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    • 3. 发明申请
    • Automated laboratory for high-throughput biological assays and RNA interference
    • 用于高通量生物测定和RNA干扰的自动化实验室
    • US20050054083A1
    • 2005-03-10
    • US10837218
    • 2004-04-30
    • Minh VuongTodd BennettJavier FloresBrian GrotDaniel HaleHuy NguyenWalter NilesTuong PhanSteve RodemsJeff StackPeter Coassin
    • Minh VuongTodd BennettJavier FloresBrian GrotDaniel HaleHuy NguyenWalter NilesTuong PhanSteve RodemsJeff StackPeter Coassin
    • B23B27/04C12M1/34C12N20060101
    • G01N35/1074G01N35/028
    • The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling. Liquid transfer to and from multiwell platforms, necessary for assay construction or for the initiation of physiological events in cells, is partitioned among different modules specialized for transferring nanoliter or smaller volume quantities of chemical concentrates, or microliter quantities of assay reagents, cells, media and other assay constituents. Applications of this invention include the quantitation and analysis of the expression of multiple genes in cells, measurement of multi-gene expression kinetics, analysis of activation or suppression of multiple signal transduction pathways, screening chemical compounds for modulatory effects on multi-gene expression or on signal transduction pathways or on other biochemical networks of cells, or other analytical biological or biochemical assays.
    • 本发明是一种自动多功能综合实验室系统,包括用于构建和测量生物测定的可互换模块化元件。 模块化元件的功能可以包括多井平台处理,化学试剂或细胞管理,用于测定构建的液体的体积转移或用于回收用于分析的反应产物,在受控环境条件下孵育,来自测定的光谱信号的测量,处理 并对所得光谱数据进行分析等功能。 模块化元件围绕若干机器人元件布置,其将板递送到不同的模块元件,将板传递到由不同的机器人元件服务的模块组或板处理中所需的其他动作。 液体转移至多孔平台,用于测定结构或细胞中生理事件发生所必需的多孔平台,在专门用于转移纳升或更小体积量的化学浓缩物或微量的测定试剂,细胞,培养基和 其他检测成分。 本发明的应用包括细胞中多个基因的表达的定量和分析,多基因表达动力学的测定,多重信号转导途径的激活或抑制分析,筛选化合物对多基因表达的调节作用或 信号转导途径或细胞的其他生物化学网络或其他分析生物或生物化学测定。
    • 6. 发明授权
    • Automated laboratory for high-throughput biological assays and RNA interference
    • 用于高通量生物测定和RNA干扰的自动化实验室
    • US07270784B2
    • 2007-09-18
    • US10837218
    • 2004-04-30
    • Minh VuongTodd BennettJavier FloresBrian GrotDaniel HaleHuy NguyenWalter D. NilesTuong PhanSteve RodemsJeff StackPeter J. Coassin
    • Minh VuongTodd BennettJavier FloresBrian GrotDaniel HaleHuy NguyenWalter D. NilesTuong PhanSteve RodemsJeff StackPeter J. Coassin
    • G01N21/00G05B15/00
    • G01N35/1074G01N35/028
    • The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling. Liquid transfer to and from multiwell platforms, necessary for assay construction or for the initiation of physiological events in cells, is partitioned among different modules specialized for transferring nanoliter or smaller volume quantities of chemical concentrates, or microliter quantities of assay reagents, cells, media and other assay constituents. Applications of this invention include the quantitation and analysis of the expression of multiple genes in cells, measurement of multi-gene expression kinetics, analysis of activation or suppression of multiple signal transduction pathways, screening chemical compounds for modulatory effects on multi-gene expression or on signal transduction pathways or on other biochemical networks of cells, or other analytical biological or biochemical assays.
    • 本发明是一种自动多功能综合实验室系统,包括用于构建和测量生物测定的可互换模块化元件。 模块化元件的功能可以包括多井平台处理,化学试剂或细胞管理,用于测定构建的液体的体积转移或用于回收用于分析的反应产物,在受控环境条件下孵育,来自测定的光谱信号的测量,处理 并对所得光谱数据进行分析等功能。 模块化元件围绕若干机器人元件布置,其将板递送到不同的模块元件,将板传递到由不同的机器人元件服务的模块组或板处理中所需的其他动作。 液体转移至多孔平台,用于测定结构或细胞中生理事件发生所必需的多孔平台,在专门用于转移纳升或更小体积量的化学浓缩物或微量的测定试剂,细胞,培养基和 其他检测成分。 本发明的应用包括细胞中多个基因的表达的定量和分析,多基因表达动力学的测定,多重信号转导途径的激活或抑制分析,筛选化合物对多基因表达的调节作用或 信号转导途径或细胞的其他生物化学网络或其他分析生物或生物化学测定。
    • 8. 发明申请
    • System and method for facilitating the real-time pricing, sale and appraisal of used vehicles
    • 二手车的实时定价,销售和鉴定的系统和方法
    • US20050108112A1
    • 2005-05-19
    • US11025033
    • 2004-12-30
    • John EllensonTodd BennettRichard Goldman
    • John EllensonTodd BennettRichard Goldman
    • G06Q30/02G06Q30/06G06F17/60
    • G06Q30/06G06Q30/0278G06Q30/0611
    • The present invention relates to a system and method for facilitating the real-time pricing, sale, and appraisal of used vehicles. In an embodiment of the present invention, there is provided a computer-based system and method of collecting data supplied from buyers in constructing appraisal profiles, and for calculating, in real-time, a guaranteed price for a used vehicle having specific attributes as described by a seller based on the appraisal profiles. According to one aspect of the present invention, there is provided a method of facilitating the real-time pricing, sale, and appraisal of a used vehicle comprising the steps of receiving input data and generating at least one associated appraisal profile for each of a first plurality of buyers, where the input data associated with an appraisal profile comprises check writing prices for a plurality of used vehicle models, where each check writing price represents a price offered by the respective buyer to purchase a used vehicle of a used vehicle model to which a plurality of base conditions apply; receiving a request from a seller for a guaranteed price for a specific seller-identified used vehicle, where the used vehicle model and actual condition of the seller-identified used vehicle are described in the request; generating at least one guaranteed price for the seller-identified used vehicle from the at least one appraisal profile; and outputting the guaranteed prices to the seller.
    • 本发明涉及一种用于便利二手车的实时定价,销售和评估的系统和方法。 在本发明的一个实施例中,提供了一种基于计算机的系统和方法,用于收集买家在构建鉴定简档中提供的数据,并实时计算具有所描述的具有特定属性的二手车的保证价格 由卖家根据评估资料。 根据本发明的一个方面,提供了一种促进二手车辆的实时定价,销售和评估的方法,包括以下步骤:接收输入数据并生成至少一个相关联的鉴定简档,用于第一 多个买家,其中与评估简档相关联的输入数据包括多个二手车模型的支票写入价格,其中每个支票写入价格表示由相应买方提供的购买二手车模型的二手车的价格, 多个基本条件适用; 在请求中描述卖方识别的二手车的二手车模型和实际状况的情况下,向卖方接收针对特定卖方识别的二手车的担保价格的请求; 从所述至少一个评估简档中为所述卖方识别的二手车产生至少一个保证价格; 并向卖方输出保证价格。