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91. 发明申请

US20170343478A1 OPTICAL EMISSION SPECTROSCOPE WITH A PIVOTABLY MOUNTED INDUCTIVELY COUPLED PLASMA SOURCE 审中-公开
公开(公告)号：US20170343478A1
公开(公告)日：2017-11-30
申请号：US15535977
申请日：2014-12-15
申请人： Spectro Analytical Instruments GmbH
发明人： Manfred A. BERGSCH
IPC分类号： G01N21/68 , H01J49/10 , G01N21/73 , H01J49/34 , G01J3/443
CPC分类号： G01N21/68 , G01J3/443 , G01N21/73 , H01J49/105 , H01J49/34
摘要： An optical emission spectrometry instrument may comprise an inductively coupled plasma generator (ICP) with an electromagnetic coil having input and ground connectors. The electromagnetic coil may be mounted to a mounting disk, and the input connector may be coupled to a power output of a radio frequency power source, and the ground connector may be connected to the mounting disk. A spectro-chemical source may be used for sample excitation. The spectro-chemical source and the ICP may have a longitudinal axis. An optical system may be included for viewing the spectro-chemical source with a fixed view axis. The electromagnetic coil may be mounted pivotably around one of its connectors so that the orientation of the ICP can be altered from a first orientation of its longitudinal axis to a second orientation of its longitudinal axis, and vice versa.

92. 发明授权

US09700251B2 Enclosed desorption electrospray ionization probes and method of use thereof 有权
公开(公告)号：US09700251B2
公开(公告)日：2017-07-11
申请号：US15400358
申请日：2017-01-06
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Zheng Ouyang , Chien-Hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC分类号： H01J49/00 , A61B5/1477 , A61M11/00 , A61M25/00 , G01N33/483 , H01J49/04 , H01J49/16 , H01J49/34
CPC分类号： A61B5/1477 , A61B5/1405 , A61B5/145 , A61B5/150015 , A61B5/150992 , A61B5/157 , A61B10/0045 , A61M11/00 , A61M25/00 , A61M2202/0468 , G01N33/4833 , G01N2001/028 , H01J49/0022 , H01J49/0404 , H01J49/0445 , H01J49/167 , H01J49/34
摘要： The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

93. 发明授权

US09538945B2 Desorption electrospray ionization sampling without damaging an in vivo tissue sample 有权
标题翻译：解吸电喷雾离子采样不损伤体内组织样品
公开(公告)号：US09538945B2
公开(公告)日：2017-01-10
申请号：US14688496
申请日：2015-04-16
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Zheng Ouyang , Chien-Hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC分类号： H01J49/00 , A61B5/1477 , H01J49/16 , H01J49/34 , H01J49/04 , A61M11/00 , A61M25/00
CPC分类号： A61B5/1477 , A61B5/1405 , A61B5/145 , A61B5/150015 , A61B5/150992 , A61B5/157 , A61B10/0045 , A61M11/00 , A61M25/00 , A61M2202/0468 , G01N33/4833 , G01N2001/028 , H01J49/0022 , H01J49/0404 , H01J49/0445 , H01J49/167 , H01J49/34
摘要： The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
摘要翻译：本发明一般涉及封闭的解吸电喷雾离子化探针，系统和方法。在某些实施方案中，本发明提供DESI活性喷雾源，其中将源的远端部分包封在转移构件内，使得DESI活性喷雾在转移构件内产生。

