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1. 发明授权

US10043648B2 High duty cycle ion spectrometer 有权
公开(公告)号：US10043648B2
公开(公告)日：2018-08-07
申请号：US15640129
申请日：2017-06-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/04 , H01J49/00 , H01J49/10 , H01J49/40 , H01J49/06 , H01J49/42 , G01N27/62
CPC分类号： H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
摘要： An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyser receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.

2. 发明申请

US20170287692A1 Combined Mass-to-Charge Ratio and Charge State Selection in Tandem Mass Spectrometry 审中-公开
公开(公告)号：US20170287692A1
公开(公告)日：2017-10-05
申请号：US15626447
申请日：2017-06-19
申请人： Micromass UK Limited
发明人： Robert Harold BATEMAN , Kevin GILES , Steven Derek PRINGLE , Jason Lee WILDGOOSE
IPC分类号： H01J49/42 , H01J49/00 , G01N27/62
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. The operation of the ion mobility spectrometer and the ion gate are synchronized so that only ions having a particular mass to charge ration and a desired charge state are onwardly transmitted to the collision cell.

3. 发明申请

US20170221694A1 SEGMENTED LINEAR ION TRAP FOR ENHANCED ION ACTIVATION AND STORAGE 有权
公开(公告)号：US20170221694A1
公开(公告)日：2017-08-03
申请号：US15015101
申请日：2016-02-03
申请人： FASMATECH SCIENCE & TECHNOLOGY LTD.
发明人： DIMITRIS PAPANASTASIOU , EMMANUEL RAPTAKIS
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/005 , H01J49/0054 , H01J49/062 , H01J49/426 , H01J49/4265
摘要： A linear ion trap includes at least two discrete trapping regions for processing ions, a RF electrical potential generator, a multi-output DC electrical potential generator, and a control unit. The RF electrical potential generator produces two RF waveforms each applied to a pair of pole electrodes of the linear ion trap forming a RF trapping field component to trap ions radially. The multi-output DC electrical potential generator produces multiple DC field components superimposed to the RF field component and distributed across the length of the linear ion trap to control ions axially. The control unit switches the DC electrical potentials and corresponding DC field components collectively forming a first trapping region populated with ions to alter ion potential energy from a first level to a second level, and enables a first ion processing step in at least one of the first and second levels.

4. 发明申请

US20160181084A1 Varying Frequency during a Quadrupole Scan for Improved Resolution and Mass Range 有权
标题翻译：在四极扫描期间改变频率以改善分辨率和质量范围
公开(公告)号：US20160181084A1
公开(公告)日：2016-06-23
申请号：US14575406
申请日：2014-12-18
申请人： Thermo Finnigan LLC
发明人： Johnathan W. SMITH
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/426 , H01J49/429
摘要： Techniques are provided for scanning frequency and voltages of a multipole mass filter while maintaining substantially the same number of AC cycles per mass during a scan across a range of masses. For example, a mass spectrum can be obtained by controlling a DC axial voltage that accelerates ions into a mass filter, a DC resolving voltage applied to the mass filter, an AC voltage amplitude applied to the mass filter, and an AC frequency of the AC voltage. The settings can be controlled such that ions of different mass-to-charge ratios are within the mass filter for substantially a same number of AC cycles. To achieve the same number of AC cycles, the AC frequency is changed during the scan. For low masses, a higher AC frequency can be used. For high masses, a lower AC frequency can be used.
摘要翻译：提供了用于扫描多极质量过滤器的频率和电压的技术，同时在跨越质量范围的扫描期间保持基本上相同数量的每个质量的AC循环。例如，可以通过控制将离子加速到质量过滤器中的DC轴向电压，施加到质量过滤器的DC分辨率电压，施加到质量过滤器的AC电压振幅和AC的AC频率来获得质谱电压。可以控制设置，使得不同质荷比的离子在大体上相同数量的AC循环的质量过滤器内。为了实现相同数量的交流循环，扫描期间交流频率发生变化。对于低质量，可以使用更高的交流频率。对于高质量，可以使用较低的交流频率。

