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1. 发明授权

US5438554A Tunable acoustic resonator for clinical ultrasonic transducers 失效
标题翻译：用于临床超声波换能器的可调谐声谐振器
公开(公告)号：US5438554A
公开(公告)日：1995-08-01
申请号：US203216
申请日：1994-02-28
申请人： Mir S. Seyed-Bolorforosh , Michael Greenstein , Turuvekere R. Gururaja , Henry Yoshida
发明人： Mir S. Seyed-Bolorforosh , Michael Greenstein , Turuvekere R. Gururaja , Henry Yoshida
IPC分类号： A61B8/14 , B06B1/06 , G01N29/24 , G10K11/02 , H04R17/00
CPC分类号： G10K11/02 , B06B1/0622
摘要： A tunable ultrasonic probe includes a body of a first piezoelectric material acoustically coupled in series with a body of a second piezoelectric material. The second piezoelectric material has a Curie temperature that is substantially different than that of the first piezoelectric material. Preferably, the first piezoelectric material is a conventional piezoelectric ceramic, such as lead zirconate titanate, while the second piezoelectric material is a relaxor ferroelectric ceramic, such as lead magnesium niobate. At an operating temperature of the probe, the first piezoelectric material has a fixed polarization. In contrast, the second piezoelectric material has a polarization that is variable relative to the fixed polarization of the first piezoelectric material. A preferred novel arrangement of electrodes electrically couples the bodies in parallel with one another. An oscillating voltage for exciting the acoustic signals in the probe is coupled with the electrodes. The polarization of the second piezoelectric material is variably controlled by a bias voltage coupled with the electrodes. In a preferred embodiment, the bias voltage has a reversible electrical polarity for selecting one resonant frequency from a plurality of resonant frequencies of the probe. In another preferred embodiment, the bias voltage source has a variable voltage level for selecting at least one of a plurality of resonant frequencies of the probe.
摘要翻译：可调谐超声波探头包括与第二压电材料的主体串联耦合的第一压电材料的主体。第二压电材料具有与第一压电材料基本不同的居里温度。优选地，第一压电材料是诸如锆钛酸铅的常规压电陶瓷，而第二压电材料是诸如铌酸铅镁之类的弛豫铁电陶瓷。在探针的工作温度下，第一压电材料具有固定的极化。相反，第二压电材料具有相对于第一压电材料的固定极化可变的极化。电极的优选新颖布置使得主体彼此平行地电耦合。用于激发探针中的声信号的振荡电压与电极耦合。第二压电材料的极化可通过与电极耦合的偏置电压来可变地控制。在优选实施例中，偏置电压具有可逆的电极性，用于从探头的多个谐振频率中选择一个谐振频率。在另一个优选实施例中，偏置电压源具有用于选择探头的多个谐振频率中的至少一个的可变电压电平。

2. 发明授权

US5485845A Rotary encoder for intravascular ultrasound catheter 失效
标题翻译：旋转编码器用于血管内超声导管
公开(公告)号：US5485845A
公开(公告)日：1996-01-23
申请号：US434616
申请日：1995-05-04
申请人： Edward Verdonk , Michael Greenstein , Hewlett E. Melton, Jr. , Mir S. Seyed-Bolorforosh
发明人： Edward Verdonk , Michael Greenstein , Hewlett E. Melton, Jr. , Mir S. Seyed-Bolorforosh
IPC分类号： A61B8/12 , A61B19/00 , G01S5/24 , G01S15/74 , G01S15/87 , G01S15/89
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461 , G01S15/74 , G01S15/874 , G01S15/8943 , A61B2090/3929 , G01S5/24
摘要： An ultrasound system and method for intravascular ultrasonic imaging includes an array of beacons that are fixed to direct ultrasonic energy toward an imaging transducer, with individual beacons being identifiable in order to determine the angular position of the imaging transducer. Based upon the data related to beacon identification, operation of the imaging device is adaptively adjusted in order to compensate for variations in angular velocity of the transducer. Adaptive compensation may be performed by adjusting the pulse repetition rate of transmitted ultrasonic energy, by adjusting the scan conversion algorithm or mapping reflected ultrasonic energy, or by varying control of the drive structure for rotating the transducer. The beacons are preferably piezoelectrically active, but passive beacons may also be used. Position identification may be performed by techniques including amplitude sensing, phase sensing, pulse length sensing, and frequency sensing. As an alternative to rotation of the transducer, ultrasonic signals may be formed at a proximal end of a probe and then conducting the energy to the distal end via a waveguide.
摘要翻译：用于血管内超声成像的超声系统和方法包括固定以朝向成像换能器直接超声能量的信标阵列，其中各个信标是可识别的，以便确定成像换能器的角位置。基于与信标识别相关的数据，自适应地调整成像装置的操作，以补偿换能器的角速度的变化。可以通过调整扫描转换算法或映射反射的超声能量，或者通过改变用于旋转传感器的驱动结构的控制来调节发射的超声能量的脉冲重复率来执行自适应补偿。信标优选地是压电有源的，但也可以使用被动信标。可以通过包括幅度感测，相位感测，脉冲长度感测和频率感测的技术来执行位置识别。作为换能器旋转的替代方案，可以在探针的近端处形成超声波信号，然后经由波导将能量传导到远端。

