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1. 发明授权

US10092903B2 Multi-compartment device with magnetic particles 有权
公开(公告)号：US10092903B2
公开(公告)日：2018-10-09
申请号：US12809208
申请日：2008-12-16
申请人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
发明人： Menno Willem Jose Prins , Joost Hubert Maas , Albert Hendrik Jan Immink , Dirkjan Bernhard Van Dam , Maatje Koets , Michel J. M. Bruyninckx , Thea Van Der Wijk , Marius Iosif Boamfa , Remco Den Dulk
IPC分类号： B01L3/00
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

2. 发明申请

US20110301047A1 SENSING DEVICE FOR SENSING A FLUID 有权
标题翻译：用于感应流体的感测装置
公开(公告)号：US20110301047A1
公开(公告)日：2011-12-08
申请号：US13140175
申请日：2009-12-07
申请人： Albert Hendrik Jan Immink , Albert F. Gootzen , Dirk Jan Nelly Vananderoye , Petrus Johannes Wilhelmu Van Lankvelt
发明人： Albert Hendrik Jan Immink , Albert F. Gootzen , Dirk Jan Nelly Vananderoye , Petrus Johannes Wilhelmu Van Lankvelt
IPC分类号： C40B30/00 , C12Q1/70 , C40B60/12 , C12Q1/02 , C12M1/34 , G01N33/566 , C12Q1/00 , G01N33/53
CPC分类号： G01N33/54373 , B01L2200/027 , B01L2200/04 , B01L2300/048 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0481 , G01N21/03 , G01N21/11 , G01N21/552 , G01N2021/0346
摘要： The invention relates to a sensing device for sensing a fluid. The sensing device comprises an inlet port (20) for receiving the fluid (100) and a measurement chamber (25) for sensing the fluid (100). The sensing device further comprises a fluid channel (30) coupling the inlet port (20) and the measurement chamber (25) for transporting the fluid (100) from the inlet port (20) to the measurement chamber (25) and a fluid stop unit (50) for stopping and controllably releasing the flow of fluid between the inlet port (20) and the measurement chamber (25). This allows stopping the fluid before reaching the measurement chamber (25) and controllably releasing the fluid for allowing the fluid to flow into the measurement chamber (25), if the sensing device is ready for analyzing the fluid.
摘要翻译：本发明涉及一种感测流体的感测装置。感测装置包括用于接收流体（100）的入口（20）和用于感测流体（100）的测量室（25）。感测装置还包括连接入口（20）和测量室（25）的流体通道（30），用于将流体（100）从入口（20）输送到测量室（25）和流体停止单元（50），用于停止和可控地释放入口（20）和测量室（25）之间的流体流。这允许在到达测量室（25）之前停止流体，并且如果感测装置准备好用于分析流体，则可控地释放流体以允许流体流入测量室（25）。

3. 发明申请

US20100289483A1 SENSOR CARTRIDGE 审中-公开
标题翻译：传感器盒
公开(公告)号：US20100289483A1
公开(公告)日：2010-11-18
申请号：US12669218
申请日：2008-07-16
申请人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
发明人： Albert Hendrik Jan Immink , Femke Karina De Theije , Menno Willem Jose Prins , Wendy Uyen Dittmer , Jeroen Hans Nieuwenhuis
IPC分类号： G01N27/74
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译：本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，并且第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b）的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

