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1. 发明授权

US06495143B2 Botulinum neurotoxin vaccine 失效
标题翻译：肉毒杆菌神经毒素疫苗
公开(公告)号：US06495143B2
公开(公告)日：2002-12-17
申请号：US09350756
申请日：1999-07-09
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Michael Parker , Mark T. Dertzbaugh , Leonard Smith
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Michael Parker , Mark T. Dertzbaugh , Leonard Smith
IPC分类号： C12N1586
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C07K14/33 , C12N2799/021
摘要： Using the nontoxic heavy chain fragment from botulinum neurotoxins A-G, compositions and methods of use in inducing an immune response which is protective against intoxication with botulinum in subjects is described.
摘要翻译：使用来自肉毒杆菌神经毒素A-G的无毒重链片段，描述了用于诱导免疫应答的组合物和方法，其在受试者中与肉毒杆菌中毒。

2. 发明授权

US06531135B1 Alphavirus RNA replicon systems 失效
标题翻译：甲病毒RNA复制子系统
公开(公告)号：US06531135B1
公开(公告)日：2003-03-11
申请号：US09598569
申请日：2000-06-21
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.
摘要翻译：本发明提供了用于在甲病毒允许细胞中表达感染性，复制缺陷型甲病毒颗粒的辅助细胞。辅助细胞包括（a）编码（i）至少一种甲病毒结构蛋白的第一辅助RNA，和（ii）不编码至少一种甲病毒属结构蛋白; 和（b）与第一辅助RNA分开的第二辅助RNA，不编码由第一辅助RNA编码的甲病毒结构蛋白的第二辅助RNA（i），和（ii）编码至少一种不是由第一辅助RNA编码的结合蛋白的结构蛋白，第一辅助RNA，使得所有甲病毒结构蛋白聚集在细胞中的甲病毒颗粒中。优选地，辅助细胞还包括编码甲病毒包装序列和插入的异质RNA的复制子RNA。

3. 发明授权

US06156558A Alphavirus RNA replicon systems 失效
公开(公告)号：US06156558A
公开(公告)日：2000-12-05
申请号：US122286
申请日：1998-07-24
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K48/00 , A61P31/12 , C07K14/18 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/00 , C12N15/33 , C12N15/86 , C12R1/92
CPC分类号： C07K14/005 , C12N15/86 , C12N7/00 , A61K2039/5254 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.

4. 发明授权

US07235235B2 Alphavirus RNA replicon systems 有权
标题翻译：甲病毒RNA复制子系统
公开(公告)号：US07235235B2
公开(公告)日：2007-06-26
申请号：US10388327
申请日：2003-03-13
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： A01N63/00 , A61K39/12 , C12N7/00 , C12N7/04 , C12N7/02 , C12N5/00
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.
摘要翻译：本发明提供了用于在甲病毒允许细胞中表达感染性，复制缺陷型甲病毒颗粒的辅助细胞。辅助细胞包括（a）编码（i）至少一种甲病毒结构蛋白的第一辅助RNA，和（ii）不编码至少一种甲病毒属结构蛋白; 和（b）与第一辅助RNA分开的第二辅助RNA，不编码由第一辅助RNA编码的甲病毒结构蛋白的第二辅助RNA（i），和（ii）编码至少一种不是由第一辅助RNA编码的结合蛋白的结构蛋白，第一辅助RNA，使得所有甲病毒结构蛋白聚集在细胞中的甲病毒颗粒中。优选地，辅助细胞还包括编码甲病毒包装序列和插入的异质RNA的复制子RNA。

5. 发明授权

US06541010B1 Alphavirus RNA replicon systems 失效
公开(公告)号：US06541010B1
公开(公告)日：2003-04-01
申请号：US08981159
申请日：1997-11-10
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least one alphavirus structural protein not encoded by the first helper RNA. Preferably, the helper cell is co-transfected with a replicon RNA encoding an alphavirus packaging segment and an inserted heterogeneous RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell, with said replicon RNA packaged therein.

6. 发明授权

US06521235B2 Alphavirus RNA replicon systems 有权
标题翻译：甲病毒RNA复制子系统
公开(公告)号：US06521235B2
公开(公告)日：2003-02-18
申请号：US09803600
申请日：2001-03-09
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least one alphavirus structural protein not encoded by the first helper RNA. Preferably, the helper cell is co-transfected with a replicon RNA encoding an alphavirus packaging segment and an inserted heterogeneous RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell, with said replicon RNA packaged therein.
摘要翻译：本发明提供了用于在甲病毒允许细胞中表达感染性，复制缺陷型甲病毒颗粒的辅助细胞。辅助细胞包括（a）编码（i）至少一种甲病毒结构蛋白的第一辅助RNA，和（ii）不编码至少一种甲病毒属结构蛋白; 和（b）与第一辅助RNA分开的第二辅助RNA，不编码由第一辅助RNA编码的甲病毒结构蛋白的第二辅助RNA（i），和（ii）编码不由第一辅助RNA编码的至少一种甲病毒结构蛋白，第一个辅助RNA。优选地，辅助细胞与编码甲病毒包装片段和插入的异质RNA的复制子RNA共转染，使得所有甲病毒属结构蛋白在一起组装成细胞中的甲病毒颗粒，其中包含所述复制子RNA。

7. 发明授权

US5792462A Alphavirus RNA replicon systems 失效
公开(公告)号：US5792462A
公开(公告)日：1998-08-11
申请号：US448630
申请日：1995-05-23
申请人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
发明人： Robert E. Johnston , Nancy L. Davis , Jonathan F. Smith , Peter Pushko , Michael Parker , George Ludwig
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K48/00 , A61P31/12 , C07K14/18 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/00 , C12N15/33 , C12N15/86 , C12R1/92 , A61K39/295
CPC分类号： C07K14/005 , C12N15/86 , C12N7/00 , A61K2039/5254 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.

