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1. 发明申请

US20130289112A1 SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF 有权
标题翻译：库卡宾B的制备方法及其用途
公开(公告)号：US20130289112A1
公开(公告)日：2013-10-31
申请号：US13884558
申请日：2011-03-21
申请人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
发明人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
IPC分类号： C07C235/34 , C07C55/10 , C07C57/145 , C07C229/24 , C07C59/08 , C07C59/255 , C07C309/04 , C07C309/30 , C07C53/10 , C07C59/245
CPC分类号： C07C309/04 , C07C53/08 , C07C53/10 , C07C53/122 , C07C53/124 , C07C55/06 , C07C55/08 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C57/44 , C07C59/08 , C07C59/245 , C07C59/255 , C07C59/265 , C07C59/50 , C07C63/06 , C07C229/24 , C07C235/34 , C07C309/25 , C07C309/30
摘要： Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
摘要翻译： kukoamine B的盐，它们的制备方法及其制备用于预防和治疗败血症药物的药物用途。实验表明，kukoamine B的盐对拮抗诱导败血症的关键因素具有很好的疗效，可用于制备预防和治疗败血症的药物。目前在临床实践中缺乏治疗败血症的有效措施的情况下，包含kukoamine B，药学上可接受的载体和/或稀释剂的盐的药物制剂提供了预防和治疗败血症的新方法。

2. 发明授权

US09365504B2 Salts of kukoamine B, preparation method and use thereof 有权
标题翻译： kukoamine B的盐，其制备方法和用途
公开(公告)号：US09365504B2
公开(公告)日：2016-06-14
申请号：US13884558
申请日：2011-03-21
申请人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
发明人： Jiang Zheng , Xinchuan Zheng , Xin Liu , Hong Zhou , Ning Wang , Hongwei Cao , Yan Li , Yongling Lu , Kecen Zhao , Jingcheng Yang , Yang Yang , Yuanfeng Zhu , Guo Wei , Min Huang
IPC分类号： C07C37/02 , C07C235/34 , C07C309/04 , C07C53/08 , C07C55/10 , C07C59/08 , C07C59/245 , C07C59/255 , C07C53/10 , C07C57/145 , C07C229/24 , C07C309/30 , C07C53/122 , C07C53/124 , C07C55/06 , C07C55/08 , C07C55/14 , C07C57/15 , C07C57/44 , C07C59/265 , C07C59/50 , C07C63/06 , C07C309/25
CPC分类号： C07C309/04 , C07C53/08 , C07C53/10 , C07C53/122 , C07C53/124 , C07C55/06 , C07C55/08 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C57/44 , C07C59/08 , C07C59/245 , C07C59/255 , C07C59/265 , C07C59/50 , C07C63/06 , C07C229/24 , C07C235/34 , C07C309/25 , C07C309/30
摘要： Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
摘要翻译： kukoamine B的盐，它们的制备方法及其制备用于预防和治疗败血症药物的药物用途。实验表明，kukoamine B的盐对拮抗诱导败血症的关键因素具有很好的疗效，可用于制备预防和治疗败血症的药物。目前在临床实践中缺乏治疗败血症的有效措施的情况下，包含kukoamine B，药学上可接受的载体和/或稀释剂的盐的药物制剂提供了预防和治疗败血症的新方法。

