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1. 发明申请

US20180094240A1 ARTIFICIAL OOCYTE ACTIVATION 审中-公开
公开(公告)号：US20180094240A1
公开(公告)日：2018-04-05
申请号：US15726672
申请日：2017-10-06
申请人： Kiho Lee , Randall S. Prather
发明人： Kiho Lee , Randall S. Prather
IPC分类号： C12N5/075 , C12N15/877 , A01K67/027
CPC分类号： C12N5/0609 , A01K67/0273 , A01K2227/108 , C12N15/877 , C12N15/8778 , C12N2500/14 , C12N2500/22 , C12N2501/405 , C12N2517/04 , C12N2517/10
摘要： The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to reduction of the intracellular Zn2+ concentration. The invention further provides unfertilized oocytes activated by the disclosed methods and viable mammalian animals produced from unfertilized oocytes activated by the disclosed methods.

2. 发明授权

US09131133B2 Stabilized camera module 有权
标题翻译：稳定相机模块
公开(公告)号：US09131133B2
公开(公告)日：2015-09-08
申请号：US13519489
申请日：2010-12-28
申请人： Kiho Lee
发明人： Kiho Lee
IPC分类号： H04N5/228 , H04N5/225
CPC分类号： H04N5/2252 , H04N5/2257
摘要： The present invention relates to a stabilized camera module configured to prevent instable movement of a bobbin caused by outside force, the module including a holder formed at a lateral surface with at least one slit, a bobbin movably coupled to an inside of the holder and having a protruder protruding outside of the holder by penetrating the slit, a lens assembly coupled to an inside of the bobbin and including one or more lenses receiving an optical image of an object, and one or more elastic members formed between the holder and the bobbin to prevent the bobbin from moving to one side of the holder.
摘要翻译：本发明涉及一种稳定的相机模块，其被配置为防止由外力引起的筒管不稳定的移动，所述模块包括形成在具有至少一个狭缝的侧表面的保持器，可移动地联接到所述保持器的内部的筒管，通过穿过狭缝而突出在保持器外侧的突出部，连接到线轴的内部并且包括容纳物体的光学图像的一个或多个透镜以及形成在保持器和线轴之间的一个或多个弹性部件的透镜组件，防止梭芯移动到支架的一侧。

3. 发明授权

US08940936B2 Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient 有权
标题翻译：具有HIF-1抑制活性的芳氧基苯氧基丙烯酸化合物及其制备方法，以及含有它们作为活性成分的药物组合物
公开(公告)号：US08940936B2
公开(公告)日：2015-01-27
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C233/07 , A61K31/167 , C07C235/28 , C07C311/16 , C07D295/088
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

4. 发明申请

US20130237542A1 ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：具有HIF-1抑制活性的芳族羟基丙烯酸酯化合物，其制备方法和含有活性成分的药物组合物
公开(公告)号：US20130237542A1
公开(公告)日：2013-09-12
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C235/28 , C07D295/088 , C07C311/16
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

5. 发明授权

US5494497A Air cleaner assembly for vehicle 失效
标题翻译：汽车空气净化器总成
公开(公告)号：US5494497A
公开(公告)日：1996-02-27
申请号：US175573
申请日：1993-12-30
申请人： Kiho Lee
发明人： Kiho Lee
IPC分类号： B01D46/42 , F02M35/024 , B01D46/10 , B01D46/52
CPC分类号： B01D46/10 , B01D46/0006 , F02M35/024 , B01D2279/60
摘要： The present invention provides an air cleaner assembly including an air cleaner housing includes an air inlet connected with an air duct through which atmospheric air is introduced and an air outlet connected with an intake hose for supplying the air to a combustion chamber, a filter element disposed in the air cleaner housing to filter out impurities within the air, a slot formed on the air cleaner housing to slidably mount the filter element in the air cleaner housing, and a guide rib for securely mounting the filter element which is inserted into the slot.
摘要翻译：本发明提供了一种空气滤清器组件，其包括空气滤清器壳体，该空气滤清器壳体包括与空气导管连接的空气入口，大气通过该空气导入，以及与用于向燃烧室供应空气的进气软管连接的空气出口，在空气滤清器壳体中，以滤除空气中的杂质，形成在空气滤清器壳体上的槽，以将过滤元件可滑动地安装在空气滤清器壳体中;以及引导肋，用于牢固地安装插入槽中的过滤元件。