8. 发明申请

US20130157372A1 WASTE RAMP FOR REAGENT CARDS 有权
标题翻译：用于试剂卡的废物RAMP
公开(公告)号：US20130157372A1
公开(公告)日：2013-06-20
申请号：US13712144
申请日：2012-12-12
申请人： Kenneth Galano , Michael Parker , Aaron Sung-Lien Tang
发明人： Kenneth Galano , Michael Parker , Aaron Sung-Lien Tang
IPC分类号： G01N35/10
CPC分类号： G01N33/4875 , G01N35/00029 , G01N35/10 , Y10T436/110833
摘要： An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. The waste receptacle has a side and a waste cavity. A ramp member positioned below the travel surface has an end and a sloped surface, and is movable between an extended position where the sloped surface extends into the waste cavity, and a retracted position where the end is spaced from the side a distance greater than the length of the reagent card. A moving mechanism operably coupled with the ramp member is configured to move the ramp member between the extended position and the retracted position.
摘要翻译：用于具有前端，后端和前端与后端之间的长度的试剂卡的自动分析器包括具有卡移动表面和边缘的行进表面组件。测试分析机构与行进表面相邻，并且废物容器邻近行进表面下方的边缘。废物容器具有侧面和废物腔。定位在行进表面下方的斜坡构件具有端部和倾斜表面，并且可在倾斜表面延伸到废物空腔的延伸位置和缩回位置之间移动，其中端部与侧面间隔大于试剂卡的长度。与斜面构件可操作地联接的移动机构被构造成在延伸位置和缩回位置之间移动斜坡构件。

9. 发明申请

US20120221830A1 CONFIGURABLE VECTOR LENGTH COMPUTER PROCESSOR 有权
标题翻译：可配置矢量长度计算机处理器
公开(公告)号：US20120221830A1
公开(公告)日：2012-08-30
申请号：US13409033
申请日：2012-02-29
申请人： Gregory J. Faanes , Eric P. Lundberg , Abdulla Bataineh , Timothy J. Johnson , Michael Parker , James Robert Kohn , Steven L. Scott , Robert Alverson
发明人： Gregory J. Faanes , Eric P. Lundberg , Abdulla Bataineh , Timothy J. Johnson , Michael Parker , James Robert Kohn , Steven L. Scott , Robert Alverson
IPC分类号： G06F15/76
CPC分类号： G06F15/8053
摘要： A processor core, comprises one or more vector units operable to change between a fine-grained vector mode having a shorter maximum vector length and a coarse-grained vector mode having a longer maximum vector length. Changing vector modes comprises halting all instruction stream execution in the core, flushing one or more registers in a register space, reconfiguring one or more vector registers in the register space, and restarting instruction execution in the core.
摘要翻译：处理器核心包括一个或多个向量单元，其可操作以在具有较短最大向量长度的细粒子矢量模式和具有较长最大向量长度的粗粒矢量模式之间进行切换。更改向量模式包括停止核心中的所有指令流执行，刷新寄存器空间中的一个或多个寄存器，重新配置寄存器空间中的一个或多个向量寄存器，以及重新启动核心中的指令执行。

10. 发明申请

US20100115232A1 LARGE INTEGER SUPPORT IN VECTOR OPERATIONS 审中-公开
标题翻译：大量整数支持向量运算
公开(公告)号：US20100115232A1
公开(公告)日：2010-05-06
申请号：US12263313
申请日：2008-10-31
申请人： Timothy J. Johnson , Eric P. Lundberg , Michael Parker , Gregory J. Faanes
发明人： Timothy J. Johnson , Eric P. Lundberg , Michael Parker , Gregory J. Faanes
IPC分类号： G06F9/302 , G06F15/76
CPC分类号： G06F7/505 , G06F9/30036 , G06F9/30109 , G06F2207/382
摘要： A vector processor or vector processing computer has a first vector register operable to store two or more vector elements that together comprise a single first large integer and a second vector register operable to store two or more vector elements that together comprise a single second large integer. An adder having a carry-in bit is operable to add the large integer in the first vector register to the large integer in the second vector register by using the carry-in bit to add sequential elements of the vector registers.
摘要翻译：向量处理器或向量处理计算机具有可操作以存储两个或更多个向量元素的第一向量寄存器，所述向量元素一起包括单个第一大整数和第二向量寄存器，该第一向量寄存器可操作以存储两个或多个向量元素，所述两个或更多个向量元具有进位位的加法器可操作以通过使用进位位将第一向量寄存器中的大整数加到第二向量寄存器中的大整数，以添加向量寄存器的顺序元件。

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