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1. 发明授权

US10514353B2 Arrangement and method for the electrochemical analysis of liquid samples by means of lateral flow assays 有权
公开(公告)号：US10514353B2
公开(公告)日：2019-12-24
申请号：US16416631
申请日：2019-05-20
申请人： Walter Gumbrecht , Peter Paulicka
发明人： Walter Gumbrecht , Peter Paulicka
IPC分类号： G01N27/26 , G01N27/30 , G01N33/487 , G01N27/327 , G01N27/40
摘要： An arrangement and to a method are provided for the electrical detection of liquid samples by lateral flow assays. The lateral flow assay includes a membrane arranged on a front side of a first carrier. The first carrier is electrically insulating. On the front side of the first carrier between the carrier and the membrane, electrically conductive electrodes are arranged in direct contact with the membrane.

2. 发明授权

US09995703B2 Device similar to electrochemical camera and method for producing device 有权
公开(公告)号：US09995703B2
公开(公告)日：2018-06-12
申请号：US13262578
申请日：2010-03-02
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
IPC分类号： C40B60/00 , C40B60/12 , G01N27/327 , G01N33/543 , C40B30/04 , C40B50/18
CPC分类号： G01N27/3277 , G01N33/5438
摘要： A device for detecting chemical or biochemical substances in fluids for use in an electrochemical camera. The device includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as the electrochemical camera.

3. 发明授权

US08975017B2 Process for concentrating nucleic acid molecules 有权
标题翻译：浓缩核酸分子的方法
公开(公告)号：US08975017B2
公开(公告)日：2015-03-10
申请号：US12734934
申请日：2008-11-03
申请人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
发明人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： C12Q1/6806 , C12Q1/6825 , C12Q1/6834 , C12Q1/6837 , Y10T436/143333 , C12Q2527/107 , C12Q2537/125 , C12Q2565/543
摘要： A process concentrates nucleic acid molecules to be detected of a sample on a surface, with capture molecules that specifically bind the nucleic acid molecules. A support material has a capture probe that can specifically be linked to the nucleic acid molecules to be detected to give complexes. The support material and the nucleic acid molecules of the sample are incubated to form the complexes. The complexes are moved to the surface. At least one portion of the complexes becomes bound to the capture molecules via the capture probe.
摘要翻译：一种方法将待检测的样品的核酸分子浓缩在表面上，其中捕获分子特异性结合核酸分子。载体材料具有捕获探针，其可以特异性地连接到待检测的核酸分子以得到复合物。将样品的载体材料和核酸分子孵育以形成复合物。络合物移动到表面。复合物的至少一部分经由捕获探针与捕获分子结合。

4. 发明授权

US08753582B2 Apparatus and method comprising a sensor array and a porous plunger and use thereof 有权
标题翻译：包括传感器阵列和多孔柱塞的装置和方法及其用途
公开(公告)号：US08753582B2
公开(公告)日：2014-06-17
申请号：US12867561
申请日：2009-02-09
申请人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
发明人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
IPC分类号： G01N35/00 , G01N31/22 , G01N33/52 , B01L3/00 , G01N31/16 , B01L99/00 , G01N30/62 , G01N30/95 , G01N33/00 , C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , B01J2219/00382 , B01J2219/00527 , B01J2219/00704 , B01L3/502707 , B01L3/502715 , B01L2200/10 , B01L2300/0636 , B01L2300/0645 , B01L2300/087 , B01L2400/0421 , B01L2400/0427 , G01N27/27 , G01N27/3277
摘要： Disclosed is an apparatus that is used for detecting liquids or substances from liquids and includes a plunger that has a porous plunger layer which is pressed onto a sensor array. Each sensor of the sensor array is surrounded by elevations which spatially separate the sensors from each other like walls. In at least one embodiment, when the plunger layer is pressed onto the sensor array, the walls are pressed into the pores of the plunger layer. Liquid-tight connections are created between the walls and the plunger layer while liquid remains over the sensors. The liquid can be measured. In at least one embodiment, when there is direct mechanical contact between the plunger layer and the sensors, the liquid over the sensors is located in open pores on the surface of the plunger layer. No liquid flows between the pores and across the walls when pressure is applied to the plunger layer such that closed reaction chambers are created.
摘要翻译：公开了一种用于从液体中检测液体或物质的装置，包括具有压在传感器阵列上的多孔柱塞层的柱塞。传感器阵列的每个传感器被高度包围，空间上将传感器彼此像墙壁分开。在至少一个实施例中，当柱塞层被压到传感器阵列上时，壁压入柱塞层的孔中。在壁和柱塞层之间产生液密连接，而液体保留在传感器上方。可以测量液体。在至少一个实施例中，当柱塞层和传感器之间存在直接机械接触时，传感器上的液体位于柱塞层表面上的开放孔中。当压力施加到柱塞层时，没有液体流过孔隙和壁之间，从而形成封闭的反应室。

