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1. 发明授权

US08390817B2 Evanescent field modulation in a biosensor 有权
标题翻译：生物传感器中的消逝场调制
公开(公告)号：US08390817B2
公开(公告)日：2013-03-05
申请号：US12810867
申请日：2008-12-18
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
IPC分类号： G01N21/55 , G01N21/00
CPC分类号： G01N21/552
摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.
摘要翻译：本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。

2. 发明申请

US20080232208A1 High Frequency Central Aperture Tracking 审中-公开
标题翻译：高频中心光圈跟踪
公开(公告)号：US20080232208A1
公开(公告)日：2008-09-25
申请号：US12064085
申请日：2006-08-16
申请人： Alexander Marc Van Der Lee , Dominique Maria Bruls
发明人： Alexander Marc Van Der Lee , Dominique Maria Bruls
IPC分类号： G11B7/09
CPC分类号： G11B7/0903
摘要： The present invention relates to an optical system for performing radial tracking on an associated optical record carrier. The optical system contains at least one radiation-emitting device capable of emitting at least three beams: a first beam for reading and/or recording information, and at least a second beam and a third beam for tracking. The optical system is adapted for radial tracking of the first spot from a tracking error signal generated based on the high-frequency component of the central-aperture signal of the second and third beams. The tracking error signal may be generated based on a difference signal of a DC-level of the power of the high-frequency components of the central-aperture signal.
摘要翻译：本发明涉及一种用于在相关联的光学记录载体上进行径向跟踪的光学系统。该光学系统包含至少一个能够发射至少三个光束的辐射发射装置：用于读取和/或记录信息的第一光束，以及用于跟踪的至少第二光束和第三光束。光学系统适于从基于第二和第三光束的中心孔径信号的高频分量产生的跟踪误差信号中径向跟踪第一光点。可以基于中心孔径信号的高频分量的功率的直流电平的差信号来生成跟踪误差信号。

3. 发明申请

US20120040475A1 SENSING DEVICE FOR DETECTING A TARGET SUBSTANCE 有权
标题翻译：用于检测目标物质的感应装置
公开(公告)号：US20120040475A1
公开(公告)日：2012-02-16
申请号：US13201927
申请日：2010-02-08
申请人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/55
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： The present invention relates to a sensing device (100) for detecting a target substance (2) in an investigation region (113). The sensing device (100) comprises a sensing surface (112) with an investigation region (113) and a reference region (120) thereon. The sensing device (100) further comprises a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing an improved correction of light reflected at the investigation region (113).
摘要翻译：本发明涉及一种用于在调查区域（113）中检测目标物质（2）的感测装置（100）。感测装置（100）包括其上具有调查区域（113）和参考区域（120）的感测表面（112）。感测装置（100）还包括位于参考区域（120）处的参考元件（121）。参考元件（121）适于屏蔽参考区域（120）与目标物质（2），使得在全内反射条件下在参考区域（120）处反射的光线不会受到目标物质的存在或不存在的影响（2）。这允许独立于目标物质（2）的存在或不存在来测量在参考区域（120）处反射的光的特性（通常为强度）。反射光的测量特性可用于对在调查区域（113）反射的光进行改进的校正。

4. 发明申请

US20080314407A1 Method of Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus and a Cleaning Device for Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus 审中-公开
$Method of Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus and a Cleaning Device for Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus$
标题翻译：清洁近场光扫描装置的折射元件的光学面的方法和用于清洁近场光学扫描装置的折射元件的光学面的清洁装置
公开(公告)号：US20080314407A1
公开(公告)日：2008-12-25
申请号：US12097557
申请日：2006-12-06
申请人： Dominique Maria Bruls , Jacobus Maria Antonius Van Den Eerenbeemd , Franciscus Marinus Andrea Maria Van Gaal
发明人： Dominique Maria Bruls , Jacobus Maria Antonius Van Den Eerenbeemd , Franciscus Marinus Andrea Maria Van Gaal
IPC分类号： B08B1/00 , B08B13/00
CPC分类号： G11B7/1387
摘要： The invention provides a method and a device for cleaning of the optical face of a refractive element for a near field optical scanning apparatus. A magnetically susceptible cleaning material is used to facilitate effective cleaning of the refractive element without damage to the element. The method according to the invention can be combined with known cleaning methods if desired.
摘要翻译：本发明提供一种用于清洁近场光学扫描装置的折射元件的光学面的方法和装置。使用磁敏感的清洁材料来促进折射元件的有效清洁而不损坏元件。如果需要，根据本发明的方法可以与已知的清洁方法组合。

5. 发明授权

US09804089B2 Sensing device for detecting a target substance 有权
公开(公告)号：US09804089B2
公开(公告)日：2017-10-31
申请号：US13201927
申请日：2010-02-08
申请人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N33/543 , G01N21/27
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： A sensing device (100) detects a target substance (2) in an investigation region (113). The sensing device (100) includes a sensing surface (112) with an investigation region (113) and a reference region (120). The sensing device (100) further includes a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing a correction of light reflected at the investigation region (113).

