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1. 发明授权

US06576445B1 Chemokine &agr;-4 失效
标题翻译：趋化因子α-4
公开(公告)号：US06576445B1
公开(公告)日：2003-06-10
申请号：US09630709
申请日：2000-08-01
申请人： Henrik S. Olsen , Steven M. Ruben , Zhi-Zhen Zeng
发明人： Henrik S. Olsen , Steven M. Ruben , Zhi-Zhen Zeng
IPC分类号： C12P2106
CPC分类号： C07K14/522 , A61K38/00
摘要： The present invention relates to a novel CK&agr;-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-4 protein. CK&agr;-4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-4 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为CXC趋化因子家族成员的新型CKalpha-4蛋白。特别地，提供编码人CKalpha-4蛋白的分离的核酸分子。也提供CKalpha-4多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定CKalpha-4活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

2. 发明授权

US07459531B2 50 Human secreted proteins 失效
标题翻译：蛋白HKGAJ54
公开(公告)号：US07459531B2
公开(公告)日：2008-12-02
申请号：US11565909
申请日：2006-12-01
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： C07K14/47
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

3. 发明授权

US06800731B2 Human oncogene induced secreted protein I 失效
标题翻译：人类致癌基因诱导分泌蛋白I
公开(公告)号：US06800731B2
公开(公告)日：2004-10-05
申请号：US09899917
申请日：2001-07-09
申请人： Henrik S. Olsen , Steven M. Ruben
发明人： Henrik S. Olsen , Steven M. Ruben
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： The present invention relates to a novel protein, the Human Oncogene Induced Secreted Protein I (“HOIPS I”) protein. In particular, isolated nucleic acid molecules are provided encoding the human HOIPS I protein. HOIPS I polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting abnormal cell proliferation and differentiation disorders and therapeutic methods for treating the same.
摘要翻译：本发明涉及一种新的蛋白质，即人癌基因诱导的分泌蛋白I（“HOIPS I”）蛋白质。特别地，提供编码人HOIPS I蛋白的分离的核酸分子。还提供HOIPS I多肽，载体，宿主细胞和用于制备其的重组方法。还提供了用于检测异常细胞增殖和分化障碍的诊断方法及其治疗方法。

4. 发明授权

US06420526B1 186 human secreted proteins 失效
标题翻译： 186人分泌蛋白
公开(公告)号：US06420526B1
公开(公告)日：2002-07-16
申请号：US09149476
申请日：1998-09-08
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel P. Soppet , Kenneth C. Carter , Daniel R. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. Lafleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： C12Q168
CPC分类号： G01N33/68 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

5. 发明授权

US06342581B1 Secreted protein HLHFP03 失效
标题翻译：分泌蛋白HLHFP03
公开(公告)号：US06342581B1
公开(公告)日：2002-01-29
申请号：US09227357
申请日：1999-01-08
申请人： Craig A. Rosen , Steven M. Ruben , Henrik S. Olsen , Reinhard Ebner
发明人： Craig A. Rosen , Steven M. Ruben , Henrik S. Olsen , Reinhard Ebner
IPC分类号： A61K3800
CPC分类号： C12N9/00 , A61K38/00 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

6. 发明授权

US06232100B1 Cortistatin Polypeptides 失效
标题翻译：皮质激素多肽
公开(公告)号：US06232100B1
公开(公告)日：2001-05-15
申请号：US09001472
申请日：1997-12-31
申请人： Henrik S. Olsen , Steven M. Ruben
发明人： Henrik S. Olsen , Steven M. Ruben
IPC分类号： C12N121
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to novel cortistatin polypeptides, and to polynucleotides encoding these polypeptides. More specifically, isolated nucleic acid molecules are provided encoding a Human Cortistatin polypeptide. Cortistatin polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting variations in Human Cortistatin gene expression and therapeutic methods for treating individuals in need of an increased level of Human Cortistatin activity.
摘要翻译：本发明涉及新的皮质抑素多肽，以及编码这些多肽的多核苷酸。更具体地，提供编码人皮质他汀多肽的分离的核酸分子。还提供了皮质肽多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了用于检测人皮质激素基因表达变化的诊断方法和用于治疗需要增加水平的人皮质激素活性的个体的治疗方法。

7. 发明授权

US08372948B2 12 human secreted proteins 有权
公开(公告)号：US08372948B2
公开(公告)日：2013-02-12
申请号：US12264040
申请日：2008-11-03
申请人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
发明人： Jian Ni , Paul E. Young , Joseph J. Kenny , Henrik S. Olsen , Paul A. Moore , Ying-Fei Wei , John M. Greene , Steven M. Ruben , Ding Liu , Paul R. Crocker
IPC分类号： C07K5/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

8. 发明申请

US20090247482A1 50 Human Secreted Proteins 审中-公开
标题翻译： 50人类分泌蛋白
公开(公告)号：US20090247482A1
公开(公告)日：2009-10-01
申请号：US12275899
申请日：2008-11-21
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： A61K31/7088 , C12N15/11 , C12N15/00 , C12N5/06 , C12N15/87 , C12P21/04
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

9. 发明申请

US20080146505A1 47 Human Secreted Proteins 审中-公开
标题翻译： 47人类分泌蛋白
公开(公告)号：US20080146505A1
公开(公告)日：2008-06-19
申请号：US11832009
申请日：2007-08-01
申请人： Steven M. Ruben , Reinhard Ebner , Craig A. Rosen , Gregory A. Endress , Daniel R. Soppet , Jian Ni , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Henrik S. Olsen , Kimberly A. Florence
发明人： Steven M. Ruben , Reinhard Ebner , Craig A. Rosen , Gregory A. Endress , Daniel R. Soppet , Jian Ni , Roxanne D. Duan , Paul A. Moore , Yanggu Shi , David W. LaFleur , Henrik S. Olsen , Kimberly A. Florence
IPC分类号： A61K38/16 , C07H21/00 , C12N15/63 , C12N5/00 , A61K31/7052 , C07K14/00 , C12P21/00 , G01N33/68 , C07K16/00 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

10. 发明授权

US07368244B2 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US07368244B2
公开(公告)日：2008-05-06
申请号：US11214796
申请日：2005-08-31
申请人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07H21/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

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