5. 发明授权

US08551424B2 Apparatus for processing a sample comprising a biochip and reagents embedded in a biodegradable material, and processes thereof 有权
标题翻译：用于处理包含生物芯片和嵌入生物可降解材料中的试剂的样品的装置及其工艺
公开(公告)号：US08551424B2
公开(公告)日：2013-10-08
申请号：US11594938
申请日：2006-11-09
申请人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Sebastian Schmidt , Christian Zilch
发明人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Sebastian Schmidt , Christian Zilch
IPC分类号： G01N33/544 , G01N33/00 , A61F2/00
CPC分类号： G01N1/42 , G01N2035/00148 , Y10T436/25
摘要： An apparatus is disclosed for processing a sample which stores processing reagents required for processing in a dry form. The processing reagents are covered by a biologically degradable medium or embedded in said biologically degradable medium.
摘要翻译：公开了一种用于处理以干燥形式存储处理所需的处理试剂的样品的装置。处理试剂被生物降解介质覆盖或嵌入所述生物降解介质中。

6. 发明申请

US20120315664A1 ASSEMBLY AND METHOD FOR THE FILTRATION OF A LIQUID AND USE IN MICROSCOPY 审中-公开
标题翻译：用于过滤液体并用于显微镜的组装和方法
公开(公告)号：US20120315664A1
公开(公告)日：2012-12-13
申请号：US13575651
申请日：2011-01-26
申请人： Katja Friedrich , Walter Gumbrecht , Karsten Hiltawsky , Peter Paulicka
发明人： Katja Friedrich , Walter Gumbrecht , Karsten Hiltawsky , Peter Paulicka
IPC分类号： B01D71/50 , G01N21/64 , C12Q1/04 , B01D63/00 , B01D61/00
CPC分类号： G01N1/4077 , B01D63/08 , B01D69/10 , B01L3/502715 , B01L3/508 , B01L2200/027 , B01L2300/0681 , B01L2300/0822 , B01L2300/0864 , G01N2001/4088
摘要： An assembly and method are disclosed for the filtration of a liquid and the use thereof, wherein a supporting body is designed in a recess of a carrier and a filter membrane lies flat on the supporting body. The filter membrane and the supporting body are designed to be permeable to liquids and thus serve as filters, in particular for filtering tumor cells from blood. The carrier can having standard shapes of an object carrier for microscopy and the filtration residue on the filter membrane can be easily handled and examined in the microscope. As a result of the filter membrane lying level on the supporting body, the filtration residue can be particularly well examined microscopically.
摘要翻译：公开了用于过滤液体的组件和方法及其用途，其中支撑体被设计在载体的凹部中，并且过滤膜平坦地位于支撑体上。过滤膜和支撑体设计成可渗透液体，因此用作过滤器，特别是用于从血液中过滤肿瘤细胞。载体可以具有用于显微镜的物体载体的标准形状，并且可以在显微镜中容易地处理和检查过滤膜上的过滤残余物。作为过滤膜在支撑体上的位置的结果，过滤残留物可以在显微镜下进行特别良好的检查。

7. 发明申请

US20120184043A1 FLAT BODY IN THE MANNER OF A CHIP CARD FOR BIOCHEMICAL ANALYSIS AND METHOD FOR THE USE THEREOF 有权
标题翻译：用于生物化学分析的芯片卡中的平板体及其使用方法
公开(公告)号：US20120184043A1
公开(公告)日：2012-07-19
申请号：US13498871
申请日：2010-09-27
申请人： Walter Gumbrecht , Peter Paulicka , Jörn Ueberfeld
发明人： Walter Gumbrecht , Peter Paulicka , Jörn Ueberfeld
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： B01L3/502715 , B01L3/021 , B01L3/5082 , B01L2200/027 , B01L2300/0663 , B01L2300/0672 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B01L2400/0406 , Y10T436/143333
摘要： At least two microfluidic devices and at least one sensor chip are formed in a flat body. The at least one sensor chip is in direct contact with at least one first microfluidic device. A second microfluidic device in the manner of a pipette is integral with the flat body or connected thereto. The flat body may be used by docking an E-cup by way of a clamping device of the flat body to the flat body and exchanging fluid between the E-cup and the flat body by way of the second microfluidic device.
摘要翻译：在平坦体中形成至少两个微流体装置和至少一个传感器芯片。至少一个传感器芯片与至少一个第一微流体装置直接接触。以移液管的方式的第二微流体装置与平坦体成一体或与其连接。扁平体可以通过将平坦体的夹持装置对准E形杯到扁平体并且通过第二微流体装置在E杯和平坦体之间交换流体来使用。

