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1. 发明申请

US20070185133A1 Aminopyrimidine compounds and methods of use 有权
标题翻译：氨基嘧啶化合物及其使用方法
公开(公告)号：US20070185133A1
公开(公告)日：2007-08-09
申请号：US11304901
申请日：2005-12-16
申请人： Adrian Smith , Paul Brennan , Frenel DeMorin , Gang Liu , Nick Paras , Daniel Retz , Elizabeth Rainbeau
发明人： Adrian Smith , Paul Brennan , Frenel DeMorin , Gang Liu , Nick Paras , Daniel Retz , Elizabeth Rainbeau
IPC分类号： A61K31/513 , A61K31/506 , C07D417/14
CPC分类号： C07D417/14 , C07D409/14
摘要： The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
摘要翻译：本发明涉及可用于治疗由polo样激酶1（Plk1）介导的疾病的氨基嘧啶化合物。本发明还涉及这种氨基嘧啶化合物及其组合物在治疗与异常细胞生长和不想要的细胞增殖相关的疾病状态中的治疗用途。

2. 发明申请

US20070054916A1 Aryl nitrogen-containing bicyclic compounds and methods of use 审中-公开
标题翻译：芳基含氮双环化合物及其使用方法
公开(公告)号：US20070054916A1
公开(公告)日：2007-03-08
申请号：US11240590
申请日：2005-09-30
申请人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
发明人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
IPC分类号： A61K31/525 , A61K31/519 , A61K31/517
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

3. 发明申请

US20070185324A1 Nitrogen-containing bicyclic heteroaryl compounds and methods of use 有权
标题翻译：含氮双环杂芳基化合物及其使用方法
公开(公告)号：US20070185324A1
公开(公告)日：2007-08-09
申请号：US11643261
申请日：2006-12-20
申请人： Frenel De Morin , Jian Chen , Elizabeth Doherty , Stephen Hitchcock , Qi Huang , Joseph Kim , Gang Liu , Thomas Nixey , Nick Paras , Jeffrey Petkus , Daniel Retz , Adrian Smith , Andrew Tasker , Jiawang Zhu
发明人： Frenel De Morin , Jian Chen , Elizabeth Doherty , Stephen Hitchcock , Qi Huang , Joseph Kim , Gang Liu , Thomas Nixey , Nick Paras , Jeffrey Petkus , Daniel Retz , Adrian Smith , Andrew Tasker , Jiawang Zhu
IPC分类号： A61K31/541 , A61K31/5377 , C07D417/02 , C07D403/02
CPC分类号： C07D401/14 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括能够调节Raf激酶的新一类化合物，因此可用于治疗Raf激酶介导的疾病，包括黑素瘤，肿瘤和其它癌症相关病症。这些化合物具有通式I，其中R 1是和A 1，A 2，A 3，A 3， X，Z，Z'，R 1，R 2，R 3，R 3，本文定义了R 5，R 5和R 6。本发明还包括药物组合物，用于治疗Raf激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

4. 发明授权

US08483762B2 Method and apparatus for enhancing link range in a wireless network using a self-configurable antenna 有权
标题翻译：使用自配置天线增强无线网络中的链路范围的方法和装置
公开(公告)号：US08483762B2
公开(公告)日：2013-07-09
申请号：US12207593
申请日：2008-09-10
申请人： David Steer , Koon Hoo Teo , Adrian Smith
发明人： David Steer , Koon Hoo Teo , Adrian Smith
IPC分类号： H04M1/00 , H04B1/06
CPC分类号： H01Q3/2611 , H01Q3/26
摘要： Embodiments of the invention facilitate providing wireless links with longer link ranges and/or better suppression of interference than can be provided by the integrated antennas of a typical wireless network node. While, in some cases, it is possible to install intermediate wireless network nodes to hop through long expanses between distant wireless network nodes, it is desirable for distantly spaced wireless network nodes to reach one another through a single transit link (i.e. one hop). This approach is preferable because a single transit link is capable of higher data rates and better interference suppression than multi-hop transit links. The present invention provides methods and apparatus for enhancing the link range achievable by typical wireless network nodes so that distantly spaced wireless network nodes are able to communicate with one another using only a single-transit link.
摘要翻译：本发明的实施例有助于提供具有比典型无线网络节点的集成天线提供的更长的链路范围和/或更好的干扰抑制的无线链路。虽然在某些情况下，有可能安装中间无线网络节点来跳过远距离无线网络节点之间的长时间扩展，但是期望远距离间隔的无线网络节点通过单个转接链路（即，一跳）彼此到达。这种方法是优选的，因为单个转接链路能够具有比多跳中继链路更高的数据速率和更好的干扰抑制。本发明提供了用于增强典型无线网络节点可实现的链路范围的方法和装置，使得远距离间隔的无线网络节点能够仅使用单一转接链路彼此通信。

