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81. 发明授权

US07067059B2 Generation of ion exchanger media 有权
标题翻译：生成离子交换介质
公开(公告)号：US07067059B2
公开(公告)日：2006-06-27
申请号：US10489468
申请日：2002-09-12
申请人： Jean-Luc Maloisel , Nicolas Thevenin
发明人： Jean-Luc Maloisel , Nicolas Thevenin
IPC分类号： B01D15/08
CPC分类号： B01J20/3212 , B01J20/3204 , B01J20/321 , B01J20/3219 , B01J39/17 , B01J39/18 , B01J39/26
摘要： The present invention relates to a method of generating a separation medium comprising mixed mode cation-exchanger ligands coupled to a base matrix, which method comprises to provide a scaffold comprising a functional group and exhibiting a cyclic core structure; derivatise the scaffold with a reagent comprising a reactive group coupled to a residue R by reacting the functional group of the scaffold with said reactive group; open the cyclic structure of the resulting derivative; and react the product with a base matrix comprising a reactive group. The scaffold presents at least two functionalities; one sulphur-comprising group for coupling to the base matrix and one group that can be transformed into an ionic group.
摘要翻译：本发明涉及一种产生分离介质的方法，该分离介质包含与基础基质偶联的混合模式阳离子交换配体，该方法包括提供包含官能团并显示环状核心结构的支架; 通过使支架的官能团与所述反应性基团反应，用包含与残基R偶联的反应性基团的试剂衍生支架; 打开所得衍生物的环状结构; 并使产物与包含反应性基团的基质基质反应。脚手架至少有两个功能; 一个用于与基础基质偶联的含硫基团和一个可以转化成离子基团的基团。

82. 发明申请

US20060131239A1 Agent for capturing substance having anionic substituent 有权
公开(公告)号：US20060131239A1
公开(公告)日：2006-06-22
申请号：US10547050
申请日：2004-03-04
申请人： Tohru Koike , Yohsuke Yamamoto , Hironori Takeda , Yoshio Sano , Satoko Yougai
发明人： Tohru Koike , Yohsuke Yamamoto , Hironori Takeda , Yoshio Sano , Satoko Yougai
IPC分类号： C07F3/10 , B01J39/00 , B01D15/00
CPC分类号： B01J20/265 , B01J20/0244 , B01J20/261 , B01J20/262 , B01J20/267 , B01J20/28016 , B01J20/28023 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3265 , B01J20/3425 , B01J20/3475 , B01J45/00 , B01J2220/58
摘要： A polymer carrier to which a prescribed zinc complex group is binding directly or through a spacer, having property to bond, under a certain condition, to an anionic substituent (a phosphate group, for example), showing low solubility to a solvent (preferably insolubility to a solvent) as a whole, and being capable of capturing, separating and purifying easily a substance having an anionic substituent (a phosphate group, for example).

83. 发明申请

US20060091228A1 Moisture-absorbing polymer particle, method for forming the same and application thereof 审中-公开
标题翻译：吸湿聚合物颗粒，其形成方法及其应用
公开(公告)号：US20060091228A1
公开(公告)日：2006-05-04
申请号：US10978374
申请日：2004-11-02
申请人： Keh-Ying Hsu , Chu-Yi Pang
发明人： Keh-Ying Hsu , Chu-Yi Pang
IPC分类号： F25D1/00
CPC分类号： B01D53/261 , B01D2253/202 , B01J20/261 , B01J20/267 , B01J20/321 , B01J20/328 , B01J20/3293
摘要： The present invention discloses a moisture-absorbing polymer particle, which either comprises PNIPAm crosslinking copolymer or a structure having PNIPAm crosslinking copolymer as a core and polymer with sulfonic acid group as a shell. The present invention also discloses a method for producing the provided moisture-absorbing polymer particle and an application thereof; the application is referred to as a continuous dehumidifying system which comprises a first module to perform a dehumidifying process and a second module to perform a regeneration process, wherein the dehumidifying process is performed at a temperature lower than 33° C. and the regeneration process is performed at a temperature higher than 40° C.
摘要翻译：本发明公开了一种吸湿聚合物颗粒，其包含PNIPAm交联共聚物或具有PNIPAm交联共聚物作为核心的结构和具有磺酸基作为壳的聚合物。本发明还公开了一种制备所述吸湿聚合物颗粒的方法及其应用; 该应用被称为连续除湿系统，其包括执行除湿过程的第一模块和执行再生过程的第二模块，其中除湿过程在低于33℃的温度下进行，再生过程是在高于40℃的温度下进行。