6. 发明授权

US09392147B2 Camera module having elastic stiffening material for efficient shock absorbing property and method for manufacturing the same 有权
标题翻译：相机模块具有用于高效冲击吸收性能的弹性加强材料及其制造方法
公开(公告)号：US09392147B2
公开(公告)日：2016-07-12
申请号：US13988237
申请日：2011-11-10
申请人： Kiho Lee
发明人： Kiho Lee
IPC分类号： H04N5/225 , G03B17/02
CPC分类号： H04N5/2252 , G03B17/02 , H04N5/2253 , H04N5/2257 , Y10T29/49128
摘要： The present invention relates to a camera module, the camera module including: a PCB (Printed Circuit Board), an image sensor mounted on the PCB and formed with an imaging device for converting light to an electrical signal; a housing fixed a bottom end to an upper surface of the PCB, the housing being a case formed with a hole at an upper center and having a bottom-opened inner space: a lens assembly having at least one lens aligned to the lens hole by being positioned at and contacted to an upper surface of the image sensor and accommodated at an inner space of the housing; and an elastic stiffening material inserted between a lens hole periphery at an upper inner side of the housing and an upper edge of the lens assembly.
摘要翻译：本发明涉及一种相机模块，该相机模块包括：PCB（印刷电路板），安装在PCB上的图像传感器，并形成有用于将光转换成电信号的成像装置; 壳体，其底部固定到PCB的上表面，所述壳体是在上部中心形成有孔的壳体，并且具有底部打开的内部空间;透镜组件，其具有至少一个透镜，其通过与所述透镜孔对准的至少一个透镜定位在图像传感器的上表面并接触图像传感器的上表面并容纳在壳体的内部空间中; 以及插入在壳体的上内侧的透镜孔周边与透镜组件的上边缘之间的弹性加强材料。

7. 发明申请

US20130242183A1 Camera Module and Method for Manufacturing the Same 有权
标题翻译：相机模块及其制造方法
公开(公告)号：US20130242183A1
公开(公告)日：2013-09-19
申请号：US13988237
申请日：2011-11-10
申请人： Kiho Lee
发明人： Kiho Lee
IPC分类号： H04N5/225
CPC分类号： H04N5/2252 , G03B17/02 , H04N5/2253 , H04N5/2257 , Y10T29/49128
摘要： The present invention relates to a camera module, the camera module including: a PCB (Printed Circuit Board), an image sensor mounted on the PCB and formed with an imaging device for converting light to an electrical signal; a housing fixed a bottom end to an upper surface of the PCB, the housing being a case formed with a hole at an upper center and having a bottom-opened inner space: a lens assembly having at least one lens aligned to the lens hole by being positioned at and contacted to an upper surface of the image sensor and accommodated at an inner space of the housing; and an elastic stiffening material inserted between a lens hole periphery at an upper inner side of the housing and an upper edge of the lens assembly.
摘要翻译：本发明涉及一种相机模块，该相机模块包括：PCB（印刷电路板），安装在PCB上的图像传感器，并形成有用于将光转换成电信号的成像装置; 壳体，其底部固定到PCB的上表面，所述壳体是在上部中心形成有孔的壳体，并且具有底部打开的内部空间;透镜组件，其具有至少一个透镜，其通过与所述透镜孔对准的至少一个透镜定位在图像传感器的上表面并接触图像传感器的上表面并容纳在壳体的内部空间中; 以及插入在壳体的上内侧的透镜孔周边与透镜组件的上边缘之间的弹性加强材料。

