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1. 发明授权

US5116949A Benzoyl urea compound-albumin complex 失效
标题翻译：苯甲酸脲化合物 - 铝复合物
公开(公告)号：US5116949A
公开(公告)日：1992-05-26
申请号：US400941
申请日：1989-08-31
申请人： Tsunetaka Nakajima , Tadao Okamoto , Nobuo Kondo , Masahiro Watanabe , Koichi Yamauchi , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
发明人： Tsunetaka Nakajima , Tadao Okamoto , Nobuo Kondo , Masahiro Watanabe , Koichi Yamauchi , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/505 , A61K38/16 , A61K47/48 , A61P35/00 , C07D213/64 , C07D213/647 , C07D239/34 , C07K14/00 , C07K14/435 , C07K14/76
CPC分类号： C07D213/647 , A61K31/44 , A61K31/505 , A61K47/48284 , C07D239/34
摘要： A benzoyl urea compound-albumin complex comprising a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom and A is CH or a nitrogen atom, and albumin.

2. 发明授权

US4727077A Benzoyl urea compounds, process for their production, and antitumorous compositions containing them 失效
标题翻译：苯甲酰脲化合物，其生产方法和含有它们的抗肿瘤组合物
公开(公告)号：US4727077A
公开(公告)日：1988-02-23
申请号：US823521
申请日：1986-01-29
申请人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Nobuo Kondo , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama
发明人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Nobuo Kondo , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama
IPC分类号： C07C273/00 , A61K9/00 , A61K9/02 , A61K9/20 , A61K9/48 , A61K31/44 , A61K31/505 , A61K47/10 , A61K47/40 , A61K47/44 , C07D239/34 , C07D251/22 , A61K31/53
CPC分类号： A61K9/02 , A61K31/44 , A61K31/505 , A61K47/10 , A61K47/40 , A61K47/44 , A61K9/0019 , A61K9/2013 , A61K9/4858 , C07D239/34 , Y10S514/946
摘要： A benzoyl urea compound having the formula: ##STR1## wherein A is a bromine atom or a chlorine atom.
摘要翻译：具有下式的苯甲酰脲化合物：其中A是溴原子或氯原子。

3. 发明授权

US4849425A Readily absorbable pharmaceutical composition 失效
标题翻译：易吸收的药物组合物
公开(公告)号：US4849425A
公开(公告)日：1989-07-18
申请号：US824088
申请日：1986-01-30
申请人： Nobuo Kondo , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Tadakazu Suyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
发明人： Nobuo Kondo , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Tadakazu Suyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
IPC分类号： C07C273/00 , A61K9/00 , A61K9/02 , A61K9/20 , A61K9/48 , A61K31/44 , A61K31/505 , A61K47/10 , A61K47/40 , A61K47/44 , C07D239/34
CPC分类号： A61K9/02 , A61K31/44 , A61K31/505 , A61K47/10 , A61K47/40 , A61K47/44 , A61K9/0019 , A61K9/2013 , A61K9/4858 , C07D239/34 , Y10S514/946
摘要： A pharmaceutical composition comprises a benzoyl urea compound having the formula: ##STR1## wherein X is a nitro group, Y is a chlorine atom, Z.sub.2 is a hydrogen atom, Z.sub.1 is a halogen atom, and A is a nitrogen atom, and at least one member selected from the group consisting of a cyclodextrin, a polyethylene glycol and a refined oil.

4. 发明授权

US5002952A Readily absorbed pharmaceutical composition 失效
标题翻译：容易吸收药物成分
公开(公告)号：US5002952A
公开(公告)日：1991-03-26
申请号：US385998
申请日：1989-07-27
申请人： Nobuo Kondo , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
发明人： Nobuo Kondo , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
IPC分类号： A61K47/44 , A61K9/14 , A61K31/44 , A61K31/505 , A61K47/06 , A61P35/00 , C07D213/64
CPC分类号： A61K9/145 , A61K31/44 , A61K31/505 , Y10S514/941 , Y10S514/975
摘要： A pharmaceutical composition comprising a benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH--group or a nitrogen atom, and a nonionic surfactant.
摘要翻译：一种药物组合物，其包含具有下式的苯甲酰脲化合物：其中X为卤素原子或硝基，Y为氢原子，卤素原子，硝基或三氟甲基，Z1为卤素原子或三氟甲基，Z 2为氢原子或卤素原子，A为= CH-基或氮原子，和非离子表面活性剂。

