分类号： A61B18/06 , A61B18/00
CPC分类号： A61B18/06 , A61B2018/00023
摘要： The present invention provides a medical device for manipulation of tissue of a patient. The medical device comprises a shaft having a proximal section extending to a distal section that has a closed distal end portion. The shaft has a plurality of lumens formed therein including a first lumen and a second lumen. The first lumen is for distally advancing a first reactant through the proximal section. The second lumen is for distally advancing a second reactant through the proximal section. Positioned longitudinally within the shaft and distally from the first and second lumens is a mixing element. The mixing element is in fluid communication with the first and second lumens. The mixing element has a series of baffles for mixing the first and second reactants together producing a reaction product to heat the closed distal end portion of the shaft for manipulation of the tissue.
摘要翻译：本发明提供了一种用于操纵患者组织的医疗装置。医疗装置包括轴，该轴具有延伸到具有封闭的远端部分的远侧部分的近端部分。轴具有形成在其中的多个腔，其包括第一腔和第二腔。第一管腔用于通过近端部分远端推进第一反应物。第二腔用于通过近端部分远端推进第二反应物。一个混合元件纵向定位在轴内并远离第一和第二管腔。混合元件与第一和第二内腔流体连通。混合元件具有一系列用于将第一和第二反应物混合在一起的挡板，产生反应产物以加热用于组织的操作的轴的封闭的远端部分。

10. 发明申请

WO2011037866A1 VESSEL CLOSURE DEVICE 审中-公开
标题翻译：船舶关闭装置
公开(公告)号：WO2011037866A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/049505
申请日：2010-09-20
申请人： COOK INCORPORATED , PAUL, Ram, H., Jr. , BATES, Brian, L. , STANLEY, Cleon, P.
发明人： PAUL, Ram, H., Jr. , BATES, Brian, L. , STANLEY, Cleon, P.
IPC分类号： A61B17/00 , A61B17/29
CPC分类号： A61B17/0057 , A61B17/29 , A61B2017/0034 , A61B2017/00473 , A61B2017/00575 , A61B2017/2905 , A61B2017/2931 , A61B2017/303
摘要： A device and system for closure of an opening formed in a body vessel includes a bioabsorbable grasping member and locking member. The grasping member includes grasping lingers that are radially collapsible to the closed positions by movement of the locking member over the fingers. A distal portion of the fingers is configured to grasp an outer wall portion of the body vessel surrounding the opening when the fingers are in the open position. Movement of the locking member can cause the fingers to at least substantially close the vessel opening. Structural features on the fingers and/or locking member can inhibit proximal or distal movement of the locking member when in a locking position. A detachable arm can be coupled to the grasping member to facilitate placement of the grasping member. A sheath can fit over the detachable arm and be configured to move the locking member over the fingers.
摘要翻译：用于封闭形成在体容器中的开口的装置和系统包括生物可吸收的抓持构件和锁定构件。抓持构件包括通过锁定构件在指状物上的移动而径向可折叠到关闭位置的抓握件。手指的远端部分构造成当手指处于打开位置时抓住围绕开口的身体血管的外壁部分。锁定构件的运动可导致手指至少基本上关闭容器开口。手指和/或锁定构件上的结构特征可以在锁定位置时阻止锁定构件的近端或远端运动。可拆卸臂可以联接到抓握构件以便于抓握构件的放置。护套可以装配在可拆卸臂上方并且被配置成使锁定构件移动超过手指。

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