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1. 发明申请

US20070185133A1 Aminopyrimidine compounds and methods of use 有权
标题翻译：氨基嘧啶化合物及其使用方法
公开(公告)号：US20070185133A1
公开(公告)日：2007-08-09
申请号：US11304901
申请日：2005-12-16
申请人： Adrian Smith , Paul Brennan , Frenel DeMorin , Gang Liu , Nick Paras , Daniel Retz , Elizabeth Rainbeau
发明人： Adrian Smith , Paul Brennan , Frenel DeMorin , Gang Liu , Nick Paras , Daniel Retz , Elizabeth Rainbeau
IPC分类号： A61K31/513 , A61K31/506 , C07D417/14
CPC分类号： C07D417/14 , C07D409/14
摘要： The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
摘要翻译：本发明涉及可用于治疗由polo样激酶1（Plk1）介导的疾病的氨基嘧啶化合物。本发明还涉及这种氨基嘧啶化合物及其组合物在治疗与异常细胞生长和不想要的细胞增殖相关的疾病状态中的治疗用途。

2. 发明申请

US20070054916A1 Aryl nitrogen-containing bicyclic compounds and methods of use 审中-公开
标题翻译：芳基含氮双环化合物及其使用方法
公开(公告)号：US20070054916A1
公开(公告)日：2007-03-08
申请号：US11240590
申请日：2005-09-30
申请人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
发明人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
IPC分类号： A61K31/525 , A61K31/519 , A61K31/517
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

3. 发明申请

US20070185324A1 Nitrogen-containing bicyclic heteroaryl compounds and methods of use 有权
标题翻译：含氮双环杂芳基化合物及其使用方法
公开(公告)号：US20070185324A1
公开(公告)日：2007-08-09
申请号：US11643261
申请日：2006-12-20
申请人： Frenel De Morin , Jian Chen , Elizabeth Doherty , Stephen Hitchcock , Qi Huang , Joseph Kim , Gang Liu , Thomas Nixey , Nick Paras , Jeffrey Petkus , Daniel Retz , Adrian Smith , Andrew Tasker , Jiawang Zhu
发明人： Frenel De Morin , Jian Chen , Elizabeth Doherty , Stephen Hitchcock , Qi Huang , Joseph Kim , Gang Liu , Thomas Nixey , Nick Paras , Jeffrey Petkus , Daniel Retz , Adrian Smith , Andrew Tasker , Jiawang Zhu
IPC分类号： A61K31/541 , A61K31/5377 , C07D417/02 , C07D403/02
CPC分类号： C07D401/14 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括能够调节Raf激酶的新一类化合物，因此可用于治疗Raf激酶介导的疾病，包括黑素瘤，肿瘤和其它癌症相关病症。这些化合物具有通式I，其中R 1是和A 1，A 2，A 3，A 3， X，Z，Z'，R 1，R 2，R 3，R 3，本文定义了R 5，R 5和R 6。本发明还包括药物组合物，用于治疗Raf激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

4. 发明授权

US07858785B2 Aminopyrimidine compounds and methods of use 有权
公开(公告)号：US07858785B2
公开(公告)日：2010-12-28
申请号：US12562853
申请日：2009-09-18
申请人： Adrian Leonard Smith , Paul Edward Brennan , Fenel F. Fils , Gang Liu , Nick A. Paras , Daniel Martin Retz , Elizabeth Rainbeau
发明人： Adrian Leonard Smith , Paul Edward Brennan , Fenel F. Fils , Gang Liu , Nick A. Paras , Daniel Martin Retz , Elizabeth Rainbeau
IPC分类号： C07D417/14 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D417/14 , C07D409/14
摘要： The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.

