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1. 发明授权

US06495143B2 Botulinum neurotoxin vaccine 失效
标题翻译：肉毒杆菌神经毒素疫苗
公开(公告)号：US06495143B2
公开(公告)日：2002-12-17
申请号：US09350756
申请日：1999-07-09
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Michael Parker , Mark T. Dertzbaugh , Leonard Smith
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Michael Parker , Mark T. Dertzbaugh , Leonard Smith
IPC分类号： C12N1586
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C07K14/33 , C12N2799/021
摘要： Using the nontoxic heavy chain fragment from botulinum neurotoxins A-G, compositions and methods of use in inducing an immune response which is protective against intoxication with botulinum in subjects is described.
摘要翻译：使用来自肉毒杆菌神经毒素A-G的无毒重链片段，描述了用于诱导免疫应答的组合物和方法，其在受试者中与肉毒杆菌中毒。

2. 发明授权

US06632640B1 Vaccine against Staphylococcus intoxication 失效
标题翻译：针对葡萄球菌中毒的疫苗
公开(公告)号：US06632640B1
公开(公告)日：2003-10-14
申请号：US09350755
申请日：1999-07-09
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
IPC分类号： C12N1509
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
摘要翻译：使用编码来自金黄色葡萄球菌的突变体SEA和SEB外毒素的核酸，用于诱导免疫应答的组合物和方法，其用于保护金黄色葡萄球菌描述了ITALIC> 中毒。

3. 发明授权

US07374931B2 Vaccine against staphylococcus intoxication 失效
标题翻译：针对葡萄球菌中毒的疫苗
公开(公告)号：US07374931B2
公开(公告)日：2008-05-20
申请号：US10405871
申请日：2003-04-02
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
IPC分类号： A01N43/04 , A01N63/00 , A01N65/00 , A61K48/00 , A61K31/70 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C07H21/02 , C07H21/04
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
摘要翻译：描述了使用编码来自金黄色葡萄球菌的突变体SEA和SEB外毒素的核酸，用于诱导在受试者中保护葡萄球菌金黄色葡萄球菌中毒的免疫应答的组合物和方法。

4. 发明授权

US07638333B2 Anthrax vaccine 失效
标题翻译：炭疽疫苗
公开(公告)号：US07638333B2
公开(公告)日：2009-12-29
申请号：US10442502
申请日：2003-05-21
申请人： John S. Lee , Peter Pushko , Michael D. Parker , Jonathan F. Smith , Susan L. Welkos
发明人： John S. Lee , Peter Pushko , Michael D. Parker , Jonathan F. Smith , Susan L. Welkos
IPC分类号： C12N15/86 , A01N43/04
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using the nontoxic PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.
摘要翻译：使用来自炭疽杆菌的无毒PA蛋白，描述了用于诱导受试者中对炭疽病有保护作用的免疫应答的方法和组合物。

5. 发明授权

US06770479B1 Anthrax vaccine 有权
标题翻译：炭疽疫苗
公开(公告)号：US06770479B1
公开(公告)日：2004-08-03
申请号：US09350729
申请日：1999-07-09
申请人： John S. Lee , Peter Pushko , Michael D. Parker , Jonathan F. Smith , Susan L. Welkos
发明人： John S. Lee , Peter Pushko , Michael D. Parker , Jonathan F. Smith , Susan L. Welkos
IPC分类号： C12N1586
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using the nontoxic PA protein from B. anthracis, a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.
摘要翻译：使用来自炭疽杆菌的无毒PA蛋白，描述了用于诱导受试者中对炭疽病有保护作用的免疫应答的方法和组合物。