5. 发明授权

US08149707B2 Minimization of radio resource usage in multi-hop networks with multiple routings 有权
标题翻译：在具有多个路由的多跳网络中最小化无线资源使用
公开(公告)号：US08149707B2
公开(公告)日：2012-04-03
申请号：US10683182
申请日：2003-10-10
申请人： David Steer , Koon Hoo Teo , Adrian Smith
发明人： David Steer , Koon Hoo Teo , Adrian Smith
IPC分类号： G06F11/00
CPC分类号： H04W40/246 , H04L45/12 , H04L45/121 , H04L45/36 , H04W28/08 , H04W40/28 , H04W84/22
摘要： Packets in a multi-hop wireless network are routed based on the available link throughputs, network node congestion and the connectivity of the network in a manner that minimizes the use of radio resources and minimizes delay for packets in multi-hop system. The routing method also avoids congestion in the access network, especially near the network access points as provided by network access nodes. Each wireless network node maintains a link table for storing link conditions and associated route costs. Packets are routed according to the low cost route. Subsequent wireless network nodes evaluate whether a lower cost route is available and, if so, route the data packet according to the lower cost route. Every wireless network node transmits the data packet, a specified route and a time stamp indicated a time of the last data entry in the link table that was used to calculate the low cost route.
摘要翻译：基于可用的链路吞吐量，网络节点拥塞和网络的连通性，以最小化无线资源的使用并最小化多跳系统中的分组的延迟的方式来路由多跳无线网络中的分组。路由方法还可以避免接入网络中的拥塞，特别是网络接入节点附近的网络接入点。每个无线网络节点维护用于存储链路条件和相关联的路由成本的链路表。数据包根据低成本路由进行路由。随后的无线网络节点评估较低成本路由是否可用，如果是，则根据较低成本路由路由数据分组。每个无线网络节点发送数据包，指定的路由和时间戳表示在用于计算低成本路由的链路表中最后一个数据条目的时间。

6. 发明授权

US07092712B2 Method and apparatus for alerting a station in one network of a requested communication from a second network 有权
公开(公告)号：US07092712B2
公开(公告)日：2006-08-15
申请号：US10241432
申请日：2002-09-12
申请人： David William James Holmes , Adrian Smith
发明人： David William James Holmes , Adrian Smith
IPC分类号： H04Q7/20
CPC分类号： H04W68/12 , H04W8/02 , H04W8/06 , H04W8/18 , H04W88/06
摘要： A mobile station can be selectively coupled to two or more networks. By maintaining an address translation table and introducing communication between the switching control units within the multiple networks, it is possible to provide notification to the mobile station of the existence of a communication request from a first network while the mobile station coupled to the second network.

7. 发明授权

US06230009B1 Method and apparatus for alerting a station in one network of a requested communication from a second network 失效
标题翻译：一种用于从一个第二网络向一个网络报警所请求的通信的站的方法和装置
公开(公告)号：US06230009B1
公开(公告)日：2001-05-08
申请号：US08777336
申请日：1996-12-27
申请人： David William James Holmes , Adrian Smith
发明人： David William James Holmes , Adrian Smith
IPC分类号： H04Q720
CPC分类号： H04W68/12 , H04W8/02 , H04W8/06 , H04W8/18 , H04W88/06
摘要： A mobile station can be selectively coupled to two or more networks. By maintaining an address translation table and introducing communication between the switching control units within the multiple networks, it is possible to provide notification to the mobile station of the existence of a communication request from a first network while the mobile station coupled to the second network.
摘要翻译：移动台可以选择性地耦合到两个或更多个网络。通过维护地址转换表并引入多个网络内的交换控制单元之间的通信，可以在移动站耦合到第二网络的同时向移动站提供来自第一网络的通信请求的存在。

