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1. 发明授权

US09075052B2 Biosensor system for single particle detection 有权
标题翻译：用于单粒子检测的生物传感器系统
公开(公告)号：US09075052B2
公开(公告)日：2015-07-07
申请号：US13498482
申请日：2010-09-23
申请人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
发明人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
IPC分类号： G01N21/00 , G01N33/543 , G01N21/47 , G01N21/552 , G01N21/64 , G01R33/12 , G01N21/51 , G01N21/49 , G01N27/72 , G01N15/10 , G01N15/00
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：用于检测颗粒的生物传感器系统包括具有传感器表面的生物传感器盒。生物传感器磁体组件设置在盒的一侧，用于在盒和传感器表面产生有效的磁场。生物传感器磁体组件包括由间隙分开的至少两个磁性子单元。第一光学检测系统检测与磁体组件布置在盒的同一侧的颗粒。磁体组件和第一光学传感器被布置成使得通过磁体组件的间隙实现光学检测。

2. 发明申请

US20130114076A1 CARTRIDGE WITH LARGE-SCALE MANUFACTURING DESIGN 审中-公开
标题翻译：具有大规模制造设计的盒子
公开(公告)号：US20130114076A1
公开(公告)日：2013-05-09
申请号：US13809304
申请日：2011-07-05
申请人： Johannes Joseph Hubertina Barbara Schleipen , Albert Hendrik Jan Immink , Menno William Jose Prins , Derk Jan Wilfred Klunder
发明人： Johannes Joseph Hubertina Barbara Schleipen , Albert Hendrik Jan Immink , Menno William Jose Prins , Derk Jan Wilfred Klunder
IPC分类号： G01N21/01
CPC分类号： G01N21/01 , A61B5/0059 , B01L3/508 , B01L2300/044 , B01L2300/0654 , B01L2300/0822 , B01L2300/0887 , B01L2400/043 , G01N21/552 , G01N21/648 , G01N21/7703
摘要： The invention relates to a cartridge (110) and an examination apparatus (100) for optical examinations of a sample. The cartridge (110) comprises a transparent bottom layer (113) that is of substantially uniform thickness and a top layer (111, 112) comprising a sample chamber (SC). The bottom layer and the top layer are preferably laminated onto each other, for example in a C roll-to-roll process. The bottom layer (113) is provided with structures like gratings (115) that allow the incoupling or outcoupling of light.
摘要翻译：本发明涉及用于样品光学检查的盒（110）和检查装置（100）。盒（110）包括具有基本均匀厚度的透明底层（113）和包括样品室（SC）的顶层（111,112）。底层和顶层优选层压在彼此上，例如以C卷对卷方法。底层（113）设置有允许光耦合或耦合的光栅（115）的结构。

3. 发明申请

US20120040475A1 SENSING DEVICE FOR DETECTING A TARGET SUBSTANCE 有权
标题翻译：用于检测目标物质的感应装置
公开(公告)号：US20120040475A1
公开(公告)日：2012-02-16
申请号：US13201927
申请日：2010-02-08
申请人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/55
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： The present invention relates to a sensing device (100) for detecting a target substance (2) in an investigation region (113). The sensing device (100) comprises a sensing surface (112) with an investigation region (113) and a reference region (120) thereon. The sensing device (100) further comprises a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing an improved correction of light reflected at the investigation region (113).
摘要翻译：本发明涉及一种用于在调查区域（113）中检测目标物质（2）的感测装置（100）。感测装置（100）包括其上具有调查区域（113）和参考区域（120）的感测表面（112）。感测装置（100）还包括位于参考区域（120）处的参考元件（121）。参考元件（121）适于屏蔽参考区域（120）与目标物质（2），使得在全内反射条件下在参考区域（120）处反射的光线不会受到目标物质的存在或不存在的影响（2）。这允许独立于目标物质（2）的存在或不存在来测量在参考区域（120）处反射的光的特性（通常为强度）。反射光的测量特性可用于对在调查区域（113）反射的光进行改进的校正。