84. 发明申请

US20060063276A1 Alteration of surface affinities 有权
标题翻译：表面亲和力的改变
公开(公告)号：US20060063276A1
公开(公告)日：2006-03-23
申请号：US11181371
申请日：2005-07-14
申请人： Xingyu Jiang , Rosaria Ferrigno , George Whitesides
发明人： Xingyu Jiang , Rosaria Ferrigno , George Whitesides
IPC分类号： G01N1/28 , G01N33/543
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/3227 , B01J20/3248 , B01J20/3251 , B01J20/3274 , B01J20/3285 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B05D3/14 , B05D3/207 , G01N33/54353 , G01N2610/00 , Y10S436/823 , Y10T436/118339
摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
摘要翻译：本发明提供了一系列用于改变表面性质（例如，细胞毒性和/或亲水性）的方法，组合物和制品，通过将至少一部分表面暴露于非化学，产生场和/或力，例如电场。场/力可以通过任何合适的技术来产生。例如，可以通过在表面上施加电压，通过电感应等来产生该场。在某些实施例中，表面包括附着于其上的分子，当暴露于非化学，力产生场和/或从而改变表面的至少一部分的化学成分。在一组实施方案中，连接到表面的分子可以包括在表面上形成自组装单层的分子。在一些实施方案中，附着于表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），通过该分子可以使分子附着于表面。在某些情况下，分子可以在一个或多个亲水基团例如未改性的乙二醇部分的非附着端封端。在一些情况下，附着于表面的分子可以包括可结合各种实体的一个或多个部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，该技术用于使新的测定方法用于确定有效增加或减少细胞形状变化和/或表面活力的药物和/或治疗的细胞运动性和/或扩散和筛选试验。

85. 发明申请

US20060040280A1 Functionalized materials and methods of using same 审中-公开
标题翻译：官能化材料及其使用方法
公开(公告)号：US20060040280A1
公开(公告)日：2006-02-23
申请号：US11085023
申请日：2005-03-15
申请人： William Lee , Saito Kyoichi
发明人： William Lee , Saito Kyoichi
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01D15/00 , B01D15/08 , B01D15/361 , B01J20/261 , B01J20/265 , B01J20/28014 , B01J20/28021 , B01J20/28023 , B01J20/28033 , B01J20/286 , B01J20/289 , B01J20/3208 , B01J20/321 , B01J20/3217 , B01J20/3219 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J20/3285 , B01J20/3289 , B01J2220/54 , B01J2220/64 , C07H21/00 , G01N33/54366 , G01N33/545
摘要： Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushers further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.
摘要翻译：本文提供了包含具有嵌入的聚合物刷的基材的组合物。聚合物刷子还包含一个或多个在多个层中沿刷子表面固定的官能团，其赋予基材组合物功能性能。使用这些组合物的方法包括样品溶液的脱氧，样品溶液中变性剂的水解，样品溶液中的外消旋混合物的拆分，以及目标化合物的浓缩。