94. 发明授权

US09429543B2 Ion mobility analyzer, combination device thereof, and ion mobility analysis method 有权
标题翻译：离子迁移率分析仪，其组合装置和离子迁移率分析方法
公开(公告)号：US09429543B2
公开(公告)日：2016-08-30
申请号：US14735876
申请日：2015-06-10
申请人： SHIMADZU CORPORATION
发明人： Gongyu Jiang , Yupeng Cheng , Xiaoqiang Zhang , Wenjian Sun
IPC分类号： H01J49/00 , H01J49/34 , H01J49/40 , G01N27/62 , H01J49/22
CPC分类号： G01N27/622 , G01N27/624 , H01J49/004 , H01J49/22
摘要： An ion mobility analyzer, combination device thereof, and ion mobility analysis method. The ion mobility analyzer comprises an electrode system that surrounds the analytical space and a power device that attaches to the electrode system an ion mobility electric potential field that moves along one space axis. During the process of analyzing mobility of ions to be measured, by always placing the ions to be measured in the moving ion mobility electric potential field, and keeping the movement direction of the ion mobility electric potential field consistent with the direction of the electric field on the ions to be measured within the ion mobility electric potential field, theoretically a mobility path of an infinite length can be formed so as to distinguish ions having mobility or ion cross sections that have very small differences.
摘要翻译：离子迁移率分析仪，其组合装置和离子迁移率分析方法。离子迁移率分析仪包括围绕分析空间的电极系统和附接到电极系统的沿着一个空间轴移动的离子迁移电位场的功率器件。在分析被测离子的迁移率的过程中，通过总是将待测离子置于移动离子迁移电势场，并保持离子迁移率电位场的移动方向与电场方向一致在离子迁移电势场内要测量的离子理论上可以形成无限长度的迁移率路径，以区分具有极小差异的迁移率的离子或离子横截面。

95. 发明授权

US09384951B2 Mass analysis using alternating fragmentation modes 有权
标题翻译：使用交替分片模式进行质量分析
公开(公告)号：US09384951B2
公开(公告)日：2016-07-05
申请号：US14136884
申请日：2013-12-20
申请人： Micromass UK Limited
发明人： Robert Harold Bateman
IPC分类号： H01J49/00 , H01J49/10 , H01J49/34
CPC分类号： H01J49/0031 , H01J49/0027 , H01J49/0045 , H01J49/10 , H01J49/34
摘要： A method of mass spectrometry is disclosed wherein a Surface Induced Dissociation fragmentation device is repeatedly switched between a high fragmentation mode and a low fragmentation mode. Parent ions from a first sample are passed through the device and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the device and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.
摘要翻译：公开了一种质谱法，其中表面诱导解离破碎装置在高碎裂模式和低碎裂模式之间重复切换。来自第一个样品的亲本离子通过器件，并获得亲本离子质谱和碎片离子质谱。然后将来自第二个样品的母离子通过该装置，并获得第二组母离子质谱和碎裂离子质谱。然后比较质谱，并且如果两个样品中的某些亲本离子或某些断裂离子不同地表达，则进行进一步分析以寻找在两个不同样品中不同表达的离子。

96. 发明授权

US09347815B2 Single-protein nanomechanical mass spectrometry in real time 有权
标题翻译：单蛋白质纳米机械质谱实时测定
公开(公告)号：US09347815B2
公开(公告)日：2016-05-24
申请号：US13890087
申请日：2013-05-08
申请人： California Institute of Technology
发明人： Michael L. Roukes , Mehmet Selim Hanay , Scott Kelber , Akshay Naik
IPC分类号： G06F19/00 , G01G9/00 , H01J49/34 , G01G3/16 , G01N5/02
CPC分类号： G01G9/00 , G01G3/16 , G01N5/02 , H01J49/34
摘要： Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution.
摘要翻译：涉及通过在谐振器谐振频率的至少两种模式中分辨吸附物诱导的频移来测量吸附到纳米机械谐振器的分析物的着陆位置和质量的方法和装置，其中在解决至少两个模式分析使得从分数 - 频率移动对到分析物质量位置对的变换（G）是一对一的。复杂的蛋白质混合物可以以高灵敏度和分辨率进行分析。

97. 发明申请

US20150230738A1 ENCLOSED DESORPTION ELECTROSPRAY IONIZATION PROBES AND METHOD OF USE THEREOF 有权
标题翻译：封装的电解电离离子探针及其使用方法
公开(公告)号：US20150230738A1
公开(公告)日：2015-08-20
申请号：US14688496
申请日：2015-04-16
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Zheng Ouyang , Chien-Hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC分类号： A61B5/1477 , H01J49/16 , A61M25/00 , H01J49/04 , A61M11/00 , H01J49/00 , H01J49/34
CPC分类号： A61B5/1477 , A61B5/1405 , A61B5/145 , A61B5/150015 , A61B5/150992 , A61B5/157 , A61B10/0045 , A61M11/00 , A61M25/00 , A61M2202/0468 , G01N33/4833 , G01N2001/028 , H01J49/0022 , H01J49/0404 , H01J49/0445 , H01J49/167 , H01J49/34
摘要： The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
摘要翻译：本发明一般涉及封闭的解吸电喷雾离子化探针，系统和方法。在某些实施方案中，本发明提供DESI活性喷雾源，其中将源的远端部分包封在转移构件内，使得DESI活性喷雾在转移构件内产生。

