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1. 发明授权

US07036667B2 Container providing a controlled hydrated environment 失效
标题翻译：集装箱提供受控的水合环境
公开(公告)号：US07036667B2
公开(公告)日：2006-05-02
申请号：US10837707
申请日：2004-05-04
申请人： Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Reed Harris , Daren Walter Hebold , Robert Andrew Howard , Andrew Leonard Zee
发明人： Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Reed Harris , Daren Walter Hebold , Robert Andrew Howard , Andrew Leonard Zee
IPC分类号： B65D85/00
CPC分类号： B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/185 , B01L2300/041 , B65D85/70
摘要： A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.
摘要翻译：提供了用于运输和存储预润湿和预调节微流控“吸嘴”芯片的容器。容器包含干燥隔室和湿隔间。基座包含配置成容纳毛细管的流体填充的储存器。储罐的开口用O形圈密封。芯片的塑料安装座位于干燥隔间的底座上。芯片的上表面包含几个含有流体的孔。垫圈设置有被配置为设置在井中并密封井的塞子。或者，孔首先用粘合剂粘附到井口上的箔膜密封，并且垫片设置在箔和盖之间，盖可拆卸地附接到基座。当盖子关闭时，垫圈和O形圈密封湿隔间，以防止泄漏并减缓蒸发。

2. 发明申请

US20050045518A1 Container providing a controlled hydrated environment 失效
标题翻译：集装箱提供受控的水合环境
公开(公告)号：US20050045518A1
公开(公告)日：2005-03-03
申请号：US10837707
申请日：2004-05-04
申请人： Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Harris , Daren Hebold , Robert Howard , Andrew Zee
发明人： Michael Greenstein , Colin Kennedy , Huan Phan , Stephan Bianchi , Jonathan Harris , Daren Hebold , Robert Howard , Andrew Zee
IPC分类号： B01L9/00 , B65D85/00 , B65D85/84
CPC分类号： B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/185 , B01L2300/041 , B65D85/70
摘要： A container is provided for shipping and storing a pre-wetted and preconditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.
摘要翻译：提供了用于运输和存储预润湿和预处理的微流控“吸嘴”芯片的容器。容器包含干燥隔室和湿隔间。基座包含配置成容纳毛细管的流体填充的储存器。储罐的开口用O形圈密封。芯片的塑料安装座位于干燥隔间的底座上。芯片的上表面包含几个含有流体的孔。垫圈设置有被配置为设置在井中并密封井的塞子。或者，孔首先用粘合剂粘附到井口上的箔膜密封，并且垫片设置在箔和盖之间，盖可拆卸地附接到基座。当盖子关闭时，垫圈和O形圈密封湿隔间，以防止泄漏并减缓蒸发。

3. 发明申请

US20060165559A1 Automated system for handling microfluidic devices 有权
公开(公告)号：US20060165559A1
公开(公告)日：2006-07-27
申请号：US11133943
申请日：2005-05-20
申请人： Michael Greenstein , Colin Kennedy , James Mikkelsen
发明人： Michael Greenstein , Colin Kennedy , James Mikkelsen
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0819 , G01N21/05 , G01N21/11 , G01N21/13 , G01N35/04 , G01N35/1095 , G01N2021/0346 , G01N2021/058
摘要： The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.

4. 发明申请

US20090321263A1 CLINICAL ANALYSIS APPARATUS 审中-公开
标题翻译：临床分析仪器
公开(公告)号：US20090321263A1
公开(公告)日：2009-12-31
申请号：US12377516
申请日：2007-09-17
申请人： Youichi Endo , Yoshihiro Seto , Shinji Satomura , Masayoshi Hayashi , Mitsuo Watanabe , Colin Kennedy , Michael Greenstein , Cheryl Cathey
发明人： Youichi Endo , Yoshihiro Seto , Shinji Satomura , Masayoshi Hayashi , Mitsuo Watanabe , Colin Kennedy , Michael Greenstein , Cheryl Cathey
IPC分类号： G01N27/26
CPC分类号： G01N35/028 , B01L3/5027 , B01L13/02 , B01L2200/027 , B01L2400/0421 , B01L2400/0487 , G01N21/6456 , G01N35/025
摘要： To enable reuse of expensive microchips in a clinical analysis apparatus, while constantly and efficiently obtaining accurate analysis results. A clinical apparatus employs microchips to analyze substances, which are contained in samples and are targets of measurement. The clinical analysis apparatus is equipped with: a stocking section; a dispensing mechanism, for dispensing reagents stocked in the stocking section and samples to the microchips; and a measuring section, for measuring the measurement target substance within the samples. The measuring section includes: a dispensing station, at which the microchips are provided; a detecting station, for detecting the measurement target substance; and a cleansing station, at which microchips are cleansed following detection of the measurement target substance. The dispensing station, the detecting station, and the cleansing station are provided at a predetermined pitch from upstream to downstream positions. The microchips are continuously rotated through the stations to perform measurement repeatedly.
摘要翻译：为了在临床分析仪器中重新使用昂贵的微芯片，同时不断有效地获得准确的分析结果。临床装置采用微芯片分析样品中含有的物质，是测量对象。临床分析仪器配有：放养部分; 分配机构，用于分配储存在放养部分中的试剂和样品到微芯片; 以及用于测量样品内的测量目标物质的测量部分。测量部分包括：分配站，在其上提供微芯片; 用于检测测量目标物质的检测站; 以及在检测到测定对象物质之后清洁微芯片的清洁台。从上游到下游位置以预定间距设置分配站，检测站和清洁站。微型芯片连续旋转通过台站进行重复测量。

