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81. 发明授权

US6162603A Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system 失效
标题翻译：与发色团和荧光团缀合的多核苷酸的杂交以产生供体到供体的能量转移系统
公开(公告)号：US6162603A
公开(公告)日：2000-12-19
申请号：US123638
申请日：1998-07-28
申请人： Michael J. Heller
发明人： Michael J. Heller
IPC分类号： G01N33/533 , C07H21/00 , C09B69/10 , C09K11/06 , C12N15/09 , C12Q1/68 , G01N33/566 , G06N3/12 , G11B7/0037 , G11B7/0045 , G11B7/005 , G11B7/244 , G11B7/246 , G11C13/02 , G11C13/04 , H01L21/98 , C07H21/02 , G01N27/00
CPC分类号： G11C13/0019 , B01J2219/00536 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B82Y10/00 , C12Q1/6818 , C12Q1/686 , G06N3/123 , G11B7/244 , G11B2007/24624 , G11C13/0014 , G11C13/04 , H01L24/95 , H01L25/50 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01012 , H01L2924/01013 , H01L2924/01019 , H01L2924/0102 , H01L2924/01023 , H01L2924/01025 , H01L2924/01032 , H01L2924/01033 , H01L2924/01039 , H01L2924/01043 , H01L2924/01044 , H01L2924/01054 , H01L2924/0106 , H01L2924/01074 , H01L2924/01075 , H01L2924/01076 , H01L2924/01077 , H01L2924/01079 , H01L2924/01082 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , Y10S435/80 , Y10S436/80 , Y10T436/13 , C12Q2531/113 , C12Q2565/101 , C12Q2563/107 , H01L2924/00
摘要： The present invention contemplates chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one fluorescing acceptor chromophore operatively linked to the polynucleotide by a linker arm, such that the fluorescing acceptor chromophore is positioned by linkage at a donor-acceptor transfer distance from at least one of the donor chromophores, to form a photonic structure for collecting photonic energy and transferring the energy to an acceptor chromophore, and methods using the photonic structures.
摘要翻译：本发明考虑了具有至少两个供体生色团的含发色团的多核苷酸，其通过接头臂与多核苷酸可操作地连接，使得通过以供体 - 供体转移距离沿多核苷酸的长度连接定位发色团，并且至少一种发荧光接受体发色团，其通过连接臂与多核苷酸可操作地连接，使得荧光受体发色团通过以至少一个供体发色团的供体 - 受体转移距离连接而定位，以形成用于收集光子能量并转移能量到受体发色团，以及使用光子结构的方法。

82. 发明授权

US6143455A Use of aluminum azo complex dyes as charge control agents 失效
标题翻译：使用铝偶氮配合物染料作为电荷控制剂
公开(公告)号：US6143455A
公开(公告)日：2000-11-07
申请号：US354806
申请日：1999-07-16
申请人： Hans-Tobias Macholdt , Ruediger Baur
发明人： Hans-Tobias Macholdt , Ruediger Baur
IPC分类号： G03G9/097 , C09B45/12 , C09B45/22 , C09B45/32 , C09D5/03 , C09D11/00 , G02B5/22 , G03G5/06 , G03G9/09 , B32B15/02 , G03F9/00 , G11C13/02
CPC分类号： G03G9/091 , C09B45/22 , C09D5/034 , G02B5/22 , Y10T428/2982
摘要： Aluminum azo complex dyes of the formula (I) or (I') ##STR1## are used as charge control agents in electrophotographic toners and developers, powder coating materials, electret materials, color filters, electrostatic separation processes and in inkjet inks.
摘要翻译：在电子照相调色剂和显影剂，粉末涂料，驻极体材料，滤色器，静电分离方法和喷墨油墨中使用式（I）或（I'）的铝偶氮配合物染料作为电荷控制剂。

