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1. 发明专利

JPH03263418A POLYSTYRENE DERIVATIVE AND ULTRAVIOLET RAY ABSORBER AND COSMETIC CONTAINING THE SAME AS ACTIVE INGREDIENT 失效
公开(公告)号：JPH03263418A
公开(公告)日：1991-11-22
申请号：JP24416890
申请日：1990-09-13
申请人： EARTH CHEMICAL CO
发明人： NAKAYAMA TORU , KOMURA YASUHIRO , KAJIFUSA NORIYUKI , HORINAKA AKIO , YAMAGUCHI HIDEO
IPC分类号： C09K3/00 , C08G12/14
摘要： PURPOSE:To obtain a percutaneously unabsorbable polystyrene derivative, having a specific structural formula, excellent in ultraviolet ray absorptivity, insoluble in water and sebum and suitable as ultraviolet ray absorbers for cosmetics, etc. CONSTITUTION:A polystyrene derivative, obtained by polymerizing, e.g. one or more styrene derivatives expressed by formula I [Y1 is group expressed by formula II (R1 is H or 1-4C lower alkyl; R2 is 2-5C lower alkoxycarbonyl, etc.; Q is S or O), etc.] using an azo-based compound such as alpha,alpha'- azobisisobutyronitrile or a peroxide such as benzoyl peroxide as a polymerization initiator in a solvent such as N,N-dimethylformamide and having a structural formula expressed by formula III (m1 is 6-1000). The aforementioned polystyrene derivative as fine particle is mixed in a cream base, etc., to afford a cosmetic excellent in ultraviolet ray absorptivity and safety.

2. 发明专利

JPH0227995A PRODUCTION OF L-CARNITINE CHLORIDE 失效
公开(公告)号：JPH0227995A
公开(公告)日：1990-01-30
申请号：JP17737388
申请日：1988-07-15
申请人： EARTH CHEMICAL CO
发明人： HORINAKA AKIO
IPC分类号： C12P41/00 , C07C229/22
摘要： PURPOSE:To efficiently produce l-carnitine chloride by treating a specific substrate with lipase in the presence of a fatty acid ester to separate l-form and converting the l-form into l-carnitine chloride. CONSTITUTION:A compound shown by formula I (X is chlorine atom, bromine atom or iodine atom; Y is cyano or alkoxycarbonyl) is treated with lipase in the presence of a fatty acid ester and subjected to ester interchange reaction. The l-form is separated and converted into l-carnitine chloride. The ester interchange reaction with lipase is preferably carried out in the presence of an aprotic organic solvent and/or carrier. gamma-Chloro-beta-hydroxybutyronitrile may be cited as the concrete example of the compound shown by formula I.

3. 发明专利

JPH04159213A COMPOSITION FOR ORAL CAVITY 失效
公开(公告)号：JPH04159213A
公开(公告)日：1992-06-02
申请号：JP28175890
申请日：1990-10-22
申请人： EARTH CHEMICAL CO
发明人： MATSUBARA AKIMASA , MATSUI TOSHIYA , HORINAKA AKIO , INAMI NORIHITO , MESAKI JUNICHIRO
IPC分类号： A23G4/00 , A61K8/96 , A61K8/97 , A61Q11/00
摘要： PURPOSE:To obtain a composition for oral cavity effectively suppressing multiplication of Streptococcus mutans, excellently preventing tooth decay and periodontitis, comprising an extract of Cnidium officinale, fruit of Rosa mltiflora, Areca catechu L. and/or root of Sophora angustifolia as an active ingredient. CONSTITUTION:An extract of one or more crude drugs selected from Cnidium officinale, fruit of Rosa mltiflora, Areca catechu L. and/or root of Sophora angustifolia as an active ingredient is blended with various compositions for oral cavity such as dentifrice, mouth wash or troche to simply give the composition having antibacterial action on Streptococcus mutans which exists in the oral cavity and causes formation of bacterial plaque, tooth decay and/or periodontitis and reduces side effects of the composition by using the extract of the readily obtainable crude drug.