5. 发明授权

US09190255B2 Control of ions 有权
标题翻译：离子的控制
公开(公告)号：US09190255B2
公开(公告)日：2015-11-17
申请号：US13699721
申请日：2011-05-23
申请人： Emmanuel Raptakis , Dimitris Papanastasiou
发明人： Emmanuel Raptakis , Dimitris Papanastasiou
IPC分类号： H01J49/40 , H01J49/06 , H01J49/34 , H01J49/42
CPC分类号： H01J49/067 , H01J49/34 , H01J49/40 , H01J49/425 , H01J49/426
摘要： A mass spectrometer comprises ion pulse means for producing ion pulses in a first vacuum chamber, ion trap means for receiving and trapping the ion pulses for mass analysis in a second vacuum chamber, and ion-optical lens means arranged between the ion pulse means and the ion trap means for receiving the ion pulses and outputting ions therefrom to the ion trap means. A first lens electrode and a second lens electrode collectively define an optical axis and are adapted for distributing a first electrical potential and second electrical potential therealong. Lens control means vary non-periodically with time the first electrical potential relative to the second electrical potential to control as a function of ion mass-to-charge ratio the kinetic energy of ions which have traversed the ion optical lens means. This controls the mass range of the ions receivable by the ion trap from the ion optical lens means.
摘要翻译：质谱仪包括用于在第一真空室中产生离子脉冲的离子脉冲装置，用于在第二真空室中接收和捕获用于质量分析的离子脉冲的离子阱装置，以及布置在离子脉冲装置和离子脉冲装置之间的离子 - 光学透镜装置用于接收离子脉冲并将离子从该离子阱输出到离子阱装置的离子阱装置。第一透镜电极和第二透镜电极共同限定光轴并且适于在其上分布第一电位和第二电位。透镜控制装置随时间变化，相对于第二电位的第一电位随着时间而变化，以便控制离子质量 - 荷电比例，其已经穿过离子光学透镜装置的离子的动能。这可以控制离子阱从离子光学透镜装置接收的离子的质量范围。

6. 发明授权

US09099290B2 Collision cell multipole 有权
标题翻译：碰撞细胞多极
公开(公告)号：US09099290B2
公开(公告)日：2015-08-04
申请号：US14367845
申请日：2012-12-21
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Gerhard Jung , Lothar Rottmann
IPC分类号： H01J49/42 , H01J49/26 , H01J49/06 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0027 , H01J49/005 , H01J49/063 , H01J49/105 , H01J49/426
摘要： Mass spectrometer collision/reaction cell multipole and method. The multipole may have first and second portions and an intermediate portion therebetween, the first and second portions operating at first and second q values lower than a third q value at the intermediate portion. A low-mass cut-off of the multipole may be controlled by varying a q value from a first to at least a second value. The multipole may have multipole electrodes disposed about a central axis and having a respective first portion, second portion, and intermediate portion therebetween which is radially closer to the central axis. This offers relatively high acceptance and ion transmission, while providing low-mass cut-off for removing undesired/interfering ions and helping reduce background count.
摘要翻译：质谱仪碰撞/反应池多极和方法。多极可以具有第一和第二部分以及它们之间的中间部分，第一和第二部分在中间部分处以第一和第二q值低于第三q值。可以通过将q值从第一值改变为至少第二值来控制多极的低质量截止。多极可以具有围绕中心轴设置的多极电极，并且具有相应的第一部分，第二部分和它们之间的中间部分，其中心部分径向靠近中心轴线。这提供了相对较高的接受和离子传输，同时提供了低质量的截止以去除不期望的/干扰的离子并有助于减少背景数。

7. 发明授权

US08373115B2 Method and apparatus for identifying proteins in mixtures 有权
标题翻译：用于鉴定混合物中蛋白质的方法和装置
公开(公告)号：US08373115B2
公开(公告)日：2013-02-12
申请号：US13460128
申请日：2012-04-30
申请人： Scott J. Geromanos , Marc Victor Gorenstein , Jeffrey Cruz Silva , Guo-Zhong Li
发明人： Scott J. Geromanos , Marc Victor Gorenstein , Jeffrey Cruz Silva , Guo-Zhong Li
IPC分类号： B01D59/44
CPC分类号： G06F19/16 , G01N33/6848 , G01N2030/8831 , H01J49/0036 , H01J49/0431 , H01J49/426 , G01N30/7233
摘要： Protein identification in a complex sample begins by selecting a database having proteins likely to be in the sample. In-silico digestion is performed and a target peptide is selected from produced peptides. The masses of the Y- and B-ion fragments of the target peptide are determined. These masses are used to search previously obtained low- and high-energy AMRTs obtained from LC/MS analysis of the complex sample for masses on the list. Any mass observed in the data within a detection threshold are considered a hit. If enough hits accumulate in a given retention time, the target peptide is identified as being in the sample. The list of peptides identified in the complex sample can be used to identify the proteins present in the sample, track the chromatographic retention times of peptides between samples, and quantitate the peptides and proteins present in complex samples.
摘要翻译：复杂样品中的蛋白质鉴定开始于选择具有可能在样品中的蛋白质的数据库。进行电泳消化，并从产生的肽中选择靶肽。确定靶肽的Y和B离子片段的质量。这些质量用于搜索从列表中的质量的复杂样品的LC / MS分析获得的先前获得的低能量和高能量AMRT。在检测阈值内的数据中观察到的任何质量都被认为是命中。如果足够的命中在给定的保留时间内积累，则目标肽被鉴定为在样品中。在复杂样品中鉴定的肽列表可用于鉴定样品中存在的蛋白质，跟踪样品间肽的色谱保留时间，并定量复杂样品中存在的肽和蛋白质。