8. 发明申请

US20130002894A1 STABILIZED CAMERA MODULE 有权
标题翻译：稳定相机模块
公开(公告)号：US20130002894A1
公开(公告)日：2013-01-03
申请号：US13519489
申请日：2010-12-28
申请人： Kiho Lee
发明人： Kiho Lee
IPC分类号： H04N5/225
CPC分类号： H04N5/2252 , H04N5/2257
摘要： The present invention relates to a stabilized camera module configured to prevent instable movement of a bobbin caused by outside force, the module including a holder formed at a lateral surface with at least one slit, a bobbin movably coupled to an inside of the holder and having a protruder protruding outside of the holder by penetrating the slit, a lens assembly coupled to an inside of the bobbin and including one or more lenses receiving an optical image of an object, and one or more elastic members formed between the holder and the bobbin to prevent the bobbin from moving to one side of the holder.
摘要翻译：本发明涉及一种稳定的相机模块，其被配置为防止由外力引起的筒管不稳定的移动，所述模块包括形成在具有至少一个狭缝的侧表面的保持器，可移动地联接到所述保持器的内部的筒管，通过穿过狭缝而突出在保持器外侧的突出部，连接到线轴的内部并且包括容纳物体的光学图像的一个或多个透镜以及形成在保持器和线轴之间的一个或多个弹性部件的透镜组件，防止梭芯移动到支架的一侧。

9. 发明授权

US07964605B2 Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof 有权
标题翻译：苯基哌嗪化合物，包含它们的药物组合物及其用途
公开(公告)号：US07964605B2
公开(公告)日：2011-06-21
申请号：US12128999
申请日：2008-05-29
申请人： Yonggil Kim , Kiho Lee , Nahmryune Cho , Jin Uk Yoo , Joon Heo , Choonho Ryu , Seonmin Dong , Man-Young Cha , Jong Gil Choi , Yunhee Kim , Mi Kyung Ji
发明人： Yonggil Kim , Kiho Lee , Nahmryune Cho , Jin Uk Yoo , Joon Heo , Choonho Ryu , Seonmin Dong , Man-Young Cha , Jong Gil Choi , Yunhee Kim , Mi Kyung Ji
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07D295/088 , C07D295/096
摘要： The present invention relates to a novel piperazine derivative or pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition for treating central nervous system diseases comprising an effective amount of the piperazine compound and a method of treating central nervous system (CNS) disorder such as psychosis in a mammal.
摘要翻译：本发明涉及一种新的哌嗪衍生物或其药学上可接受的盐，其制备方法，用于治疗中枢神经系统疾病的药物组合物，其包含有效量的哌嗪化合物和治疗中枢神经系统（CNS）的方法，疾病如精神病在哺乳动物中。

10. 发明申请

US20110118264A1 PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF 有权
标题翻译：苯基哌嗪化合物，包括它们的药物组合物及其用途
公开(公告)号：US20110118264A1
公开(公告)日：2011-05-19
申请号：US13015717
申请日：2011-01-28
申请人： Yonggil Kim , Nahmryune Cho , Yunhee Kim , Joon Heo , Seonmin Dong , Mi Kyung Ji , Man-Young Cha , Kiho Lee
发明人： Yonggil Kim , Nahmryune Cho , Yunhee Kim , Joon Heo , Seonmin Dong , Mi Kyung Ji , Man-Young Cha , Kiho Lee
IPC分类号： A61K31/5377 , A61K31/496 , A61P25/22 , A61P25/24
CPC分类号： A61K31/496 , A61K31/5377 , C07D231/54 , C07D233/58 , C07D235/08 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/14 , C07D285/135 , C07D295/088 , C07D295/096
摘要： The present invention relates to novel piperazine derivatives or pharmaceutically acceptable salts thereof, a process for preparing the same, and in particular, a high binding for Serotonin 1A(5-hydroxytryptamine; 5-HT1A) receptor, a pharmaceutical composition for treatment and/or prevention of depression and anxiety including an effective amount of the piperazine compound, and a method of treating depression, anxiety and other conditions related to 5-HT1A receptor in a mammal
摘要翻译：本发明涉及新颖的哌嗪衍生物或其药学上可接受的盐，其制备方法，特别是5-羟色胺1A（5-羟色胺; 5-HT1A）受体的高结合，用于治疗和/或预防抑郁和焦虑，包括有效量的哌嗪化合物，以及在哺乳动物中治疗与5-HT1A受体有关的抑郁，焦虑和其它病症的方法

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