86. 发明申请

US20050267295A1 Method for selective removal of a substance from samples containing compounds having nucleic acid structure 审中-公开
标题翻译：从含有具有核酸结构的化合物的样品中选择性去除物质的方法
公开(公告)号：US20050267295A1
公开(公告)日：2005-12-01
申请号：US11076477
申请日：2005-03-09
申请人： Makonnen Belew , Jan Bergstrom , Rolf Berglund , Lennart Soderberg
发明人： Makonnen Belew , Jan Bergstrom , Rolf Berglund , Lennart Soderberg
IPC分类号： C12N15/09 , B01D15/00 , B01D15/08 , B01D15/36 , B01J20/32 , B01J41/20 , C12N15/10 , C07H21/04
CPC分类号： B01J20/3293 , B01D15/363 , B01J20/321 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J41/20 , C12N15/1003
摘要： A method for purifying a desired substance by separating from each other a substance (I) from a substance (II), one of which is the desired substance, both of which have affinity for the same ligand structure, and wherein substance (I) is smaller than substance (II). The method comprising the steps of: (i) providing substances I and II in a liquid; (ii) contacting the liquid with an adsorbent which selectively adsorbs substance I; (iii) recovering the desired substance; The adsorbent has (a) an interior part which carries a ligand structure that is capable of binding to substances I and II, and is accessible to substance I, and (b) an outer surface layer that does not adsorb substance II, and is more easily penetrated by substance I than by substance II.
摘要翻译：通过从物质（II）彼此分离出物质（I）的方法，其中一种物质（II）是所需物质，两者对相同的配体结构具有亲和性，并且其中物质（I）为小于物质（II）。该方法包括以下步骤：（i）在液体中提供物质I和II; （ii）使液体与选择性吸附物质I的吸附剂接触; （iii）回收所需物质; 吸附剂具有（a）内部部分，其携带能够结合物质I和II的物质I可接近的配体结构，和（b）不吸附物质II的外表面层，并且更多物质I易于被物质II渗透。

87. 发明申请

US20050239041A1 Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products 审中-公开
标题翻译：用于降低血液制品中促炎症或抗炎刺激物或介质的水平的装置，系统和方法
公开(公告)号：US20050239041A1
公开(公告)日：2005-10-27
申请号：US11105140
申请日：2005-04-13
申请人： James Brady , James Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank Norris , Peter Quartararo , Jamie Salsberg
发明人： James Brady , James Winchester , Vadim Davankov , Maria Tsyurupa , Ludmila Pavlova , Frank Norris , Peter Quartararo , Jamie Salsberg
IPC分类号： A01N1/02 , A61B20060101 , A61M1/14 , A61M1/16 , A61M1/28 , A61M1/34 , A61M1/36 , B01D15/00 , B01D15/04 , B01D39/04 , B01D61/00 , B01D61/24 , B01J20/26 , B01J20/32
CPC分类号： A61M1/3679 , A01N1/02 , A01N1/0226 , A61M1/16 , A61M1/1678 , A61M1/1686 , A61M1/169 , A61M1/1696 , A61M1/1698 , A61M1/28 , A61M1/281 , A61M1/284 , A61M1/34 , A61M1/3403 , A61M1/3486 , A61M1/3681 , B01D39/04 , B01J20/26 , B01J20/261 , B01J20/321 , B01J20/327 , B01J20/3272 , B01J20/3293
摘要： Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.
摘要翻译：装置，系统和方法通过选择性吸附降低血液中促炎症或抗炎刺激物或介质的水平。器官，系统和方法适用于在促炎症或抗炎刺激物或介质发生异常水平或不协调或过度相互作用的情况下，或在诱导或有可能引起异常生产促炎症炎性或抗炎刺激物或介质。装置，系统和方法用于预防，控制，减少或减轻与促炎症或抗炎刺激剂或介体的异常水平或不协调或过度相互作用相关的炎症反应和疾病状态的严重性。