3. 发明申请

US20130172421A1 USE OF KUKOAMINE A AND KUKOAMINE B 审中-公开
标题翻译： KUKOAMINE A和KUKOAMINE B的使用
公开(公告)号：US20130172421A1
公开(公告)日：2013-07-04
申请号：US13638966
申请日：2011-03-21
申请人： Jiang Zheng , Xin Liu , Xinchuan Zheng , Hong Zhou , Hongwei Cao , Ning Wang , Yongling Lu
发明人： Jiang Zheng , Xin Liu , Xinchuan Zheng , Hong Zhou , Hongwei Cao , Ning Wang , Yongling Lu
IPC分类号： A61K31/165
CPC分类号： A61K31/165 , A61K36/815
摘要： The use of Kukoamine A and Kukoamine B in the preparation of drugs for the prevention and treatment of sepsis and autoimmune disease is disclosed. Bacterial endotoxin/lipopolysaccaride (LPS) and unmethylated DNA (CpG DNA) of bacteria, the major pathogen-associated molecular patterns in sepsis and autoimmune disease, are specifically targeted, while the disclosed use directionally isolates lead compounds from traditional Chinese medicine. These measures can overcome the major defects of uncertainty of pharmacological material basis and drug targets of extracts and constituents of traditional Chinese medicine. The disclosed use can help in developing a safe, effective and quality controllable drug for prevention and treatment of sepsis and autoimmune disease so as to help solve the present lack of effective drugs in clinical treatment.
摘要翻译：公开了使用Kukoamine A和Kukoamine B制备用于预防和治疗败血症和自身免疫疾病的药物。细菌内毒素/脂多糖（LPS）和细菌的未甲基化DNA（CpG DNA）是败血症和自身免疫性疾病中主要病原体相关分子模式的特异性靶向，而所公开的用途定向分离中药中的铅化合物。这些措施可以克服中药提取物和成分的药理学基础和药物靶标不确定性的主要缺陷。所公开的用途有助于开发一种安全，有效和质量可控的药物，用于预防和治疗败血症和自身免疫性疾病，以帮助解决目前缺乏有效药物的临床治疗。

4. 发明授权

US06495370B1 Inhibition of glutathione transferase by haloenol lactones 失效
标题翻译：通过卤代烯内酯抑制谷胱甘肽转移酶
公开(公告)号：US06495370B1
公开(公告)日：2002-12-17
申请号：US09639392
申请日：2000-08-15
申请人： A. Daniel Jones , Alyson E. Mitchell , Bruce D. Hammock , Jiang Zheng
发明人： A. Daniel Jones , Alyson E. Mitchell , Bruce D. Hammock , Jiang Zheng
IPC分类号： G01N3300
CPC分类号： C07D405/06 , C07D307/58 , Y10S977/893 , Y10S977/896 , Y10S977/915 , Y10T436/20
摘要： This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.
摘要翻译：本发明涉及新的卤烯醇内酯化合物。这些化合物具有以下一般结构：其中Ar是芳基，Y是卤代烯内酯部分。本发明的化合物可用于特异性测量谷胱甘肽S-转移酶的特定同工酶。谷胱甘肽S-转移酶同工酶的测定在诊断医学中具有重要意义。本发明的化合物还可用于治疗癌症中的耐药性和用于防止植物中的除草剂抗性。

5. 发明申请

US20060035869A1 Inhibitors of epoxide hydrolases for the treatment of hypertension 审中-公开
标题翻译：环氧化物水解酶抑制剂治疗高血压
公开(公告)号：US20060035869A1
公开(公告)日：2006-02-16
申请号：US11240444
申请日：2005-09-29
申请人： Bruce Hammock , Christophe Morisseau , Jiang Zheng , Marvin Goodrow , Tonya Severson , James Sanborn
发明人： Bruce Hammock , Christophe Morisseau , Jiang Zheng , Marvin Goodrow , Tonya Severson , James Sanborn
IPC分类号： A61K31/17 , A61K31/66
CPC分类号： A61K31/325 , A61K31/00 , A61K31/336
摘要： Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the epoxide hydrolases, and in agricultural applications. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 are each independently a substituted or unsubstituted alkyl, haloalkyl, cycloalkyl, aryl, acyl, or heterocyclic, or being a metabolite or degradation product thereof.
摘要翻译：提供了生物稳定的可溶性环氧化物水解酶抑制剂。抑制剂可用于例如在治疗应用中选择性抑制环氧化物水解酶，例如治疗炎症，用于环氧化物水解酶的亲和分离，以及在农业应用中。用于实施本发明的一类优选的化合物具有式1所示的结构，其中X和Y各自独立地为氮，氧或硫，X可以进一步为碳，R 1， -R 4是氢，当X是氮时，R 2是氢，但当X是硫或氧时，R 2不是存在的，R 4是氢当Y为氮时，当Y为硫或氧时不存在，R 1和R 3各自独立地为取代或未取代的烷基，卤代烷基，环烷基，芳基，酰基，或杂环，或其代谢产物或降解产物。