3. 发明授权

US5396143A Elevation aperture control of an ultrasonic transducer 失效
标题翻译：超声波换能器的高程孔径控制
公开(公告)号：US5396143A
公开(公告)日：1995-03-07
申请号：US246593
申请日：1994-05-20
申请人： Mir S. Seyed-Bolorforosh , Michael Greenstein , Hewlett E. Melton, Jr.
发明人： Mir S. Seyed-Bolorforosh , Michael Greenstein , Hewlett E. Melton, Jr.
IPC分类号： A61B8/00 , B06B1/06 , H01L41/09 , H04R17/00 , H04R17/08 , H01L41/08
CPC分类号： B06B1/06 , B06B1/0622 , H04R17/08
摘要： An ultrasonic transducer for controlling an elevation aperture utilizes the electric field-induced polarization properties of relaxor ferroelectric materials. The Curie temperature of the material is typically close to room temperature, so that the application of a bias voltage provides piezoelectric activity. By varying the thickness of a dielectric layer that spaces apart the relaxor ferroelectric material from an electrode or providing the bias voltage, the piezoelectric activity can be tailored. That is, degrees of polarization of the relaxor ferroelectric material are varied spatially in correspondence with changes in thickness of the dielectric layer. The effective elevation aperture of the transducer can be varied by adjusting the bias voltage.
摘要翻译：用于控制仰角孔的超声换能器利用了弛豫铁电材料的电场诱导极化特性。材料的居里温度通常接近室温，因此施加偏置电压提供压电活性。通过改变将弛豫铁电体材料与电极隔开或提供偏置电压的电介质层的厚度，可以调整压电活性。也就是说，弛豫铁电材料的偏振度根据电介质层的厚度的变化在空间上变化。可以通过调整偏置电压来改变传感器的有效仰角孔径。

4. 发明授权

US5638822A Hybrid piezoelectric for ultrasonic probes 失效
标题翻译：超声波探头混合压电
公开(公告)号：US5638822A
公开(公告)日：1997-06-17
申请号：US497238
申请日：1995-06-30
申请人： Mir Said Seyed-Bolorforosh , Michael Greenstein , Douglas Harriott , Turuvekere R. Gururaja
发明人： Mir Said Seyed-Bolorforosh , Michael Greenstein , Douglas Harriott , Turuvekere R. Gururaja
IPC分类号： B06B1/06 , G10K11/02 , A61B8/00
CPC分类号： G10K11/02 , B06B1/0607 , B06B1/067
摘要： An ultrasonic probe for coupling acoustic signals between the probe and a medium is provided. The ultrasonic probe has a piezoelectric element having a plurality of piezoelectric layers each having a different acoustic impedance. The piezoelectric layers are stacked in progressive order of acoustic impedance such that the layer with the acoustic impedance nearest to that of the medium is proximate the medium. At least one of said piezoelectric layers is made of piezoelectric composite material. The ultrasonic probe further has an electrode means for electrically coupling the piezoelectric layers to a voltage source for applying an oscillation voltage potential to each piezoelectric layer. The probe further has a control means for controlling the polarization of at least one of the piezoelectric layers.
摘要翻译：提供用于耦合探针和介质之间的声信号的超声波探头。超声波探头具有压电元件，该压电元件具有各自具有不同声阻抗的多个压电层。压电层以声阻抗的渐进顺序堆叠，使得具有最接近介质的声阻抗的层接近介质。所述压电层中的至少一个由压电复合材料制成。超声波探头还具有用于将压电层电耦合到电压源的电极装置，用于向每个压电层施加振荡电压电位。探头还具有用于控制至少一个压电层的极化的控制装置。

