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1. 发明授权

US09612239B2 Substance determining apparatus 有权
公开(公告)号：US09612239B2
公开(公告)日：2017-04-04
申请号：US14001566
申请日：2012-02-27
申请人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
发明人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
IPC分类号： G01N21/17 , G01N33/543 , G01N21/552 , G01N21/64 , G01N21/77 , G01N27/74
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N21/7703 , G01N27/745
摘要： The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.

2. 发明授权

US09075052B2 Biosensor system for single particle detection 有权
标题翻译：用于单粒子检测的生物传感器系统
公开(公告)号：US09075052B2
公开(公告)日：2015-07-07
申请号：US13498482
申请日：2010-09-23
申请人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
发明人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
IPC分类号： G01N21/00 , G01N33/543 , G01N21/47 , G01N21/552 , G01N21/64 , G01R33/12 , G01N21/51 , G01N21/49 , G01N27/72 , G01N15/10 , G01N15/00
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：用于检测颗粒的生物传感器系统包括具有传感器表面的生物传感器盒。生物传感器磁体组件设置在盒的一侧，用于在盒和传感器表面产生有效的磁场。生物传感器磁体组件包括由间隙分开的至少两个磁性子单元。第一光学检测系统检测与磁体组件布置在盒的同一侧的颗粒。磁体组件和第一光学传感器被布置成使得通过磁体组件的间隙实现光学检测。

3. 发明申请

US20130114076A1 CARTRIDGE WITH LARGE-SCALE MANUFACTURING DESIGN 审中-公开
标题翻译：具有大规模制造设计的盒子
公开(公告)号：US20130114076A1
公开(公告)日：2013-05-09
申请号：US13809304
申请日：2011-07-05
申请人： Johannes Joseph Hubertina Barbara Schleipen , Albert Hendrik Jan Immink , Menno William Jose Prins , Derk Jan Wilfred Klunder
发明人： Johannes Joseph Hubertina Barbara Schleipen , Albert Hendrik Jan Immink , Menno William Jose Prins , Derk Jan Wilfred Klunder
IPC分类号： G01N21/01
CPC分类号： G01N21/01 , A61B5/0059 , B01L3/508 , B01L2300/044 , B01L2300/0654 , B01L2300/0822 , B01L2300/0887 , B01L2400/043 , G01N21/552 , G01N21/648 , G01N21/7703
摘要： The invention relates to a cartridge (110) and an examination apparatus (100) for optical examinations of a sample. The cartridge (110) comprises a transparent bottom layer (113) that is of substantially uniform thickness and a top layer (111, 112) comprising a sample chamber (SC). The bottom layer and the top layer are preferably laminated onto each other, for example in a C roll-to-roll process. The bottom layer (113) is provided with structures like gratings (115) that allow the incoupling or outcoupling of light.
摘要翻译：本发明涉及用于样品光学检查的盒（110）和检查装置（100）。盒（110）包括具有基本均匀厚度的透明底层（113）和包括样品室（SC）的顶层（111,112）。底层和顶层优选层压在彼此上，例如以C卷对卷方法。底层（113）设置有允许光耦合或耦合的光栅（115）的结构。

4. 发明申请

US20100320397A1 MOLECULAR DIAGNOSTIC SYSTEM BASED ON EVANESCENT ILLUMINATION AND FLUORESCENCE 有权
标题翻译：基于历史照明和荧光的分子诊断系统
公开(公告)号：US20100320397A1
公开(公告)日：2010-12-23
申请号：US12864910
申请日：2009-01-26
申请人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
发明人： Marius Iosif Boamfa , Maarten Marinus Johannes Wilhelmus Van Herpen , Derk Jan Wilfred Klunder
IPC分类号： G01N21/64 , G01N21/55
CPC分类号： G01N21/648
摘要： An illumination detection system comprises an excitation radiation source and associated radiation processing arrangement, and a focusing arrangement for focusing the excitation radiation from the radiation processing arrangement onto an analysis region of a sample. A radiation collection arrangement collects radiation from the analysis region of the sample resulting from the excitation, and a detector detects the collected radiation. The focused excitation radiation comprises an excitation line which is evanescent in the sample. This combines the advantages of line scanning (reduced analysis time) and evanescent excitation (reduced background signal) and therewith enables increased measurement speed and precision for point of care application.
摘要翻译：照明检测系统包括激发辐射源和相关联的辐射处理装置，以及用于将来自辐射处理装置的激发辐射聚焦到样品的分析区域上的聚焦装置。辐射收集装置从由激发产生的样品的分析区域收集辐射，并且检测器检测收集的辐射。聚焦的激发辐射包括在样品中消逝的激发线。这结合了线扫描的优点（减少的分析时间）和ev逝激发（降低的背景信号），并且因此可以提高点护理应用的测量速度和精度。