6. 发明申请

US20120064079A1 Compositions and Methods for Preventing Erythropoietin-Associated Hypertension 审中-公开
标题翻译：防止红细胞生成素相关性高血压的组合物和方法
公开(公告)号：US20120064079A1
公开(公告)日：2012-03-15
申请号：US13044818
申请日：2011-03-10
申请人： Jong Y. Lee , Mary S. Lee , John S. Lee
发明人： Jong Y. Lee , Mary S. Lee , John S. Lee
IPC分类号： A61K39/395 , A61P7/06 , A61K38/02 , A61P9/12 , A61K38/18 , C07K16/28
CPC分类号： A61K39/39533 , A61K38/179 , A61K38/1816 , A61K39/3955 , A61K2039/505 , A61K2121/00 , A61K2300/00 , C07K16/2863 , C07K2317/55
摘要： The inventors have discovered that both soluble erythropoietin-binding protein and antibodies against the erythropoietin-binding protein, when they are administered to a mammal along with erythropoietin (Epo), prevent or reduce the blood pressure increase normally caused by erythropoietin, while not affecting the hematocrit increase that is the purpose of Epo treatment. The invention provides a method of treating anemia in a mammal involving: administering erythropoietin (Epo) to the mammal; and administering to the mammal an agent selected from a soluble Epo-binding protein (Epo-bp), a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor, and a combination thereof. The invention also provides a method of reducing hypertension in a mammal receiving Epo, and pharmaceutical compositions containing a soluble Epo-bp and/or a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor.
摘要翻译：本发明人已经发现，当将可溶性促红细胞生成素结合蛋白和抗红细胞生成素结合蛋白的抗体与促红细胞生成素（Epo）一起施用于哺乳动物时，可预防或降低通常由促红细胞生成素引起的血压升高，同时不影响促红细胞生成素结合蛋白血细胞比容增加是Epo治疗的目的。本发明提供一种治疗哺乳动物的贫血的方法，涉及：向哺乳动物施用促红细胞生成素（Epo）; 以及向哺乳动物施用选自可溶性Epo结合蛋白（Epo-bp），结合Epo受体的细胞外可溶部分上的Epo受体的识别蛋白及其组合的药剂。本发明还提供一种降低接受Epo的哺乳动物的高血压的方法，以及含有可溶于Epo-bp和/或识别蛋白的药物组合物，所述可溶性Epo-bp和/或识别蛋白在Epo受体的胞外可溶部分上结合Epo受体。

7. 发明授权

US07092320B1 Medium handler and organizer 有权
标题翻译：中等处理者和组织者
公开(公告)号：US07092320B1
公开(公告)日：2006-08-15
申请号：US09501434
申请日：2000-02-10
申请人： John S. Lee , David J. Suden , Westin W. Nelson , Phillip C. Salisbury , Darrin William Piekkola
发明人： John S. Lee , David J. Suden , Westin W. Nelson , Phillip C. Salisbury , Darrin William Piekkola
IPC分类号： G11B17/22
CPC分类号： G11B17/10 , G11B17/225
摘要： A compact disc processing system allows for more efficient processing of compact discs. The system included a transporter mechanism that can grip and transport more than one compact disc at a time. As such, a second disc can be gripped while a first disc is being processed. This eliminates the need to wait for processing operations, such as recording or printing, to be completed prior to transporting the second disc. The system includes a gripping head with at least two vacuum controlled mechanisms for selectively gripping the discs. A disc organizer can be provided which includes trays that can be used to store discs for selective retrieval. The organizer eliminates the difficulty encountered in locating a processed disc from a large stack of discs.
摘要翻译：光盘处理系统允许更有效地处理光盘。该系统包括一个可以一次抓住和运输多个光盘的运输机构。这样，在处理第一盘时可以抓住第二盘。这消除了在运送第二盘之前等待诸如记录或打印之类的处理操作的需要。该系统包括具有至少两个用于选择性地夹紧盘的真空控制机构的夹头。可以提供盘组织器，其包括可用于存储用于选择性检索的盘的托盘。组织者消除了从大堆光盘定位经处理的光盘所遇到的困难。

8. 发明授权

US5316998A HCl adsorbent and method for making and using same 失效
标题翻译： HCl吸附剂及其制备和使用方法
公开(公告)号：US5316998A
公开(公告)日：1994-05-31
申请号：US878857
申请日：1992-05-05
申请人： John S. Lee , Michael J. Pearson
发明人： John S. Lee , Michael J. Pearson
IPC分类号： B01D53/04 , B01D53/68 , B01J20/04 , B01J20/08 , C01B7/01 , C01B7/00
CPC分类号： B01J20/08 , B01D53/68 , B01J20/041 , B01J20/28011 , B01J20/28069 , B01J20/28078 , B01J20/3078 , B01J20/3204 , B01J20/3236 , C01B7/01
摘要： An HCl adsorbent, and method of making and using the adsorbent, the adsorbent comprising an activated alumina promoted with an alkali metal in an amount such that if calculated as alkali metal oxide, the adsorbent contains at least about 5% by weight alkali metal oxide.
摘要翻译： HCl吸附剂，以及制造和使用吸附剂的方法，所述吸附剂包含用碱金属促进的活性氧化铝，其量使得如果以碱金属氧化物计算，则吸附剂含有至少约5重量％的碱金属氧化物。