8. 发明申请

US20110135431A1 HAY BALE STACKER 失效
标题翻译： HAY BACK STACKER
公开(公告)号：US20110135431A1
公开(公告)日：2011-06-09
申请号：US13057597
申请日：2009-08-06
申请人： Adrian Smith
发明人： Adrian Smith
IPC分类号： B60P1/00 , B65G57/00 , B65G47/04
CPC分类号： A01D90/08 , A01D85/005
摘要： An apparatus and method for stacking hay bales. The hay bale stacker includes a trailer having chassis and a platform, a hay clamping assembly (J) positioned at a longitudinal edge of the platform, the clamping assembly is pivotally coupled to the hay bale platform to selectively move between a horizontal bale clamping position and a vertical bale unloading position.
摘要翻译：一种用于堆放干草捆的设备和方法。干草包装机包括具有底盘和平台的拖车，位于平台纵向边缘处的干草夹紧组件（J），夹紧组件可枢转地联接到干草包平台，以选择性地在水平捆包夹紧位置和垂直捆包卸货位置。

9. 发明申请

US20100279317A1 Method 有权
标题翻译：方法
公开(公告)号：US20100279317A1
公开(公告)日：2010-11-04
申请号：US12745862
申请日：2007-12-03
申请人： Adrian Smith
发明人： Adrian Smith
IPC分类号： G01N33/53 , C12Q1/02 , C07K7/08
CPC分类号： C07K14/7051 , G01N33/505 , G01N2333/7051
摘要： The present invention provides a method for identifying a single or group of T cell receptors (TCR) protective and/or effective against a disease, having the following steps: i) obtaining T cells from a donor non-human animal; ii) adoptive transfer of the T cells into a plurality of T cell-deficient recipient non-human animals in a number such that at least one recipient animal is protected against the disease but at least one animal remains unprotected; and iii) determination of the TCR(s) present only in the protected animals. These TCR can be used to identify the determinants or antigens for inclusion in a vaccine or other treatment.
摘要翻译：本发明提供了用于鉴定对疾病有保护和/或有效的单个或一组T细胞受体（TCR）的方法，其具有以下步骤：i）从供体非人动物获得T细胞; ii）将T细胞过继转移到多个T细胞缺陷型受体非人动物中，使得至少一种受体动物被保护免受疾病，但至少一种动物保持不受保护; 和iii）确定仅在受保护的动物中存在的TCR。这些TCR可用于鉴定包含在疫苗或其他治疗中的决定簇或抗原。

10. 发明授权

US07742738B2 Method and system for diversity using orthogonal frequency/division multiplexing 有权
标题翻译：使用正交频分复用的分集方法和系统
公开(公告)号：US07742738B2
公开(公告)日：2010-06-22
申请号：US11645880
申请日：2006-12-27
申请人： Adrian Smith , Xiao-Dong Li , David Steer , Kelvin Kar-Kin Au , Robert Novak , Mark Earnshaw
发明人： Adrian Smith , Xiao-Dong Li , David Steer , Kelvin Kar-Kin Au , Robert Novak , Mark Earnshaw
IPC分类号： H04H1/00
CPC分类号： H04L27/2646 , H04B7/18534 , H04L5/0007 , H04L5/023 , H04W56/0045
摘要： A method and system for achieving a link budget improvement in a diverse OFDM radio system by addressing the timing misalignment issue that can occur due to the differences in propagation time in signals between mobile stations and Radio Access Nodes. Timing misalignment is shared or split between the primary path to a primary Radio Access Node and a diverse path to a diverse Radio Access Node. The relative timing offsets between mobile stations are adjusted, the mobile stations are grouped into zones using a variety of different grouping techniques, and the transmission for each mobile station is scheduled, using one or more of a variety of scheduling techniques.
摘要翻译：一种用于通过解决由于移动台和无线电接入节点之间的信号中的传播时间差异而可能发生的定时未对准问题来在多个OFDM无线电系统中实现链路预算改进的方法和系统。在主无线接入节点的主要路径和到各种无线接入节点的不同路径之间共享或分割定时偏移。调整移动站之间的相对定时偏移，使用各种不同的分组技术将移动站分组成区域，并且使用各种调度技术中的一种或多种调度每个移动站的传输。

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