4. 发明授权

US07881165B2 Optical scanning device with compact spherical aberration compensation 有权
标题翻译：光学扫描装置具有紧凑的球面像差补偿
公开(公告)号：US07881165B2
公开(公告)日：2011-02-01
申请号：US11575139
申请日：2005-09-12
申请人： Johannes Joseph Hubertina Barbara Schleipen
发明人： Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G11B7/00
CPC分类号： G11B7/13927 , G11B7/1362 , G11B7/13925 , G11B2007/0013
摘要： The invention relates to an optical scanning device for scanning at least one information layer (101, 102) in an information carrier (10), comprising means (1) for generating a radiation beam (11) intended to be focused on the information layer (101, 102). A spherical aberration (SA) compensation module (40) is arranged in the light path of the radiation beam (11) and comprises a SA compensation means (41) and a reflective means (42) for folding the light path of the radiation beam (11).
摘要翻译：本发明涉及一种用于扫描信息载体（10）中的至少一个信息层（101,102）的光学扫描装置，包括用于产生旨在聚焦在信息层上的辐射束（11）的装置（1） 101,102）。球面像差（SA）补偿模块（40）布置在辐射束（11）的光路中，并且包括SA补偿装置（41）和用于折叠辐射束的光路的反射装置（42） 11）。

5. 发明申请

US20100165824A1 INFORMATION CARRIER, AND SYSTEM FOR READING SUCH AN INFORMATION CARRIER 审中-公开
标题翻译：信息载体和用于读取这种信息载体的系统
公开(公告)号：US20100165824A1
公开(公告)日：2010-07-01
申请号：US12377149
申请日：2007-07-31
申请人： Donato Pasquariello , Jacobus Maria Antonius Eerenbeemd , Johannes Joseph Hubertina Barbara Schleipen
发明人： Donato Pasquariello , Jacobus Maria Antonius Eerenbeemd , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G11B7/26 , G11B7/00
CPC分类号： G11B7/0033 , G06K19/06 , G06K19/06046 , G11B7/005 , G11B7/24085
摘要： The invention relates to an information carrier comprising a layer (L) for storing data, said layer forming a light-guide having an internal face (IF) having placed thereon a matrix of indentations (ID1, ID2), said indentations (ID1) being shaped so as to deviate part of an input light beam (ILB) applied to said layer towards a first edge (E1) of said information carrier along a first direction (d1), the presence of an indentation reflecting a stored data having a first state, the absence of an indentation reflecting a stored data having a second state. The invention also relates to a reading system for reading this information carrier.
摘要翻译：本发明涉及一种信息载体，其包括用于存储数据的层（L），所述层形成具有其上放置有凹陷矩阵（ID1，ID2）的内表面（IF）的导光体，所述凹陷（ID1）形成为沿着第一方向（d1）将施加到所述层的输入光束（ILB）的一部分朝向所述信息载体的第一边缘（E1）偏离，存在反映存储的具有第一状态的数据的缩进没有反映具有第二状态的存储数据的缩进。本发明还涉及一种读取该信息载体的读取系统。

6. 发明授权

US07489448B2 Optical scanning device 失效
标题翻译：光学扫描装置
公开(公告)号：US07489448B2
公开(公告)日：2009-02-10
申请号：US10599330
申请日：2005-03-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Johannes Joseph Hubertina Barbara Schleipen , Stein Kuiper
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Johannes Joseph Hubertina Barbara Schleipen , Stein Kuiper
IPC分类号： G02B3/00 , G02B13/14
CPC分类号： G11B7/13925 , G02B3/14 , G02B26/005 , G11B2007/0013
摘要： An optical scanning device provides a radiation source (2,200), a collimator lens (4,40), an objective (7,90) for converting a beam (5,30′) to a scanning spot at the position of an information layer (101) of a record carrier (1,100). The device also includes an electrowetting cell (6). The electrowetting cell (6) acts such that a beam (5,30′) enters the objective (7,90) at a predetermined height of an entrance pupil of the objective (7,90) independent of the position of the objective (7,90) and that the beam (5,30′) forms a predetermined angle at the entrance pupil of the objective (7,90) with the optical axis (8). In this way the rim intensity may be kept constant over the entrance pupil of the objective (7,90).
摘要翻译：光学扫描装置提供辐射源（2,200），准直透镜（4,40），用于将光束（5,30'）转换到信息层位置上的扫描点的物镜（7,90） 101）记录载体（1,100）。该装置还包括电润湿池（6）。电润湿池（6）的作用使得梁（5,30'）在目标（7,90）的入射光瞳的预定高度处进入物镜（7,90），而与物镜（7）的位置无关，90），并且光束（5,30'）在物镜（7,90）的入射光瞳上与光轴（8）形成预定角度。以这种方式，轮辋强度可以在物镜（7,90）的入射光瞳上保持恒定。