83. 发明授权

US6124102A Methods for determining receptor-ligand binding using probe arrays 失效
标题翻译：使用探针阵列测定受体 - 配体结合的方法
公开(公告)号：US6124102A
公开(公告)日：2000-09-26
申请号：US63936
申请日：1998-04-21
申请人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
发明人： Stephen P. A. Fodor , Lubert Stryer , James L. Winkler , Christopher P. Holmes , Dennis W. Solas
IPC分类号： B01J19/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K17/06 , C07K17/14 , C08F2/46 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G01N21/25 , G01N21/64 , G03F7/00 , G03F7/004 , G03F7/26 , G03F7/38 , G11C13/02 , G01N33/53 , C07H19/00 , C07H21/04 , G09G3/06 , G09G5/00
CPC分类号： G01N21/6452 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K17/06 , C07K17/14 , C07K7/06 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B80/00 , G01N21/253 , G01N21/6428 , G03F7/00 , G03F7/0045 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6458 , Y02P20/55 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809
摘要： The invention provides a method for analyzing the binding between a receptor and ligand using a probe array. The method generally involves contacting a labeled receptor with a substrate that includes a plurality of known locations to permit labeled receptor/ligand complexes to form. Intensity values based upon signal generated from bound labeled receptor are determined for a plurality of pixels within each of the known locations. A subset of pixels within each known location that fall within a statistical norm of intensity values for all the pixels within the known location is identified using a computer and then utilized to determine relative binding.
摘要翻译：本发明提供了使用探针阵列分析受体和配体之间的结合的方法。该方法通常包括使标记的受体与包含多个已知位置的底物接触以允许标记的受体/配体复合物形成。针对每个已知位置内的多个像素，确定基于从绑定的标记受体产生的信号的强度值。使用计算机识别属于已知位置内所有像素的强度值的统计范围内的每个已知位置内的像素子集，然后用于确定相对绑定。

84. 发明授权

US6055180A Electrically addressable passive device, method for electrical addressing of the same and uses of the device and the method 有权
标题翻译：可寻址的无源器件，其电气寻址方法以及器件的使用和方法
公开(公告)号：US6055180A
公开(公告)日：2000-04-25
申请号：US147680
申请日：1999-02-12
申请人： Hans Gude Gudesen , Per-Erik Nordal , Geirr Ivarsson Leistad
发明人： Hans Gude Gudesen , Per-Erik Nordal , Geirr Ivarsson Leistad
IPC分类号： G11C11/42 , G11C11/21 , G11C13/00 , G11C13/02 , G11C13/04 , G11C16/02 , G11C17/00 , G11C17/14 , H03K19/12 , H03K19/14 , G11C11/36
CPC分类号： G11C13/0014 , B82Y10/00 , G11C13/0016 , G11C13/04 , G11C17/00 , G11C17/14 , G11C17/165 , G11C17/16 , G11C2213/71 , G11C2213/77
摘要： An electrically addressable passive device for registration, storage and/or processing of data comprises a functional medium (1) in the form of a continuous or patterned structure (S) which may undergo a physical or chemical change of state. The functional medium (1) comprises individually addressable cells (2) which represent a registered or detected value or are assigned a predetermined logical value for the cell. The cell (2) is provided between the anode (3) and cathode (4) in an electrode means (E) which contacts the function medium in the cell and causes an electrical coupling therethrough, the functional medium having a non-linear impedance characteristic, whereby the cell (2) directly can be supplied with energy which effects a change in the state of the cell. In a method for electrical addressing of the passive device wherein the addressing comprises operations for i.a. detection and registration as well as further operations for writing, reading and switching of a logical value assigned to the cell, electric energy is applied directly to the functional medium of the cell in order to change its state and hence effect an addressing operation. Use in optical detector means, volumetric data storage devices or data processing devices.
摘要翻译： PCT No.PCT / NO98 / 00185 Sec。 371日期1999年2月12日 102（e）1999年2月12日PCT PCT。1998年6月17日PCT公布。公开号WO98 / 58383 日期1998年12月23日用于数据的配准，存储和/或处理的电可寻址无源器件包括可能经历物理或化学状态变化的连续或图案化结构（S）形式的功能介质（1）。功能介质（1）包括单独的可寻址单元（2），其表示已注册或检测到的值，或者为该单元分配了预定的逻辑值。电池（2）设置在阳极（3）和阴极（4）之间的电极装置（E）中，电极装置（E）与电池中的功能介质接触并引起电耦合，功能介质具有非线性阻抗特性，从而可以直接向电池（2）提供影响电池状态变化的能量。在一种用于无源器件的电寻址的方法中，其中所述寻址包括对于i.a的操作。检测和注册以及分配给单元的逻辑值的写入，读取和切换的进一步操作，将电能直接施加到单元的功能介质，以便改变其状态，从而实现寻址操作。用于光检测装置，体积数据存储装置或数据处理装置。

