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81. 发明授权

US09006164B2 Resist remover composition and method for removing resist using the composition 有权
标题翻译：抗蚀剂去除剂组合物和使用该组合物去除抗蚀剂的方法
公开(公告)号：US09006164B2
公开(公告)日：2015-04-14
申请号：US13394005
申请日：2010-09-01
申请人： Hironori Mizuta , Masahiko Kakizawa
发明人： Hironori Mizuta , Masahiko Kakizawa
IPC分类号： C11D7/60 , G03F7/42 , C11D11/00
CPC分类号： G03F7/426 , C11D11/0047 , G03F7/422 , G03F7/423
摘要： The present invention is directed to provide a resist remover composition for semiconductor substrate which enables to remove a resist simply and easily in the photolithography process in the semiconductor field, and a method for removing a resist comprising that the composition is used. The present invention relates to a resist remover composition for semiconductor substrate, comprising [I] a carbon radical generating agent, [II] an acid, [III] a reducing agent, and [IV] an organic solvent, and having pH of lower than 7, and a method for removing a resist, comprising that the composition is used.
摘要翻译：本发明旨在提供一种半导体衬底的抗蚀剂去除剂组合物，其能够在半导体领域的光刻工艺中简单且容易地除去抗蚀剂，以及除去使用该组合物的抗蚀剂的方法。本发明涉及一种用于半导体衬底的抗蚀剂去除剂组合物，其包含[I]碳自由基产生剂，[II]酸，[III]还原剂和[IV]有机溶剂，并且pH低于 7和除去抗蚀剂的方法，包括使用该组合物。

82. 发明申请

US20150050649A1 METHOD FOR DETECTING DNA HAVING MICROSATELLITE REGION 审中-公开
标题翻译：用于检测具有微晶区的DNA的方法
公开(公告)号：US20150050649A1
公开(公告)日：2015-02-19
申请号：US14387097
申请日：2013-03-22
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD. , KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION
发明人： Shoichi Matsukuma , Tomokazu Ishikawa , Tatsuo Kurosawa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： The invention provides a method of detecting DNA having a microsatellite region without causing the problem of a non-specific reaction product. The method includes (1) contacting a probe, which does not have a nucleotide sequence complementary to the microsatellite region and hybridizes with both sides of the nucleotide sequences of the microsatellite region, with DNA having the microsatellite region, to form a hybrid of the DNA and the probe, which has a loop structure including a microsatellite region, (2) separating the obtained hybrid, (3) detecting the hybrid. The invention also provides a hybrid of DNA and a probe, having a loop structure including a microsatellite region, which is made by contacting DNA having a microsatellite region with the probe which does not have a nucleotide sequence complementary to the microsatellite region, and hybridizes with both sides of the nucleotide sequence of the microsatellite region.
摘要翻译：本发明提供了检测具有微卫星区域的DNA而不引起非特异性反应产物的问题的方法。该方法包括：（1）将不具有与微卫星区域互补的核苷酸序列并与微卫星区域的核苷酸序列的两侧杂交的探针与具有微卫星区域的DNA接触以形成DNA的杂交体和具有包含微卫星区域的环结构的探针，（2）分离得到的杂交体，（3）检测杂交体。本发明还提供了具有包含微卫星区的环结构的DNA和探针的杂交体，该微卫星区通过将具有微卫星区的DNA与不具有与微卫星区互补的核苷酸序列的探针接触而制备，并与微卫星区域的核苷酸序列的两侧。