5. 发明申请

US20050279635A1 Controller/detector interfaces for microfluidic systems 审中-公开
标题翻译：用于微流体系统的控制器/检测器接口
公开(公告)号：US20050279635A1
公开(公告)日：2005-12-22
申请号：US11005120
申请日：2004-12-06
申请人： Calvin Chow , J. Parce , Richard McReynolds , Colin Kennedy , Luc Bousse
发明人： Calvin Chow , J. Parce , Richard McReynolds , Colin Kennedy , Luc Bousse
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , C25B11/00 , G01N27/27 , G01N27/447 , G01N27/453
CPC分类号： G01N27/453 , B01J19/0093 , B01J2219/00853 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/0415 , G01N27/44743 , G01N27/44791 , Y10T436/2575
摘要： The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems (620) for controlling the performance of the processes carried out within the device, e.g., monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.
摘要翻译：本发明总体上涉及用于将微流体装置与与这种装置结合使用的辅助系统进行接口的改进的方法，结构和系统。这些系统通常包括用于控制在设备内执行的过程的性能的控制和监视系统（620），例如监视和控制环境条件并监视所执行的过程的结果，例如检测。

6. 发明授权

US07727477B2 Apparatus for priming microfluidics devices with feedback control 有权
标题翻译：用于启动具有反馈控制的微流体装置的装置
公开(公告)号：US07727477B2
公开(公告)日：2010-06-01
申请号：US11288838
申请日：2005-11-28
申请人： Allen Boronkay , Colin Kennedy , Matthew Latham
发明人： Allen Boronkay , Colin Kennedy , Matthew Latham
IPC分类号： G01N1/00 , G01N21/01
CPC分类号： B01L3/0293 , B01L3/5027 , B01L9/527 , B01L2200/146 , B01L2400/0487 , G01N27/44743 , G01N27/44756 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control feature is particularly useful in controlling the exposure time of the microchannels to dyes in the priming liquids since certain dyes tend to adhere to the walls of the channels and produce non-uniform results.
摘要翻译：用于微流体装置的起动单元包含加压单元和作为反馈回路的一部分的压力和温度检测器，其控制由加压单元施加的压力和施加压力的时间。这种控制特征特别适用于控制微通道对底漆中染料的曝光时间，因为某些染料倾向于粘附到通道的壁上并产生不均匀的结果。

7. 发明申请

US20070196238A1 Integrated dissolution processing and sample transfer system 有权
标题翻译：综合溶解处理和样品转移系统
公开(公告)号：US20070196238A1
公开(公告)日：2007-08-23
申请号：US11648050
申请日：2006-12-28
申请人： Colin Kennedy , Syed Husain , Dale von Behren , Rick Bernal
发明人： Colin Kennedy , Syed Husain , Dale von Behren , Rick Bernal
IPC分类号： G01N15/06
CPC分类号： G01N1/38 , G01N13/00 , G01N33/15 , G01N35/025 , G01N2013/003 , G01N2013/006 , G01N2035/00198
摘要： The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle.
摘要翻译：本发明提供了用于溶出度测试的系统和方法。该系统包括多个溶解容器和位于溶解容器上方的剂量载体。剂量载体保持多个可移除的转盘，其接收单独的剂量以进行溶解测试。接收片剂或沉降片的转盘通常具有第一配置，而接收篮子的转盘通常具有第二配置。转盘的两种不同配置可在相同的剂量环上互换。所述系统还包括位于所述剂量载体上方的驱动头，所述驱动头具有篮状心轴和可移除地且可互换地连接的混合桨。与系统整合的移液器将样品等分试样从溶出容器转移至50ml至1ml的范围至外部容器的孔。