6. 发明申请

US20130189710A1 Method And Assay Kit For Detection Of Toxicity Induced By Pyrrolizidine Alkaloids 有权
标题翻译：用于检测吡罗西泮生物碱诱导的毒性的方法和测定试剂盒
公开(公告)号：US20130189710A1
公开(公告)日：2013-07-25
申请号：US13354341
申请日：2012-01-20
申请人： Ge Lin , Jiang Zheng , Na Li
发明人： Ge Lin , Jiang Zheng , Na Li
IPC分类号： G01N33/53 , G01N33/567 , C07K16/44
CPC分类号： C07K16/44 , C07K2317/33 , G01N33/53 , G01N33/5308 , G01N33/567
摘要： An antibody, which specifically recognizes adducts between pyrrole and cellular macromolecules. Such adducts are likely to occur in mammals suffering an incident of pyrrolizidine alkaloid poisoning. The antibody can be produced using a synthetic immunogen conjugated with a pyrrole as a hapten and it can be used, for example in an assay kit and/or by itself, as a novel means for detecting or diagnosing pyrrolizidine alkaloid poisoning both clinics and research laboratories.
摘要翻译：抗体，其特异性识别吡咯和细胞大分子之间的加合物。这种加合物很可能发生在遭受吡咯烷酮生物碱中毒事件的哺乳动物中。可以使用与吡咯缀合的合成免疫原作为半抗原来产生抗体，并且其可以用于例如测定试剂盒和/或其本身，作为用于检测或诊断吡咯烷酮生物碱中毒两种诊所和研究实验室的新手段。

7. 发明授权

US06756210B2 Linoleic acid diol and glucuronide conjugate levels as diagnostic markers of disorders of abnormal regulation of cytochrome P450 metabolism of unsaturated fatty acids 失效
标题翻译：亚油酸二醇和葡糖苷酸缀合物水平作为不饱和脂肪酸细胞色素P450代谢异常调节障碍的诊断标志物
公开(公告)号：US06756210B2
公开(公告)日：2004-06-29
申请号：US09867963
申请日：2001-05-29
申请人： Bruce Hammock , Gabriela Zurek , Shirley Gee , John W. Newman , Jiang Zheng
发明人： Bruce Hammock , Gabriela Zurek , Shirley Gee , John W. Newman , Jiang Zheng
IPC分类号： C12Q126
CPC分类号： C12Q1/26 , A61K49/0004 , G01N33/92 , G01N2333/90245
摘要： The invention provides methods of using dihydroxy unsaturated fatty acids as markers for identifying patients with a disorder associated with abnormal regulation of the cytochrome P450 metabolism or oxidation of unsaturated fatty acids. For example, linoleic acid diols, including leukotoxindiol, can be used as a diagnostic tool for identifying patients with pre-eclampsia, eclampsia, and pregnancy-induced hypertension.
摘要翻译：本发明提供了使用二羟基不饱和脂肪酸作为标识物的方法，用于鉴定与不饱和脂肪酸的细胞色素P450代谢异常调节相关的病症的患者。例如，亚油酸二醇（包括白细胞毒素二氢吲哚）可用作诊断先兆子痫，子痫和妊娠高血压患者的诊断工具。