5. 发明授权

US07786132B2 Aminopyrimidine compounds and methods of use 有权
标题翻译：氨基嘧啶化合物及其使用方法
公开(公告)号：US07786132B2
公开(公告)日：2010-08-31
申请号：US11304901
申请日：2005-12-16
申请人： Adrian Leonard Smith , Paul Edward Brennan , Frenel Fils DeMorin , Gang Liu , Nick A. Paras , Daniel Martin Retz , Elizabeth Rainbeau
发明人： Adrian Leonard Smith , Paul Edward Brennan , Frenel Fils DeMorin , Gang Liu , Nick A. Paras , Daniel Martin Retz , Elizabeth Rainbeau
IPC分类号： C07D409/14 , C07D417/14 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D417/14 , C07D409/14
摘要： The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
摘要翻译：本发明涉及可用于治疗由polo样激酶1（Plk1）介导的疾病的氨基嘧啶化合物。本发明还涉及这种氨基嘧啶化合物及其组合物在治疗与异常细胞生长和不想要的细胞增殖相关的疾病状态中的治疗用途。

6. 发明授权

US10914361B2 Multi-gear torquer 有权
公开(公告)号：US10914361B2
公开(公告)日：2021-02-09
申请号：US16201979
申请日：2018-11-27
申请人： Gang Liu
发明人： Gang Liu
IPC分类号： F16H1/28 , F16H57/04 , F16H3/44 , F16H57/031 , F16H57/038
摘要： Disclosed is a multi-gear torquer with end covers on both sides of the casing. An input shaft and an output shaft are respectively arranged at the center of the two end covers. A sun gear is fixed on the input shaft and moves along a planet gear engaged in the transmission mechanism. The planet gear meshes with a gear ring and moves around the sun gear, then the planet gear drives the turntable centrally fixed with the output shaft connected to the load end. The multi-gear torquer disclosed herein has the following advantages: large output torque and high mechanical efficiency, and it can be used as power transmission equipment for a car or a train and used as other mechanical transmission equipment.

7. 发明授权

US10670143B2 Motor 审中-公开
公开(公告)号：US10670143B2
公开(公告)日：2020-06-02
申请号：US15939342
申请日：2018-03-29
申请人： Gang Liu
发明人： Gang Liu
IPC分类号： F16H1/32 , F16H61/662 , H02K7/116 , H02K1/27 , F16H61/14 , H02K21/16 , F16H57/02
摘要： A motor with a variable-speed torque converter is disclosed. A rotor of the motor has a common permanent magnet structure. Permanent magnets are disposed on the rotor. The variable-speed torque converter includes a wheel disc, a wheel ring, a roller, a transmission gear II, a transmission gear III, a round wheel, an annular gear, a driving gear, turning discs, a transmission shaft, and an output shaft. The driving gear fixedly connected to the transmission shaft of the motor drives the transmission gear. The transmission gear is in contact with the annular gear. The transmission gear rotates around the driving gear to drive the wheel disc to rotate together. The wheel disc is fixedly connected to the output shaft to drive a driving wheel to rotate. Therefore, a working capability of the motor is enhanced. The converter can be applied to an electromotor, a generator, or any other power device.

8. 发明授权

US09883797B1 System and method for automatically tracking a contact lens in a wearer's eye 有权
公开(公告)号：US09883797B1
公开(公告)日：2018-02-06
申请号：US14277139
申请日：2014-05-14
申请人： Gang Liu , Lei Wang , Lowell D. Jacobson
发明人： Gang Liu , Lei Wang , Lowell D. Jacobson
IPC分类号： A61B3/14 , A61B3/10 , A61B3/00 , A61B3/113
CPC分类号： A61B3/113 , A61B3/0041 , A61B3/14 , G06K9/0061
摘要： A system and method for automated determination of position and movement of a contact lens with respect to a subject wearer's eye based upon a complimentary pair of images, acquired in rapid succession, in which one image of the pair is acquired using light that allows viewing of the pupil and/or limbus through the lens and the other image is acquired using light that is absorbed by the lens to generate an opaque image with a defined edge relative to the surrounding sclera. The images of the pair are acquired in close enough temporal proximity to ensure that eye movement in the interval therebetween is insignificant and both images are in the same approximate reference frame. Thus, the location of the pupil and limbus in one image can be accurately compared with the location of the contact lens edge in the other image.

