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1. 发明授权

US10035790B2 RORγ modulators 有权
公开(公告)号：US10035790B2
公开(公告)日：2018-07-31
申请号：US14436355
申请日：2013-10-17
申请人： BRISTOL-MYERS SQUIBB COMPANY , EXELIXIS, INC.
发明人： Wei Xu , Yong Wang , Sunghoon Ma , Elena S. Koltun , Byung Gyu Kim , Joon Won Jeong , T. G. Murali Dhar , Lynne Canne Bannen
IPC分类号： C07D403/04 , C07D403/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D405/14 , C07D417/14
CPC分类号： C07D403/04 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof, wherein R1, R2, R3, R4, R5, R6, Ra, x, y, L, G, Z, the bond denoted by “q”, the ring system denoted by “A” and the ring system denoted by “B” are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORy activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORy activity, for example, autoimmune and/or inflammatory disorders.

2. 发明授权

US09956205B2 Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and uses thereof 有权
公开(公告)号：US09956205B2
公开(公告)日：2018-05-01
申请号：US15150053
申请日：2016-05-09
申请人： Ardea Biosciences, Inc.
发明人： Laszlo R. Treiber , Irina Zamansky , Jean-Luc Girardet
IPC分类号： A61K31/4196 , C07D249/12 , A61K31/426 , A61K31/522 , A61K31/519 , C07D249/06
CPC分类号： A61K31/4196 , A61K31/426 , A61K31/519 , A61K31/522 , C07D249/06 , C07D249/12
摘要： Crystalline polymorph forms of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of a variety of diseases and conditions are also presented.

3. 发明授权

US09320942B2 Golf ball with cover layer having zones of differing materials 有权
标题翻译：高尔夫球带覆盖层，具有不同材质的区域
公开(公告)号：US09320942B2
公开(公告)日：2016-04-26
申请号：US13337989
申请日：2011-12-27
申请人： Kerby LaVar Maxwell , Yasushi Ichikawa , Chia-Chyi Cheng
发明人： Kerby LaVar Maxwell , Yasushi Ichikawa , Chia-Chyi Cheng
IPC分类号： A63B37/06 , A63B37/00 , A63B37/12 , A63B45/00
CPC分类号： A63B37/0004 , A63B37/0006 , A63B37/0009 , A63B37/0011 , A63B37/0012 , A63B37/0013 , A63B37/0022 , A63B37/0024 , A63B37/0045 , A63B37/0076 , A63B37/008 , A63B37/0083 , A63B37/0092 , A63B37/12 , A63B45/00
摘要： Generally disclosed is a golf ball having a core and a cover layer. The cover layer includes areas that are hard corresponding to the dimples, and areas that are soft corresponding to the land between the dimples. The cover layer may comprise two different materials, such as polyurethane and ionomer, that are laterally adjacent to each other in the cover layer. Alternatively, the cover layer may be selectively coated with a coating material having a different hardness, such as polyurethane or ionomer. As a result of the arrangement of the hard dimples and the soft land, the golf ball achieves reduced spin, and greater distances, when struck with a larger force (such as during a dive) while also achieving increased spin, and better control, when struck with a smaller force (such as during a chip).
摘要翻译：通常公开的是具有芯和覆盖层的高尔夫球。覆盖层包括对应于凹坑的硬区域，以及对应于凹坑之间的区域的柔软区域。覆盖层可以包括在覆盖层中彼此横向相邻的两种不同的材料，例如聚氨酯和离聚物。或者，覆盖层可以选择性地涂覆具有不同硬度的涂层材料，例如聚氨酯或离聚物。由于硬凹坑和软土地的布置，高尔夫球实现减少的旋转和更大的距离，当用更大的力（例如在潜水期间）时，同时也实现增加的旋转和更好的控制，当受到较小的力（例如在芯片期间）。