8. 发明授权

US5767147A Inhibition of glutathione transferase by haloenol lactones 失效
标题翻译：通过卤代烯内酯抑制谷胱甘肽转移酶
公开(公告)号：US5767147A
公开(公告)日：1998-06-16
申请号：US426593
申请日：1995-04-21
申请人： A. Daniel Jones , Alyson E. Mitchell , Bruce D. Hammock , Jiang Zheng
发明人： A. Daniel Jones , Alyson E. Mitchell , Bruce D. Hammock , Jiang Zheng
IPC分类号： C07D307/58 , C07D405/06 , C12Q1/48 , G01N33/00 , A61K31/35
CPC分类号： C07D405/06 , C07D307/58 , Y10S977/893 , Y10S977/896 , Y10S977/915 , Y10T436/20
摘要： This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.
摘要翻译：本发明涉及新的卤烯醇内酯化合物。这些化合物具有以下一般结构：其中Ar是芳基，Y是卤代烯内酯部分的。本发明的化合物可用于特异性测量谷胱甘肽S-转移酶的特定同工酶。谷胱甘肽S-转移酶同工酶的测定在诊断医学中具有重要意义。本发明的化合物还可用于治疗癌症中的耐药性和用于防止植物中的除草剂抗性。

9. 发明授权

US06174695B1 Epoxide hydrolase inhibitor methods 有权
标题翻译：环氧化物水解酶抑制剂方法
公开(公告)号：US06174695B1
公开(公告)日：2001-01-16
申请号：US09312207
申请日：1999-05-14
申请人： Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
发明人： Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
IPC分类号： C12Q134
CPC分类号： C12Q1/34 , G01N2500/10
摘要： The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the epoxide hydrolase inhibitors for inhibitory specificity and for toxicity, and novel biologically active tetrahydrofuran diols of arachidonic acid, including antibodies thereto.
摘要翻译：本发明提供了通过抑制环氧化物水解酶来治疗由多不饱和脂质代谢物介导的炎性疾病的方法，用于测定或筛选环氧化物水解酶抑制剂以抑制特异性和毒性的方法，以及花生四烯酸的新型生物活性四氢呋喃二醇，包括其抗体。

10. 发明授权

US6150415A Epoxide hydrolase complexes and methods therewith 有权
标题翻译：环氧化物水解酶复合物及其方法
公开(公告)号：US6150415A
公开(公告)日：2000-11-21
申请号：US252148
申请日：1999-02-18
申请人： Bruce D. Hammock , Christophe H. Morisseau , Jiang Zheng , Marvin H. Goodrow , Tonya Severson , James Sanborn
发明人： Bruce D. Hammock , Christophe H. Morisseau , Jiang Zheng , Marvin H. Goodrow , Tonya Severson , James Sanborn
IPC分类号： C12N9/14 , A01N47/10 , A01N47/28 , A61K31/00 , A61K31/155 , A61K31/17 , A61K31/20 , A61K31/336 , A61K38/46 , A61P11/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07C275/06 , C07C275/26 , C07C333/06 , C12N9/99
CPC分类号： A61K31/155 , A61K31/00 , A61K31/17 , A61K31/20 , A61K31/27 , A61K31/336 , A61K31/7088 , G01N2500/10
摘要： Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the epoxide hydrolases, and in agricultural applications. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 ##STR1## wherein X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R.sub.1 -R.sub.4 is hydrogen, R.sub.2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R.sub.4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R.sub.1 and R.sub.3 are each independently a substituted or unsubstituted alkyl, haloalkyl, cycloalkyl, aryl, acyl, or heterocyclic, or being a metabolite or degradation product thereof.
摘要翻译：提供了生物稳定的可溶性环氧化物水解酶抑制剂。抑制剂可用于例如在治疗应用中选择性抑制环氧化物水解酶，例如治疗炎症，用于环氧化物水解酶的亲和分离，以及在农业应用中。用于实施本发明的优选类化合物具有式1所示的结构，其中X和Y各自独立地为氮，氧或硫，X可以进一步为碳，R 1 -R 4中的至少一个为氢，R 2为氢当X是氮而X是硫或氧时不存在，当Y是氮时，R4是氢，当Y是硫或氧时不存在，R 1和R 3各自独立地是取代或未取代的烷基，卤代烷基，环烷基，芳基，酰基或杂环，或其代谢产物或降解产物。

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