88. 发明申请

US20050098501A1 Use of a composite polymer-coated sorbent for separation, purification, desalting and concentration of biopolymers 有权
标题翻译：使用复合聚合物涂覆的吸附剂分离，纯化，脱盐和浓缩生物聚合物
公开(公告)号：US20050098501A1
公开(公告)日：2005-05-12
申请号：US10936723
申请日：2004-09-09
申请人： Robert-Matthias Leiser , Lutz Plobner , Elena Yaroshevskaya , Vitali Zubov , Dmitry Kapustin , Elena Yagudaeva
发明人： Robert-Matthias Leiser , Lutz Plobner , Elena Yaroshevskaya , Vitali Zubov , Dmitry Kapustin , Elena Yagudaeva
IPC分类号： B01D15/08 , B01J20/32 , C07K1/16
CPC分类号： B01J20/3272 , B01D15/08 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J2220/58 , B01J2220/62 , B01J2220/84 , C07K1/16
摘要： Use of a composite sorbent having an at least partial coating on a support, which coating comprises essentially polyanilines or derivatives of polyanilines for the separation, isolation, identification, purification and/or detection of biomolecules in particular nucleic acids, proteins, polysaccharides in analytical or preparative scale.
摘要翻译：在载体上具有至少部分涂层的复合吸附剂的使用，该涂层基本上包含聚苯胺或聚苯胺衍生物，用于分离，分离，鉴定，纯化和/或检测生物分子，特别是分析中的核酸，蛋白质，多糖，或制备规模。

89. 发明申请

US20050079554A1 Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications 有权
公开(公告)号：US20050079554A1
公开(公告)日：2005-04-14
申请号：US10956825
申请日：2004-10-01
申请人： Edward Watson , Kenneth Heuermann , John Dapron
发明人： Edward Watson , Kenneth Heuermann , John Dapron
IPC分类号： G01N33/543 , B01D15/00 , B01J20/24 , B01J20/28 , B01J20/286 , B01J20/32 , C07K1/22 , C12Q1/68 , G01N21/78 , G01N27/447 , G01N33/53 , G01N33/548
CPC分类号： B01J20/286 , B01D15/00 , B01D15/3804 , B01D15/3809 , B01D15/3823 , B01J20/28004 , B01J20/321 , B01J20/3212 , B01J20/3274 , B01J20/3282 , C07K1/22 , C12Q1/6837 , G01N33/543 , G01N33/54313 , G01N33/582
摘要： An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an affinity ligand other than the dye attached to a fraction of the polymeric support for the capture of a molecule. Also provided is a method for the isolation of a biomolecule from an aqueous solution. The method comprises combining the aqueous solution with an affinity matrix comprising a polymeric support and separating the affinity matrix from the aqueous solution. A dye is attached to a fraction of the polymeric support which enables optical detection and monitoring of the affinity matrix and, accordingly, reduces the likelihood of the loss of affinity matrix during the separation step. In addition, an affinity ligand other than the dye is also attached to a fraction of the polymeric support for the capture of the biomolecule.

90. 发明申请

US20050043522A1 Separation method 有权
标题翻译：分离方法
公开(公告)号：US20050043522A1
公开(公告)日：2005-02-24
申请号：US10499883
申请日：2002-12-17
申请人： Jean-Luc Maloisel
发明人： Jean-Luc Maloisel
IPC分类号： G01N30/88 , B01D15/08 , B01D15/36 , B01J20/281 , B01J20/285 , B01J20/32 , C07K1/16 , G01N30/02 , G01N30/16 , G01N30/26 , G01N30/34 , C07K1/10
CPC分类号： B01J20/262 , B01D15/368 , B01D15/3847 , B01J20/265 , B01J20/285 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3253 , B01J20/3255 , C07K1/16
摘要： The present invention relates to a method of separating a compound from a liquid, which method comprises providing a separation matrix comprising at least one uncharged ligand; providing a liquid wherein the compound to be separated is present in a positively charged state; contacting said matrix with said liquid to adsorb the compound; and removing the liquid. The uncharged ligands possess a quadrupole or dipole moment, allowing for a cation-π interaction between the compound and the ligand. The present invention also encompasses the use of a separation matrix, which comprises an uncharged group that possesses a quadrupole or dipole moment, in said method.
摘要翻译：本发明涉及从液体中分离化合物的方法，该方法包括提供包含至少一种不带电配位体的分离基质; 提供其中待分离的化合物以带正电的状态存在的液体; 使所述基质与所述液体接触以吸附化合物; 并除去液体。不带电荷的配体具有四极或偶极矩，允许化合物和配体之间的阳离子-Ip相互作用。本发明还包括在所述方法中使用分离基质，其包含具有四极或偶极矩的不带电荷的基团。

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