4. 发明专利

JPH01131143A OPTICAL RESOLUTION OF D,L-CARNITINENITRILE CHLORIDE 失效
公开(公告)号：JPH01131143A
公开(公告)日：1989-05-24
申请号：JP29021687
申请日：1987-11-16
申请人： EARTH CHEMICAL CO
发明人： HORINAKA AKIO
IPC分类号： C07B57/00 , C07C67/00 , C07C253/00 , C07C255/28
摘要： PURPOSE:To reduce the amount of an optically resolving agent used and to carry out optical resolution readily and efficiently, by using a specific amount of N-acetyl-L-glutamic acid as the optically resolving agent and another acid and subjecting dl-carnitinenitrile chloride to optical resolution. CONSTITUTION:A solution of dl-carnitinenitrile chloride is treated with N-acetyl- L (or D)-glutamic acid as an optically resolving agent and another acid such as acetic acid or conc. hydrochloric acid capable of forming a noncrystallizing salt of dl-carnitinenitrile, d-carnitinenitrile N-acetyl-acetyl-D-glutamate or l- carnitinenitrile N-acetyl-D-glutamate slightly soluble in a polar solvent is crystallized and the dl-carnitinenitrile chloride is subjected to optical resolution industrially and economically to give an optically active carnitinenitrile chloride useful as a remedy for cardiac diseases. The amount of the optically resolving agent added is 1.1-1.3 equivalent based on the theoretical amount to form the slightly soluble salt.

5. 发明专利

JPH069494A PRODUCTION OF LONG-CHAIN FATTY ACID DERIVATIVE HAVING FUNCTIONAL GROUPS AT BOTH TERMINALS 失效
公开(公告)号：JPH069494A
公开(公告)日：1994-01-18
申请号：JP19133692
申请日：1992-06-26
申请人： EARTH CHEMICAL CO
发明人： HORINAKA AKIO , NAKAYAMA TORU , KAJIFUSA NORIYUKI , KOMURA YASUHIRO
IPC分类号： B01J27/138 , C07B61/00 , C07C67/38 , C07C69/34 , C07C69/63 , C07C69/67 , C07C69/675 , C07C69/716 , C07C231/02 , C07C233/05 , C07C235/06 , C07C253/16 , C07C255/19
摘要： PURPOSE:To readily produce a long-chain fatty acid derivative having a wide range of uses as functional resins, cold-resistant plasticizers, synthetic lubricating oils, textile softening agents, etc., and functional groups at both terminals in a simple process. CONSTITUTION:A halogenated compound expressed by the formula X(CH2)mY (X is bromine atom or iodine atom; Y is chlorine atom, bromine atom, iodine atom, hydroxymethyl, acyloxymethyl, carboxy, etc.; m is an integer of >=7) is made to react with acrylic acid esters, acrylamide, acrylonitrile or an alkyl vinyl ketone in the presence of a 0-valent nickel catalyst to produce the objective long-chain fatty acid derivative, expressed by the formula Z(CH2)nW (Z is chlorine atom, hydroxymethyl, acyloxymethyl, carboxy, etc.; W is alkoxycarbonyl, carbamoyl, etc.; n is an integer of >=11) and having functional groups at both terminals.

6. 发明专利

JPH04120104A POLYVALENT METALLIC SALT COLLOID OF POLYSTYRENE DERIVATIVE, PRODUCTION THEREOF AND ULTRAVIOLET ABSORBER CONTAINING SAID COLLOID AS ACTIVE INGREDIENT 失效
公开(公告)号：JPH04120104A
公开(公告)日：1992-04-21
申请号：JP24202490
申请日：1990-09-11
申请人： EARTH CHEMICAL CO
发明人： NAKAYAMA TORU , KOMURA YASUHIRO , HORINAKA AKIO , YAMAGUCHI HIDEO
IPC分类号： A61K8/00 , A61K8/04 , A61Q1/00 , A61Q1/12 , A61Q17/04 , C08F12/00 , C08F12/26 , C09K3/00
摘要： PURPOSE:To obtain the subject colloid for ultraviolet absorber, etc., having high absorbing power of ultraviolet rays insoluble in water nor oil with excellent dispersing stability by rendering semicarbazone group-containing polystyrene derivative a water-soluble salt and reacting the resultant salt with a water-soluble polyvalent metal salt in water. CONSTITUTION:A semicarbazone group-containing polystyrene derivative expressed by formula I [Y2 is a group expressed by formula II (R is H, lower alkyl or carboxyl, etc., R is H, lower alkyl or 2-5C carboxyalkyl, etc., Q is S or O) or a group expressed by formula III; m is 6-1000] is made to a water-soluble salt, which is then reacted with a water-soluble polyvalent metal salt (e.g. calcium chloride) in water to afford the aimed polyvalent metallic salt colloid containing polyvalent metallic salt of carboxylic acid of polystyrene derivative expressed by formula IV [Y1 is a group expressed by formula V (R is H, lower alkyl or carboxyl, etc., R is H, lower alkyl or 2-5C carboxyalkyl, etc.) or a group expressed by formula VI].