4. 发明授权

US09283437B2 Golf ball having partial cured UV coating 有权
标题翻译：高尔夫球具有部分固化的UV涂层
公开(公告)号：US09283437B2
公开(公告)日：2016-03-15
申请号：US13336780
申请日：2011-12-23
申请人： Arthur P. Molinari , Bradley C. Tutmark
发明人： Arthur P. Molinari , Bradley C. Tutmark
IPC分类号： A63B37/06 , A63B37/00 , A63B43/00 , A63B45/00 , A63B45/02 , G09F23/00 , A63B71/06
CPC分类号： A63B37/0022 , A63B37/0003 , A63B37/0004 , A63B37/0074 , A63B43/008 , A63B45/00 , A63B45/02 , A63B2071/0694 , G09F23/0066
摘要： A golf ball may include a UV curable coating layer that is only partially cured upon finishing. The golf ball may be used in its partially cured state in a game of golf, where the partially cured state may be advantageous for play under wet conditions. The coating layer may then further cure upon exposure to UV light, such as ambient environmental light from the sun during a game of golf in sunny conditions. As a result of this further curing, the coating may transition to a cured state that is associated with play characteristics that are advantageous for play under sunny dry conditions.
摘要翻译：高尔夫球可以包括仅在精加工时部分固化的可UV固化涂层。高尔夫球可以在高尔夫球场的部分固化状态下使用，其中部分固化状态可能有利于在潮湿条件下玩耍。然后可以在暴露于紫外线的过程中进一步固化涂层，例如在阳光充足的条件下的高尔夫球场期间来自太阳的环境光。作为这种进一步固化的结果，涂层可以转变到与在阳光干燥条件下玩耍有利的游戏特性相关联的固化状态。

5. 发明授权

US09227368B2 Golf balls including a crosslinked thermoplastic polyurethane cover layer having improved scuff resistance 有权
标题翻译：高尔夫球包括具有改进的抗磨损性的交联热塑性聚氨酯覆盖层
公开(公告)号：US09227368B2
公开(公告)日：2016-01-05
申请号：US14133133
申请日：2013-12-18
申请人： NIKE, Inc.
发明人： Hideyuki Ishii , Yasushi Ichikawa , Chien-Hsin Chou , Hsin Cheng , Chung-Yu Huang , Chen-Tai Liu
IPC分类号： A63B37/00 , A63B37/04 , A63B37/12 , C08G18/86 , C08G18/67 , B29C70/70 , B29C45/14 , C08G18/48 , C08G18/66 , C08G18/76 , C08L75/14 , C08F299/06
CPC分类号： B29C70/70 , A63B37/0003 , A63B37/0023 , A63B37/0024 , A63B37/0031 , A63B37/0037 , A63B37/0039 , A63B37/0059 , A63B37/0061 , A63B37/0076 , A63B37/12 , B29C45/14819 , C08F299/065 , C08G18/4854 , C08G18/6674 , C08G18/675 , C08G18/7671 , C08G18/86 , C08L75/14
摘要： This disclosure relates to golf balls having a cover layer made from a crosslinked thermoplastic polyurethane elastomer. The crosslinked thermoplastic polyurethane elastomer includes crosslinks located in the hard segments, where the crosslinks being the reaction product of unsaturated bonds located in the hard segments catalyzed by a free radical initiator. The crosslinks may be formed from an unsaturated diol as a chain extender. The unsaturated diol may be trimethylolpropane monoallylether (TMPME). The cover layer may have certain properties, such as a desirable flexural modulus value and a desirable Shore D hardness value, that further contribute to the golf ball having a high degree of scuff resistance.
摘要翻译：本公开涉及具有由交联热塑性聚氨酯弹性体制成的覆盖层的高尔夫球。交联的热塑性聚氨酯弹性体包括位于硬链段中的交联，其中交联作为由自由基引发剂催化的硬链段中的不饱和键的反应产物。交联物可以由不饱和二醇作为扩链剂形成。不饱和二醇可以是三羟甲基丙烷单烯丙基醚（TMPME）。覆盖层可以具有某些特性，例如期望的弯曲模量值和期望的肖氏D硬度值，其进一步有助于具有高抗磨损性的高尔夫球。

