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1. 发明授权

US08895920B2 Mass spectrometer with beam expander 有权
公开(公告)号：US08895920B2
公开(公告)日：2014-11-25
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/00 , H01J49/06
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.

2. 发明授权

US08283628B2 Ion mobility spectrometer 有权
标题翻译：离子迁移谱仪
公开(公告)号：US08283628B2
公开(公告)日：2012-10-09
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： B01D59/44
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

3. 发明申请

US20110291001A1 Ion Mobility Spectrometer 有权
标题翻译：离子流动光谱仪
公开(公告)号：US20110291001A1
公开(公告)日：2011-12-01
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： H01J49/26
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

4. 发明授权

US07960694B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07960694B2
公开(公告)日：2011-06-14
申请号：US12373204
申请日：2007-07-09
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4235
摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass ((analyser 2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC′ or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser (2).
摘要翻译：提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。沿着质量轴（（分析仪2））产生多个伪电位波纹，伪电位波纹的振幅或深度与离子的质荷比成反比，一个或多个瞬态直流电压被施加到质量分析器（2）的电极，以沿着质量分析器（2）的长度推动离子，施加到电极的瞬态DC电压的幅度随时间增加并且离子被发射从质量分析器（2）以其质量与电荷比的相反顺序将两个AC或RF电压施加到电极上，第一AC或RF电压被布置成提供最佳伪电位波纹，而第二AC'或RF 电压被布置成在质量分析器（2）内提供离子的最佳径向约束。

5. 发明授权

US06992283B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06992283B2
公开(公告)日：2006-01-31
申请号：US10739041
申请日：2003-12-19
申请人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
发明人： Robert Harold Bateman , John Brian Hoyes , James Ian Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/40 , G01N27/622 , H01J49/0036 , H01J49/004
摘要： A mass spectrometer is disclosed wherein ions are passed through an ion mobility separator and are then mass analysed by a Time of Flight mass analyzer. Multiple sets of mass spectral data are obtained which are then post-processed so that mass spectral data relating to ions having undesired charge state(s) is filtered out. The resultant mass spectrum comprises ions having a desired charge state.
摘要翻译：公开了一种质谱仪，其中离子通过离子迁移率分离器，然后通过飞行时间质量分析仪进行质量分析。获得多组质谱数据，然后对其进行后处理，从而滤出与具有不期望的电荷状态的离子相关的质谱数据。所得质谱包括具有所需电荷状态的离子。

6. 发明授权

US06884995B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06884995B2
公开(公告)日：2005-04-26
申请号：US10610677
申请日：2003-07-02
申请人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle
发明人： Robert Harold Bateman , Kevin Giles , John Brian Hoyes , Steve Pringle
IPC分类号： H01J49/02 , H01J49/26
CPC分类号： H01J49/005 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a collision cell wherein ions having substantially different mass to charge ratios are arranged to be transmitted through at least a portion of the collision cell at substantially the same time and with substantially the same velocity preferably by means of one or more transient DC voltages or one or more transient DC voltage waveforms which are applied to the electrodes forming the collision cell so that ions are urged through the collision cell at a constant controlled velocity. By appropriate setting of the velocity of the DC voltage or DC voltage waveform passing along the length of the collision cell an efficient collision cell is provided which is able to fragment ions having considerably different mass to charge ratio at substantially the same time in an optimal manner.
摘要翻译：公开了一种质谱仪，其包括碰撞池，其中具有基本上不同的质荷比的离子被布置成在基本相同的时间和基本上相同的速度下通过至少一部分的碰撞池传播通过一个或多个瞬态DC电压或一个或多个瞬态DC电压波形，其被施加到形成碰撞电池的电极，使得离子以恒定的受控速度被迫穿过碰撞池。通过适当设定沿着碰撞电池的长度通过的直流电压或直流电压波形的速度，提供了一种有效的碰撞电池，其能够以最佳方式在基本上相同的时间将具有相当不同质荷比的离子分解。