7. 发明专利

JPH0495020A ENZYME INHIBITOR 失效
公开(公告)号：JPH0495020A
公开(公告)日：1992-03-27
申请号：JP21313890
申请日：1990-08-10
申请人： EARTH CHEMICAL CO
发明人： MATSUBARA AKIMASA , MATSUI TOSHIYA , INAMI NORIHITO , MESAKI JUNICHIRO , HORINAKA AKIO
IPC分类号： A23G3/34 , A23G3/00 , A23L29/00 , A61K8/96 , A61K8/97 , A61K36/00 , A61K36/18 , A61P1/02 , A61P31/04 , A61Q11/00 , C12N9/99
摘要： PURPOSE:To provide an enzyme inhibitor employed in a oral treatment for preventing the generation of dental caries and periodontitis by compounding the solvent extract of a specific plant. CONSTITUTION:An enzyme inhibitor containing one kind or more of the solvent extracts of plants such as Paeoniae Radix and Eriobotrya japonica Lindl (preferably extracts using ethyl alcohol and/or water). The solvent extract inhibits glucosyl transferase originated from Streptococcus mutans and effectively prevents the formation of bacterial plaques.

8. 发明专利

JPS6115691A Beta-urogastrone gene, corresponding plasmid recombinant, corresponding transformat, and preparation of beta-urogastrone 失效
标题翻译： BETA-UROGASTRONE基因，相应的PLASMID重组体，相应的转化体和BETA-UROGASTRONE的制备
公开(公告)号：JPS6115691A
公开(公告)日：1986-01-23
申请号：JP13769184
申请日：1984-07-02
申请人： Earth Chem Corp Ltd
发明人： AOKI SHIGEMASA , OOKAI HIDEO , HORINAKA AKIO , HIRAMATSU HIROSHI , KAWAMOTO SHIYOUICHI , NISHIMURA AKIRA , MATSUSHIRO AIZOU
IPC分类号： C12N15/09 , C07H21/04 , C07K14/485 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/16 , C12N15/73 , C12P21/02 , C12R1/19
CPC分类号： C12N15/73 , C07K14/485 , C07K2319/00 , C07K2319/61 , C07K2319/75
摘要： PURPOSE:To design and to synthesize a gene of beta-urogastrone having physiological activities such as inhibition of secretion of acid in the stomach, cell growth promotion, etc., and to obtain a large amount of the gene in high purity by a genetic engineering method. CONSTITUTION:A promotor, SD sequence, restricted enzyme recognition site, etc. necessary for developing beta-urogstrone gene sequence shown by the formula are connected. lambdaPL or lacUV5 is cited as the promotor, and pBR322 as a plasmid vector is used. A fused protein with a different protein such as beta-lactomase, etc. may be developed as method of development of peptide. Since the fused protein is transferred and accumulated in a periplasmic layer of Escherichia coil and it exists partially, it is easily separated and purified. Oligonucleotide of beta- urogastrone can be synthesized by a well-known method using polystyrene resin, etc.
摘要翻译：目的：设计并合成具有抑制胃酸分泌，细胞生长促进等生理活性的β-urogastrone基因，并通过遗传工程获得大量高纯度基因方法。构成：与公式所示的β-urogstrone基因序列开发所必需的启动子，SD序列，限制酶识别位点等相连接。引用λPL或lacUV5作为启动子，并且使用pBR322作为质粒载体。可以开发具有不同蛋白质的融合蛋白如β-乳糖酶等作为肽发育的方法。由于融合蛋白被转移并积聚在大肠杆菌的周质层中，部分存在，容易分离和纯化。 β-尿嘧啶的寡核苷酸可以通过使用聚苯乙烯树脂等的公知方法合成。