8. 发明申请

US20060163070A1 Apparatus for priming microfluidics devices with feedback control 有权
标题翻译：用于启动具有反馈控制的微流体装置的装置
公开(公告)号：US20060163070A1
公开(公告)日：2006-07-27
申请号：US11288838
申请日：2005-11-28
申请人： Allen Boronkay , Colin Kennedy , Matthew Latham
发明人： Allen Boronkay , Colin Kennedy , Matthew Latham
IPC分类号： G01N27/447
CPC分类号： B01L3/0293 , B01L3/5027 , B01L9/527 , B01L2200/146 , B01L2400/0487 , G01N27/44743 , G01N27/44756 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control feature is particularly useful in controlling the exposure time of the microchannels to dyes in the priming liquids since certain dyes tend to adhere to the walls of the channels and produce non-uniform results.
摘要翻译：用于微流体装置的起动单元包含加压单元和作为反馈回路的一部分的压力和温度检测器，其控制由加压单元施加的压力和施加压力的时间。这种控制特征特别适用于控制微通道对底漆中染料的曝光时间，因为某些染料倾向于粘附到通道的壁上并产生不均匀的结果。

9. 发明申请

US20090224907A1 Sanitation Tracking and Alerting System 审中-公开
标题翻译：卫生跟踪和警报系统
公开(公告)号：US20090224907A1
公开(公告)日：2009-09-10
申请号：US12042699
申请日：2008-03-05
申请人： Sidhartha R. Sinha , Colin Kennedy
发明人： Sidhartha R. Sinha , Colin Kennedy
IPC分类号： H04Q7/00 , G08B13/00 , G08B23/00
CPC分类号： G08B21/245 , A61B5/1113
摘要： The invention provides a sanitization tracking and alerting system and method that automatically monitors hand sanitization actions of workers within a facility and reminds them of violations of hand sanitization requirements. The sanitization system may comprise a communications network providing interaction between a central computer with a database and one or more sanitizer dispenser systems, which dispense a sanitizer to the workers upon demand. The sanitizer dispensing system may have a reader for reading an identification device associated with the worker and a motion detector that detects when the worker is in the proximity of the dispensing mechanism. The sanitizer dispenser system may contain logic for determining which one of a number of workers in its vicinity may press a dispensing means, sending that information to the central computer, and activating an audio or visual indicator if the central computer determines that the worker is not sanitized, as determined by the length of time since the last hand sanitization event of the worker or whether or not the worker had done something that would require another hand sanitization action.
摘要翻译：本发明提供了一种消毒跟踪和警报系统和方法，其自动监视设施内的工人的手消毒行为，并提醒他们违反手消毒要求。消毒系统可以包括提供中央计算机与数据库之间的交互的通信网络和一个或多个消毒剂分配器系统，其根据需要向工人分配消毒剂。消毒剂分配系统可以具有用于读取与工作人员相关联的识别装置的读取器和检测工人何时位于分配机构附近的运动检测器。消毒剂分配器系统可以包含用于确定其附近的多个工人中的哪一个可以按下分配装置的逻辑，将该信息发送到中央计算机，以及如果中央计算机确定工作人员不是，则启动音频或视觉指示器根据工人最后一次消毒事件发生的时间长短或者工人是否已经做了需要另一种手部消毒措施的事情来确定的消毒方式。

10. 发明申请

US20050135655A1 Ultra high throughput microfluidic analytical systems and methods 审中-公开
标题翻译：超高通量微流体分析系统和方法
公开(公告)号：US20050135655A1
公开(公告)日：2005-06-23
申请号：US11036722
申请日：2005-01-13
申请人： Anne Kopf-Sill , Andrea Chow , Peter Jann , Morten Jensen , Michael Spaid , Colin Kennedy , Michael Kennedy
发明人： Anne Kopf-Sill , Andrea Chow , Peter Jann , Morten Jensen , Michael Spaid , Colin Kennedy , Michael Kennedy
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , G01N21/05 , G01N21/64 , G01N27/447 , G01N35/00 , G01N37/00 , G01L9/18
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/54 , B01L9/527 , B01L2200/023 , B01L2200/027 , B01L2200/028 , B01L2200/147 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44782 , G01N35/0099 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421
摘要： Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided. Increased throughput and improved emissions detection is provided by the present invention by simultaneously illuminating multiple parallel microchannels at a non-normal incidence using an excitation beam including multiple excitation frequencies, and simultaneously detecting emissions from the substances in the microchannels in a direction normal to the substrate using a detection module with multiple detectors.
摘要翻译：分析系统和方法使用模块化接口结构来提供样品基底和分析单元之间的界面，其中分析单元通常具有用于实现各种分析和控制功能的特定界面布置。使用模块化接口结构的每个模块的许多变体有利地提供了使用具有特定分析和控制系统接口布置的特定基板或类别的基板执行大量测试的成本有效和有效的方式。还提供了用于同时分析多个并行微通道中的反应或条件的改进的光学照明和检测系统。通过使用包括多个激发频率的激发束同时照射非法线入射的多个平行微通道并且同时在垂直于衬底的方向上检测来自微通道中的物质的发射，本发明提供了增加的吞吐量和改进的排放物检测使用具有多个检测器的检测模块。

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