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1. 发明授权

US5712165A Method and apparatus for detecting hydrocarbon oxidation 失效
标题翻译：检测烃类氧化的方法和装置
公开(公告)号：US5712165A
公开(公告)日：1998-01-27
申请号：US294173
申请日：1994-08-22
申请人： Juan G. Alvarez , Mark Modell
发明人： Juan G. Alvarez , Mark Modell
IPC分类号： G01N31/00 , G01N21/33 , G01N21/35 , G01N21/65 , G01N33/02 , G01N33/03 , G01N33/04 , G01N33/12 , G01N33/28 , G01N33/483
CPC分类号： G01N33/03 , G01N21/3563 , G01N21/359 , Y10S250/91 , Y10T436/216 , Y10T436/24
摘要： Systems and methods for material analysis are disclosed in which an organic sample (e.g., a foodstuff, tissue sample or petroleum product) is illuminated at a plurality of discrete wavelengths which are absorbed by fatty acid and fatty acid oxidation products in the sample. Measurements of the intensity of reflected or absorbed light at such wavelengths are taken, and a analysis of absorbance ratios for various wavelengths is performed. Changes in the reflection ratios are correlated with the oxidative state of fatty acids present in the material.
摘要翻译：公开了用于材料分析的系统和方法，其中有机样品（例如，食品，组织样品或石油产品）以在样品中被脂肪酸和脂肪酸氧化产物吸收的多个离散波长照射。测量这些波长的反射或吸收光的强度，并进行各种波长的吸光度比的分析。反射率的变化与材料中存在的脂肪酸的氧化态有关。

2. 发明授权

US08634067B2 Method and apparatus for detecting microscopic objects 有权
标题翻译：用于检测微观物体的方法和装置
公开(公告)号：US08634067B2
公开(公告)日：2014-01-21
申请号：US11596096
申请日：2005-05-11
申请人： Lev T. Perelman , Juan G. Alvarez , Mark D. Modell
发明人： Lev T. Perelman , Juan G. Alvarez , Mark D. Modell
IPC分类号： G01N21/00
CPC分类号： G02B21/0052
摘要： Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.
摘要翻译：装置包括宽带照明源和共焦光学系统。共焦光学系统被配置和布置成通过宽带照明源接收投射到物体上的一部分光。该装置可以包括照明源，共焦光学系统和至少一个被配置和布置为接收对应于共焦体积的角度分离的光的检测器。还提供了一种包括宽带照明源，二维检测器和光谱分离装置的光散射光谱装置，其被配置和布置成接收来自物体的散射光并将至少一部分散射光引导到二维维度检测器。该方法和装置可以将共焦显微技术与光散射光谱学技术结合起来，以产生共焦光散射光谱（CLSS）系统。

3. 发明授权

US06180671B2 Methods for treating disorders in which docosahexaenoic acid (DHA) levels are affected 失效
标题翻译：治疗二十二碳六烯酸（DHA）水平受影响的疾病的方法
公开(公告)号：US06180671B2
公开(公告)日：2001-01-30
申请号：US09248471
申请日：1999-02-11
申请人： Steven Freedman , Juan G. Alvarez
发明人： Steven Freedman , Juan G. Alvarez
IPC分类号： A61K3120
CPC分类号： A61K31/202 , A23L33/12
摘要： A method of treating disorders in which DHA levels are affected is described. The method includes administering to a subject suffering from the disorder a therapeutically affective amount of DHA. This method is particularly useful in treating subjects suffering from a disorder characterized by a defect in the CF, gene, e.g. cystic fibrosis, or a chronic inflammatory disorder, e.g., ulcerative colitis, Crohn's disease, chronic pancreatitis, asthma, rheumatoid arthritis or chronic gastritis. A method of ameliorating affects of cystic fibrosis in a newborn and a method of increasing surfactant levels in a fetus are also described.
摘要翻译：描述了一种治疗其中DHA水平受到影响的疾病的方法。该方法包括给患有该病症的受试者施用治疗上有意义的量的DHA。该方法特别可用于治疗患有以CF，基因例如缺陷为特征的疾病的受试者。囊性纤维化或慢性炎症性疾病，例如溃疡性结肠炎，克罗恩病，慢性胰腺炎，哮喘，类风湿性关节炎或慢性胃炎。还描述了改善新生儿囊性纤维化的影响的方法和增加胎儿中表面活性剂水平的方法。