9. 发明专利

JPS59205391A Novel substance 失效
标题翻译：新物质
公开(公告)号：JPS59205391A
公开(公告)日：1984-11-20
申请号：JP8051583
申请日：1983-05-09
申请人： Earth Chem Corp Ltd
发明人： HORINAKA AKIO , MASUDA KAZUNORI , YAMAGUCHI MASANAGA , UCHIUMI KIYOSHI , KIMURA HIROSHI
IPC分类号： A01N65/00 , C07G99/00
CPC分类号： Y02A50/322
摘要： NEW MATERIAL:A novel substance having the following physico-chemical propperties; properties; white needle-like crystal. Elementary analysis (%); C, 58.65; H, 7.58; N, 9.70. Molecular weight; 1,001.5. Molecular formula; C
49 H
75 N
7 O
15 . Specific rotatory power; [α]D
25 =-92.0°(C=0.1, methanol). Melting point;206W 208°C, etc.
USE: An insecticide, acaricide, antifeedant and growth inhibitor, having low toxicity to humans, cattle and fishes.
PREPARATION: A crude drug, e.g. a dried leaf of Ardirisia crenata Sims., is dipped in a leaching agent, e.g. methanol, for e.g. 1W15hr, and the solvent is then distilled from the resultant liquid under reduced pressure to give a concentrated residue, which is then dissolved in a mixed liquid of ether, etc. with water to extract the organic layer. The resultant extracted solution is then subjected to silica column chromatography and eluted with chloroform and chloroform-methanol (30:1 volume ratio) one after another to afford the aimed fraction. The resultant fraction is then isolated and purified by the silica gel column chromatography, etc.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：具有以下物理化学性质的新物质：性能; 白色针状晶体。基本分析（％）; C，58.65; H，7.58 N，9.70。分子量 1,001.5。分子式 C49H75N7O15。具体旋转力 αD 25 = -92.0度（C = 0.1，甲醇）。熔点：206-208℃等。用途：杀虫剂，杀螨剂，抗饵剂和生长抑制剂，对人类，牛类和鱼类毒性低。制备方法：将Ardirisia crenata Sims的干叶浸入浸出剂中，例如甲醇。 1-15hr，然后在减压下从得到的液体中蒸馏出溶剂，得到浓缩残余物，然后用水将其溶于乙醚等的混合液中以提取有机层。然后将得到的提取液进行二氧化硅柱色谱分离，用氯仿和氯仿 - 甲醇（30:1体积比）逐次洗脱，得到目的馏分。然后将所得馏分通过硅胶柱色谱等分离和纯化。

10. 发明专利

JPS59128319A Agent for combatting pest organisms 失效
标题翻译：复合有机物代理
公开(公告)号：JPS59128319A
公开(公告)日：1984-07-24
申请号：JP395483
申请日：1983-01-12
申请人： Earth Chem Corp Ltd
发明人： MASUDA KAZUNORI , HORINAKA AKIO , YAMAGUCHI MASANAGA , UCHIUMI KIYOSHI , KIMURA HIROSHI
IPC分类号： A01N65/00
CPC分类号： Y02A50/322 , Y02A50/327
摘要： PURPOSE: The whole part or a part of MANRYO (an evergreen bush, Ardisia crenata) or their dried products or extract is used to produce the objective agent for combatting pest organisms, which can be used as an excellent insecticide, acaricide, antifeedant or growth inhibitor.
CONSTITUTION: The whole part or a part (such as leaves, wood parts, fruits) is processed by physical means such as cutting or crushing to form a powder or juice. Or it is dried naturally or under heating or extracted. Then, the resultant powder, juice, dried product or extract is used to produce the objective agent for combatting pest organisms such as agricultural insect pests, e.g., rice plant hopper or aphid, insect pests in cereal storage, e.g., acarus or rice weevil, unpleasant insects, e.g., ixodid, centipode or millipede, hygienic insect pests, e.g., fly, mosquito or cockroach or forestry insect pests, e.g., termites or wood borers.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：MANRYO（常绿灌木，Ardisia crenata）或其干制品或提取物的全部或一部分用于生产用于对抗有害生物的目标试剂，可用作优异的杀虫剂，杀螨剂，拒食或生长抑制剂。构成：整个部分或部分（如叶子，木质部分，水果）通过切割或破碎的物理手段加工成粉末或果汁。或者是自然干燥或加热或提取。然后，使用得到的粉末，果汁，干燥产物或提取物来生产用于对抗农作物害虫的有害生物的目标试剂，例如稻谷料斗或蚜虫，谷物贮藏中的害虫，例如阿卡鲁斯或稻象鼻虫，不愉快的昆虫，例如ixodid，centipode或千足虫，卫生昆虫害虫，如蝇，蚊子或蟑螂或林业昆虫害虫，如白蚁或木蛀虫。

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