5. 发明授权

US07750326B2 Lithographic apparatus and cleaning method therefor 失效
标题翻译：平版印刷设备及其清洁方法
公开(公告)号：US07750326B2
公开(公告)日：2010-07-06
申请号：US11150466
申请日：2005-06-13
申请人： Maarten Marinus Johannes Wilhelmus Van Herpen , Vadim Yevgenyevich Banine , Derk Jan Wilfred Klunder
发明人： Maarten Marinus Johannes Wilhelmus Van Herpen , Vadim Yevgenyevich Banine , Derk Jan Wilfred Klunder
IPC分类号： H05G2/00
CPC分类号： G03F7/70925 , B82Y10/00 , G03F7/70166 , G03F7/70916
摘要： A lithographic apparatus is disclosed. The apparatus includes a source for supplying hydrogen radicals, a guide for use in conjunction with the source, for directing hydrogen radicals to an application surface to be targeted by the hydrogen radicals. The guide is provided with a coating having a hydrogen radical recombination constant of less than 0.2. In this way, the radicals can be transported with reduced losses and are able to better interact with remaining contaminants on application surfaces, such as mirror surfaces.
摘要翻译：公开了一种光刻设备。该装置包括用于提供氢自由基的源，与源结合使用的引导件，用于将氢自由基引导到由氢自由基靶向的施用表面。引导件具有氢自由基复合常数小于0.2的涂层。以这种方式，可以以较少的损失运输自由基，并且能够更好地与应用表面（例如镜面）上的剩余污染物相互作用。

6. 发明申请

US20100149512A1 SPECTRAL PURITY FILTER FOR MULTI-LAYER MIRROR, LITHOGRAPHIC APPARATUS INCLUDING SUCH MULTI-LAYER MIRROR, METHOD FOR ENLARGING THE RATIO OF DESIRED RADIATION AND UNDESIRED RADIATION, AND DEVICE MANUFACTURING METHOD 审中-公开
标题翻译：用于多层镜的光谱滤光器，包括这种多层镜的平面设备，用于放大所需辐射和未辐射的比例的方法以及器件制造方法
公开(公告)号：US20100149512A1
公开(公告)日：2010-06-17
申请号：US12718682
申请日：2010-03-05
申请人： Maarten Marinus Johannes Wilhelmus VAN HERPEN , Levinus Pieter Bakker , Vadim Yevgenyevich Banine , Derk Jan Wilfred Klunder
发明人： Maarten Marinus Johannes Wilhelmus VAN HERPEN , Levinus Pieter Bakker , Vadim Yevgenyevich Banine , Derk Jan Wilfred Klunder
IPC分类号： G03B27/72 , G02B5/22
CPC分类号： G02B1/10 , B82Y10/00 , B82Y40/00 , G02B5/0816 , G02B5/0891 , G02B5/283 , G03F1/24 , G03F7/70575 , G03F7/70958 , G21K1/062 , G21K2201/067
摘要： A multi-layer mirror includes a multi-layer stack. The multi-layer stack includes a plurality of alternating layers with a multi-layer stack top layer and a spectral filter top layer arranged on the multi-layer stack. The spectral filter top layer includes a first spectral purity enhancement layer that includes a first material m1 and has a first layer thickness d1, an intermediate layer that includes a second material m2 and has a second layer thickness d2. The intermediate layer is arranged on the multi-layer stack top layer. The first material is selected from SiN, Si3N4, SiO2, ZnS, Te, diamond, CsI, Se, SiC, amorphous carbon, MgF2, CaF2, TiO2, Ge, PbF2, ZrO2, BaTiO3, LiF or NaF. The second material includes a material different from the first material, and d1+d2 has a thickness between 1.5 and 40 nm.
摘要翻译：多层反射镜包括多层堆叠。多层堆叠包括多层交叠层，多层叠层顶层和布置在多层堆叠上的光谱过滤器顶层。光谱过滤器顶层包括第一光谱纯度增强层，其包括第一材料m1并且具有第一层厚度d1，包括第二材料m2并具有第二层厚度d2的中间层。中间层布置在多层堆叠顶层上。第一种材料选自SiN，Si3N4，SiO2，ZnS，Te，金刚石，CsI，Se，SiC，无定形碳，MgF2，CaF2，TiO2，Ge，PbF2，ZrO2，BaTiO3，LiF或NaF。第二材料包括与第一材料不同的材料，并且d1 + d2具有在1.5和40nm之间的厚度。