6. 发明授权

US09193102B2 Method of making and recycling a golf ball 有权
标题翻译：制造和回收高尔夫球的方法
公开(公告)号：US09193102B2
公开(公告)日：2015-11-24
申请号：US13485619
申请日：2012-05-31
申请人： Hideyuki Ishii , Yasushi Ichikawa , Arthur Molinari , Bradley C. Tutmark , Takahisa Ono
发明人： Hideyuki Ishii , Yasushi Ichikawa , Arthur Molinari , Bradley C. Tutmark , Takahisa Ono
IPC分类号： B29C73/00 , B29C45/16 , B29B17/04 , A63B45/00 , B29L31/54 , B29B17/02 , A63B37/00
CPC分类号： A63B45/00 , A63B37/0075 , A63B37/0076 , A63B2209/00 , B29B13/022 , B29B17/0404 , B29B2017/0203 , B29B2017/0244 , B29C45/16 , B29C45/1642 , B29C45/1643 , B29K2071/00 , B29K2075/00 , B29K2086/00 , B29K2995/0037 , B29L2009/00 , B29L2031/546 , Y02W30/524 , Y02W30/622 , Y02W30/625
摘要： A method of making and recycling a golf ball is disclosed. The method may include processing a used golf ball to make the materials of the used golf ball reusable in a new golf ball. As a result, the disclosed method may decrease the waste of disposing of used golf balls and the costs associated with acquiring and/or processing new materials. The method of recycling a golf ball may generally include pulverizing used golf balls into particles. The used golf balls may be made of materials having different densities. The particles may be placed in a liquid that causes the particles of different materials to float to different levels based on the densities of the materials. At least a portion of the particles may be melted and injected into a sandwich mold to create a new golf ball.
摘要翻译：公开了制造和回收高尔夫球的方法。该方法可以包括处理使用过的高尔夫球以使所使用的高尔夫球的材料可重新使用在新的高尔夫球中。结果，所公开的方法可以减少废弃处理用过的高尔夫球以及与获取和/或处理新材料相关的成本。回收高尔夫球的方法通常可以包括将使用过的高尔夫球粉碎成颗粒。所使用的高尔夫球可以由具有不同密度的材料制成。颗粒可以放置在液体中，导致不同材料的颗粒基于材料的密度漂浮到不同的水平。可以将至少一部分颗粒熔化并注入三明治模具中以形成新的高尔夫球。

7. 发明授权

US09102825B2 Dynamically crosslinked thermoplastic material process 有权
标题翻译：动态交联热塑性材料工艺
公开(公告)号：US09102825B2
公开(公告)日：2015-08-11
申请号：US14029136
申请日：2013-09-17
申请人： NIKE, Inc.
发明人： John C. Chen
IPC分类号： C08L23/04 , C08L23/10 , C08L33/02 , C08L9/00 , C08F8/00 , B29B7/46 , C08J3/11 , C08J3/24
CPC分类号： C08L87/00 , A63B37/0018 , A63B37/0039 , A63B37/0051 , A63B37/0076 , B29B7/40 , B29B7/46 , B29B7/60 , B29B7/726 , B29B7/728 , B29B7/82 , B29B7/90 , C08F8/00 , C08J3/11 , C08J3/24 , C08J3/244 , C08J3/246 , C08J5/00 , C08J2300/22 , C08J2323/08 , C08J2347/00 , C08J2357/00 , C08J2387/00 , C08J2409/00 , C08J2447/00 , C08J2457/00 , C08J2487/00 , C08L9/00 , C08L33/02 , C08L47/00 , C08L57/00 , C08L2205/02 , C08L2207/04 , C08L2308/00 , C08L2314/02
摘要： A method for making a thermoplastic material includes: (a) partially crosslinking an elastomer composition at a first crosslinking temperature to form a thermoplastic, partially crosslinked elastomer composition; (b) mixing a thermoplastic polymer composition with the thermoplastic, partially crosslinked elastomer composition and heating the mixture to a second crosslinking temperature higher than the first crosslinking temperature, wherein the thermoplastic polymer composition is liquid at the second crosslinking temperature; and (c) continuously mixing the mixture while further crosslinking the elastomer composition to form a thermoplastic material having a dispersed phase of crosslinked elastomer composition in the thermoplastic polymer composition. The elastomer composition may include an elastomer compounded with a curing agent and optionally additional components. A thermoplastic material resulting from this process may be molded or shaped by any method used for forming thermoplastic materials into articles, such as molding, extrusion, or thermoforming.
摘要翻译：制造热塑性材料的方法包括：（a）在第一交联温度下使弹性体组合物部分交联以形成热塑性部分交联的弹性体组合物; （b）将热塑性聚合物组合物与热塑性部分交联的弹性体组合物混合并将混合物加热至高于第一交联温度的第二交联温度，其中热塑性聚合物组合物在第二交联温度下为液体; 和（c）连续混合混合物，同时进一步交联弹性体组合物以形成在热塑性聚合物组合物中具有交联弹性体组合物分散相的热塑性材料。弹性体组合物可以包括与固化剂和任选的附加组分混合的弹性体。由该方法得到的热塑性材料可以通过用于将热塑性材料形成成型，挤出或热成型的制品中的任何方法来模制或成型。