85. 发明授权

US6046925A Photochromic fluorescent proteins and optical memory storage devices based on fluorescent proteins 失效
标题翻译：基于荧光蛋白的光致变色荧光蛋白和光学记忆存储装置
公开(公告)号：US6046925A
公开(公告)日：2000-04-04
申请号：US839685
申请日：1997-04-14
申请人： Roger Y. Tsien , Roger Heim , Andrew B. Cubitt , Robert M. Dickson , William E. Moerner
发明人： Roger Y. Tsien , Roger Heim , Andrew B. Cubitt , Robert M. Dickson , William E. Moerner
IPC分类号： C07K14/435 , G11B7/0045 , G11B7/005 , G11B7/0055 , G11B7/244 , G11B7/26 , G11C11/56 , G11C13/02 , G11C13/04
CPC分类号： G11C13/0019 , B82Y10/00 , C07K14/43595 , G11B7/00455 , G11B7/0052 , G11B7/244 , G11B7/26 , G11C11/5664 , G11C13/0014 , G11C13/04 , G11B2007/24624 , G11B7/00552
摘要： Photochromic fluorescent protein moiety having two or more stable states having excitation or emission spectra that are shifted from one wavelength region to another wavelength region in the two states are described. The photochromic material switches between states by irradiation with light of appropriate wavelengths. The two states are preferably stable at room temperature and in the dark. The switching between states can be reversible.
摘要翻译：描述具有两个或更多个稳定状态的光致变色荧光蛋白部分，其具有在两种状态下从一个波长区域移动到另一个波长区域的激发或发射光谱。光致变色材料通过用适当波长的光照射而在状态之间切换。两个状态优选在室温下和黑暗中稳定。状态之间的切换可以是可逆的。

86. 发明授权

US6025129A Remotely programmable matrices with memories and uses thereof 失效
标题翻译：具有存储器及其用途的远程可编程矩阵
公开(公告)号：US6025129A
公开(公告)日：2000-02-15
申请号：US567746
申请日：1995-12-05
申请人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David
发明人： Michael P. Nova , Andrew E. Senyei , Zahra Parandoosh , Gary S. David
IPC分类号： B01J19/00 , B01L3/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , C12Q1/68 , C07H21/04 , C12P19/34 , G01N33/53
CPC分类号： G11C13/0014 , B01J19/0046 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , G01N35/00732 , G01N35/00871 , G11C13/0019 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0609 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

87. 发明授权

US5925562A Remotely programmable matrices with memories 失效
公开(公告)号：US5925562A
公开(公告)日：1999-07-20
申请号：US480196
申请日：1995-06-07
申请人： Michael P. Nova , Andrew E. Senyei , Gary S. David
发明人： Michael P. Nova , Andrew E. Senyei , Gary S. David
IPC分类号： B01J19/00 , B01L3/00 , C07K1/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N15/14 , G01N35/00 , G11C13/02 , G01N33/50 , G01B13/14 , G01N33/566
CPC分类号： G01N35/00732 , B01J19/0046 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , G01N35/00871 , G11C13/0014 , G11C13/0019 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N2015/149 , G01N2035/00782 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are preferably non-volatile antifuse memories. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, chemical modification and other uses.