7. 发明申请

US20100140464A1 OPTICAL SYSTEM FOR MAPPING SIGNAL LIGHT ONTO A DETECTOR 失效
标题翻译：用于将信号光映射到探测器的光学系统
公开(公告)号：US20100140464A1
公开(公告)日：2010-06-10
申请号：US11909638
申请日：2006-03-27
申请人： Marcello Balistreri , Derk Jan Wilfred Klunder , Maarten Van Herpen
发明人： Marcello Balistreri , Derk Jan Wilfred Klunder , Maarten Van Herpen
IPC分类号： H01L31/0232 , G02B27/42 , G02B5/18 , G02B27/44
CPC分类号： G01N21/645 , G02B27/0037 , G02B27/4205 , G02B27/4277
摘要： The invention relates to an optical system that particularly allows an improved detection of signal light propagating from a light source (1) through a flat glass substrate (11). SC-modes of this signal light that would normally be totally internally reflected at the backside (10) of the substrate (11) are coupled out by a first diffractive optical element DOE (21). To map all signal light leaving the substrate (11) onto a single target location (51), a focusing lens (31) and a second DOE (41) are disposed in the optical path behind the substrate (11). The DOEs (21, 41) may for example be a ID sinusoidal grating or a 2D blaze grating. The optical system may particularly be applied in an investigation apparatus for detecting multiple spots of a fluorescent sample material.
摘要翻译：本发明涉及一种特别允许改进从光源（1）通过平板玻璃基板（11）传播的信号光的检测的光学系统。通常在基板（11）的背面（10）处内部反射的该信号光的SC模式由第一衍射光学元件DOE（21）耦合出来。为了将离开基板（11）的所有信号光映射到单个目标位置（51）上，在基板（11）后面的光路中设置聚焦透镜（31）和第二DOE（41）。 DOE（21,41）可以例如是ID正弦光栅或2D火焰光栅。光学系统可以特别应用于用于检测荧光样品材料的多个点的检查装置中。

8. 发明申请

US20100051788A1 MULTI-SPOT INVESTIGATION APPARATUS 审中-公开
标题翻译：多点调查装置
公开(公告)号：US20100051788A1
公开(公告)日：2010-03-04
申请号：US11721392
申请日：2005-12-13
申请人： Derk Jan Wilfred Klunder , Maarten Van Herpen , Marcello Balistreri , Menno Prins
发明人： Derk Jan Wilfred Klunder , Maarten Van Herpen , Marcello Balistreri , Menno Prins
IPC分类号： G01J1/58 , H01J40/02 , G01N21/00
CPC分类号： G01N21/645 , B01L3/5085 , G01N21/6452 , G01N2201/0635
摘要： The invention relates to a method and an apparatus for the investigation of a sample material that is stored in the sample chamber (303) of a storage unit (300). A multi-spot generator MSG (100) and a transmission section (200) generate an array of sample light spots (501) within the sample chamber. Input light (504) that leaves the storage unit (300) in forward direction is mapped onto a CCD array (401) and measured as reference. Moreover, fluorescence light (500) that is stimulated in the sample chamber (303) is measured by a second CCD array which is disposed perpendicular to the optical path of the input light (504).
摘要翻译：本发明涉及一种用于研究存储在存储单元（300）的样品室（303）中的样品材料的方法和装置。多点发生器MSG（100）和透射部分（200）在样品室内产生样品光点阵列（501）。将存储单元（300）向前移动的输入光（504）映射到CCD阵列（401）上并作为参考进行测量。此外，通过垂直于输入光（504）的光路设置的第二CCD阵列来测量在样品室（303）中被刺激的荧光（500）。

