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1. 发明申请

US20070185133A1 Aminopyrimidine compounds and methods of use 有权
标题翻译：氨基嘧啶化合物及其使用方法
公开(公告)号：US20070185133A1
公开(公告)日：2007-08-09
申请号：US11304901
申请日：2005-12-16
申请人： Adrian Smith , Paul Brennan , Frenel DeMorin , Gang Liu , Nick Paras , Daniel Retz , Elizabeth Rainbeau
发明人： Adrian Smith , Paul Brennan , Frenel DeMorin , Gang Liu , Nick Paras , Daniel Retz , Elizabeth Rainbeau
IPC分类号： A61K31/513 , A61K31/506 , C07D417/14
CPC分类号： C07D417/14 , C07D409/14
摘要： The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
摘要翻译：本发明涉及可用于治疗由polo样激酶1（Plk1）介导的疾病的氨基嘧啶化合物。本发明还涉及这种氨基嘧啶化合物及其组合物在治疗与异常细胞生长和不想要的细胞增殖相关的疾病状态中的治疗用途。

2. 发明授权

US08849431B2 Configuration based programmable logic controller (PLC) programming 有权
标题翻译：基于配置的可编程逻辑控制器（PLC）编程
公开(公告)号：US08849431B2
公开(公告)日：2014-09-30
申请号：US13038368
申请日：2011-03-01
申请人： Keith Thomson , Paul Brennan
发明人： Keith Thomson , Paul Brennan
IPC分类号： G05B19/42 , G05B11/01 , G05B19/05 , G05B19/042
CPC分类号： G05B19/0426 , G05B19/056 , G05B2219/23297
摘要： Systems and methods for dynamic reconfiguration of an application of a programmable process controller are provided. According to one embodiment, a configuration device reads a new configuration file, which contains information regarding a desired number of instances and desired configurations of modules of the process control application, from its local memory. The configuration device then causes the application to instantiate the desired number of instances with the desired configurations by replacing an existing configuration file of the programmable process controller with the new configuration file. In another embodiment, a process control application of a programmable process controller dynamically configures its structure and memory allocation usage. During startup of the application, a configuration file is read that defines a number of instances and configurations of modules for the application. Based thereon, the application creates the defined number of instances of the modules having the defined configurations.
摘要翻译：提供了用于可编程过程控制器的应用的动态重新配置的系统和方法。根据一个实施例，配置设备从其本地存储器读取新配置文件，其包含关于期望数量的实例和过程控制应用的模块的期望配置的信息。然后，配置设备通过用新的配置文件替换可编程过程控制器的现有配置文件，使应用程序实例化具有所需配置的所需数量的实例。在另一个实施例中，可编程过程控制器的过程控制应用程序动态配置其结构和存储器分配使用。在启动应用程序期间，将读取一个配置文件，该配置文件定义了应用程序的多个实例和模块配置。基于此，应用程序创建具有定义的配置的模块的定义数量的实例。

3. 发明申请

US20060079931A1 Surgical deep needle driver 审中-公开
标题翻译：手术深针驱动
公开(公告)号：US20060079931A1
公开(公告)日：2006-04-13
申请号：US11186385
申请日：2005-07-21
申请人： Paul Brennan , Amit Kumar
发明人： Paul Brennan , Amit Kumar
IPC分类号： A61B17/28
CPC分类号： A61B17/062 , A61B2017/2837
摘要： The disclosure is directed to an improved deep needle driver for use when working on patients having significant tissue thicknesses, where conventional instruments are too short or do not provide suitable maneuverability within deep tissue. The driver includes a pair arms bent at two positions, where the arms are pivotally joined to form a movable jaw.
摘要翻译：本公开涉及一种改进的深针式驱动器，用于在具有显着组织厚度的患者上使用，其中常规仪器太短或不能在深部组织内提供适当的机动性。驾驶员包括在两个位置弯曲的一对臂，其中臂被枢转地连接以形成可动颚。