83. 发明授权

US08772037B2 Analysis assisting method, analyzer, remote computer, data analyzing method, program, and reagent container 失效
标题翻译：分析辅助方法，分析仪，远程计算机，数据分析方法，程序和试剂容器
公开(公告)号：US08772037B2
公开(公告)日：2014-07-08
申请号：US11632710
申请日：2005-07-22
申请人： Masahiro Satomura , Hishiri Komiyama
发明人： Masahiro Satomura , Hishiri Komiyama
IPC分类号： G01N35/00 , B01L3/00
CPC分类号： G01N35/00663 , B01L3/545 , G01N1/28 , G01N35/00732 , G01N35/00871 , G01N2035/00673 , G01N2035/00782 , G01N2035/00811 , G01N2035/00841 , G01N2035/00851 , Y10T436/11 , Y10T436/115831 , Y10T436/12
摘要： In an analysis system having an analysis apparatus using a reagent container having a memory to store reagent information concerning the reagent in the reagent container and a remote computer, the following steps are executed: reading out the reagent information from the memory of the reagent container; judging, based on the read reagent information, whether or not the reagent in the reagent container is usable; when it is judged that the reagent in the reagent container is unusable, writing data representing the reagent is unusable into the memory of the reagent container; and when it is judged that the reagent in the reagent container is unusable, registering the data representing the reagent is unusable, into a reagent database managed by the remote computer in association with identification information to identify the reagent container. Thus, it is possible to automatically identify the reagent, which should not be used, and to manage the reagent not so as to use it for the analysis. In addition, it is possible to use the data for the enhancement of the business efficiency such as the automatic order of the reagent, the stock management in the manufacturer and the like.
摘要翻译：在具有分析装置的分析装置中，使用具有存储试剂容器的试剂容器的试剂容器和远程计算机的试剂容器，执行以下步骤：从试剂容器的存储器读出试剂信息; 基于所读取的试剂信息判断试剂容器中的试剂是否可用; 当判断试剂容器中的试剂不可用时，表示试剂的数据的写入不能用于试剂容器的存储器中; 并且当判断试剂容器中的试剂不可用时，将表示试剂的数据登记到由远程计算机管理的试剂数据库中，与识别信息相关联以识别试剂容器。因此，可以自动识别不应该使用的试剂和管理试剂，以便将其用于分析。此外，可以使用数据来提高业务效率，例如试剂的自动顺序，制造商中的库存管理等。

84. 发明授权

US08742136B2 Method for producing cyclic disulfonic acid ester 失效
标题翻译：环状二磺酸酯的制备方法
公开(公告)号：US08742136B2
公开(公告)日：2014-06-03
申请号：US12304409
申请日：2007-06-14
申请人： Kuniaki Okamoto , Tsutomu Watahiki , Motoshige Sumino
发明人： Kuniaki Okamoto , Tsutomu Watahiki , Motoshige Sumino
IPC分类号： C07D327/00
CPC分类号： C07D327/00 , C07D327/06
摘要： It is an object of the present invention to provide a commercially advantageous method for producing a cyclic disulfonic acid ester with high yield, the present invention discloses a method for producing a cyclic disulfonic acid ester represented by the general formula (3), which comprises reacting a silver alkanedisulfonate represented by the general formula (1) with a dihaloalkane represented by the general formula (2) in a nonpolar solvent. Wherein X1 and X2 are each independently a chlorine atom, a bromine atom or an iodine atom; and Y and Z are each independently a substituted or unsubstituted alkylene chain which may have a heteroatom in the chain.
摘要翻译：本发明的目的是提供一种以高收率生产环状二磺酸酯的商业上有利的方法，本发明公开了一种由通式（3）表示的环状二磺酸酯的制备方法，该方法包括使通式由通式（1）表示的烷撑二磺酸烷基酯与通式（2）表示的二卤代烷烃在非极性溶剂中反应。其中X1和X2各自独立地为氯原子，溴原子或碘原子; 并且Y和Z各自独立地是在链中可以具有杂原子的取代或未取代的亚烷基链。

85. 发明申请

US20140113311A1 AGGLUTINATION ENHANCER 有权
公开(公告)号：US20140113311A1
公开(公告)日：2014-04-24
申请号：US14123899
申请日：2012-06-04
申请人： Naoyuki Yamamoto , Tsutomu Masuda
发明人： Naoyuki Yamamoto , Tsutomu Masuda
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , C08F220/36 , C08F220/60 , G01N33/542
摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.
摘要翻译：本发明的目的是提供一种与常规免疫凝集增强剂相比具有优异的凝集增强作用的凝集增强剂，本发明涉及用于免疫凝集测定方法的凝集增强剂，其包含具有单体单元以下通式[1]表示：（其中R1表示氢原子或甲基; R2和R3分别独立地表示甲基或乙基; X表示-NH-或氧原子; n表示1的整数）至6; m表示1〜3的整数），以及免疫凝集测定方法，其中在上述用于免疫凝集测定法的凝集增强剂的共存下，将分析物的抗体或分析物的抗原进入与分析物接触以引起抗原 - 抗体反应。

