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    • 3. 发明授权
    • Method and system for precise dispensation of a liquid
    • 精确分配液体的方法和系统
    • US07258253B2
    • 2007-08-21
    • US10837221
    • 2004-04-30
    • David NicolBinh NguyenPeter J. Coassin
    • David NicolBinh NguyenPeter J. Coassin
    • B67D5/08
    • B01L3/0241B01L3/0275B01L2300/0838B01L2400/0439B01L2400/0487
    • Devices, systems, and methods for the precise dispensation of small volumes of liquids are presented. A fluid microdispenser comprises a liquid-filled tube, an actuator coupled to the tube, and a tip at one end of the tube. When the actuator applies an actuation pressure, a precise volume of liquid is ejected from the orifice of the tip. The orifice is manufactured to control the volume of liquid ejected by each actuation and, therefore, may have a diameter smaller than that of the liquid-filled tube. The invention comprises systems, methods, and devices so that the inner diameter of the liquid-filled tube is decreased (tapered) to that of the orifice so as to maximize transmission to the orifice of the pressure generated by the actuation stimulus. This enables the volume of liquid ejected by each stimulus to be reproducibly controlled by the amplitude of the actuation stimulus.
    • 提出了用于精确分配少量液体的装置,系统和方法。 流体微分配器包括充满液体的管,耦合到管的致动器和管的一端的尖端。 当致动器施加致动压力时,精确体积的液体从尖端的孔喷出。 制造孔口以控制由每次致动喷射的液体的体积,因此可以具有比液体填充管的直径更小的直径。 本发明包括系统,方法和装置,使得充满液体的管的内径减小(锥形)到孔口的内径,从而最大程度地使通过致动刺激产生的压力对孔的传递。 这使得可以通过致动刺激的振幅可再现地控制由每个刺激喷射的液体的体积。
    • 4. 发明申请
    • Reagent dispenser and dispensing method
    • 试剂分配器和分配方法
    • US20050032241A1
    • 2005-02-10
    • US10789183
    • 2004-02-26
    • Peter CoassinJavier FloresDavid NicolTroy PetersonPhilip SalzmannT. Vuong
    • Peter CoassinJavier FloresDavid NicolTroy PetersonPhilip SalzmannT. Vuong
    • B01D20060101B01J4/00B01L3/02G01N35/10
    • B01L3/0241B01J4/001G01N35/1002G01N35/1009G01N35/1074Y10T436/2575
    • A method and apparatus is disclosed for automated on-the-fly dispensing of reagents. The apparatus includes a detachable reagent dispensing module supported by a support frame. The dispensing module includes a self-contained pressurized fluid delivery subsystem that facilitates efficient attachment and detachment of the module, including pressurized reagent containers and associated accessories arranged such that each reagent container has a discrete fluid path terminating at a corresponding discrete reagent dispensing tip. The dispensing tips are supported in a common dispensing head, and are arranged geometrically such that the centers of the dispensing tips are separated by distances corresponding to relevant dimensions of particular assay plates to be used therewith. Such a geometric arrangement allows for dispensing of multiple reagents substantially simultaneously into multiple corresponding target wells of the assay plate, efficiently and precisely.
    • 公开了用于自动化的试剂分配的方法和装置。 该装置包括由支撑框架支撑的可拆卸的试剂分配模块。 分配模块包括独立的加压流体递送子系统,其有助于模块的有效附接和分离,包括加压的试剂容器和相关联的附件,其布置成使得每个试剂容器具有终止于相应的分立的试剂分配尖端的离散流体路径。 分配尖端被支撑在共同的分配头中,并且几何地布置成使得分配尖端的中心与对应于要与其一起使用的特定测定板的相关尺寸相对应的距离分开。 这种几何布置允许基本上同时将多个试剂分配到分析板的多个相应的目标孔中,并且被有效和准确地分配。