98. 发明授权

US09006647B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US09006647B2
公开(公告)日：2015-04-14
申请号：US14156838
申请日：2014-01-16
申请人： Micromass UK Limited
发明人： Daniel James Kenny , Robert Harold Bateman , Martin Raymond Green , Jason Lee Wildgoose , Steven Derek Pringle
IPC分类号： H01J49/42 , H01J49/00 , H01J49/06 , H01J49/34
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/065 , H01J49/34 , H01J49/4235
摘要： A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimized by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimized by the second different RF voltage applied to the downstream group of electrodes.
摘要翻译：公开了包括多个电极的碰撞或分裂单元，其中将第一RF电压施加到上游电极组，并且将第二不同的RF电压施加到下游电极组。通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池的母体离子的径向约束，并且通过第二不同RF电压优化在碰撞或断裂电池内产生的子或碎片离子的径向约束应用于下游电极组。

99. 发明授权

US08829427B2 Charged particle spectrum analysis apparatus 有权
标题翻译：带电粒子谱分析仪
公开(公告)号：US08829427B2
公开(公告)日：2014-09-09
申请号：US13811117
申请日：2011-07-20
申请人： Mark Brouard , Claire Vallance , Andrei Nomerotski
发明人： Mark Brouard , Claire Vallance , Andrei Nomerotski
IPC分类号： H01J49/00 , H01J49/34 , H01J49/40 , H01J49/06
CPC分类号： H01J49/403 , H01J49/0004 , H01J49/0031 , H01J49/061 , H01J49/34 , H01J49/40
摘要： A charged particle spectrum analysis apparatus comprising an electric field generator arranged to subject charged particles to a time-varying electric field, a detector to record charged particle time spectrum data of charged particles which have passed through the electric field, the detector comprising a position-sensitive detection portion, and the time-varying electric field arranged to be activated in synchrony with activation of detector, and the time-varying electric field arranged to subject a predetermined region of said detection portion to consecutive charged particle deflection cycles.
摘要翻译：一种带电粒子谱分析装置，包括：电场发生器，被布置成使带电粒子受到时变电场;检测器，记录已经通过电场的带电粒子的带电粒子时间谱数据;检测器，灵敏检测部分，以及被布置成与检测器的激活同步地激活的时变电场，以及布置成使所述检测部分的预定区域经受连续带电粒子偏转周期的时变电场。

100. 发明申请

US20140131566A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20140131566A1
公开(公告)日：2014-05-15
申请号：US14156838
申请日：2014-01-16
申请人： Micromass UK Limited
发明人： Daniel James Kenny , Robert Harold Bateman , Martin Raymond Green , Jason Lee Wildgoose , Steven Derek Pringle
IPC分类号： H01J49/06 , H01J49/34
CPC分类号： H01J49/005 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/065 , H01J49/34 , H01J49/4235
摘要： A collision or fragmentation cell is disclosed comprising a plurality of electrodes wherein a first RF voltage is applied to an upstream group of electrodes and a second different RF voltage is applied to a downstream group of electrodes. The radial confinement of parent ions entering the collision or fragmentation cell is optimised by the first RF voltage applied to the upstream group of electrodes and the radial confinement of daughter or fragment ions produced within the collision or fragmentation cell is optimised by the second different RF voltage applied to the downstream group of electrodes.
摘要翻译：公开了包括多个电极的碰撞或分裂单元，其中将第一RF电压施加到上游电极组，并且将第二不同的RF电压施加到下游电极组。通过施加到上游电极组的第一RF电压来优化进入碰撞或破碎电池的母体离子的径向约束，并且通过第二不同RF电压优化在碰撞或断裂电池内产生的子或碎片离子的径向约束应用于下游电极组。

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