4. 发明申请

US20120226368A1 CONFIGURATION BASED PROGRAMMABLE LOGIC CONTROLLER (PLC) PROGRAMMING 有权
标题翻译：基于配置的可编程逻辑控制器（PLC）编程
公开(公告)号：US20120226368A1
公开(公告)日：2012-09-06
申请号：US13038368
申请日：2011-03-01
申请人： Keith Thomson , Paul Brennan
发明人： Keith Thomson , Paul Brennan
IPC分类号： G05B19/00
CPC分类号： G05B19/0426 , G05B19/056 , G05B2219/23297
摘要： Systems and methods for dynamic reconfiguration of an application of a programmable process controller are provided. According to one embodiment, a configuration device reads a new configuration file, which contains information regarding a desired number of instances and desired configurations of modules of the process control application, from its local memory. The configuration device then causes the application to instantiate the desired number of instances with the desired configurations by replacing an existing configuration file of the programmable process controller with the new configuration file. In another embodiment, a process control application of a programmable process controller dynamically configures its structure and memory allocation usage. During startup of the application, a configuration file is read that defines a number of instances and configurations of modules for the application. Based thereon, the application creates the defined number of instances of the modules having the defined configurations.
摘要翻译：提供了用于可编程过程控制器的应用的动态重新配置的系统和方法。根据一个实施例，配置设备从其本地存储器读取新配置文件，其包含关于期望数量的实例和过程控制应用的模块的期望配置的信息。然后，配置设备通过用新的配置文件替换可编程过程控制器的现有配置文件，使应用程序实例化具有所需配置的所需数量的实例。在另一个实施例中，可编程过程控制器的过程控制应用程序动态配置其结构和存储器分配使用。在启动应用程序期间，将读取一个配置文件，该配置文件定义了应用程序的多个实例和模块配置。基于此，应用程序创建具有定义的配置的模块的定义数量的实例。

5. 发明申请

US20110039344A1 METHOD AND TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO LUNG CANCER 审中-公开
标题翻译：方法和测试一个想要预测到肺癌的主体
公开(公告)号：US20110039344A1
公开(公告)日：2011-02-17
申请号：US12735037
申请日：2008-12-12
申请人： Paul Brennan , Ivo Glynne Gut , Simon Heath , Mark Lathrop
发明人： Paul Brennan , Ivo Glynne Gut , Simon Heath , Mark Lathrop
IPC分类号： G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/172 , Y10T436/143333
摘要： The present invention concerns a method of testing a human thought to be predisposed to having lung cancer which comprises the step of analyzing a biological sample from said human for detecting the presence of a polymorphism on chromosome 15q25 associated with lung cancer.
摘要翻译：本发明涉及一种测试易患肺癌的人类思想的方法，该方法包括分析来自所述人类的生物样品的步骤，用于检测与肺癌相关的染色体15q25上的多态性的存在。

6. 发明授权

US07928099B2 Pyrimido [4,5-D] azepine derivatives as 5-HT2c agonists 失效
标题翻译：嘧啶并[4,5-D]吖庚因衍生物，为5-HT 2C激动剂
公开(公告)号：US07928099B2
公开(公告)日：2011-04-19
申请号：US12532715
申请日：2008-03-14
申请人： Mark Andrews , Julian Blagg , Paul Brennan , Paul Fish , R. Ian Storer , Gavin Whitlock
发明人： Mark Andrews , Julian Blagg , Paul Brennan , Paul Fish , R. Ian Storer , Gavin Whitlock
IPC分类号： A61P15/00 , A61P25/00 , A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein the variables R1, R2, R3a, R3b, R3b, R3d, and R100 are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a 5-HT2c receptor-mediated disorders with a compound of formula (I) or a pharmaceutical composition comprising a compound of formula (I).
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中变量R1，R2，R3a，R3b，R3b，R3d和R100如本文所定义。本发明还涉及包含式（I）化合物的药物组合物和用式（I）化合物治疗5-HT 2C受体介导的病症的方法或包含式（I）化合物的药物组合物的方法。

7. 发明申请

US20100113422A1 Pyrimido [4,5-D] Azepine Derivatives As 5-HT2C Agonists 失效
标题翻译：嘧啶并[4,5-D]吖庚因衍生物作为5-HT2C激动剂
公开(公告)号：US20100113422A1
公开(公告)日：2010-05-06
申请号：US12532715
申请日：2008-03-14
申请人： Mark Andrews , Julian Blagg , Paul Brennan , Paul Fish , R. Ian Storer , Gavin Whitlock
发明人： Mark Andrews , Julian Blagg , Paul Brennan , Paul Fish , R. Ian Storer , Gavin Whitlock
IPC分类号： A61K31/55 , C07D487/04 , A61P15/00 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein the variables R1, R2, R3a, R3b, R3b, R3d, and R100 are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a 5-HT2c receptor-mediated disorders with a compound of formula (I) or a pharmaceutical composition comprising a compound of formula (I).
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中变量R1，R2，R3a，R3b，R3b，R3d和R100如本文所定义。本发明还涉及包含式（I）化合物的药物组合物和用式（I）化合物治疗5-HT 2C受体介导的病症的方法或包含式（I）化合物的药物组合物的方法。