86. 发明申请

US20140110260A1 ISOTACHOPHORESIS OF BLOOD-DERIVED SAMPLES 有权
标题翻译：血液衍生样本的异位症
公开(公告)号：US20140110260A1
公开(公告)日：2014-04-24
申请号：US14068334
申请日：2013-10-31
申请人： Wako Pure Chemical Industries, Ltd.
发明人： Tatsuo Kurosawa , Mitsuo Watanabe , Takuma Ohtsubo
IPC分类号： G01N27/447
CPC分类号： G01N27/44773 , G01N27/44726
摘要： Methods are provided for forming a complex comprising an analyte (or an analyte analogue) from a blood-derived sample and labeling substances, and separating the complex from excess labeling substances and coexisting substances from the blood-derived sample, in a rapid, simple, convenient, and highly precise isotachophoresis (ITP) process by adding 2-(N-morpholino)ethane sulfonate (MES) salt and/or glutamate salt to the ITP sample. Methods are also provided for measuring the analyte in blood-derived samples with high precision and high sensitivity, based on the amount of the complex separated or the amount of uncomplexed labeling substance-containing molecules.
摘要翻译：提供了用于形成包含来自血液来源样品的分析物（或分析物类似物）和标记物质的复合物的复合物的方法，并且以快速，简单的方式将复合物与来自血液衍生的样品的过量标记物质和共存物质分离，通过向ITP样品中加入2-（N-吗啉代）乙烷磺酸盐（MES）盐和/或谷氨酸盐，方便和高度精确的等速电泳（ITP）方法。还提供了用于以高精度和高灵敏度测量血液来源的样品中的分析物的方法，基于分离的复合物的量或未复合的含标记物质的分子的量。

87. 发明授权

US08673963B2 Method for producing cyclic sulfonic acid ester and intermediate thereof 有权
标题翻译：环状磺酸酯及其中间体的制备方法
公开(公告)号：US08673963B2
公开(公告)日：2014-03-18
申请号：US13388405
申请日：2010-08-03
申请人： Ayako Kuramoto , Kuniaki Okamoto , Tsutomu Watahiki , Motoshige Sumino
发明人： Ayako Kuramoto , Kuniaki Okamoto , Tsutomu Watahiki , Motoshige Sumino
IPC分类号： A61K31/381 , C07D327/10
CPC分类号： C07D327/04 , C07D327/10
摘要： The present invention is directed to provide an efficient production method which is capable of not only obtaining a cyclic sulfonic acid ester (sultone) at low cost and in high yield, but also the sulfonic acid ester (sultone) stably even in a commercial scale. The present invention relates to a method for producing hydroxysultone comprising a first step where a diol having a specified structure and a thionyl halide are reacted to obtain a cyclic sulfite having a specified structure, and a second step where the cyclic sulfite is reacted with water or/and alcohol; a method for producing an unsaturated sultone having a specified structure comprising a third step where a hydroxylsultone having a specified structure is reacted with an acid halide or an acid anhydride to obtain an intermediate, subsequently the intermediate is treated with a base; as well as a cyclic sulfite having a specified structure.
摘要翻译：本发明的目的在于提供一种能够以低成本，高收率地获得环状磺酸酯（磺内酯），而且能够以工业规模稳定地获得磺酸酯（磺内酯）的有效的制造方法。本发明涉及一种生产羟基培养基的方法，包括第一步骤，其中具有特定结构的二醇和亚硫酰卤反应得到具有特定结构的环状亚硫酸盐，第二步是将环状亚硫酸盐与水或 /和酒精; 一种具有特定结构的不饱和磺内酯的制造方法，其特征在于，具有将具有规定结构的羟基磺内酯与酰卤或酸酐反应得到中间体的第3工序，接着用碱处理中间体; 以及具有特定结构的环状亚硫酸盐。

88. 发明授权

US08669375B2 Process for producing ester compound 有权
标题翻译：酯化合物的制备方法
公开(公告)号：US08669375B2
公开(公告)日：2014-03-11
申请号：US13658362
申请日：2012-10-23
申请人： Wako Pure Chemical Industries, Ltd.
发明人： Shigeaki Imazeki , Ryohiko Kinoshita
IPC分类号： C07D305/00 , C07D307/00 , C07D265/32
CPC分类号： C07C319/20 , C07C67/08 , C07D307/68 , C07C69/708 , C07C69/612 , C07C69/716 , C07C69/653 , C07C69/017 , C07C69/63 , C07C69/14 , C07C323/52 , C07C69/157 , C07C69/72
摘要： PROBLEMTo provide an environmentally-friendly method for producing industrially an ester compound.SOLUTIONThe present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.
摘要翻译：问题提供工业上生产酯化合物的环保方法。解决方案本发明是一种酯化合物的制备方法，其包括使用非挥发性酸催化剂使羧酸和醇进行脱水缩合反应，然后通过使弱碱性物质与残留酸接触来除去残留的酸催化剂催化剂。

