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1. 发明授权

US09200284B2 Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA 有权
标题翻译：通过不对称双链RNA特异性抑制KRAS的方法和组合物
公开(公告)号：US09200284B2
公开(公告)日：2015-12-01
申请号：US13738024
申请日：2013-01-10
申请人： Dicerna Pharmaceuticals, Inc.
发明人： Bob D. Brown
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1135 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for reducing KRAS target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA) agents possessing asymmetric end structures.
摘要翻译：本发明涉及通过使用具有不对称末端结构的Dicer底物siRNA（DsiRNA）试剂来减少KRAS靶RNA和蛋白质水平的化合物，组合物和方法。

2. 发明授权

US09024071B2 Therapeutic compounds 有权
标题翻译：治疗化合物
公开(公告)号：US09024071B2
公开(公告)日：2015-05-05
申请号：US13318877
申请日：2010-05-05
申请人： Raymond G. Booth
发明人： Raymond G. Booth
IPC分类号： C07C211/00 , C07C211/42 , A61K31/13
CPC分类号： C07C211/42 , A61K31/13 , C07C217/74 , C07C2601/14 , C07C2602/10
摘要： The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs.
摘要翻译：本发明涉及蛋白质结合相互作用/结合化合物以及鉴定和使用它们的方法。本发明还涉及用于治疗5-HT2C和/或RSK病症的药物组合物和方法，包括由GPCR和/或RSK介导的疾病和病症。

3. 发明授权

US09002529B2 Power control method and device 有权
标题翻译：功率控制方法及装置
公开(公告)号：US09002529B2
公开(公告)日：2015-04-07
申请号：US13513326
申请日：2010-12-02
申请人： Hee Sang Ko , Jung Hoon Kim , Won Deok Baek , Tai Yeon Cho
发明人： Hee Sang Ko , Jung Hoon Kim , Won Deok Baek , Tai Yeon Cho
IPC分类号： G06F19/00 , H02J3/50 , H02J3/16
CPC分类号： H02J3/50 , H02J3/16 , H02J3/386 , Y02E10/763 , Y02E40/34
摘要： The present invention discloses a method and an apparatus for power control. An apparatus for power control in accordance with an embodiment of the present invention can include: a voltage comparing part configured to compute an error voltage by using a measured voltage measured at the generator and a reference voltage that is designated; a control module configured to compute a first reactive power value for power control of the generator by being inputted with the error voltage; and a driving module configured to compute a reference reactive power value by using the first reactive power value and a second reactive power value computed using an active power value of the power converter and configured to control the power converter in correspondence with the computed reference reactive power value.
摘要翻译：本发明公开了一种用于功率控制的方法和装置。根据本发明的实施例的用于功率控制的装置可以包括：电压比较部件，被配置为通过使用在发电机处测量的测量电压和指定的参考电压来计算误差电压; 控制模块，被配置为通过输入所述误差电压来计算所述发电机的功率控制的第一无功功率值; 以及驱动模块，被配置为通过使用所述第一无功功率值和使用所述功率转换器的有功功率值计算的第二无功功率值来计算参考无功功率值，并且被配置为根据所计算的参考无功功率来控制所述功率转换器值。

4. 外观设计

USD724470S1 Expandable bangle with double end-beads 有权
标题翻译：带双端珠的可扩展手镯
公开(公告)号：USD724470S1
公开(公告)日：2015-03-17
申请号：US29457620
申请日：2013-06-11
申请人： Alex and Ani, LLC
设计人： Carolyn Rafaelian

5. 发明授权

US08956534B2 Passive column pre-heater with sample band spreading reduction feature 有权
公开(公告)号：US08956534B2
公开(公告)日：2015-02-17
申请号：US11631730
申请日：2005-08-05
申请人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
发明人： Edward J. Ognibene , Joseph A. Kareh , Uwe D. Neue , Theodore D. Ciolkosz , Richard W. Andrews , Marc Lemelin , Peyton C. Beals
IPC分类号： G01N30/30 , B01D15/20 , B01D15/12 , B01D15/16
CPC分类号： B01D15/161 , B01D15/12 , B01D15/20 , G01N30/30 , G01N2030/3046
摘要： Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column. The thermally conductive film conveys heat from an active heating source of a chromatographic column to the convoluted tube when the pre-heater assembly is positioned adjacent to the active heating source. The central fluid passage in the convoluted tube has a series of bends which function to create a secondary fluid flow field that is substantially orthogonal to a primary flow field established when fluid is traversing the fluid passage in the tube.