4. 发明授权

US5912179A Method for determining a level of oxidative stress of a tissue sample 失效
标题翻译：用于确定组织样品的氧化应激水平的方法
公开(公告)号：US5912179A
公开(公告)日：1999-06-15
申请号：US013449
申请日：1998-01-26
申请人： Juan G. Alvarez , Mark Modell
发明人： Juan G. Alvarez , Mark Modell
IPC分类号： G01N31/00 , G01N21/33 , G01N21/35 , G01N21/65 , G01N33/02 , G01N33/03 , G01N33/04 , G01N33/12 , G01N33/28 , G01N33/483 , G01N33/50
CPC分类号： G01N33/03 , G01N21/3563 , G01N21/359 , Y10S250/91 , Y10T436/216 , Y10T436/24
摘要： Systems and methods for material analysis are disclosed in which an organic sample (e.g., a foodstuff, tissue sample or petroleum product) is illuminated at a plurality of discrete wavelengths which are absorbed by fatty acid and fatty acid oxidation products in the sample. Measurements of the intensity of reflected or absorbed light at such wavelengths are taken, and a analysis of absorbance ratios for various wavelengths is performed. Changes in the reflection ratios are correlated with the oxidative state of fatty acids present in the material.
摘要翻译：公开了用于材料分析的系统和方法，其中有机样品（例如，食品，组织样品或石油产品）以在样品中被脂肪酸和脂肪酸氧化产物吸收的多个离散波长照射。测量这些波长的反射或吸收光的强度，并进行各种波长的吸光度比的分析。反射率的变化与材料中存在的脂肪酸的氧化态有关。

5. 发明授权

US5895749A Male fertility and contraception home test kits 失效
标题翻译：男性生育和避孕家庭测试包
公开(公告)号：US5895749A
公开(公告)日：1999-04-20
申请号：US332825
申请日：1994-10-31
申请人： Juan G. Alvarez
发明人： Juan G. Alvarez
IPC分类号： A61D19/00 , C12Q1/28 , G01N33/50 , G01N33/573 , G01N33/68 , G01N33/537 , G01N33/543
CPC分类号： C12Q1/28 , A61D19/00 , G01N33/5091 , G01N33/573 , G01N33/689 , Y10S435/806 , Y10S435/975 , Y10S436/906 , Y10T436/25125 , Y10T436/25375
摘要： Kits and assays, incorporating antibodies specific for glutathione peroxidase, for determining the fertilizing ability of a male at home or in a clinical laboratory are disclosed.
摘要翻译：公开了包含对谷胱甘肽过氧化物酶特异性的抗体的试剂盒和测定法，用于确定在家或临床实验室中男性的受精能力。

6. 发明授权

US5856196A Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor 失效
标题翻译：用于定量脂质混合物中的磷酸甘油酯的方法及其诊断用途
公开(公告)号：US5856196A
公开(公告)日：1999-01-05
申请号：US388759
申请日：1995-02-16
申请人： Juan G. Alvarez , Jack Ludmir
发明人： Juan G. Alvarez , Jack Ludmir
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/689 , G01N33/92 , G01N2800/36 , G01N2800/368 , Y10S436/907 , Y10T436/163333 , Y10T436/25
摘要： Processes for detecting or quantitating a particular phosphoglyceride in a sample containing the phosphoglyceride and other lipids and clinical uses for the process (e.g. for diagnosing improperly functioning lungs and other conditions) are disclosed.
摘要翻译：公开了用于检测或定量含有磷酸甘油酯和其它脂质的样品中的特定磷酸甘油酯的方法和用于该方法的临床用途（例如用于诊断不正常功能的肺和其它病症）。

7. 发明授权

US06552081B1 Methods for treating disorders in which docosahexaenoic acid (DHA) levels are affected 失效
标题翻译：治疗二十二碳六烯酸（DHA）水平受影响的疾病的方法
公开(公告)号：US06552081B1
公开(公告)日：2003-04-22
申请号：US09706404
申请日：2000-11-03
申请人： Steven Freedman , Juan G. Alvarez
发明人： Steven Freedman , Juan G. Alvarez
IPC分类号： A61K3120
CPC分类号： A61K31/202 , A23L33/12
摘要： A method of treating disorders in which DHA levels are affected is described. The method includes administering to a subject suffering from the disorder a therapeutically affective amount of DHA. This method is particularly useful in treating subjects suffering from a disorder characterized by a defect in the CF gene, e.g., cystic fibrosis, or a chronic inflammatory disorder, e.g., ulcerative colitis, Crohn's disease, chronic pancreatitis, asthma, rheumatoid arthritis or chronic gastritis. A method of ameliorating affects of cystic fibrosis in a newborn and a method of increasing surfactant levels in a fetus are also described.
摘要翻译：描述了一种治疗其中DHA水平受到影响的疾病的方法。该方法包括给患有该病症的受试者施用治疗上有意义的量的DHA。该方法特别适用于治疗以CF基因缺陷为特征的疾病，例如囊性纤维化或慢性炎症性疾病，例如溃疡性结肠炎，克罗恩病，慢性胰腺炎，哮喘，类风湿性关节炎或慢性胃炎。还描述了改善新生儿囊性纤维化的影响的方法和增加胎儿中表面活性剂水平的方法。