8. 发明申请

US20110234447A1 ACTIVE TARGET 审中-公开
标题翻译：活动目标
公开(公告)号：US20110234447A1
公开(公告)日：2011-09-29
申请号：US13070103
申请日：2011-03-23
申请人： David E. Patrick , Paul Brennan
发明人： David E. Patrick , Paul Brennan
IPC分类号： G01S13/74
CPC分类号： G01S7/025 , G01S3/14 , G01S5/0247 , G01S13/825 , G01S13/9307
摘要： An active radar target comprising: a receive antenna for receiving a radar signal, an amplifier for amplifying the signal, and a transmit antenna for retransmitting the amplified signal, characterised in that the active radar target further includes a memory for storing an identity code or means for receiving an identity code, a modulator for receiving the identity code and modulating the radar signal with at least the identity code prior to retransmission of the amplified signal, and wherein the modulator is a single sideband modulator.
摘要翻译：一种主动雷达目标，包括：用于接收雷达信号的接收天线，用于放大信号的放大器和用于重发放大信号的发射天线，其特征在于，所述主动雷达目标还包括存储器，用于存储识别码或装置用于接收身份码，调制器，用于接收所述身份码，并且在重放所述放大的信号之前至少使用所述身份码调制所述雷达信号，并且其中所述调制器是单个边带调制器。

9. 发明授权

US07709199B2 Chronic lymphocytic leukaemia 失效
标题翻译：慢性淋巴细胞性白血病
公开(公告)号：US07709199B2
公开(公告)日：2010-05-04
申请号：US11525517
申请日：2006-09-22
申请人： Chris Pepper , Paul Brennan , Naomi Price-Lloyd , Janet E. Williams , Jeff D. Griffiths , Chris Fegan
发明人： Chris Pepper , Paul Brennan , Naomi Price-Lloyd , Janet E. Williams , Jeff D. Griffiths , Chris Fegan
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/16 , G01N33/57426
摘要： The invention relates to materials and methods for evaluating the prognosis of a patient presenting with chronic myelogenous leukaemia (CLL) and for CLL therapy.
摘要翻译：本发明涉及用于评估呈现慢性骨髓性白血病（CLL）和CLL治疗的患者的预后的材料和方法。

10. 发明申请

US20080042850A1 Radio Frequency Identification (RFID) Tag Antenna Design 有权
标题翻译：射频识别（RFID）标签天线设计
公开(公告)号：US20080042850A1
公开(公告)日：2008-02-21
申请号：US11747700
申请日：2007-05-11
申请人： Erik De Witte , Paul Brennan , Philip Royston , Rajinder Bridgelall
发明人： Erik De Witte , Paul Brennan , Philip Royston , Rajinder Bridgelall
IPC分类号： G08B13/14
CPC分类号： G06K19/07749 , G06K19/0724 , G06K19/07767 , H01Q1/2225 , H01Q1/38 , H01Q7/00 , H01Q9/26 , H01Q9/285 , H01Q21/28
摘要： In certain embodiments, a hybrid radio frequency identification (RFID) tag includes circuitry, a battery, and a first antenna. The circuitry includes one or more passive RFID elements and one or more semi-active RFID elements operable to transmit and receive communications to and from one or more RFID tag tracking systems. The battery is coupled to the one or more semi-active elements. The first antenna is coupled to the passive RFID elements and to the semi-active RFID elements, the first antenna comprising a shape that defines a first open area and a second open area. The circuitry is positioned within one of the first and second open areas defined by the shape of the first antenna, and the battery is positioned within the other of the first and second open areas defined by the shape of the first antenna.
摘要翻译：在某些实施例中，混合射频识别（RFID）标签包括电路，电池和第一天线。电路包括一个或多个无源RFID元件和一个或多个半有源RFID元件，其可操作以发送和接收来自一个或多个RFID标签跟踪系统的通信。电池耦合到一个或多个半活性元件。第一天线耦合到无源RFID元件和半有源RFID元件，第一天线包括限定第一开放区域和第二开放区域的形状。电路位于由第一天线的形状限定的第一和第二开放区域之一内，并且电池位于由第一天线的形状限定的第一和第二开放区域的另一个内。

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