4. 发明申请

US20090209042A1 CONTROLLABLE MAGNETIC SYSTEM FOR BIOSENSORS 审中-公开
标题翻译：生物传感器的可控磁系统
公开(公告)号：US20090209042A1
公开(公告)日：2009-08-20
申请号：US12299788
申请日：2007-05-08
申请人： Petrus Johannus Wilhelmus Van Lankvelt , Menno Willem Jose Prins , Albert Hendrik Jan Immink
发明人： Petrus Johannus Wilhelmus Van Lankvelt , Menno Willem Jose Prins , Albert Hendrik Jan Immink
IPC分类号： G01N27/00
CPC分类号： G01N33/54333 , G01N27/745
摘要： The invention relates to a magnetic system for biosensors and in particular to a magnetic system which can switch between attraction force and repulsion force near the sensor surface with more easy but also more effective means. This is realised with at least one coil (2) and at least two ferromagnetic cores (3) which are arranged in a concentric multilayered package, and a sensor or a sensor surface exposed to or covered with the biomaterial, which is arranged near to the magnetic system.
摘要翻译：本发明涉及一种用于生物传感器的磁性系统，特别涉及一种能够以更容易但更有效的方式在传感器表面附近的吸引力和排斥力之间切换的磁性系统。这是通过布置在同心多层封装中的至少一个线圈（2）和至少两个铁磁芯（3）实现的，以及暴露于或覆盖生物材料的传感器或传感器表面，其布置在磁系统。

5. 发明申请

US20080314749A1 Microelectronic Device with Magnetic Excitation Wires 审中-公开
标题翻译：具有励磁线的微电子器件
公开(公告)号：US20080314749A1
公开(公告)日：2008-12-25
申请号：US12159465
申请日：2006-10-25
申请人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
发明人： Mark Thomas Johnson , Albert Hendrik Jan Immink , Marc Wilhelmus Gijsbert Ponjee , Mirielle Ann Reijme , Josephus Arnoldus Henricus Maria Kahlman , Jeroen Hans Nieuwenhuis , Bart Michiel De Boer
IPC分类号： G01N27/26
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
摘要翻译：本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。因此，B / E电极用于两个目的。样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

6. 发明申请

US20080219392A1 Data-Dependent Noise Predictor in Data-Aided Timing Recovery 审中-公开
标题翻译：数据辅助定时恢复中的数据依赖噪声预测器
公开(公告)号：US20080219392A1
公开(公告)日：2008-09-11
申请号：US11995013
申请日：2006-07-06
申请人： Jamal Riani , Steven J-M.L. Van Beneden , Johannes Wilhelmus Maria Bergmans , Albert Hendrik Jan Immink
发明人： Jamal Riani , Steven J-M.L. Van Beneden , Johannes Wilhelmus Maria Bergmans , Albert Hendrik Jan Immink
IPC分类号： H04L7/00 , H04L25/00
CPC分类号： H04L7/0062 , G11B20/10009 , G11B20/10037 , G11B20/1403 , H04L7/04
摘要： A communication system includes a communication channel (110) for time-synchronous transfer of data symbols a1, . . . , aN to a receiver (130). A sampling unit (132) is used for time-sequential sampling the channel under control of a sampling clock signal that is synchronous with transmittal of the data symbols. Each sample includes a representation of a data symbol and noise. A data-aided timing error detector (133) receives a representation of the samples. The detector includes a data-dependent noise predictor (310) for generating a predicted noise sequence ñ1, . . . , ñN where each predicted noise value nk for the k-th sample of the sequence depends on a cluster of a plurality of sampled data symbols and a noise whitening unit (320) for whitening of noise in the sample sequence by removing the predicted noise value ñk. The detector is arranged to provide a signal for correcting the sampling clock signal in dependence on the whitened sample sequence.
摘要翻译：一种通信系统包括用于数据符号a 1的时间同步传送的通信信道（110）。。。，向接收机（130）发送一个“N”。采样单元（132）用于在与数据符号的发送同步的采样时钟信号的控制下对信道进行时间序列采样。每个样本包括数据符号和噪声的表示。数据辅助定时误差检测器（133）接收样本的表示。检测器包括用于产生预测噪声序列的数据相关噪声预测器（310）。。。，其中序列的第k个样本的每个预测噪声值n k k取决于多个采样数据符号的簇和噪声白化单元（ 320），用于通过去除预测的噪声值ñN k来采样序列中的噪声增白。检测器被布置成根据白化样本序列提供用于校正采样时钟信号的信号。