7. 发明申请

US20080316901A1 Optical Scanning Device 有权
标题翻译：光学扫描装置
公开(公告)号：US20080316901A1
公开(公告)日：2008-12-25
申请号：US11575139
申请日：2005-09-12
申请人： Johannes Joseph Hubertina Barbara Schleipen
发明人： Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G11B7/00
CPC分类号： G11B7/13927 , G11B7/1362 , G11B7/13925 , G11B2007/0013
摘要： The invention relates to an optical scanning device for scanning at least one information layer (101, 102) in an information carrier (10), comprising means (1) for generating a radiation beam (11) intended to be focused on the information layer (101, 102). A spherical aberration (SA) compensation module (40) is arranged in the light path of the radiation beam (11) and comprises a SA compensation means (41) and a reflective means (42) for folding the light path of the radiation beam (11).
摘要翻译：本发明涉及一种用于扫描信息载体（10）中的至少一个信息层（101,102）的光学扫描装置，包括用于产生旨在聚焦在信息层上的辐射束（11）的装置（1） 101,102）。球面像差（SA）补偿模块（40）布置在辐射束（11）的光路中，并且包括SA补偿装置（41）和用于折叠辐射束的光路的反射装置（42） 11）。

8. 发明申请

US20080239463A1 Optical Scanning Device 失效
标题翻译：光学扫描装置
公开(公告)号：US20080239463A1
公开(公告)日：2008-10-02
申请号：US10599330
申请日：2005-03-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Johannes Joseph Hubertina Barbara Schleipen , Stein Kuiper
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Johannes Joseph Hubertina Barbara Schleipen , Stein Kuiper
IPC分类号： G02F1/29 , G02B7/04
CPC分类号： G11B7/13925 , G02B3/14 , G02B26/005 , G11B2007/0013
摘要： An optical scanning device provides a radiation source 2,200), a collimator lens (4,40), an objective (7,90) for converting a beam (5,30′) to a scanning spot at the position of an information layer (101) of a record carrier (1,100). The device also includes an electrowetting cell (6). The electrowetting cell (6) acts such that a beam (5,30′) enters the objective (7,90) at a predetermined height of an entrance pupil of the objective (7,90) independent of the position of the objective (7,90) and that the beam (5,30′) forms a predetermined angle at the entrance pupil of the objective (7,90) with the optical axis (8). In this way the rim intensity may be kept constant over the entrance pupil of the objective (7,90).
摘要翻译：光学扫描装置提供辐射源2,200），准直透镜（4,40），用于将光束（5,30'）转换为在信息层（101）的位置处的扫描点的物镜（7,90））的记录载体（1,100）。该装置还包括电润湿池（6）。电润湿池（6）的作用使得梁（5,30'）在目标（7,90）的入射光瞳的预定高度处进入物镜（7,90），而与物镜（7）的位置无关，90），并且光束（5,30'）在物镜（7,90）的入射光瞳上与光轴（8）形成预定角度。以这种方式，轮辋强度可以在物镜（7,90）的入射光瞳上保持恒定。

9. 发明授权

US09804089B2 Sensing device for detecting a target substance 有权
公开(公告)号：US09804089B2
公开(公告)日：2017-10-31
申请号：US13201927
申请日：2010-02-08
申请人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N33/543 , G01N21/27
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： A sensing device (100) detects a target substance (2) in an investigation region (113). The sensing device (100) includes a sensing surface (112) with an investigation region (113) and a reference region (120). The sensing device (100) further includes a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing a correction of light reflected at the investigation region (113).

10. 发明授权

US09285303B2 Optical biosensor with a plurality of sensor regions and a detector having a detector plane wherein at least one primary image is mapped onto the whole detector plane 有权
标题翻译：具有多个传感器区域的光学生物传感器和具有检测器平面的检测器，其中至少一个主图像被映射到整个检测器平面上
公开(公告)号：US09285303B2
公开(公告)日：2016-03-15
申请号：US14342058
申请日：2012-08-27
申请人： Johannes Joseph Hubertina Barbara Schleipen , Jacobus Hermanus Maria Neijzen
发明人： Johannes Joseph Hubertina Barbara Schleipen , Jacobus Hermanus Maria Neijzen
IPC分类号： G01N21/01 , G01N21/25 , G02B21/02 , G01N21/552 , G02B3/00
CPC分类号： G01N21/01 , G01N21/253 , G01N21/552 , G02B3/0056 , G02B3/0062 , G02B21/02
摘要： The invention relates to an optical sensor device (100) that comprises a plurality of objectives (152) for generating primary images of corresponding sensor regions (111). The primary images are then mapped with intermediate optics (153) onto a detector plane (154), particularly onto the sensitive plane of an image sensor.
摘要翻译：本发明涉及一种光学传感器装置（100），其包括用于产生对应的传感器区域（111）的原始图像的多个物镜（152）。然后，主图像被中间光学器件（153）映射到检测器平面（154）上，特别是在图像传感器的敏感平面上。

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