8. 发明授权

US08105478B2 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device 有权
标题翻译：用于测量氧化还原活性物质浓度或浓度变化的方法及相应的装置
公开(公告)号：US08105478B2
公开(公告)日：2012-01-31
申请号：US10587837
申请日：2005-01-26
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N27/26 , G01N33/53 , G01N33/487
CPC分类号： G01N27/3277 , G01N2333/916 , Y10T436/143333
摘要： In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of the measuring phase and relaxation phase being predetermined in a suitable manner. In this manner, a rapid relaxation of the concentration gradient is forced electrochemically so that the measurement can be carried out on simple transducer arrays. The device includes a transducer array in addition to a suitable potentiostat. The transducer array may include a planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is located. The array is generated by suitably structuring the substrate.
摘要翻译：为了跟踪氧化还原活性物质的浓度变化，适用于还原过程或氧化过程的电位被施加到测量装置的工作电极。工作电极的电位是脉冲的，交替地产生测量相位和弛豫阶段，测量相位和弛豫阶段的脉冲长度以合适的方式被预先确定。以这种方式，电化学强迫浓缩梯度的快速松弛，使得可以在简单的换能器阵列上进行测量。除了合适的恒电位仪之外，该装置还包括一个换能器阵列。换能器阵列可以包括平面金属基底，其上定位有在金属表面和绝缘体表面之间具有牢固连接的至少一个柔性绝缘体。该阵列通过适当地构造基底而产生。

9. 发明申请

US20100155263A1 METHOD AND SYTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE/ENZUME COMPLEX OR OF AN ANALYTE/ENZYME CONJUGATE, ESPECIALLY FOR THE ELECTROCHEMICAL DETECTION OF THE ANALYTE, AND CORRESPONDING MEASURING DEVICE 有权
标题翻译：用于确定分析物/酶复合物浓度或分析物/酶合成浓度的方法和系统，特别是用于分析仪的电化学检测和相应的测量装置
公开(公告)号：US20100155263A1
公开(公告)日：2010-06-24
申请号：US11989938
申请日：2006-07-31
申请人： Heike Barlag , Walter Gumbrecht , Konrad Mund
发明人： Heike Barlag , Walter Gumbrecht , Konrad Mund
IPC分类号： G01N33/543
CPC分类号： C12Q1/001 , G01N27/3271 , Y10S435/817
摘要： A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a measuring device. The potential of the working electrode is pulsed and measuring phases and relaxation phases are alternately produced, the pulse lengths of measuring phase and relaxation phase being determined in a suitable manner. A rapid relaxation of the concentration gradient is electrochemically forced so that the measurement can be carried out on simple transducer arrays. A device for carrying out the method includes a transducer array in addition to a suitable potentiostat. The transducer array can be formed of a planar metal substrate on which at least one flexible insulator is disposed, the metal surface and the insulator surface being firmly linked. The transducer array can also be formed of silicone-based CMOS structures.
摘要翻译：一种遵循氧化还原活性物质浓度变化的方法，由此将适当的还原过程或氧化过程的电位施加到测量装置的工作电极上。工作电极的电位是脉冲的，并且交替地产生测量相位和松弛相位，测量相位和弛豫阶段的脉冲长度以适当的方式确定。浓度梯度的快速弛豫是电化学强制的，以便可以在简单的换能器阵列上进行测量。用于执行该方法的装置包括除合适的恒电位仪之外的换能器阵列。换能器阵列可以由其上设置有至少一个柔性绝缘体的平面金属基板形成，金属表面和绝缘体表面牢固地连接。换能器阵列也可以由硅基CMOS结构形成。

10. 发明申请

US20090130658A1 Arrangement for integrated and automated dna or protein analysis in a single-use cartridge, method for producing such a cartridge and operating method for dna or protein analysis using such a cartridge 审中-公开
标题翻译：在一次性盒中进行综合和自动化的dna或蛋白质分析的布置，用于生产这种盒的方法和使用这种盒的dna或蛋白质分析的操作方法
公开(公告)号：US20090130658A1
公开(公告)日：2009-05-21
申请号：US11665380
申请日：2005-10-17
申请人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
发明人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502723 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A cartridge (card) having a system of microchannels and/or microcavities is used for automated DNA or protein analysis. In at least one embodiment, the microchannels or microcavities include geometrical structures for receiving dry reagents. For the purpose of industrial production, the cartridge is produced from a flat card support, e.g., by injection moulding. The reagents are spotted into the open channels, dried and then the channels are sealed by way of a film. A finished cartridge can thus be provided with a test sample and the fully automated measuring sequence can be initiated by inserting said cartridge into a read-out device.
摘要翻译：具有微通道和/或微腔系统的药筒（卡）用于自动化DNA或蛋白质分析。在至少一个实施例中，微通道或微腔包括用于接收干试剂的几何结构。为了工业生产的目的，墨盒由平板卡支撑件制成，例如通过注射成型。将试剂点入开放通道，干燥，然后通过膜封闭通道。因此，成品墨盒可以设置有测试样品，并且可以通过将所述墨盒插入读出装置来启动完全自动测量顺序。

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