7. 发明授权

US06717130B2 Methods and apparatus for mass spectrometry 有权
标题翻译：质谱方法和仪器
公开(公告)号：US06717130B2
公开(公告)日：2004-04-06
申请号：US09876122
申请日：2001-06-08
申请人： Robert Harold Bateman , John Brian Hoyes , Edward James Clayton
发明人： Robert Harold Bateman , John Brian Hoyes , Edward James Clayton
IPC分类号： B01D5944
CPC分类号： H01J49/0045
摘要： A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source are incident upon a collision cell which alternately and repeatedly switches between a first mode wherein the ions are substantially fragmented to produce daughter ions and a second mode wherein the ions are not substantially fragmented. Mass spectra are taken in both modes, and at the end of an experimental run parent and daughter ions are recognized by comparing the mass spectra obtained in the two different modes. Daughter ions are matched to particular parent ions on the basis of the closeness of fit of their elution times, and this enables parent ions to then be identified.
摘要翻译：公开了一种通过匹配发现在母体离子从混合物中洗脱出的基本上同时产生的子离子来鉴定亲本离子的方法。从离子源发射的离子入射到碰撞单元上，该碰撞单元在离子基本上分裂以产生子离子的第一模式之间交替重复地切换，而第二模式其中离子基本上不分段。在两种模式下都采用质谱，在实验运行结束时，通过比较两种不同模式中获得的质谱来识别母体和子离子。基于其洗脱时间的拟合程度，子离子与特定的母体离子相匹配，这使母体离子能够被识别。

8. 发明授权

US09177776B2 Mass to charge ratio selective ejection from ion guide having supplemental RF voltage applied thereto 有权
标题翻译：离子导向器的质荷比选择性喷射具有施加到其上的补充RF电压
公开(公告)号：US09177776B2
公开(公告)日：2015-11-03
申请号：US13522888
申请日：2011-01-18
申请人： John Brian Hoyes , Daniel James Kenny , David Langridge
发明人： John Brian Hoyes , Daniel James Kenny , David Langridge
IPC分类号： H01J49/34 , H01J49/06 , H01J49/42
CPC分类号： H01J49/34 , H01J49/065 , H01J49/4235 , H01J49/4275 , H01J49/429
摘要： An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order.
摘要翻译：公开了一种离子导向器，其中在离子导向器的出口处产生轴向DC电压屏障。将初级RF电压施加到电极，以便将离子径向限制在离子导向器内。补充的RF电压也被施加到电极。补充RF电压具有比初级RF电压更大的轴向重复长度。补充RF电压的幅度随时间增加，导致离子变得不稳定并获得足够的轴向动能，使得离子克服轴向DC电压屏障。离子以质量与电荷的比例顺序从离子导向器轴向出现。

9. 发明申请

US20140054454A1 Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers 有权
标题翻译：用于校正飞行时间质谱误差的静电万向节
公开(公告)号：US20140054454A1
公开(公告)日：2014-02-27
申请号：US14004946
申请日：2012-03-13
申请人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

10. 发明申请

US20130099110A1 Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto 有权
标题翻译：离子导向器的质量比充放电比例应用于补充RF电压
公开(公告)号：US20130099110A1
公开(公告)日：2013-04-25
申请号：US13522888
申请日：2011-01-18
申请人： John Brian Hoyes , Daniel James Kenny , David Langridge
发明人： John Brian Hoyes , Daniel James Kenny , David Langridge
IPC分类号： H01J49/34
CPC分类号： H01J49/34 , H01J49/065 , H01J49/4235 , H01J49/4275 , H01J49/429
摘要： An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order.
摘要翻译：公开了一种离子导向器，其中在离子导向器的出口处产生轴向DC电压屏障。将初级RF电压施加到电极，以便将离子径向限制在离子导向器内。补充的RF电压也被施加到电极。补充RF电压具有比初级RF电压更大的轴向重复长度。补充RF电压的幅度随时间增加，导致离子变得不稳定并获得足够的轴向动能，使得离子克服轴向DC电压屏障。离子以质量与电荷的比例顺序从离子导向器轴向出现。

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