8. 发明授权

US5443989A Method for assessing fetal lung maturity using amniotic fluid samples 失效
标题翻译：使用羊水样品评估胎儿肺成熟的方法
公开(公告)号：US5443989A
公开(公告)日：1995-08-22
申请号：US140569
申请日：1993-10-25
申请人： Juan G. Alvarez , Jack Ludmir
发明人： Juan G. Alvarez , Jack Ludmir
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/689 , G01N33/92 , G01N2800/36 , G01N2800/368 , Y10T436/255
摘要： The present invention provides an accurate, rapid and precise methodology for assessing maturity of the lungs in a fetus prior to birth, especially for premature fetuses having a gestation period of 37 weeks or less. The methodology quantitatively measures a specific phosphoglyceride, dipalmitoyl phosphatidyl choline, in samples of amniotic fluid for the assessment of fetal lung maturity. The process enzymatically cleaves such phophoglycerides and preferably detects the resulting diacylglycerols by HPTLC-reflectance spectrodensitometry.
摘要翻译：本发明提供了一种用于评估出生前胎儿肺部成熟度的准确，快速和精确的方法，特别是对于怀孕期为37周或更短的早产胎儿。该方法定量测量羊水样品中特定的磷酸甘油酯，二棕榈酰磷脂酰胆碱，用于评估胎儿肺成熟度。该方法酶促切割这种磷酸甘油酯，并优选通过HPTLC反射光谱法测定所得的二酰基甘油。

9. 发明申请

US20110122487A1 Method and Apparatus For Detecting Microscopic Objects 有权
标题翻译：用于检测微观物体的方法和装置
公开(公告)号：US20110122487A1
公开(公告)日：2011-05-26
申请号：US11596096
申请日：2005-05-11
申请人： Lev T. Perelman , Juan G. Alvarez , Mark Modell
发明人： Lev T. Perelman , Juan G. Alvarez , Mark Modell
IPC分类号： G02B21/00
CPC分类号： G02B21/0052
摘要： Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.
摘要翻译：装置包括宽带照明源和共焦光学系统。共焦光学系统被配置和布置成通过宽带照明源接收投射到物体上的一部分光。该装置可以包括照明源，共焦光学系统和至少一个被配置和布置为接收对应于共焦体积的角度分离的光的检测器。还提供了一种包括宽带照明源，二维检测器和光谱分离装置的光散射光谱装置，其被配置和布置成接收来自物体的散射光并将至少一部分散射光引导到二维维度检测器。该方法和装置可以将共焦显微技术与光散射光谱学技术结合起来，以产生共焦光散射光谱（CLSS）系统。

10. 发明授权

US5935800A Assays and kits for determining male fertility 失效
标题翻译：确定男性生育力的测定和试剂盒
公开(公告)号：US5935800A
公开(公告)日：1999-08-10
申请号：US719756
申请日：1996-09-25
申请人： Juan G. Alvarez
发明人： Juan G. Alvarez
IPC分类号： A61D19/00 , C12Q1/28 , G01N33/50 , G01N33/573 , G01N33/68 , G01N33/52 , G01N21/00 , G01N33/53
CPC分类号： C12Q1/28 , A61D19/00 , G01N33/5091 , G01N33/573 , G01N33/689 , G01N2800/367 , Y10S435/806 , Y10S435/975 , Y10S436/808 , Y10S436/81 , Y10S436/906 , Y10T436/255
摘要： Assays and kits for identifying fertile sperm samples (e.g. for use in an assisted reproductive technology or as an indication of an ineffective male contraception (vasectomy)) and sub-fertile sperm samples (e.g. as an indication of a potentially infertile male donor or an effective male contraception) are disclosed.
摘要翻译：用于识别肥沃精子样品的检测和试剂盒（例如用于辅助生殖技术或作为无效男性避孕（输精管切除术））的指示）和亚育种精子样品（例如，作为潜在不育男性供体或有效的男性避孕）。

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