7. 发明申请

US20080206104A1 Accurate Magnetic Biosensor 审中-公开
标题翻译：精确的磁性生物传感器
公开(公告)号：US20080206104A1
公开(公告)日：2008-08-28
申请号：US11917211
申请日：2006-06-12
申请人： Menno Willem Jose Prins , Albert Hendrik Jan Immink
发明人： Menno Willem Jose Prins , Albert Hendrik Jan Immink
IPC分类号： B01J19/00 , G01R33/09
CPC分类号： G01N33/54333 , G01N27/745 , G01N33/54366
摘要： The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.
摘要翻译：本发明提供了一种用于确定在流体中含有至少一种可极化的极化磁性标签的流体中的至少一种靶的浓度的方法，装置和系统，所述感测表面包括至少一种结合所述感测装置还包括至少一个磁性传感器元件，所述感测装置还包括用于时间分辨的区分装置，所述区别装置用于特别附着于所述磁性标签的磁性标签结合位点与非特异性连接的标记。根据本发明的方法和装置可以应用于生物分子诊断。

8. 发明申请

US20080205242A1 Multi-Radiation Beam Optical Scanning Device 审中-公开
标题翻译：多光束光学扫描装置
公开(公告)号：US20080205242A1
公开(公告)日：2008-08-28
申请号：US11913318
申请日：2006-04-26
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Sjoerd Stallinga , Stein Kuiper , Teunis Willem Tukker , Coen Theodorus Hubertus Fransiscus Liedenbaum , Albert Hendrik Jan Immink
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Sjoerd Stallinga , Stein Kuiper , Teunis Willem Tukker , Coen Theodorus Hubertus Fransiscus Liedenbaum , Albert Hendrik Jan Immink
IPC分类号： G11B7/135
CPC分类号： G11B7/1275 , G11B7/1369 , G11B7/13922 , G11B2007/0006
摘要： An optical scanning device (1) for scanning an information layer (2) of an optical record carrier (3). The device includes a radiation source (7) for providing at least a first radiation beam along a first optical path, and a second radiation beam along a second, different optical path. An objective lens system (8) converges the radiation beams on the information layer A beam-deflecting element (30) is arranged to refract said second radiation beam towards the optical axis of the lens system. The beam-deflecting element includes at least one fluid (A). A controller is provided to vary the configuration of the fluid to control the amount of refraction provided by the beam deflector element over a predetermined range.
摘要翻译：一种用于扫描光学记录载体（3）的信息层（2）的光学扫描装置（1）。该装置包括用于沿着第一光路提供至少第一辐射束的辐射源（7）和沿着第二不同光路的第二辐射束。物镜系统（8）将辐射束会聚在信息层A上。光束偏转元件（30）被布置成将所述第二辐射束朝向透镜系统的光轴折射。光束偏转元件包括至少一个流体（A）。提供控制器以改变流体的配置以控制由偏转器偏转元件在预定范围内提供的折射量。