9. 发明授权

US09301248B2 Methods and apparatuses for communication in a personal area network 有权
标题翻译：用于个人区域网络通信的方法和装置
公开(公告)号：US09301248B2
公开(公告)日：2016-03-29
申请号：US13996059
申请日：2010-12-20
申请人： Zheng Liang , Gang Liu , Jun Zheng , Haibo Wen , Fanxiang Bin , Chunyan Yao
发明人： Zheng Liang , Gang Liu , Jun Zheng , Haibo Wen , Fanxiang Bin , Chunyan Yao
IPC分类号： H04W52/02 , H04W28/16 , H04W84/18 , H04W76/04
CPC分类号： H04W52/0203 , H04W28/16 , H04W52/0216 , H04W52/0219 , H04W52/0229 , H04W52/0258 , H04W76/28 , H04W84/18 , Y02D70/144
摘要： An exemplary technique is provided for communication in a personal area network. The technique includes transmitting, to a personal area network coordinator, joint information of a sensor device indicated by reserved bits and includes a type, a channel access rate, and a latest node buffer occupation rate of the sensor device; receiving, from the personal area network coordinator, information regarding adjusted active duration and duty cycle of the communication of the sensor device; and performing further communication based upon the adjusted active duration and duty cycle. Also, the technique includes receiving, from a sensor device, joint information indicated by reserved bits and includes a type, a channel access rate, and a latest node buffer occupation rate of the sensor device; adjusting an active duration and a duty cycle of the communication of the sensor device; and transmitting information regarding the adjusted active duration and duty cycle to the sensor device.
摘要翻译：提供了一种用于个人区域网络中的通信的示例性技术。该技术包括向个人区域网络协调器发送由保留位指示的传感器设备的联合信息，并且包括传感器设备的类型，信道访问速率和最新节点缓冲器占用率; 从个人区域网络协调器接收关于传感器设备的通信的调整的有效持续时间和占空比的信息; 并且基于调整的有效持续时间和占空比执行进一步的通信。此外，该技术包括从传感器设备接收由保留位指示的联合信息，并且包括传感器设备的类型，信道访问速率和最新节点缓冲器占用率; 调整传感器装置的通信的有效持续时间和占空比; 以及将关于经调节的有效持续时间和占空比的信息发送到传感器装置。

10. 发明授权

US08971663B2 System and method for producing synthetic golden template image for vision system inspection of multi-layer patterns 有权
标题翻译：用于生成合成金色模板图像的系统和方法，用于多层图案的视觉系统检查
公开(公告)号：US08971663B2
公开(公告)日：2015-03-03
申请号：US13625021
申请日：2012-09-24
申请人： Lowell D. Jacobson , Gang Liu
发明人： Lowell D. Jacobson , Gang Liu
IPC分类号： G06K9/36 , G06K9/32 , G06K9/62 , G06T7/00 , G06K9/00
CPC分类号： G06K9/3216 , G06K9/6255 , G06T7/001 , G06T2207/10024 , G06T2207/20221 , G06T2207/30144
摘要： A system and method for generating golden template images in a vision system to inspect an acquired runtime image of an object with a multi-layer printed pattern is provided. The system and method performs a registration process on runtime images using registration models each trained on respective canonical layer mask images, and outputting poses. Based upon the poses, warped layer masks are generated. Combination masks are computed based upon differing combinations of the warped layer masks. Intensity values for pixels of the foreground regions for the combination masks are estimated. The estimated intensity values are then blended associated with the combination masks to generate a golden template image. This golden template image can be used to compare with a runtime image. An exemplary application of this system and method is in print inspection on flat and non-flat surfaces.
摘要翻译：提供了一种用于在视觉系统中生成金色模板图像以用多层印刷图案检查对象的获取的运行时图像的系统和方法。该系统和方法使用每个训练在各个规范层掩模图像上的注册模型并输出姿势来对运行时图像执行注册过程。基于姿态，产生翘曲层掩模。基于翘曲层掩模的不同组合来计算组合掩模。估计用于组合掩码的前景区域的像素的强度值。然后将估计的强度值与组合掩模相关联以生成金色模板图像。此黄金模板图像可用于与运行时映像进行比较。该系统和方法的示例性应用是在平坦和非平坦表面上进行打印检查。

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