5. 发明授权

US4983605A Pharmaceutical composition 失效
标题翻译：药物组成
公开(公告)号：US4983605A
公开(公告)日：1991-01-08
申请号：US110284
申请日：1987-10-20
申请人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
发明人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
IPC分类号： A61K9/14 , A61K9/19 , A61K31/44 , A61K31/50 , A61K31/505 , A61K47/14 , A61K47/26
CPC分类号： A61K31/505 , A61K31/44 , A61K31/50 , A61K9/145 , A61K9/146 , A61K9/19 , A61K47/14 , A61K47/26 , Y10S514/961 , Y10S514/964
摘要： A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula: ##STR2## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, as an active ingredient; a nonionic surfactant as a dispersant; and at least one member selected from the group consisting of a saccharide, a saccharide alcohol, silicic anhydride and a nonionic surfactant, as a disintegrator.
摘要翻译：提供一种药物组合物，其包含选自具有下式的苯甲酰脲化合物（I）的苯甲酰脲化合物（A）：其中X为卤素原子，硝基或三氟甲基，其提供当Y为硝基时，X为卤原子或硝基，Y为氢原子，卤原子，硝基或三氟甲基，Z1为卤原子或三氟甲基，Z2为氢原子或卤素原子，A为= CH-基或氮原子，和具有下式的苯甲酰脲化合物（II）：其中X1和X2各自为氢原子，卤素原子或硝基，条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤素原子，硝基或三氟甲基，Z为氢原子，卤素原子或三氟甲基作为活性成分; 作为分散剂的非离子表面活性剂; 和选自糖，糖醇，硅酸酐和非离子表面活性剂的至少一种作为崩解剂。

6. 发明授权

US4904668A Benzoyl urea compound 失效
标题翻译：苯甲酰脲化合物
公开(公告)号：US4904668A
公开(公告)日：1990-02-27
申请号：US101005
申请日：1987-09-25
申请人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
发明人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kazumasa Yokoyama , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
IPC分类号： A61K9/14 , C07D213/64 , C07D213/643 , C07D237/14 , C07D239/34
CPC分类号： C07D213/643 , A61K9/14 , A61K9/145 , A61K9/146 , C07D237/14 , C07D239/34
摘要： A benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, or the formula: ##STR2## wherein each of X.sub.1 is X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, characterized in that its average particle size is not larger than 1 .mu.m.
摘要翻译：具有下式的苯甲酰脲化合物：其中X是卤素原子，硝基或三氟甲基，条件是当Y是硝基时，X是卤原子或硝基，Y是氢原子，卤素原子，硝基或三氟甲基，Z1为卤素原子或三氟甲基，Z2为氢原子或卤素原子，A为a-CH-基或氮原子，或其中X 1为X 2的每一个为氢原子，卤原子或硝基的式：其中Y为硝基时，X 1为氢原子，Y为氢原子，卤原子，硝基或三氟甲基，Z为氢原子，卤素原子或三氟甲基，其特征在于，其平均粒径为1μm以下。

7. 发明授权

US5098907A Powdery pharmaceutical composition containing benzoyl urea, a dispersant and silicic acid 失效
标题翻译：含有苯甲酸尿素，分散剂和硅酸的粉末药物组合物
公开(公告)号：US5098907A
公开(公告)日：1992-03-24
申请号：US469054
申请日：1990-01-23
申请人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kouichi Yamauchi , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
发明人： Nobuo Kondo , Masahiro Kikuchi , Tsunetaka Nakajima , Masahiro Watanabe , Kouichi Yamauchi , Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi
IPC分类号： A61K9/14 , A61K31/44 , A61K31/505 , A61K47/14 , A61K47/26 , A61P35/00
CPC分类号： A61K9/14 , A61K31/44 , A61K31/505 , A61K47/14 , A61K47/26 , Y10S514/975
摘要： A powdery pharmaceutical composition comprising a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is CH or a nitrogen atom, as an active ingredient, a nonionic surfactant as a dispersant, at least one member selected from the group consisting of sugar, sugar-alcohol and a nonionic surfactant as a disintegrant, and anhydrous silicic acid as a fluidizer.