8. 发明授权

US07842918B2 Chemical structure-insensitive method and apparatus for dissociating ions 有权
标题翻译：用于离子离子化学结构不敏感的方法和装置
公开(公告)号：US07842918B2
公开(公告)日：2010-11-30
申请号：US11715199
申请日：2007-03-07
申请人： Mingda Wang
发明人： Mingda Wang
IPC分类号： B01D59/44
CPC分类号： H01J49/426 , H01J49/005
摘要： In a method for exciting a precursor ion in an ion trap, the ion is trapped in a nonlinear trapping field that includes a quadrupolar field and a multipole field. The quadrupolar field is generated by applying a radio-frequency (RF) trapping voltage to the ion trap at a trapping amplitude and trapping frequency. A supplemental alternating-current (AC) voltage is applied to the ion trap at a supplemental amplitude and supplemental frequency. The supplemental amplitude is low enough to prevent ejection of the ion from the ion trap, and the supplemental frequency differs from the secular frequency of the ion by an offset amount. One or more operating parameters of the ion trap are adjusted, such that the ion absorbs energy from the supplemental field sufficient to undergo collision-induced dissociation (CID) without being in resonance with the supplemental field.
摘要翻译：在用于在离子阱中激发前体离子的方法中，离子被捕获在包括四极场和多极场的非线性捕获场中。通过以捕获幅度和捕获频率向离子阱施加射频（RF）捕获电压来产生四极场。补充的交流（AC）电压以补充的幅度和补充频率施加到离子阱。辅助振幅足够低以防止离子从离子阱中喷射，并且补充频率与离子的长期频率不同，具有偏移量。调整离子阱的一个或多个操作参数，使得离子从补充场吸收足以进行碰撞诱导解离（CID）的能量，而不与补充场共振。

9. 发明申请

US20100108879A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100108879A1
公开(公告)日：2010-05-06
申请号：US12514972
申请日：2007-11-15
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer (8) and an ion gate (9). A collision cell (10) is arranged downstream of the ion gate (9). The operation of the ion mobility spectrometer (8) and the ion gate (9) are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell (10).
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪（8）和离子门（9）。碰撞室（10）布置在离子门（9）的下游。离子迁移谱仪（8）和离子浇口（9）的操作是同步的，使得只有具有特定质荷比的离子和期望的电荷状态向上传输到碰撞池（10）。

10. 发明申请

US20090256067A1 Electron capture dissociation in radiofrequency ion traps 审中-公开
标题翻译：射频离子阱中的电子俘获解离
公开(公告)号：US20090256067A1
公开(公告)日：2009-10-15
申请号：US12082536
申请日：2008-04-10
申请人： Jack A. Syage
发明人： Jack A. Syage
IPC分类号： B01D59/44
CPC分类号： H01J49/0054 , H01J49/426
摘要： A system and method that includes injecting low-energy electrons in a radiofrequency (RF) ion trap in order to dissociate positive ions by electron capture. The system includes an ion trap, a controller to provide RF that can be switched on and off rapidly, and a source of low-energy electrons that can be turned on and off synchronously with the radiofrequency on/off periods.
摘要翻译：一种系统和方法，其包括在射频（RF）离子阱中注入低能电子，以通过电子俘获解离正离子。该系统包括离子阱，用于提供可以快速接通和断开的RF的控制器，以及能够与射频开/关时间同步地接通和关断的低能电子源。

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