6. 发明授权

US08951486B2 Valuable metal extraction agent and valuable metal extraction method using said extraction agent 有权
标题翻译：有价值的金属提取剂和有价值的金属提取方法使用所述提取剂
公开(公告)号：US08951486B2
公开(公告)日：2015-02-10
申请号：US14001832
申请日：2012-11-02
申请人： Kyushu University, National University Corporation , Sumitomo Metal Mining Co., Ltd.
发明人： Masahiro Goto , Fukiko Kubota , Yuzo Baba
IPC分类号： C01F17/00 , C07C237/06 , C22B3/26 , C22B59/00 , C22B23/00 , C22B3/00 , C07D233/26 , H01M8/00
CPC分类号： C22B23/0461 , B01D11/00 , C01F17/0006 , C07C237/06 , C07D233/26 , C22B3/0005 , C22B3/0032 , C22B23/00 , C22B23/0453 , C22B59/00 , H01M8/008 , H01M10/54 , Y02P10/234 , Y02W30/84 , Y02W30/86
摘要： The objective of the present invention is to selectively extract light rare earth metals, and by extension, europium, from an acidic solution containing a plurality of types of rare earth metal. This valuable metal extraction agent is represented by the general formula. In the formula: R1 and R2 each indicate the same or different alkyl group; R3 indicates a hydrogen atom or an alkyl group; and R4 indicates a hydrogen atom or any given group other than an amino group bonded to the α carbon as an amino acid. Preferably, the general formula has a glycine unit, a histidine unit, a lysine unit, an aspartic acid unit, or an N-methylglycine unit. Preferably, when extracting europium using the extraction agent, the pH is adjusted into the range of 2.0-3.0 inclusive, and when selectively extracting light rare earth metals, the pH is adjusted to 1.7-2.7 inclusive.
摘要翻译：本发明的目的是从含有多种类型的稀土金属的酸性溶液中选择性地提取轻稀土金属，并延伸铕。这种有价值的金属提取剂由通式表示。式中R1和R2各自表示相同或不同的烷基; R3表示氢原子或烷基; R 4表示氢原子或与作为氨基酸的α碳键合的氨基以外的任意给定基团。优选地，通式为甘氨酸单元，组氨酸单元，赖氨酸单元，天冬氨酸单元或N-甲基甘氨酸单元。优选地，当使用提取剂提取铕时，将pH调节到2.0-3.0的范围内，并且当选择性提取轻稀土金属时，将pH调节至1.7-2.7（含）。

7. 发明授权

US08951302B2 Biomimetic vascular network and devices using the same 有权
标题翻译：生物模拟血管网和使用该装置的装置
公开(公告)号：US08951302B2
公开(公告)日：2015-02-10
申请号：US12576826
申请日：2009-10-09
申请人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
发明人： Howard I. Pryor , Ira Spool , David M. Hoganson , Joseph P. Vacanti , Jeffrey T. Borenstein
IPC分类号： A61F2/04 , A61F2/06 , G01N33/50
CPC分类号： A61F2/06 , A61F2/022 , A61F2/04 , A61F2/062 , A61F2002/068 , G01N33/5008 , G06F19/00
摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.
摘要翻译：本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。