8. 发明授权

US4863924A N-benzoyl urea compounds, antitumorous compositions containing them 失效
标题翻译： N-苯甲酰脲化合物，含有它们的抗肿瘤组合物
公开(公告)号：US4863924A
公开(公告)日：1989-09-05
申请号：US939025
申请日：1986-12-08
申请人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Hiroshi Okada
发明人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Hiroshi Okada
IPC分类号： C07D213/64 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/50 , A61K31/505 , A61P35/00 , C07D213/643 , C07D237/14 , C07D239/34
CPC分类号： C07D213/643 , C07D237/14 , C07D239/34
摘要： An N-benzoyl urea compound having the formula: ##STR1## wherein X is a hydrogen atom, a halogen atom or a nitro group, n is an integer of from 1 to 3, and Q is ##STR2## wherein Y.sub.1 is an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Y.sub.2 is a hydrogen atom, a halogen atom, a nitro group, an unsubstituted or substituted alkyl group, or an alkoxy or alkoxycarbonyl group with its alkyl moiety unsubstituted or substituted, Z is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and each of A and B is .dbd.CH-- or a nitrogen atom, provided that one of A and B is .dbd.CH-- and the other is a nitrogen atom, with the provisos (1) that when Q is ##STR3## where when X is a hydrogen atom and Y.sub.1 is an alkyl group, Z is not a hydrogen atom, a halogen atom nor a trifluoromethyl group, and (2) that when Q is ##STR4## wherein A is a nitrogen atom and Y.sub.1 is a trifluoromethyl group, Y.sub.2 is other than a hydrogen atom.
摘要翻译：具有下式的N-苯甲酰脲化合物：其中X是氢原子，卤素原子或硝基，n是1至3的整数，Q是＆lt; IMAGE＆gt; 其中Y1是未取代或取代的烷基，或其烷基部分被未取代或取代的烷氧基或烷氧基羰基，Y2是氢原子，卤素原子，硝基，未取代或取代的烷基或烷氧基或其烷基部分为未取代或取代的烷氧基羰基，Z为氢原子，卤素原子，三氟甲基或硝基，A和B各自为= CH-或氮原子，条件是A和 B是= CH-，另一个是氮原子，条件是（1）当Q是 + TR 时，当X是氢原子且Y1是烷基时，Z是不是氢原子，卤素原子或三氟甲基，和（2）当Q是氮时，其中A是氮原子，Y 1是三氟甲基堆，Y2不是氢原子。

9. 发明授权

US4845093A N-benzoyl-N'-pyridazinyloxyphenyl urea compounds, and antitumorous compositions containing them, and process for their preparation 失效
标题翻译： N-苯甲酰基-N'-哒嗪氧基苯基脲化合物和含有它们的抗肿瘤组合物及其制备方法
公开(公告)号：US4845093A
公开(公告)日：1989-07-04
申请号：US111080
申请日：1987-10-19
申请人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , hiroshi Okada
发明人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , hiroshi Okada
IPC分类号： A61K31/50 , A61P35/00 , C07D237/14
CPC分类号： C07D237/14 , A61K31/50
摘要： An N-benzoyl-N'-pyridazinyloxyphenyl urea compound having the formula: ##STR1## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom or a methyl group which may be substituted by fluorine, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, provided that when X.sub.1 is a hydrogen atom and X.sub.2 is a hydrogen atom or a halogen atom, Y is a methyl group which may be substituted by fluorine and/or Z is a hydrogen atom or a trifluoromethyl group. The compound is useful as an active ingredient for an antitumorous composition.
摘要翻译：具有下式的N-苯甲酰基-N'-哒嗪氧基苯基脲化合物：其中X1和X2各自为氢原子，卤素原子或硝基，Y为氢原子，卤素原子或可以被氟取代的甲基，Z是氢原子，卤素原子或三氟甲基，条件是当X1为氢原子，X2为氢原子或卤素原子时，Y为甲基，可以被氟取代，和/或Z是氢原子或三氟甲基。该化合物可用作抗肿瘤组合物的活性成分。

10. 发明授权

US4677111A N-benzoyl-N'-(3-nitrophenyl) urea compounds, and antitumorous compositions containing them 失效
标题翻译： N-苯甲酰基-N' - （3-硝基苯基）脲化合物和含有它们的抗肿瘤组合物
公开(公告)号：US4677111A
公开(公告)日：1987-06-30
申请号：US782570
申请日：1985-10-01
申请人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Hiroshi Okada
发明人： Takahiro Haga , Nobutoshi Yamada , Hideo Sugi , Toru Koyanagi , Hiroshi Okada
IPC分类号： C07D213/64 , A61K31/44 , A61K31/4418 , A61K31/50 , A61K31/505 , A61P35/00 , C07D213/643 , C07D237/14 , C07D239/34 , C07D237/12 , C07D239/30
CPC分类号： C07D213/643 , C07D237/14 , C07D239/34
摘要： An N-benzoyl-N'-(3-nitrophenyl) urea compound having the formula ##STR1## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group, and Y is ##STR2## (wherein R is a hydrogen atom, a halogen atom or a tirfluoromethyl group), provided that when Y is ##STR3## X.sub.1 and/or X.sub.2 is a nitro group. The compound is useful as an active ingredient of an antitumorous composition.
摘要翻译：具有式“IMAGE”的N-苯甲酰基-N' - （3-硝基苯基）脲化合物，其中X1和X2各自为氢原子，卤素原子，三氟甲基或硝基，Y为（其中R是氢原子，卤素原子或三氟甲基），条件是当Y是X 1和/或X 2是硝基时。该化合物可用作抗肿瘤组合物的活性成分。

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