9. 发明申请

US20090309048A1 Radiation System and Lithographic Apparatus Comprising the Same 有权
标题翻译：包括辐射系统和平版印刷设备
公开(公告)号：US20090309048A1
公开(公告)日：2009-12-17
申请号：US12465118
申请日：2009-05-13
申请人： Maarten Marinus Johannes Wilhelmus VAN HERPEN , Vadim Yevgenyevich Banine , Derk Jan Wilfred Klunder , Wouter Anthon Soer , Johannes Christiaan Leonardu Franken , Olav Waldemar Vladimir Frijns , Niels Machiel Driessen
发明人： Maarten Marinus Johannes Wilhelmus VAN HERPEN , Vadim Yevgenyevich Banine , Derk Jan Wilfred Klunder , Wouter Anthon Soer , Johannes Christiaan Leonardu Franken , Olav Waldemar Vladimir Frijns , Niels Machiel Driessen
IPC分类号： G01J3/10 , G21K5/00
CPC分类号： G03F7/70916 , G01N21/15 , G03F7/70558
摘要： An optical sensor apparatus for use in an extreme ultraviolet lithographic system is disclosed. The apparatus includes an optical sensor comprising a sensor surface and a removal mechanism configured to remove debris from the sensor surface. Accordingly, dose and/or contamination measurements may be carried out conveniently for the lithographic system.
摘要翻译：公开了一种用于极紫外光刻系统的光学传感器装置。该装置包括光学传感器，其包括传感器表面和被配置为从传感器表面去除碎屑的移除机构。因此，可以方便地为光刻系统进行剂量和/或污染测量。

10. 发明申请

US20090194693A1 Imaging Apparatus for Combined Temperature and Luminescence Spatial Imaging of an Object 审中-公开
标题翻译：用于物体的组合温度和发光空间成像的成像装置
公开(公告)号：US20090194693A1
公开(公告)日：2009-08-06
申请号：US12301642
申请日：2007-05-14
申请人： Derk Jan Wilfred Klunder , Aleksey Kolesnychenko
发明人： Derk Jan Wilfred Klunder , Aleksey Kolesnychenko
IPC分类号： G01N21/64 , G01N21/76
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/76
摘要： An imaging apparatus is disclosed for combined temperature and luminescence spatial imaging of an object (1), such as a bio-array for detection of biological molecules. Light (5) is separated into a first (10) and a second (20) optical path, where the first optical path (10) guides infrared (IR), and the second optical path (20) guides luminescence light, preferably fluorescence light, from the object (1). Image intensifying means (30) converts infrared light (10a) in the first optical path into intensified light (10b), preferably visible light. Photo detection means (100) are arranged for spatial imaging of the object (1), the photo detection means being arranged for alternately receiving light from the first (10) and the second (20) optical path. Processing means (200) are capable of combining a temperature image (11) with a luminescence image (21) so as to obtain a combined image (25) of the object with a direct spatial correspondence between the two images. For bio-arrays this provides many advantages in relation to combined imaging of an array, whereupon numerous probe molecules are located.
摘要翻译：公开了用于物体（1）的组合温度和发光空间成像的成像装置，例如用于检测生物分子的生物阵列。光（5）被分离为第一光路（10）和第二光路（20），其中第一光路（10）引导红外（IR），第二光路（20）引导发光，优选荧光，从对象（1）。图像增强装置（30）将第一光路中的红外光（10a）转换成强光（10b），优选可见光。照片检测装置（100）布置成用于物体（1）的空间成像，光检测装置被布置成交替地接收来自第一光（10）和第（20）光路的光。处理装置（200）能够将温度图像（11）与发光图像（21）组合，从而以两个图像之间的直接空间对应来获得对象的组合图像（25）。对于生物阵列，这提供了与阵列的组合成像相关的许多优点，因此存在许多探针分子。

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