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1. 发明授权

US09460906B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US09460906B2
公开(公告)日：2016-10-04
申请号：US11813221
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap. A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap. The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap in a substantially non-resonant manner.
摘要翻译：公开了一种离子导向器或离子阱，其包括分段线性离子导向器或离子阱。通过向电极施加AC或RF电压，离子限制在离子导向器或离子阱内径向。沿着离子导向器或离子阱的轴向长度的至少一部分保持静电势阱。沿着离子导向器或离子阱的轴向长度的至少一部分施加时变均匀电场。静态轴向势阱和随时间变化的轴向均匀电场的组合导致离子以基本上非共振的方式从离子导向器或离子阱排出。

2. 发明授权

US09214328B2 Space focus time of flight mass spectrometer 有权
标题翻译：空间聚焦时间飞行质谱仪
公开(公告)号：US09214328B2
公开(公告)日：2015-12-15
申请号：US13996893
申请日：2011-12-22
申请人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyzer is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译：公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致减少到达离子检测器的离子到达时间和离子浓度Dgr。

3. 发明授权

US09136098B2 Ion guide coupled to MALDI ion source 有权
标题翻译：离子导轨耦合到MALDI离子源
公开(公告)号：US09136098B2
公开(公告)日：2015-09-15
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/40 , H01J49/10 , H01J49/06 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energized one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

4. 发明授权

US08952320B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08952320B2
公开(公告)日：2015-02-10
申请号：US11719665
申请日：2005-11-18
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器装置（6）。

5. 发明授权

US08921775B2 Electrostatic gimbal for correction of errors in time of flight mass spectrometers 有权
标题翻译：用于校正飞行时间质谱仪误差的静电万向架
公开(公告)号：US08921775B2
公开(公告)日：2014-12-30
申请号：US14004946
申请日：2012-03-13
申请人： David J. Langridge , Jason Lee Wildgoose , John Brian Hoyes
发明人： David J. Langridge , Jason Lee Wildgoose , John Brian Hoyes
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

6. 发明申请

US20140246575A1 Segmented Planar Calibration for Correction of Errors in Time of Flight Mass Spectrometers 有权
标题翻译：分段平面校正用于校正飞行时间质谱中的误差
公开(公告)号：US20140246575A1
公开(公告)日：2014-09-04
申请号：US14117756
申请日：2012-05-16
申请人： David J. Langridge , Jason Lee Wildgoose
发明人： David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/02
CPC分类号： H01J49/0036 , H01J49/0009 , H01J49/02 , H01J49/025 , H01J49/40 , H01J49/401
摘要： An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions. The ion detector system generates separate first mass spectral data sets for each detector element and then applies a calibration coefficient to each of the first mass spectral data sets to produce a plurality of second calibrated mass spectral data sets. The plurality of second calibrated mass spectral data sets are then combined to form a composite mass spectral data set.
摘要翻译：公开了一种用于质谱仪的离子检测器系统，其包括具有检测器元件阵列的离子检测器。离子检测器系统被布置成校正离子的等时平面中的倾斜和非线性像差。离子检测器系统为每个检测器元件生成单独的第一质谱数据集，然后将校准系数应用于每个第一质谱数据集以产生多个第二校准质谱数据集。然后将多个第二校准质谱数据组合以形成复合质谱数据集。

7. 发明申请

US20140191123A1 Ion Guide Coupled to MALDI Ion Source 有权
标题翻译：离子导向器与MALDI离子源耦合
公开(公告)号：US20140191123A1
公开(公告)日：2014-07-10
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/10 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

8. 发明授权

US08716660B2 Ion guide with orthogonal sampling 有权
标题翻译：离子导向与正交采样
公开(公告)号：US08716660B2
公开(公告)日：2014-05-06
申请号：US14004529
申请日：2012-03-13
申请人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/06
CPC分类号： H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/063 , H01J49/36
摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.
摘要翻译：公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不是轴向的被捕获或以其它方式轴向限制在RF离子导向器内。离子导向器在使用中保持在选自以下的压力：（i）0.0001-0.001毫巴; （ii）0.001-0.01毫巴; （iii）0.01-0.1毫巴; （iv）0.1-1毫巴; （v）1-10毫巴; （vi）10-100毫巴; 和（vii）> 100mbar。

9. 发明申请

US20140048702A1 Ion Guide With Orthogonal Sampling 有权
标题翻译：离子指南与正交采样
公开(公告)号：US20140048702A1
公开(公告)日：2014-02-20
申请号：US14004529
申请日：2012-03-13
申请人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/02
CPC分类号： H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/063 , H01J49/36
摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The Ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.
摘要翻译：公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不是轴向的被捕获或以其它方式轴向限制在RF离子导向器内。离子导向器在使用中以选自以下的压力保持：（i）0.0001-0.001毫巴; （ii）0.001-0.01毫巴; （iii）0.01-0.1毫巴; （iv）0.1-1毫巴; （v）1-10毫巴; （vi）10-100毫巴; 和（vii）> 100mbar。

10. 发明申请

US20140014830A1 Space Focus Time of Flight Mass Spectrometer 有权
标题翻译：空间聚焦时间飞行质谱仪
公开(公告)号：US20140014830A1
公开(公告)日：2014-01-16
申请号：US13996893
申请日：2011-12-22
申请人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译：公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致降低到达离子检测器的离子到达时间ΔT的离子扩散。

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