9. 发明申请

US20080192600A1 Spherical Aberration Detector 审中-公开
标题翻译：球面异常检测器
公开(公告)号：US20080192600A1
公开(公告)日：2008-08-14
申请号：US11915633
申请日：2006-05-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Sjoerd Stallinga , Coen Theodorus Hubertus Fransiscus Liedenbaum , Stein Kuiper , Albert Hendrik Jan Immink , Teunis Willem Tukker
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Sjoerd Stallinga , Coen Theodorus Hubertus Fransiscus Liedenbaum , Stein Kuiper , Albert Hendrik Jan Immink , Teunis Willem Tukker
IPC分类号： G11B5/58
CPC分类号： G11B7/13927 , G11B7/0948 , G11B2007/0006
摘要： An optical scanning device (1) for scanning at least one information layer (2) of at least one optical record carrier (3). The device includes a radiation source (7) for providing at least a first radiation beam (4) comprising a first wavelength, an objective lens system (8) for converging the first radiation beam on a respective information layer (2), an information detector (23) for detecting at least a portion of the first radiation beam (22) reflected from the respective information layer, for determining information on said layer, and a spherical aberration detection system. The spherical aberration detection system includes an aberration detector (24) for detecting at least a portion of the reflected first radiation beam for determining spherical aberration of the first radiation beam, and a diffractive element (26) for diffracting at least a portion of the reflected first radiation beam towards the aberration detector (24), and for transmitting at least a portion of the reflected first radiation beam towards the information detector (23). In a first mode of operation the grating is arranged to introduce a phase change to an incident portion of a radiation beam for transmitting that portion towards the information detector (23). In a second mode of operation the grating is arranged to introduce a phase change to an incident portion of the reflected first radiation beam for diffracting that portion towards the aberration detector (24).
摘要翻译：一种用于扫描至少一个光学记录载体（3）的至少一个信息层（2）的光学扫描装置（1）。该装置包括用于提供至少包括第一波长的第一辐射束（4）的辐射源（7），用于将第一辐射束会聚在相应的信息层（2）上的物镜系统（8），信息检测器（23），用于检测从各个信息层反射的第一辐射束（22）的至少一部分，用于确定关于所述层的信息，以及球面像差检测系统。球面像差检测系统包括：像差检测器（24），用于检测用于确定第一辐射束的球面像差的反射的第一辐射束的至少一部分;以及衍射元件（26），用于衍射至少部分反射朝向像差检测器（24）的第一辐射束，并且用于将反射的第一辐射束的至少一部分传送到信息检测器（23）。在第一操作模式中，光栅布置成将相位变化引入辐射束的入射部分，以将该部分传送到信息检测器（23）。在第二操作模式中，光栅布置成将相变引入到反射的第一辐射束的入射部分，以将该部分衍射到像差检测器（24）。

10. 发明授权

US07248194B2 Bit-detection arrangement and apparatus for reproducing information 失效
公开(公告)号：US07248194B2
公开(公告)日：2007-07-24
申请号：US10558712
申请日：2004-05-25
申请人： Albertus Johannes Antonius Rutten , Nicolaas Johannes Hendricus Maria Van Beurden , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
发明人： Albertus Johannes Antonius Rutten , Nicolaas Johannes Hendricus Maria Van Beurden , Josephus Arnoldus Henricus Maria Kahlman , Albert Hendrik Jan Immink
IPC分类号： H03M1/00
CPC分类号： G11B20/10037 , G11B20/10009 , G11B20/1403 , H03L7/07 , H03L7/0994 , H04L7/0029 , H04L7/0334
摘要： Disclosed is a bit-detection arrangement able to convert an analog signal (AS) having an amplitude into a digital signal (DS) representing a bit sequence from which the analog signal (AS) is derived. The bit-detection arrangement has a phase detector which detect the phase difference between a quantized analog signal and a clock signal C2. The phase difference is sampled by an AD converter. The AD converter can sample at a relatively slow rate as the phase difference is a low frequency signal. The sampled phase difference is fed to a digital PLL which outputs a phase signal PHI. The phase signal and the quantized analog signal are used to recreate the digital signal (DS). The current invention is characterized in that the bit decision unit further comprises—at least one additional sample and hold unit SH2 able to sample the output signal S1, using a clock signal CSH2 and wherein the frequency of the clock signal CSH2 is equal to the frequency of clock signal CSH1 and the phase of clock signal CSH2 is substantially different from the phase of clock signal CSH1, and an output unit for outputting samples of either the sample and hold units SH1 or SH2, wherein the samples of the sample and hold unit SH1 are outputted when the phase signal PH1 indicates that the phase difference ΔP1 is in a first region and the samples of the additional sample and hold unit SH2 are outputted when the phase signal PH1 indicates that the phase difference ΔP1 is in a second region. This has the advantage that the change of bit errors occurring in the presence of phase jitter is reduced.

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