88. 发明授权

US5925525A Method of identifying nucleotide differences 失效
标题翻译：识别核苷酸差异的方法
公开(公告)号：US5925525A
公开(公告)日：1999-07-20
申请号：US54420
申请日：1998-04-03
申请人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
发明人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/004 , G03F7/26 , G03F7/38 , G11C13/02 , C07H21/02 , C07H21/04
CPC分类号： G11C13/0019 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6874 , G03F7/00 , G03F7/0045 , G03F7/265 , G03F7/38 , G11C13/0014 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
摘要翻译：本发明提供了用于测序，指纹和绘制生物大分子（通常为生物聚合物）的方法和装置。该方法利用多种序列特异性识别试剂，其也可用于生物样品的分类和表征其来源。

89. 发明授权

US5922843A Analog bacteriorhodopsin molecules 失效
标题翻译：模拟细菌视紫红质分子
公开(公告)号：US5922843A
公开(公告)日：1999-07-13
申请号：US731328
申请日：1996-10-15
申请人： Eric Hock Lye Tan , Robert R. Birge
发明人： Eric Hock Lye Tan , Robert R. Birge
IPC分类号： G11C13/02 , C07K13/00
CPC分类号： G11C13/0019 , B82Y10/00 , G11C13/0014 , G11C13/04 , Y10S530/825
摘要： A method of preparing an analog of bacteriorhodopsin in which organic cations selectively replace calcium and magnesium cations. The method comprises preparing a cation-free blue membrane and incubating the blue membrane with an organic cation selected from the group consisting of monovalent quaternary ammonium cations, bolaform cations and pyridinal cations.
摘要翻译：制备细菌视紫红质的类似物的方法，其中有机阳离子选择性地取代钙和镁阳离子。该方法包括制备无阳离子的蓝色膜并将蓝色膜与选自单价季铵阳离子，沸点阳离子和吡啶基阳离子的有机阳离子一起孵育。

90. 发明授权

US5883397A Plastic functional element 失效
标题翻译：塑料功能元件
公开(公告)号：US5883397A
公开(公告)日：1999-03-16
申请号：US862741
申请日：1997-05-23
申请人： Satoru Isoda , Hiroaki Kawakubo , Satoshi Nishikawa , Kouichi Akiyama
发明人： Satoru Isoda , Hiroaki Kawakubo , Satoshi Nishikawa , Kouichi Akiyama
IPC分类号： H01L51/05 , A61N1/372 , B82Y10/00 , G02F1/15 , G11C7/00 , G11C13/02 , H01G9/20 , H01G9/22 , H01L21/336 , H01L21/8247 , H01L29/788 , H01L29/792 , H01L29/86 , H01L51/30 , H01L35/24 , H01L51/00
CPC分类号： H01G9/22 , B82Y10/00 , G11C13/0014 , G11C13/0016 , G11C7/005 , H01G11/02 , H01G11/12 , H01G11/26 , H01G9/20 , H01L51/0595 , Y02E60/13
摘要： A plastic functional element comprising a lower electrode and a transparent upper electrode provided perpendicular to the contact surface between a first oxidation reduction material membrane and a second oxidation reduction material membrane, the oxidation reduction potentials of which being different each other, wherein, based on the difference in oxidation reduction potentials between the oxidation reduction material membranes, by irradiating light to the contact surface or applying a voltage between the electrodes, the condition of electron in the oxidation reduction material is controlled, so as to store information of incident light or applied voltage, and an operational function responding to an input voltage is given, thereby the minimization in size is possible to realize a high density and high speed operation.
摘要翻译：一种塑料功能元件，包括下电极和透明上电极，其垂直于第一氧化还原材料膜和第二氧化还原材料膜之间的接触表面设置，其氧化还原电位彼此不同，其中，基于氧化还原材料膜之间的氧化还原电位差异，通过向接触表面照射光或在电极之间施加电压，控制氧化还原材料中的电子状态，以便存储入射光或施加电压的信息并且给出响应于输入电压的操作功能，从而可以实现最小化的尺寸以实现高密度和高速度操作。

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