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1. 发明申请

US20070190640A1 Device and method for the detection of an analyte 有权
标题翻译：用于检测分析物的装置和方法
公开(公告)号：US20070190640A1
公开(公告)日：2007-08-16
申请号：US11655943
申请日：2007-01-22
申请人： Joachim Bangert , Ludwig Bar , Thomas Ehben , Hans-Dieter Feucht , Christian Zilch
发明人： Joachim Bangert , Ludwig Bar , Thomas Ehben , Hans-Dieter Feucht , Christian Zilch
IPC分类号： C12M3/00
CPC分类号： G01N33/54333 , B82Y15/00 , B82Y25/00 , H01F1/0054
摘要： A device and a method are disclosed for the detection and/or for the quantification of an analyte. In at least one embodiment, the device includes a basic matrix and magnetized nanoparticles, which are arranged in moveable fashion in or at the basic matrix and to which catcher molecules that bind specifically to the analyte are anchored. Further, the mobility of the nanoparticle in the basic matrix can be influenced by a binding of the analyte to be detected to the catcher molecules and can be read out magnetically.
摘要翻译：公开了用于检测和/或定量分析物的装置和方法。在至少一个实施方案中，该装置包括基本基质和磁化纳米颗粒，其以可移动的方式设置在碱性基质中或基本基质上，并且特异性结合分析物的捕获剂分子被锚固。此外，纳米颗粒在碱性基质中的迁移率可能受待检测的分析物与捕获剂分子的结合的影响，并且可以磁性地读出。

2. 发明申请

US20070003959A1 Oligonucleotide arrangements, processes for their employment and their use 审中-公开
标题翻译：寡核苷酸安排，就业及其使用过程
公开(公告)号：US20070003959A1
公开(公告)日：2007-01-04
申请号：US11474454
申请日：2006-06-26
申请人： Thomas Ehben , Christian Zilch
发明人： Thomas Ehben , Christian Zilch
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6876 , B82Y5/00 , B82Y10/00 , Y10T436/143333
摘要： Oligonucleotide arrangements are disclosed which, in each case, have at least two oligonucleotide sequences linked via at least one spacer. A process is disclosed using the oligonucleotide arrangements for the amplification and/or detection of nucleic acid sequences with formation of crosslinked conglomerates. The process can be used, for example, for the sensitive, simple and inexpensive detection of nucleic acid sequences.
摘要翻译：公开了寡核苷酸排列，其在每种情况下具有通过至少一个间隔物连接的至少两个寡核苷酸序列。公开了使用寡核苷酸排列来扩增和/或检测与形成交联聚集体的核酸序列的方法。该方法可用于例如核酸序列的灵敏，简单且廉价的检测。

3. 发明授权

US08551424B2 Apparatus for processing a sample comprising a biochip and reagents embedded in a biodegradable material, and processes thereof 有权
标题翻译：用于处理包含生物芯片和嵌入生物可降解材料中的试剂的样品的装置及其工艺
公开(公告)号：US08551424B2
公开(公告)日：2013-10-08
申请号：US11594938
申请日：2006-11-09
申请人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Sebastian Schmidt , Christian Zilch
发明人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Sebastian Schmidt , Christian Zilch
IPC分类号： G01N33/544 , G01N33/00 , A61F2/00
CPC分类号： G01N1/42 , G01N2035/00148 , Y10T436/25
摘要： An apparatus is disclosed for processing a sample which stores processing reagents required for processing in a dry form. The processing reagents are covered by a biologically degradable medium or embedded in said biologically degradable medium.
摘要翻译：公开了一种用于处理以干燥形式存储处理所需的处理试剂的样品的装置。处理试剂被生物降解介质覆盖或嵌入所述生物降解介质中。

4. 发明申请

US20120295366A1 DIAGNOSTIC SYSTEM 审中-公开
标题翻译：诊断系统
公开(公告)号：US20120295366A1
公开(公告)日：2012-11-22
申请号：US13388980
申请日：2010-07-21
申请人： Christian Zilch , Sonya Faber , Wilhelm Gerdes
发明人： Christian Zilch , Sonya Faber , Wilhelm Gerdes
IPC分类号： G01N27/72 , G01N1/28 , B01L3/00
CPC分类号： B01L3/502761 , B01L3/502784 , B01L2200/0673 , B01L2400/043 , G01N35/0098 , Y10T436/25
摘要： The invention relates to a device for contactless control of magnetic beads on a microfluidic card by means of external magnetic fields, without having to use complicated mechanics or hydraulics. Based on a modulation of the gradient of a magnetic field, magnetic beads are lifted in a first step in a contactless way out of different reaction chambers of the microfluidic card. By means of a translation movement or a variation or modulation of the gradient of a magnetic field, horizontal transport of the magnetic beads over a mechanical barrier of the microfluidic card is facilitated in a second step. It is possible in a third step to use a further modulation of the gradient of the magnetic field to lower the magnetic beads into a desired further fluid zone.
摘要翻译：本发明涉及一种用于通过外部磁场对微流控卡上的磁珠进行非接触式控制的装置，而不必使用复杂的机械或液压。基于磁场梯度的调制，磁珠以非接触方式从第一步骤中提取出微流控卡的不同反应室。通过平移运动或磁场梯度的变化或调制，在第二步骤中便于在微流控卡的机械屏障上磁珠的水平传输。在第三步骤中可以使用磁场梯度的进一步调制来将磁珠降低成所需的另外的流体区域。

