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81. 发明授权

US08164052B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08164052B2
公开(公告)日：2012-04-24
申请号：US12593006
申请日：2008-03-26
申请人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
发明人： Martin R. Green , Jason Lee Wildgoose , Jeffery Mark Brown
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译：公开了包含电子转移离解电池（1）的质谱仪。当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子（1）。电池包括形成球形捕获体积的多个环形电极（1）。离子经验可忽略大部分的RF加热，捕集体积使分析物和试剂离子的动能降低到高于热温度。由此提供了具有增强的灵敏度的电子转移解离单元（1）。在细胞（1）内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，能够显着提高质量分析仪的分辨率。

82. 发明授权

US08106350B2 Correction of deadtime effects in mass spectrometry 有权
标题翻译：修正质谱中的死时效应
公开(公告)号：US08106350B2
公开(公告)日：2012-01-31
申请号：US11816643
申请日：2006-02-22
申请人： Martin Green , Jason Lee Wildgoose , Marc V. Gorenstein
发明人： Martin Green , Jason Lee Wildgoose , Marc V. Gorenstein
IPC分类号： H01J49/26
CPC分类号： H01J49/025 , H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actual total number of ion arrival events recorded in the ith time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.
摘要翻译：公开了一种质谱法，其中通过确定或估计到达第i个时间仓的离子数Qi来校正质谱中的失真，其中：式（I），其中qi是离子到达的实际总数记录在第i个时间段中的事件和x是对应于与估计的死时间周期相对应的时间段数的整数。

83. 发明授权

US08076637B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08076637B2
公开(公告)日：2011-12-13
申请号：US12524378
申请日：2008-01-25
申请人： Steven Derek Pringle , Jason Lee Wildgoose
发明人： Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
摘要翻译：公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。所得到的离子信号被去卷积以提供质谱。

84. 发明申请

US20100327157A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20100327157A1
公开(公告)日：2010-12-30
申请号：US12518173
申请日：2007-12-10
申请人： Martin Green , Jason Lee Wildgoose
发明人： Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/065 , H01J49/40 , H01J49/4225 , H01J49/426
摘要： A mass spectrometer is disclosed comprising a time of flight mass analyser (7). The time of flight mass analyser (7) comprises an ion guide comprising a plurality of electrodes (1) which are interconnected by a series of resistors (2) forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes (1). A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide.
摘要翻译：公开了一种包括飞行时间质量分析器（7）的质谱仪。飞行时间质量分析器（7）包括离子导向器，其包括由形成分压器的一系列电阻器（2）互连的多个电极（1）。通过向电极（1）施加两相RF电压，离子在径向上被限制在离子导向器内。在分压器上施加单相附加RF电压，使得沿着离子导向器的长度保持不均匀的伪势力。

85. 发明授权

US07586088B2 Mass spectrometer and method of mass spectrometry 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US07586088B2
公开(公告)日：2009-09-08
申请号：US10176072
申请日：2002-06-21
申请人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/40 , G01N27/624 , H01J49/004 , H01J49/4215
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer in combination with a quadrupole mass filter which is scanned in synchronization with the pulsing of ions into the ion mobility spectrometer thereby enabling ions having a particular charge state to be preferentially transmitted. Another embodiment replaces the quadrupole mass filter with an axial time of flight mass filter and an injection electrode.
摘要翻译：公开了一种质谱仪，其包括与四极质量过滤器组合的离子迁移谱仪，其与离子脉冲离子扫描到离子迁移谱仪中，从而使具有特定电荷状态的离子能够被优先传输。另一实施例用轴向飞行时间质量过滤器和注入电极取代四极质量过滤器。

86. 发明申请

US20140005970A1 Method Of Deadtime Correction in Mass Spectrometry 审中-公开
标题翻译：质谱法死亡时间校正方法
公开(公告)号：US20140005970A1
公开(公告)日：2014-01-02
申请号：US13977863
申请日：2012-01-09
申请人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
发明人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A method of improving the fidelity of m/z dependent and/or intensity measurements for a species of interest in an analyte to correct for hardware limitations within a mass spectrometer, which method comprises the steps of acquiring raw data produced by a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent and/or intensity measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent and/or intensity measurements with associated uncertainties.
摘要翻译：一种提高分析物感兴趣的物种的m / z依赖和/或强度测量的保真度以校正质谱仪内的硬件限制的方法，该方法包括以下步骤：获取由质谱仪产生的原始数据，识别原始数据中与感兴趣物种相关的区域，形成数学模型以计算影响m / z依赖和/或强度测量的参数的联合概率分布，从联合概率分布中分析获取样本以产生校正的或精确的m / z依赖和/或强度测量与相关的不确定性。