89. 发明授权

US08394324B2 Microchip large-volume PCR with integrated real-time CE detection 有权
标题翻译： Microchip大容量PCR，集成实时CE检测
公开(公告)号：US08394324B2
公开(公告)日：2013-03-12
申请号：US12664018
申请日：2008-06-11
申请人： Luc Bousse , Jian-ping Zhang
发明人： Luc Bousse , Jian-ping Zhang
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/68 , C12P19/34 , C12M1/36 , C12M1/38 , C12M3/00 , C12M1/34
CPC分类号： G01N27/44791 , B01L3/502746 , B01L3/502753 , B01L7/52 , B01L2300/0816 , B01L2400/0421 , G01N27/44721
摘要： A microfluidic device is provided with appropriate integrated structures to conduct large volume PCR and end-point or real-time capillary electrophoresis detection. The microfluidic device includes a substrate having an amplification chamber of a volume of nucleic acid, wells disposed on the substrate, flow channels connecting the wells and the chamber in the substrate to allow for solution flow through the chamber, and one or more separation channels provided in the substrate and connected to the chamber for separating and detecting a fraction of the amplified nucleic acid. The chamber, the flow channels, and the one or more separation channels are configured such that the hydrodynamic flow resistance of the chambers and the flow channels combined is at least 10Λ3 times smaller than the hydrodynamic flow resistance in the one or more separation channels. The microfluidic device can achieve a very high sensitivity in detection while being highly cost effective.
摘要翻译：微流体装置具有适当的整合结构，可进行大容量PCR和终点或实时毛细管电泳检测。微流体装置包括具有一定体积的核酸的扩增室的衬底，设置在衬底上的阱，连通阱的流动通道和衬底中的室，以允许溶液流过腔室，以及提供一个或多个分离通道在底物中并连接到室以分离和检测一部分扩增的核酸。腔室，流动通道和一个或多个分离通道被构造成使得腔室和流动通道组合的流体动力学流动阻力比一个或多个分离通道中的流体动力流动阻力小至少10 ^ 3倍。微流体装置在检测中可以获得非常高的灵敏度，同时具有高成本效益。

90. 发明申请

US20120157680A1 IONIC LIQUID CONTAINING ALLYLSULFONATE ANION 有权
标题翻译：含离子液体的亚硫酸盐阴离子
公开(公告)号：US20120157680A1
公开(公告)日：2012-06-21
申请号：US13393144
申请日：2010-08-30
申请人： Tsutomu Watahiki , Kuniaki Okamoto , Motoshige Sumino
发明人： Tsutomu Watahiki , Kuniaki Okamoto , Motoshige Sumino
IPC分类号： C07C309/04 , C07D213/20 , C07D295/037 , C07D403/06 , C07D295/088 , C07D233/58 , C07D401/06
CPC分类号： C07C309/20 , C07D213/06 , C07D213/20 , C07D213/68 , C07D233/58 , C07D295/04 , C07D295/08
摘要： PROBLEM:Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point.MEANS FOR SOLVING THE PROBLEM:The present invention is the invention of the ionic liquid represented by the general formula [1]: {wherein, R1 to R3 and n pieces of R4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R5 to R7 each independently represent alkyl group, aralkyl group, or aryl group, R8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R1 to R7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R3 and R4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R5 to R7 or R5 to R6 may form hetero ring with nitrogen atom binding thereto}.
摘要翻译：问题：提供低成本，环保的低粘度和熔点的新型离子液体。解决问题的手段：本发明是由通式[1]表示的离子液体的发明：{其中，R 1〜R 3和n个R 4各自独立地表示氢原子或碳原子数1〜4的烷基 R 5至R 7各自独立地表示烷基，芳烷基或芳基，R 8表示烷基，芳烷基，芳基或由通式[2]表示的基团：（其中T表示亚烷基链，具有1〜8个碳原子，n表示1或2，并且R 1至R 7与上述相同），X表示氮原子或磷原子，n表示1或2.当n为1时，R 3和R 4结合并形成环己烯环与相邻的碳原子一起环。此外，当X是氮原子时，R 5至R 7或R 5至R 6可以与与其结合的氮原子形成杂环}。

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