5. 发明授权

US08263331B2 Device and method for the detection of an analyte 有权
标题翻译：用于检测分析物的装置和方法
公开(公告)号：US08263331B2
公开(公告)日：2012-09-11
申请号：US11655943
申请日：2007-01-22
申请人： Joachim Bangert , Ludwig Bär , Thomas Ehben , Hans-Dieter Feucht , Christian Zilch
发明人： Joachim Bangert , Ludwig Bär , Thomas Ehben , Hans-Dieter Feucht , Christian Zilch
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： G01N33/54333 , B82Y15/00 , B82Y25/00 , H01F1/0054
摘要： A device and a method are disclosed for the detection and/or for the quantification of an analyte. In at least one embodiment, the device includes a basic matrix and magnetized nanoparticles, which are arranged in moveable fashion in or at the basic matrix and to which catcher molecules that bind specifically to the analyte are anchored. Further, the mobility of the nanoparticle in the basic matrix can be influenced by a binding of the analyte to be detected to the catcher molecules and can be read out magnetically.
摘要翻译：公开了用于检测和/或定量分析物的装置和方法。在至少一个实施方案中，该装置包括基本基质和磁化纳米颗粒，其以可移动的方式设置在碱性基质中或基本基质上，并且特异性结合分析物的捕获剂分子被锚固。此外，纳米颗粒在碱性基质中的迁移率可能受待检测的分析物与捕获剂分子的结合的影响，并且可以磁性地读出。

6. 发明申请

US20110008797A1 METHOD AND DEVICE FOR THE THERMAL CONTROL OF TEMPERATURE-DEPENDENT ENZYMATIC REACTIONS USING MAGNETIC PARTICLES OR MAGNETIC BEADS AND ALTERNATING MAGNETIC FIELDS 审中-公开
标题翻译：使用磁性颗粒或磁珠和替代磁场对温度依赖性酶反应进行热控制的方法和装置
公开(公告)号：US20110008797A1
公开(公告)日：2011-01-13
申请号：US12922470
申请日：2009-03-19
申请人： Christian Zilch , Wilhelm Gerdes , Johann Bauer , Karl Holschuh
发明人： Christian Zilch , Wilhelm Gerdes , Johann Bauer , Karl Holschuh
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/00 , C12M1/34
CPC分类号： H01F1/0063 , B01L7/52 , B01L2200/0647 , B01L2200/14 , B01L2300/0829 , B01L2300/18 , B01L2300/1894 , B82Y5/00 , B82Y25/00 , C12N15/1096 , H01F1/0054 , H01F1/37 , H01F1/407
摘要： The invention relates to a method for the thermal control of at least one temperature-dependent enzymatic reaction in the presence of magnetic particles, particularly nanoparticles, or magnetic beads in vitro by means of the heating of the magnetic beads or magnetic particles to at least one certain target temperature by means of alternating magnetic fields. The enzymatic reaction which can be controlled with the method according to the invention is preferably a PCR reaction or another reaction for the elongation or amplification of nucleic acids, including DNA, RNA or hybrids or derivatives thereof, which takes place directly on the functionalized magnetic beads. Further aspects of the invention relate to a reactor for carrying out the method and the use of the method or the reactor in analytics and diagnostics.
摘要翻译：本发明涉及一种用于在磁性颗粒，特别是纳米颗粒或磁珠的存在下，通过将磁珠或磁性颗粒加热至少至少一种在体外热控制至少一种温度依赖性酶反应的方法某些目标温度通过交变磁场。可用本发明方法控制的酶反应优选是直接在功能化磁珠上进行的PCR反应或用于延伸或扩增核酸（包括DNA，RNA或其杂合物或衍生物）的另一反应。本发明的其它方面涉及用于在分析和诊断中执行该方法和使用该方法或反应器的反应器。