5. 发明授权

US5592730A Method for fabricating a Z-axis conductive backing layer for acoustic transducers using etched leadframes 失效
标题翻译：用于使用蚀刻引线框架制造用于声学换能器的Z轴导电背衬层的方法
公开(公告)号：US5592730A
公开(公告)日：1997-01-14
申请号：US283136
申请日：1994-07-29
申请人： Michael Greenstein , Henry Yoshida
发明人： Michael Greenstein , Henry Yoshida
IPC分类号： G01N29/24 , A61B8/00 , B06B1/02 , B06B1/06 , H04R17/00 , H04R31/00 , H01L41/22
CPC分类号： B06B1/0622 , Y10T29/42 , Y10T29/49005 , Y10T29/49121
摘要： A Z-axis backing layer for an acoustic transducer is provided, which comprises a matrix of electrical conductors disposed in parallel and potted within an electrically insulating acoustic backing material. The acoustic transducers are disposed on a first end of the backing layer, with each individual transducer element connecting electrically to a respective one of the conductors. At the other end of the backing layer, the conductors connect electrically to a corresponding circuit element. The backing layer is fabricated from a plurality of leadframes each having an outer frame member and a plurality of conductors extending in parallel across the leadframes terminating at the frame members at opposite ends thereof. The plurality of leadframes are stacked such that respective conductors of adjacent ones of the leadframes are disposed in parallel with a space provided between the respective conductors equivalent to a width of one of the leadframes. Acoustic backing material is poured onto the stacked plurality of leadframes to completely fill the spaces between conductors. The frame members and excess acoustic backing material are then removed from the stacked and poured plurality of leadframes.
摘要翻译：提供了一种用于声学换能器的Z轴背衬层，其包括平行放置并封装在电绝缘声学背衬材料内的电导体矩阵。声学传感器设置在背衬层的第一端上，每个单独的换能器元件电连接到相应的导体之一。在背衬层的另一端，电导体与相应的电路元件电连接。背衬层由多个引线框架制成，每个引线框架具有外框架构件和多个导体，跨过引线框架并联延伸，终端于框架构件的相对端。多个引线框架被堆叠，使得相邻的引线框架的各个导体与设置在相当于引线框之一的宽度的各个导体之间的空间平行设置。声学衬垫材料被倒在堆叠的多个引线框架上以完全填充导体之间的空间。然后将框架构件和多余的声学衬垫材料从堆叠和倒入的多个引线框架中移除。

6. 发明申请

US20090321259A1 Portable Preparation, Analysis, and Detection Apparatus for Nucleic Acid Processing 审中-公开
标题翻译：用于核酸加工的便携式制备，分析和检测装置
公开(公告)号：US20090321259A1
公开(公告)日：2009-12-31
申请号：US12433201
申请日：2009-04-30
申请人： Charles S. Vann , Michael Greenstein , yuh-Min Chiang
发明人： Charles S. Vann , Michael Greenstein , yuh-Min Chiang
IPC分类号： C12Q1/68 , G01N27/447
CPC分类号： G01N27/447 , C12M47/06 , C12Q1/6806 , C12Q1/686
摘要： The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through the production of a pulsed electrical field. The electrodes can also be configured to heat lyse the biological sample. The electrodes can also be configured to electrophoretically move the biological sample through one or more sieving matrices. A portion of the sample can be isolated on a membrane. The portion of the sample isolated on the membrane can be amplified and detected. A portion of the sample can be isolated in a collection area present in the cartridge. The portion of the sample isolated in the collection area can be removed from the cartridge.
摘要翻译：本教导包括用于裂解和/或纯化生物样品的装置和方法。该装置可以包括具有包含生物样品接收区域，多个电极和一个或多个筛分基质的腔室的药筒。电极可以被配置成通过产生脉冲电场来裂解生物样品。电极也可以被配置为热裂解生物样品。电极还可以被配置成通过一个或多个筛分基质电泳移动生物样品。样品的一部分可以在膜上分离。可以扩增和检测在膜上分离的样品的部分。样品的一部分可以在存在于盒中的收集区域中分离。分离在收集区域中的样品的部分可以从盒中取出。