9. 发明授权

US4866824A Centering mechanism 失效
标题翻译：定中心机制
公开(公告)号：US4866824A
公开(公告)日：1989-09-19
申请号：US178842
申请日：1988-04-06
申请人： Ronald J. Falk , John S. Lee
发明人： Ronald J. Falk , John S. Lee
IPC分类号： H05K13/04
CPC分类号： H05K13/0413 , Y10T29/51 , Y10T29/53191
摘要： Apparatus (10) for centering an integrated circuit device (12) along X and Y axes (95, 97) with respect to a Z axis (39). First and second jaw pairs (98, 100), are actuated so that corresponding jaws of each pair are, at all times, disposed along their respective axis at equal distances from the Z axis (39). Corresponding jaws of each pair (98, 100) are, concurrently, moved toward and away from the Z axis, therefore. In a preferred embodiment, actuation is effected by means of linear extender rods, (70, 72) which, in turn, in effect rotation of discs (26, 28) and their corresponding turnstiles (106, 114). Turnstile (106, 114) rotation, in turn, effects linear movement of track riders (84, 86) to which the jaw pairs, (98, 100) are mounted.
摘要翻译：用于使集成电路装置（12）相对于Z轴（39）沿着X和Y轴（95,97）定心的装置（10）。第一和第二钳口对（98,100）被致动，使得每对的对应的钳口始终沿着它们各自的轴线以与Z轴（39）相等的距离设置。因此，每对（98,100）的相应的钳口同时朝向和远离Z轴移动。在一个优选实施例中，通过线性延伸杆（70,72）进行致动，其进而有效地转动盘（26,28）及其对应的十字门（106,114）。旋转门（106,114）旋转，进而影响安装有卡爪对（98,100）的轨道车手（84,86）的直线运动。

10. 发明授权

US09539308B2 Compositions and methods for preventing erythropoietin-associated hypertension 有权
标题翻译：用于预防红细胞生成素相关性高血压的组合物和方法
公开(公告)号：US09539308B2
公开(公告)日：2017-01-10
申请号：US14042702
申请日：2013-09-30
申请人： Jong Y. Lee , John S. Lee , Mary S. Lee
发明人： Jong Y. Lee , John S. Lee , Mary S. Lee
IPC分类号： A61K38/17 , A61K38/18 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39533 , A61K38/179 , A61K38/1816 , A61K39/3955 , A61K2039/505 , A61K2121/00 , A61K2300/00 , C07K16/2863 , C07K2317/55
摘要： The inventors have discovered that both soluble erythropoietin-binding protein and antibodies against the erythropoietin-binding protein, when they are administered to a mammal along with erythropoietin (Epo), prevent or reduce the blood pressure increase normally caused by erythropoietin, while not affecting the hematocrit increase that is the purpose of Epo treatment. The invention provides a method of treating anemia in a mammal involving: administering erythropoietin (Epo) to the mammal; and administering to the mammal an agent selected from a soluble Epo-binding protein (Epo-bp), a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor, and a combination thereof. The invention also provides a method of reducing hypertension in a mammal receiving Epo, and pharmaceutical compositions containing a soluble Epo-bp and/or a recognition protein that binds Epo receptor on an extracellular soluble portion of the Epo receptor.
摘要翻译：本发明人已经发现，当将可溶性促红细胞生成素结合蛋白和抗红细胞生成素结合蛋白的抗体与促红细胞生成素（Epo）一起施用于哺乳动物时，可预防或降低通常由促红细胞生成素引起的血压升高，同时不影响促红细胞生成素结合蛋白血细胞比容增加是Epo治疗的目的。本发明提供一种治疗哺乳动物的贫血的方法，涉及：向哺乳动物施用促红细胞生成素（Epo）; 以及向哺乳动物施用选自可溶性Epo结合蛋白（Epo-bp），结合Epo受体的细胞外可溶部分上的Epo受体的识别蛋白及其组合的药剂。本发明还提供一种降低接受Epo的哺乳动物的高血压的方法，以及含有可溶于Epo-bp和/或识别蛋白的药物组合物，所述可溶性Epo-bp和/或识别蛋白在Epo受体的胞外可溶部分上结合Epo受体。

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