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91. 发明授权

US08779354B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08779354B2
公开(公告)日：2014-07-15
申请号：US13453657
申请日：2012-04-23
申请人： Martin Green , Jason Lee Wildgoose , Jeffrey Mark Brown
发明人： Martin Green , Jason Lee Wildgoose , Jeffrey Mark Brown
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了一种质谱仪，其包括电子转移解离单元。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。电池包括形成球形捕获体积的多个环形电极。在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。从而提供具有增强的灵敏度的电子转移解离电池。在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。

92. 发明授权

US08598518B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08598518B2
公开(公告)日：2013-12-03
申请号：US12518173
申请日：2007-12-10
申请人： Martin Green , Jason Lee Wildgoose
发明人： Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/42
CPC分类号： H01J49/403 , H01J49/065 , H01J49/40 , H01J49/4225 , H01J49/426
摘要： A mass spectrometer is disclosed comprising a time of flight mass analyzer. The time of flight mass analyszr comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes. A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide.
摘要翻译：公开了一种质谱仪，其包括飞行时间质量分析器。飞行时间质量分析器包括离子导向器，其包括通过一系列形成分压器的电阻器互连的多个电极。离子通过向电极施加两相RF电压而在离子导向器内径向限制。在分压器上施加单相附加RF电压，使得沿着离子导向器的长度保持不均匀的伪势力。

93. 发明授权

US08354634B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08354634B2
公开(公告)日：2013-01-15
申请号：US12601094
申请日：2008-05-22
申请人： Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0036 , H01J49/40
摘要： A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
摘要翻译：公开了一种质谱仪，其中离子信号被分成第一和第二信号。第一和第二信号乘以不同的增益并被数字化。对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。然后将光谱与其他对应的光谱组合以形成相加光谱。

94. 发明申请

US20110057097A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110057097A1
公开(公告)日：2011-03-10
申请号：US12528173
申请日：2008-02-21
申请人： Robert Harold Bateman , Martin Green , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/0095 , H01J49/423 , H01J49/424
摘要： A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods 1 to allow ions to be ejected radially from the ion trap. The 3D ion trap comprises a central ring electrode which is radially segmented and wherein a slot is provided in each radial segment to allow ions to be ejected radially from the ion trap. Ions having different mass to charge ratios and/or opposite polarities may be simultaneously ejected from the ion trap via different exit pathways.
摘要翻译：公开了包括2D或3D离子阱的质谱仪。 2D离子阱包括四极棒组离子阱，其中在每个棒1中设置槽，以允许离子从离子阱径向喷射。 3D离子阱包括径向分段的中心环电极，并且其中在每个径向段中设置狭槽以允许离子从离子阱径向喷射。具有不同质荷比和/或相反极性的离子可以通过不同的出口通道从离子阱同时喷出。

95. 发明授权

US09184039B2 Mass spectrometer with corrugations, wells, or barriers and a driving DC voltage or potential 有权
标题翻译：具有波纹，孔或障碍物和驱动直流电压或电位的质谱仪
公开(公告)号：US09184039B2
公开(公告)日：2015-11-10
申请号：US12092313
申请日：2006-11-01
申请人： Steven Pringle , Jason Lee Wildgoose
发明人： Steven Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/36 , H01J49/06 , H01J49/00 , H01J49/42
CPC分类号： H01J49/062 , H01J49/004 , H01J49/4235 , H01J49/427
摘要： A mass analyzer (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of seudo-potential corrugations are created along the axis of the mass analyzer (2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyzer (2) in order to urge ions along the length of the mass analyzer (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyzer (2) in reverse order of mass to charge ratio.
摘要翻译：提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。沿着质量分析器（2）的轴线产生多个潜在的波纹。伪电位波纹的振幅或深度与离子的质荷比成反比。为了沿着质量分析器（2）的长度推动离子，一个或多个瞬态直流电压被施加到质量分析器（2）的电极。施加到电极的瞬态直流电压的幅度随着时间而增加，并且使质子分析器（2）以与质荷比相反的顺序发射离子。

96. 发明授权

US08809767B2 Time of flight mass spectrometer with analog to digital converter and method of using 有权
标题翻译：具有模数转换器的飞行时间质谱仪及其使用方法
公开(公告)号：US08809767B2
公开(公告)日：2014-08-19
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
IPC分类号： H01J49/26 , H01J49/00 , G06K9/00
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译：公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。

97. 发明申请

US20120208289A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20120208289A1
公开(公告)日：2012-08-16
申请号：US13453657
申请日：2012-04-23
申请人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
发明人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
IPC分类号： G01N27/62
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了一种质谱仪，其包括电子转移解离单元。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。电池包括形成球形捕获体积的多个环形电极。在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。从而提供具有增强的灵敏度的电子转移解离电池。在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。

98. 发明申请

US20100213361A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100213361A1
公开(公告)日：2010-08-26
申请号：US12601094
申请日：2008-05-22
申请人： Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26 , G12B13/00
CPC分类号： H01J49/0036 , H01J49/40
摘要： A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum.
摘要翻译：公开了一种质谱仪，其中离子信号被分成第一和第二信号。第一和第二信号乘以不同的增益并被数字化。对于两个数字化信号计算到达时间和强度对，并且将所得到的时间和强度对组合以形成高动态范围谱。然后将光谱与其他对应的光谱组合以形成相加光谱。

99. 发明申请

US20100084547A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100084547A1
公开(公告)日：2010-04-08
申请号：US12524378
申请日：2008-01-25
申请人： Steven Derek Pringle , Jason Lee Wildgoose
发明人： Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
摘要翻译：公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。所得到的离子信号被去卷积以提供质谱。

100. 发明申请

US20100072360A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100072360A1
公开(公告)日：2010-03-25
申请号：US12593006
申请日：2008-03-26
申请人： Martin Green , Jason Lee Wildgoose , Jeffery Mark Brown
发明人： Martin Green , Jason Lee Wildgoose , Jeffery Mark Brown
IPC分类号： H01J49/26 , H01J49/04
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority. of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了包含电子转移离解电池（1）的质谱仪。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子（1）。电池包括形成球形捕获体积的多个环形电极（1）。在多数情况下，离子经验可以忽略不计。的捕获体积，其使分析物和试剂离子的动能降低到恰好高于热温度。由此提供了具有增强的灵敏度的电子转移解离单元（1）。在细胞（1）内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，能够显着提高质量分析仪的分辨率。

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