7. 发明授权

US07514046B2 Methods and systems for processing microscale devices for reuse 有权
标题翻译：用于处理微量元件进行再利用的方法和系统
公开(公告)号：US07514046B2
公开(公告)日：2009-04-07
申请号：US10861784
申请日：2004-06-04
申请人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron J. Rulison
发明人： Persefoni Kechagia , Michael Greenstein , Bruce Brogden , Ed Donlon , Masayoshi Hayashi , Aaron J. Rulison
IPC分类号： B01L1/00
CPC分类号： B01L9/527 , B01L3/5027 , B01L3/502715 , B01L99/00 , B01L2300/022 , B01L2300/024 , B01L2400/0415 , B01L2400/0487 , G01N1/40 , G01N27/44704 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for flushing, washing, and priming microscale devices for reuse. Washing and priming methods include flowing solutions from a manifold to flush wells and microchannels of a microfluidic chip. Systems include manifolds adapted to seal and flow solutions or gasses into chip wells. Devices include microfluidic devices with data storage modules to track the reprocessing status of the microscale devices.
摘要翻译：本发明提供用于冲洗，洗涤和引发微型装置以重新使用的方法和系统。洗涤和引发方法包括从歧管流动的溶液冲洗微流体芯片的阱和微通道。系统包括适于密封并将溶液或气体流入芯片井的歧管。设备包括具有数据存储模块的微流体设备，以跟踪微型设备的再处理状态。

8. 发明授权

US07344894B2 Thermal regulation of fluidic samples within a diagnostic cartridge 有权
标题翻译：诊断墨盒内流体样品的热调节
公开(公告)号：US07344894B2
公开(公告)日：2008-03-18
申请号：US09981440
申请日：2001-10-16
申请人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
发明人： Michael Greenstein , Frederick Stawitcke , Vladimir Drbal , Ganapati R. Mauze , Rick Pittaro , Richard Pering , Ed Verdonk , Don Alden , Frank Ingle , Klaus Stefan Drese , Hans-Joachim Hartmann , Olaf Soerensen
IPC分类号： G01N33/543
CPC分类号： B01L7/00 , B01L3/5027 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2300/1872
摘要： A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes (“LED”s) and vertical cavity surface emitting lasers (“VCSEL”s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.
摘要翻译：使用能够发射电磁辐射的局部热源的反应物的热调节方法和微型分析装置，例如发光二极管（“LED”）和垂直腔表面发射激光器（“VCSEL”），产生内部热量，例如电阻式，感应型和珀耳帖式加热器，或外部加热。微型分析装置包括温度控制区的阵列，以通过使局部热源包括发射器或加热器的阵列来限制加热的体积并定位加热。

9. 发明授权

US07341861B2 Non-ribosomal peptide synthetases and associated biosynthetic genes 失效
标题翻译：非核糖体肽合成酶和相关生物合成基因
公开(公告)号：US07341861B2
公开(公告)日：2008-03-11
申请号：US11357566
申请日：2006-02-17
申请人： John A. Hucul , Nathan Magarvey , Michael Greenstein
发明人： John A. Hucul , Nathan Magarvey , Michael Greenstein
IPC分类号： C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/93 , C07K2319/00
摘要： The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
摘要翻译：本发明描述了来自吸水链霉菌的新型非核糖体肽合成酶和相关生物合成基因的鉴定。本发明还提供从这些合成酶和相关基因产生新型化合物如抗生素的方法。

10. 发明授权

US07195907B2 Non-ribosomal peptide synthetases and associated biosynthetic genes 失效
标题翻译：非核糖体肽合成酶和相关生物合成基因
公开(公告)号：US07195907B2
公开(公告)日：2007-03-27
申请号：US10746795
申请日：2003-12-23
申请人： John A. Hucul , Nathan Magarvey , Michael Greenstein
发明人： John A. Hucul , Nathan Magarvey , Michael Greenstein
IPC分类号： C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/93 , A61K38/00 , C07K14/36
摘要： The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.
摘要翻译：本发明描述了来自吸水链霉菌的新型非核糖体肽合成酶和相关生物合成基因的鉴定。本发明还提供从这些合成酶和相关基因产生新型化合物如抗生素的方法。

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