8. 发明授权

US08949973B2 Image processing apparatus 有权
标题翻译：图像处理装置
公开(公告)号：US08949973B2
公开(公告)日：2015-02-03
申请号：US12079541
申请日：2008-03-27
申请人： Akiko Nagata
发明人： Akiko Nagata
IPC分类号： H04L9/32 , H04L29/06 , G06F21/34 , G06F21/82 , H04N1/00 , H04N1/44
CPC分类号： H04L63/083 , G06F21/34 , G06F21/82 , G06F2221/2149 , H04N1/00204 , H04N1/00514 , H04N1/4413 , H04N1/4433 , H04N2201/0039 , H04N2201/0094
摘要： An image processing apparatus is provided that is capable of displaying a customized screen without requiring direct input operations to the image processing apparatus. The image processing apparatus (for example, a multi-function peripheral, or MFP) is communicably connected to an information processing apparatus (for example, a personal computer, or PC) and includes a displaying portion. The MFP acquires user information related to a login user who logs in to the PC, authenticates based on the acquired user information to determine whether the login user is a usage permitted user who is permitted to use the MFP, and displays a customized screen corresponding to the login user on the displaying portion of the MFP when the login user is authenticated as the usage permitted user.
摘要翻译：提供一种图像处理装置，其能够显示定制的屏幕，而不需要对图像处理装置的直接输入操作。图像处理装置（例如，多功能外围设备或MFP）可通信地连接到信息处理装置（例如，个人计算机或PC），并且包括显示部分。 MFP获取与登录到PC的登录用户相关的用户信息，基于获取的用户信息进行认证，以确定登录用户是否被允许使用MFP的使用许可用户，并且显示对应于当登录用户被认证为使用许可用户时，MFP的显示部分上的登录用户。

9. 发明授权

US08949259B2 Systems, methods, software, and interfaces for analyzing, mapping, and depicting search results in a topical space 有权
标题翻译：系统，方法，软件和界面，用于在主题空间中分析，映射和描绘搜索结果
公开(公告)号：US08949259B2
公开(公告)日：2015-02-03
申请号：US11469426
申请日：2006-08-31
申请人： James E. Brei
发明人： James E. Brei
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30864 , G06F17/30651 , G06F17/30696
摘要： The present inventor devised, among other things, information retrieval systems, methods, software, and related interfaces that help users assess and if necessary bolster the quality of their manual selections from search results. One exemplary system receives a set of documents selected from search results for an input query, identifies key subjects in the selected documents, and outputs a graphic, such as a pie chart, that shows not only how well these selected documents relate to the query, but also whether there are gaps in the topical scope of the selected documents related to the input query.
摘要翻译：本发明人设计了诸如帮助用户评估信息检索系统，方法，软件和相关接口，并且如果必要的话，可以从搜索结果提高其手动选择的质量。一个示例性系统接收从用于输入查询的搜索结果中选择的一组文档，识别所选择的文档中的关键主题，并且输出诸如饼图的图形，其不仅显示了这些所选文档与查询的关联程度，而且与输入查询相关的选定文档的主题范围是否存在差距。

10. 发明授权

US08948792B2 Moving body and system for managing inventory information of moving body 有权
标题翻译：移动身体和系统，用于管理移动体的库存信息
公开(公告)号：US08948792B2
公开(公告)日：2015-02-03
申请号：US13263185
申请日：2010-04-06
申请人： Shuuji Arakawa
发明人： Shuuji Arakawa
IPC分类号： H04W24/00 , G08B1/08 , G08B21/00 , G06Q10/08 , G06Q10/06 , G06Q50/08 , G06Q50/28
CPC分类号： G06Q10/087 , G06Q10/06 , G06Q50/08 , G06Q50/28 , G08G1/20
摘要： An object is to easily manage inventory information of an moving body such as a work machine at each physical distribution center substantially in real time, and an moving body 1 is provided with a positional information obtaining unit 22 for obtaining positional information of the moving body 1 at a predetermined timing, an operating state information obtaining unit 23 for obtaining operating state information of the moving body 1, and an inventory information output controller 24 for transmitting management information 37 which identifies the moving body 1, area information 35 which indicates an area in which the moving body 1 is located, and stay period information 38 in which this stays in the area to a management device 2 as the inventory information when the moving body 1 is located in any of one or more areas set in advance based on the positional information.
摘要翻译：目的在于，基本上实时地容易地在每个物理配送中心管理诸如作业机械的移动体的库存信息，移动体1设置有位置信息获取单元22，用于获得移动体1的位置信息在预定定时，获取运动状态信息的操作状态信息获取单元23，以及用于发送标识移动体1的管理信息37的库存信息输出控制器24，指示移动体1的区域的区域信息35 以及移动体1位于哪一个或多个区域中的任何一个区域中的停留时间信息38，其中作为库存信息停留在管理装置2的区域中的停留期间信息38，信息。

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