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71. 发明申请

US20110263497A1 APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
标题翻译： APO A-I MIME技术和治疗方法
公开(公告)号：US20110263497A1
公开(公告)日：2011-10-27
申请号：US13177473
申请日：2011-07-06
申请人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
发明人： Katsuyuki Murase , Li Zhao , Irina Astafieva , Paul M. Consigny
IPC分类号： A61K38/10 , A61P9/10
CPC分类号： A61K38/17 , A61K31/661 , A61K38/10 , A61K38/1709
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与内源性Apo AI相关肽的顺序相反的顺序。一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

72. 发明申请

US20110207751A1 HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 审中-公开
标题翻译：杂环化合物和作为反应剂的用途
公开(公告)号：US20110207751A1
公开(公告)日：2011-08-25
申请号：US13031134
申请日：2011-02-18
申请人： Long Mao , Xiaobo Wang , Xiao Xu , Li Zhao , Jia Liu
发明人： Long Mao , Xiaobo Wang , Xiao Xu , Li Zhao , Jia Liu
IPC分类号： A61K31/519 , C07D487/04 , A61P35/00 , A61P35/02 , A61K31/429 , C07D513/04 , A61K31/4439
CPC分类号： C07D471/04 , C07D513/04
摘要： Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有被噻唑环取代的稠合双环杂芳环体系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

73. 发明申请

US20090081298A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
公开(公告)号：US20090081298A1
公开(公告)日：2009-03-26
申请号：US11946026
申请日：2007-11-27
申请人： Katsuyuki Murase , Syed F. A. Hossainy , Irina Astafieva , Li Zhao , Hong Ma
发明人： Katsuyuki Murase , Syed F. A. Hossainy , Irina Astafieva , Li Zhao , Hong Ma
IPC分类号： A61K9/14 , A61K38/02 , A61K38/10 , A61K38/17 , C07K14/775 , C07K7/08
CPC分类号： C07K7/08 , A61F2/95 , A61K9/1075 , A61K9/127 , A61K38/00 , A61L29/16 , A61L2300/25 , A61L2300/802 , A61M25/1011 , A61M2025/0086 , A61M2025/105 , A61M2025/1075 , C07K7/06 , C07K14/775
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

74. 发明授权

US06392195B1 Heated steering wheel 失效
标题翻译：加热方向盘
公开(公告)号：US06392195B1
公开(公告)日：2002-05-21
申请号：US09723138
申请日：2000-11-27
申请人： Li Zhao , Scott G. Warhover
发明人： Li Zhao , Scott G. Warhover
IPC分类号： B60L102
CPC分类号： B62D1/065
摘要： A heated steering wheel having a heated element that provides a uniform distribution of heat throughout the rim of the steering wheel. The heating element is a thin fabric woven made from nylon coated with silver and has a constant temperature coefficient. The heated steering wheel provides a foam layer surrounding the heating element, and this layer prevents the leather wrapping from being uneven due to the presence of the bus bar. The heating element can also be used in a steering wheel having a wood veneer shell.
摘要翻译：一种具有加热元件的加热方向盘，其在方向盘的整个轮缘上提供均匀的热分布。加热元件是由涂覆有银的尼龙制成的薄织物并且具有恒定的温度系数。加热的方向盘提供围绕加热元件的泡沫层，并且该层防止由于母线的存在而使皮革包裹不均匀。加热元件也可用于具有木材单板壳的方向盘。

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