会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 24. 发明申请
    • Novel cancer-associated genes
    • 新型癌症相关基因
    • US20050037347A1
    • 2005-02-17
    • US10451000
    • 2001-12-21
    • Osamu OharaTakahiro NagaseDaisuke NakajimaShin-ichi Funahashi
    • Osamu OharaTakahiro NagaseDaisuke NakajimaShin-ichi Funahashi
    • A61P13/08A61P15/00A61P35/00C07K14/47C12N15/12C12Q1/68C07H21/04C07K14/72C07K16/30G01N33/574
    • C07K14/47A61K2039/505
    • The present invention is related to a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with an amino acid sequence represented by SEQ ID No. 1 or No. 2, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No. 1 or No. 2 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a). The present invention is further related to an antibody binding to the polypeptide or protein, an anti-cancer agent comprising the antibody, a method of screening a substance that binds to the protein or a peptide fragment thereof, and a polynucleotide having at least 15 bases and hybridizing with the DNA according to the present invention under stringent conditions, and a method of detecting cancer with the use of said polynucleotide. The DNA according to the present invention is a cancer-associated gene, and that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
    • 本发明涉及包含编码以下多肽(a)或(b)的核苷酸序列的DNA:(a)由与SEQ ID NO:1所示氨基酸序列相同或基本相同的氨基酸序列组成的多肽 1或2,(b)由SEQ ID No.1或No.2所示的氨基酸序列组成的多肽,其中部分氨基酸被缺失,取代或添加并且具有基本上相同的生物活性 作为多肽(a)的功能。 本发明还涉及与多肽或蛋白质结合的抗体,包含抗体的抗癌剂,筛选与蛋白质结合的物质或其肽片段的方法,以及具有至少15个碱基的多核苷酸 并且在严格条件下与根据本发明的DNA杂交,以及使用所述多核苷酸检测癌症的方法。 根据本发明的DNA是癌相关基因,并且可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此,本发明的抗体不仅用于检测本发明的蛋白质,而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
    • 25. 发明授权
    • Voice learning apparatus, voice learning method, and storage medium storing voice learning program
    • 语音学习装置,语音学习方法以及存储语音学习程序的存储介质
    • US09483953B2
    • 2016-11-01
    • US13568397
    • 2012-08-07
    • Daisuke Nakajima
    • Daisuke Nakajima
    • G10L13/00G10L13/08G09B5/06
    • G09B5/06G10L13/00
    • A voice learning apparatus includes a learning-material voice storage unit that stores learning material voice data including example sentence voice data; a learning text storage unit that stores a learning material text including an example sentence text; a learning-material text display controller that displays the learning material text; a learning-material voice output controller that performs voice output based on the learning material voice data; an example sentence specifying unit that specifies the example sentence text during the voice output; an example-sentence voice output controller that performs voice output based on the example sentence voice data associated with the specified example sentence text; and a learning-material voice output restart unit that restarts the voice output from a position where the voice output is stopped last time, after the voice output is performed based on the example sentence voice data.
    • 语音学习装置包括学习材料语音存储单元,其存储包括例句语音数据的学习材料语音数据; 学习文本存储单元,其存储包括例句文本的学习材料文本; 学习材料文本显示控制器,显示学习材料文本; 基于学习材料语音数据执行语音输出的学习材料语音输出控制器; 在语音输出期间指定例句文本的例句指定单元; 基于与指定的例句文本相关联的例句语音数据执行语音输出的示例语音输出控制器; 以及学习材料语音输出重启单元,在基于该例句语音数据执行语音输出之后,从上次停止语音输出的位置重新启动语音输出。
    • 26. 发明授权
    • Sliced specimen preparing apparatus
    • 切片标本制备装置
    • US09109982B2
    • 2015-08-18
    • US14113951
    • 2012-04-24
    • Daisuke NakajimaYuko Nanjo
    • Daisuke NakajimaYuko Nanjo
    • G01N1/28G01N1/06
    • G01N1/286G01N1/06
    • A sliced specimen preparing apparatus prepares a sliced specimen by slicing a surface of a specimen block in which a specimen is embedded in an embedding-substance. The apparatus includes: a cutter configured to slice the surface of the specimen block; a surface exposure determination unit configured to determine whether or not the area of a specimen portion on the surface of the specimen block is sufficient for the preparation of the sliced specimen; and a specimen block transporting unit configured to transport the specimen block between the surface exposure determination unit and the cutter. The surface exposure determination unit includes a humidifying unit configured to humidify the surface of the specimen block; an irradiating unit configured to irradiate the surface of the specimen block with light; an imaging unit configured to receive reflected light from the humidified surface of the specimen block which is irradiated from the irradiating unit to acquire image data; an image data processing unit configured to discriminate the specimen portion on the surface of the specimen block from the embedding-substance portion based on the image data acquired by the imaging unit; and a controller configured to control the imaging unit, the irradiating unit, and the image data processing unit, and to determine whether or not the area of the specimen portion on the surface of the specimen block, the specimen portion being acquired by the image data processing unit, is sufficient for the preparation of the sliced specimen.