8. 发明授权

US08948848B2 Angiography catheter 有权
标题翻译：血管造影导管
公开(公告)号：US08948848B2
公开(公告)日：2015-02-03
申请号：US13311265
申请日：2011-12-05
申请人： William M Merhi
发明人： William M Merhi
IPC分类号： A61B6/00 , A61B5/05 , A61M29/00 , A61M25/098 , A61F2/01 , A61B6/12 , A61B18/14 , A61B17/00 , A61B19/00 , A61F2/24
CPC分类号： A61F2/013 , A61B6/12 , A61B18/1492 , A61B2017/00243 , A61B2090/3966 , A61F2/2433 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2230/008 , A61F2250/0098
摘要： Embolic protection devices and methods for capturing embolic debris. An embolic protection device includes a pigtail catheter having a lumen for housing a guidewire. The distal portion of the catheter has one or more apertures in fluid communication with the lumen and one or more radiopaque markers on the distal-most section. The device includes a self-expanding filter coupled to a side of the catheter and a movable outer sheath surrounding the catheter. The outer sheath holds the filter in a collapsed configuration when surrounding the filter. The outer sheath is proximally retracted to deploy the filter. A method of capturing embolic debris includes inserting a guidewire into a body lumen, tracking the device over the guidewire, retracting the guidewire, positioning the device using the radiopaque marker, retracting the outer sheath and deploying the filter, performing a procedure, and advancing the outer sheath to recapture the filter.
摘要翻译：栓塞保护装置和捕获栓塞残留物的方法。栓塞保护装置包括具有用于容纳导丝的内腔的猪尾导管。导管的远侧部分具有一个或多个与内腔流体连通的孔，以及最远部分上的一个或多个不透射线的标记。该装置包括耦合到导管侧的自扩张滤器和围绕导管的可移动外护套。当围绕过滤器时，外护套将过滤器保持在折叠构造中。外护套向近端缩回以部署过滤器。捕获栓塞残渣的方法包括将导丝插入体腔内，在导丝上跟踪装置，缩回导丝，使用不透射线的标记定位装置，缩回外护套并展开过滤器，执行程序，以及推进外护套重新捕获过滤器。

9. 发明授权

US08912335B2 PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases 有权
标题翻译：用于治疗代谢疾病的PPAR保留噻唑烷二酮盐
公开(公告)号：US08912335B2
公开(公告)日：2014-12-16
申请号：US13515508
申请日：2010-12-15
申请人： Gerard R. Colca , Steven P. Tanis , Scott D. Larsen
发明人： Gerard R. Colca , Steven P. Tanis , Scott D. Larsen
IPC分类号： C07D417/12 , C07D277/34
CPC分类号： C07D277/34 , C07D417/12
摘要： The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
摘要翻译：本发明涉及可用于治疗和/或预防代谢性疾病（例如，糖尿病或神经变性疾病（例如阿尔茨海默氏病））的噻唑烷二酮类和其它药剂的新型盐。

10. 发明授权

US08853152B2 Pharmaceutical compositions 有权
标题翻译：药物组合物
公开(公告)号：US08853152B2
公开(公告)日：2014-10-07
申请号：US12481962
申请日：2009-06-10
申请人： Kevin Bittorf , Jeffrey Kastra , Filipe Gaspar
发明人： Kevin Bittorf , Jeffrey Kastra , Filipe Gaspar
IPC分类号： A61K31/00
CPC分类号： A61K9/14 , A61K9/1652 , A61K9/1694 , A61K47/20 , A61K47/38
摘要： Methods of spray drying are described.
摘要翻译：描述了喷雾干燥的方法。

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