7. 发明授权

US08771609B2 Module for processing a biological sample, biochip kit, and use of the module 有权
标题翻译：用于处理生物样品的模块，生物芯片套件和模块的使用
公开(公告)号：US08771609B2
公开(公告)日：2014-07-08
申请号：US11653230
申请日：2007-01-16
申请人： Thomas Ehben , Walter Gumbrecht , Manfred Stanzel , Christian Zilch
发明人： Thomas Ehben , Walter Gumbrecht , Manfred Stanzel , Christian Zilch
IPC分类号： B01L3/00
CPC分类号： G01N1/40 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2300/0816 , G01N35/0098 , Y10T436/2575
摘要： A module for processing a biological sample for an analysis test is disclosed. The processing module includes, in at least one embodiment, an interface at which the processing module can be connected to a cartridge with a lab-on-a-chip, in which cartridge the analysis steps are carried out. A biochip kit is also disclosed. In at least one embodiment, the biochip kit includes one or more processing modules which are intended for different sample materials and which can be connected to the same cartridge type.
摘要翻译：公开了用于处理用于分析测试的生物样品的模块。处理模块在至少一个实施例中包括接口，在该界面处，处理模块可以与芯片上的实验室连接，其中进行分析步骤。还公开了一种生物芯片套件。在至少一个实施例中，生物芯片套件包括一个或多个处理模块，其用于不同的样品材料并且可以连接到相同的盒式。

8. 发明申请

US20110207619A1 ARRANGEMENT FOR PROCESSING A PLURALITY OF SAMPLES FOR ANALYSIS 审中-公开
标题翻译：处理多样化分析样本的安排
公开(公告)号：US20110207619A1
公开(公告)日：2011-08-25
申请号：US12448015
申请日：2007-11-29
申请人： Thomas Ehben , Mitja Schonecke , Christian Zilch
发明人： Thomas Ehben , Mitja Schonecke , Christian Zilch
IPC分类号： C40B30/04 , C40B60/04
CPC分类号： B01L9/527 , B01L2300/021 , G01N35/04
摘要： An arrangement is provided in at least one embodiment, having a magazine for supplying a plurality of microfluidic devices. The microfluidic devices each contain at least one element/device for binding at least one biological molecule, wherein the at least one element/device for binding the at least one biological molecule can be moved relative to the microfluidic device. A sample presumably containing biological molecules to be examined is introduced into the microfluidic device. The biological molecule to be examined is bound by the at least one element/device for binding the biological molecule. In at least one embodiment, the at least one element/device for binding the at least one biological molecule, or the substrate-molecule complex, can then be moved in the microfluidic device, e.g. in accordance with a predetermined reaction sequence, for example by means of a magnetic field. The microfluidic device is transported through the arrangement.
摘要翻译：在至少一个实施例中提供了一种布置，其具有用于供应多个微流体装置的盒。微流体装置各自包含用于结合至少一个生物分子的至少一个元件/装置，其中用于结合至少一个生物分子的至少一个元件/装置可以相对于微流体装置移动。将含有待检测的生物分子的样品引入微流体装置。待检测的生物分子被至少一个用于结合生物分子的元件/装置结合。在至少一个实施方案中，用于结合至少一个生物分子或底物 - 分子复合物的至少一种元件/装置然后可以在微流体装置中移动，例如，根据预定的反应顺序，例如借助于磁场。微流体装置通过该装置输送。

9. 发明授权

US07932082B2 Device and method for extracting a smear sample 有权
标题翻译：用于提取涂片样品的装置和方法
公开(公告)号：US07932082B2
公开(公告)日：2011-04-26
申请号：US11599424
申请日：2006-11-15
申请人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
发明人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
IPC分类号： C12M1/26 , C12M3/00
CPC分类号： B01L3/502715 , A61B10/0051 , A61B10/0096 , B01L3/502738 , B01L3/502761 , B01L3/5029 , B01L2200/027 , B01L2300/042 , B01L2400/0478 , B01L2400/0633 , G01N2001/028
摘要： A device is disclosed for extracting a smear sample. The device includes a cavity, into which a sample carrier carrying a smear sample can be introduced. Liquid can be introduced into the cavity through at least one liquid feed connected to the cavity, and the liquid can be removed from the cavity through at least one liquid discharge connected to the cavity.
摘要翻译：公开了一种用于提取涂片样品的装置。该装置包括可以引入携带涂片样品的样品载体的空腔。可以通过连接到空腔的至少一个液体进料将液体引入空腔中，并且可以通过连接到空腔的至少一个液体排出物从腔中去除液体。

10. 发明申请

US20070274840A1 Magnetohydrodynamic pump 审中-公开
标题翻译：磁流体动力泵
公开(公告)号：US20070274840A1
公开(公告)日：2007-11-29
申请号：US11637781
申请日：2006-12-13
申请人： Thomas Ehben , Walter Gumbrecht , Sebastian Schmidt , Christian Zilch
发明人： Thomas Ehben , Walter Gumbrecht , Sebastian Schmidt , Christian Zilch
IPC分类号： B60L9/16
CPC分类号： H02K44/04
摘要： A MHD pump, in an example embodiment, includes a fluid channel, an electrode pair that generates an electric field in the fluid channel, and an electromagnet that generates a magnetic field, the magnetic field lines of which intersect the electric field lines of the electric field. The fluid channel is defined in an exchangeable cassette.
摘要翻译：在示例性实施例中，MHD泵包括流体通道，在流体通道中产生电场的电极对，以及产生磁场的电磁体，其磁场线与电气线的电场线相交领域。流体通道限定在可更换的盒中。

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