    • 切片试样制备装置通过将样品嵌入嵌入物质中的样品块的表面切片来制备切片试样。 该装置包括:切割器,被配置为切片样品块的表面; 表面曝光判定单元,其被配置为确定样本块的表面上的样本部分的面积是否足以制备切片样本; 以及被配置为在所述表面曝光判定单元和所述切割器之间输送所述检体块的检体块传送单元。 表面曝光判定单元包括:加湿单元,其构造成对样本块的表面进行加湿; 照射单元,被配置为用光照射所述样本块的表面; 成像单元,被配置为从所述照射单元接收从所述样本块的所述加湿表面接收的反射光,以获取图像数据; 图像数据处理单元,被配置为基于由所述成像单元获取的图像数据,将所述样本块的表面上的样本部分与所述嵌入物部分区分开; 以及控制器,被配置为控制成像单元,照射单元和图像数据处理单元,并且确定样本块的表面上的样本部分的面积,样本部分是否由图像数据获取 处理单元,足以制备切片样品。
    • 27. 发明申请
    • LAMINATED BODY
    • 层压体
    • US20130236728A1
    • 2013-09-12
    • US13415755
    • 2012-03-08
    • Kazuho UchidaTsutomu AndoDaisuke Nakajima
    • Kazuho UchidaTsutomu AndoDaisuke Nakajima
    • B32B27/08B32B27/28
    • C09D4/06C09D133/14C09D143/04Y10T428/31507Y10T428/31663
    • A laminated body with surface layers having excellent abrasion resistance is disclosed. The laminated body is provided with a resin base material; a first layer laminated over at least part of the resin base material; and a second layer laminated on the second surface of the first layer opposite the first surface on which the resin base material is laminated. The first layer is formed by curing a first composition that contains: an inorganic polymer obtainable by hydrolytic condensation of inorganic polymer components including a silane compound represented by the following formula (1); Si(R1)p(OR2)4-p  (1) a water-soluble polyfunctional (meth)acrylate; and an active energy ray polymerization initiator, and the second layer is formed by curing a second composition containing a thermosetting organosiloxane. In the formula (1), R1 represents a C1-30 organic group containing a polymerizable double bond; R2 represents a C1-6 alkyl group; and p is 1 or 2.
    • 公开了具有优异耐磨性的表层的层叠体。 层叠体设置有树脂基材; 在所述树脂基材的至少一部分上层叠的第一层; 以及层叠在与层叠有树脂基材的第一表面相反的第一层的第二表面上的第二层。 第一层通过固化第一组合物形成,所述第一组合物包含:通过包含由下式(1)表示的硅烷化合物的无机聚合物组分的水解缩合得到的无机聚合物; Si(R1)p(OR2)4-p(1)水溶性多官能(甲基)丙烯酸酯; 和活性能量射线聚合引发剂,并且通过固化含有热固性有机硅氧烷的第二组合物形成第二层。 在式(1)中,R 1表示含有可聚合双键的C1-30有机基团; R2表示C1-6烷基; p为1或2。
    • 28. 发明申请
    • MEMORY DEVICE AND MEMORY SYSTEM
    • 存储器件和存储器系统
    • US20120198186A1
    • 2012-08-02
    • US13340981
    • 2011-12-30
    • Junichi KoshiyamaTamaki KonnoDaisuke NakajimaToshifumi Nishiura
    • Junichi KoshiyamaTamaki KonnoDaisuke NakajimaToshifumi Nishiura
    • G06F12/02
    • G06F12/0246G06F2212/7201Y02D10/13
    • A memory device includes a plurality of nonvolatile memories configured to be erased at updating of data, and a memory controller configured to control the nonvolatile memory. The memory controller includes an address conversion table configured to convert a logical address specified by at data writing into a physical address of the nonvolatile memory, an erased physical block managing unit configured to manage an erased physical block address, the nonvolatile memory of the erased physical block address, and an erased physical block count on each nonvolatile memory, an erasable physical block managing unit configured to manage an erasable physical block address, the nonvolatile memory of the erasable physical block address, and an erasable physical block count on each nonvolatile memory, and a memory control unit configured to control writing and erasing on the plurality of nonvolatile memories.
    • 一种存储装置,包括被配置为在更新数据时被擦除的多个非易失性存储器,以及配置成控制非易失性存储器的存储器控​​制器。 存储器控制器包括:地址转换表,被配置为将由数据写入指定的逻辑地址转换为非易失性存储器的物理地址;擦除物理块管理单元,被配置为管理擦除的物理块地址;擦除的物理的非易失性存储器 块地址和每个非易失性存储器上擦除的物理块计数;可擦除物理块管理单元,被配置为管理可擦除物理块地址,可擦除物理块地址的非易失性存储器和每个非易失性存储器上的可擦除物理块计数, 以及存储器控制单元,被配置为控制对所述多个非易失性存储器的写入和擦除。