6. 发明授权

US09134201B2 Fluid providing apparatus 有权
标题翻译：流体提供装置
公开(公告)号：US09134201B2
公开(公告)日：2015-09-15
申请号：US13000031
申请日：2009-06-22
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
IPC分类号： G01N35/10 , G01N1/02 , G01N35/00
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译：本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。

7. 发明申请

US20110206560A1 BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE 审中-公开
标题翻译：生物传感器与多个盒子
公开(公告)号：US20110206560A1
公开(公告)日：2011-08-25
申请号：US13126000
申请日：2009-10-27
申请人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
发明人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
IPC分类号： G01N30/00
CPC分类号： G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译：本发明提供了一种生物传感器，其包括用于容纳流体样品的盒，所述盒包括至少两个室，其中每个室包括具有一个或多个结合位点的传感器表面。生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。其中，结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。

8. 发明申请

US20080112304A1 Spot Alignment For Parrallel Read-Out Of Two-Dimensional Encoded Optical Storage Media 审中-公开
标题翻译：用于二维编码光存储介质的Parrallel读出的点对齐
公开(公告)号：US20080112304A1
公开(公告)日：2008-05-15
申请号：US11568116
申请日：2005-04-14
申请人： Alexander Marc Van Der Lee , Christopher Busch , Dominique Maria Bruls
发明人： Alexander Marc Van Der Lee , Christopher Busch , Dominique Maria Bruls
IPC分类号： G11B7/00 , G11B7/24
CPC分类号： G11B7/0938 , G11B7/14 , G11B7/24085
摘要： The present invention provides a two-dimensional encoded optical storage medium (12) comprising at least one alignment pattern (14) for aligning a spot array (16) intended to read out the optical storage medium (12). Furthermore, the present invention is directed to a method and a device for reading out a two-dimensional encoded optical storage medium (12) having at least one alignment pattern (14) comprising a plurality of bit rows (R1, R2, R3, R4, R5, R6, R7, R8), wherein at least one bit row (R2, R3, R4, R6, R7, R8) of said alignment pattern (14) is empty.
摘要翻译：本发明提供了一种二维编码光学存储介质（12），其包括用于对准用于读出光学存储介质（12）的光点阵列（16）的至少一个对准图案（14）。此外，本发明涉及一种用于读出具有至少一个对齐图案（14）的二维编码光学存储介质（12）的方法和装置，所述对准图案包括多个位行（R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8），其中所述对准图案（14）的至少一个位列（R 2，R 3，R 4，R 6，R 7，R 8）是空的。

9. 发明授权

US09658219B2 Microelectronic sensor device for detecting label particles 有权
公开(公告)号：US09658219B2
公开(公告)日：2017-05-23
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N21/64 , G01N33/543 , G01N27/74 , G01N21/39
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.

10. 发明授权

US08228506B2 Microelectronic sensor device with a modulated light source 有权
标题翻译：具有调制光源的微电子传感器装置
公开(公告)号：US08228506B2
公开(公告)日：2012-07-24
申请号：US12670148
申请日：2008-07-17
申请人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01B9/02 , G01N21/00 , G01N21/55
CPC分类号： G01N21/552 , G01N21/648 , G01N27/745 , G01N2201/064 , G01N2201/0691 , G01N2201/0696
摘要： A microelectronic sensor device and a method for making optical examinations at a carrier for the detection of magnetic particles, for example, at a contact surface of the carrier by frustrated total internal reflection (FTIR), include a light source with a laser modulator for emitting an input light beam into the carrier. The input light beam is modulated such that optical interferences with reflections of the input light beam from the entrance window, or from other components of the carrier, are reduced or minimized. This can be achieved by a pulsed on/off modulation in which the first relaxation minimum of a currently emitted pulse (PN) coincides in the light source with the first relaxation maximum of a reflected pulse (PN-1′). By reducing the effect of interferences, the setup is less prone to disturbances from dimensional variations that are induced by thermal extension, for example.
摘要翻译：微电子传感器装置和用于在载体处用于检测磁性颗粒的光学检查的方法，例如通过沮丧的全内反射（FTIR）在载体的接触表面处，包括具有用于发射的激光调制器的光源输入光束进入载体。输入光束被调制成使得来自入口窗口的输入光束或者来自载体的其它部件的反射的光学干涉被减小或最小化。这可以通过脉冲开/关调制来实现，其中当前发射的脉冲（PN）的第一弛豫最小值在光源中与反射脉冲（PN-1'）的第一弛豫最大值重合。通过减少干扰的影响，例如，该设置不容易受到由热延伸引起的尺寸变化的干扰。

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