87. 发明申请

US20130317756A1 Method Of Deadtime Correction In Mass Spectrometry 审中-公开
标题翻译：质谱中死时间校正方法
公开(公告)号：US20130317756A1
公开(公告)日：2013-11-28
申请号：US13977861
申请日：2012-01-09
申请人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
发明人： Keith Richardson , Richard Denny , Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/0036
摘要： A method of improving the fidelity of m/z dependent measurements for a species of interest in an analyte in a mass spectrometer, which method comprises the steps of acquiring raw data produced in a mass spectrometer, identifying a region within the raw data that relates to the species of interest, forming a mathematical model to calculate the joint probability distribution of the parameters effecting the m/z dependent measurements, analytically obtaining samples from the joint probability distribution to produce corrected or refined m/z dependent measurements with associated uncertainties.
摘要翻译：一种提高质谱仪中分析物中感兴趣的物种的m / z依赖性测量的保真度的方法，该方法包括以下步骤：获取在质谱仪中产生的原始数据，识别与原始数据相关的原始数据中的区域形成感兴趣的物种，形成一个数学模型，以计算影响m / z依赖性测量的参数的联合概率分布，从联合概率分布中分析获得样本，以产生具有相关不确定性的校正或精确的m / z相关度量。

88. 发明申请

US20100001180A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20100001180A1
公开(公告)日：2010-01-07
申请号：US12302168
申请日：2007-06-01
申请人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
发明人： Robert Harold Bateman , Jeffery Mark Brown , Martin Green , Jason Lee Wildgoose , Anthony James Gilbert , Steven Derek Pringle
IPC分类号： H01J49/40 , H01J49/26
CPC分类号： H01J49/0036 , G06K9/0053
摘要： A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
摘要翻译：公开了一种飞行时间质量分析仪，其包括离子检测器，该离子检测器包括模数转换器。来自离子检测器的输出信号被数字化，确定与离子到达事件有关的到达时间和强度值。如果从两个信号确定的到达时间落在相同的时间窗口内，则以加权的方式将到达时间相加在一起并且强度值被组合。

89. 发明申请

US20090072136A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090072136A1
公开(公告)日：2009-03-19
申请号：US12092313
申请日：2006-11-01
申请人： Steven Pringle , Jason Lee Wildgoose
发明人： Steven Pringle , Jason Lee Wildgoose
IPC分类号： B01D59/44
CPC分类号： H01J49/062 , H01J49/004 , H01J49/4235 , H01J49/427
摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of seudo-potential corrugations are created along the axis of the mass analyser (2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of mass to charge ratio.
摘要翻译：提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。沿着质量分析器（2）的轴线产生多个潜在的波纹。伪电位波纹的振幅或深度与离子的质荷比成反比。为了沿着质量分析器（2）的长度推动离子，一个或多个瞬态直流电压被施加到质量分析器（2）的电极。施加到电极的瞬态直流电压的幅度随着时间而增加，并且使质子分析器（2）以与质荷比相反的顺序发射离子。

90. 发明授权

US06992283B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06992283B2
公开(公告)日：2006-01-31
申请号：US10739041
申请日：2003-12-19
申请人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/0036 , H01J49/004
摘要： A mass spectrometer is disclosed wherein ions are passed through an ion mobility separator and are then mass analysed by a Time of Flight mass analyzer. Multiple sets of mass spectral data are obtained which are then post-processed so that mass spectral data relating to ions having undesired charge state(s) is filtered out. The resultant mass spectrum comprises ions having a desired charge state.
摘要翻译：公开了一种质谱仪，其中离子通过离子迁移率分离器，然后通过飞行时间质量分析仪进行质量分析。获得多组质谱数据，然后对其进行后处理，从而滤出与具有不期望的电荷状态的离子相关的质谱数据。所得质谱包括具有所需电荷状态的离子。

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