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1. 发明授权

US08940936B2 Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient 有权
标题翻译：具有HIF-1抑制活性的芳氧基苯氧基丙烯酸化合物及其制备方法，以及含有它们作为活性成分的药物组合物
公开(公告)号：US08940936B2
公开(公告)日：2015-01-27
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C233/07 , A61K31/167 , C07C235/28 , C07C311/16 , C07D295/088
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

2. 发明申请

US20130237542A1 ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：具有HIF-1抑制活性的芳族羟基丙烯酸酯化合物，其制备方法和含有活性成分的药物组合物
公开(公告)号：US20130237542A1
公开(公告)日：2013-09-12
申请号：US13880642
申请日：2011-10-17
申请人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
发明人： Kyeong Lee , Mi Sun Won , Hwan Mook Kim , Song Kyu Park , Kiho Lee , Ki Hoon Lee , Chang Woo Lee , Jung Joon Lee , Kyung Sook Chung , Bo Kyung Kim , Yinglan Jin , Seung-hee Lee
IPC分类号： C07C235/28 , C07D295/088 , C07C311/16
CPC分类号： A61K31/5375 , A61K9/0019 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/167 , A61K31/196 , A61K31/24 , A61K31/34 , A61K31/40 , A61K31/417 , A61K31/4409 , C07C233/07 , C07C235/28 , C07C311/16 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D295/088
摘要： The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
摘要翻译：本发明涉及抑制HF-1活性的化合物，其制备方法以及含有该化合物作为活性成分的药物组合物。本发明的化合物通过非选择性细胞毒性表现出抗癌活性，但通过抑制HIF-1的活性，该转录因子在癌细胞生长和转移中起重要作用。因此，根据本发明的化合物或其药学上可接受的盐抑制HIF-1活性，因此可以用作结肠癌，肝癌，胃癌和乳腺癌等实体瘤的治疗剂。此外，根据本发明的化合物或其药学上可接受的盐可以用作用于糖尿病性视网膜病变或关节炎的治疗剂的活性成分，当HIF-1的缺氧诱导的VEGF表达增加时，可能变差。

3. 发明授权

US07846963B2 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same 失效
标题翻译： 2-氧杂环化合物和包含它们的药物组合物
公开(公告)号：US07846963B2
公开(公告)日：2010-12-07
申请号：US10557085
申请日：2004-05-17
申请人： Yung Hee Kho , Gyoon Hee Han , Ho Jae Lee , Bum Woo Park , Hyo Kon Chun , Hwan Mook Kim , Song Kyu Park , Sang Bae Han , Dong Kyu Ryu , Tae Gyu Chun , Jin Ha Lee , Chang Woo Lee , Ki Hoon Lee , Hee Yoon Lee
发明人： Yung Hee Kho , Gyoon Hee Han , Ho Jae Lee , Bum Woo Park , Hyo Kon Chun , Hwan Mook Kim , Song Kyu Park , Sang Bae Han , Dong Kyu Ryu , Tae Gyu Chun , Jin Ha Lee , Chang Woo Lee , Ki Hoon Lee , Hee Yoon Lee
IPC分类号： A01N43/36 , A61K31/40 , C07D207/00 , C07D295/00 , C09B1/00
CPC分类号： C07D207/26 , C07D207/38 , C07D211/86 , C07D409/06
摘要： The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.
摘要翻译：本发明涉及新的2-氧代环状化合物及其制备方法和包含其的药物组合物。本发明提供了用于预防和治疗炎性疾病的药物组合物，其包括由风湿性疾病引起的疼痛或炎症，例如类风湿性关节炎，脊椎动物病变，痛风，骨关节炎，系统性红斑狼疮和幼年关节炎以及炎性综合征，例如，肌炎，牙龈炎，滑膜炎，强直性脊柱炎，爆发性炎症，烧伤和瘢痕，炎性克罗恩病，I型糖尿病。因此，它可以用作治疗和预防炎性疾病的治疗剂。

4. 发明授权

US07723376B2 2-oxo-heterocyclic compounds and pharmaceutical compositions 失效
标题翻译： 2-氧杂环化合物和药物组合物
公开(公告)号：US07723376B2
公开(公告)日：2010-05-25
申请号：US10564653
申请日：2004-07-15
申请人： Hwan Mook Kim , Gyoon Hee Han , Song Kyu Park , Chang Woo Lee , Sang Bae Han , Ki Hoon Lee , Yung Hee Kho , Jin Hyuk Yang , Bum Woo Park , Hyang Woo Lee , Jeung Whan Han , Dong Kyu Ryu , Jin Ha Lee , Tae Gyu Chun , Yong Kee Kim , Hee Yoon Lee , Bong Yong Lee , Jeom Yong Kim , Ji Duck Kim , Kyunga Yu , Sun Young Kim
发明人： Hwan Mook Kim , Gyoon Hee Han , Song Kyu Park , Chang Woo Lee , Sang Bae Han , Ki Hoon Lee , Yung Hee Kho , Jin Hyuk Yang , Bum Woo Park , Hyang Woo Lee , Jeung Whan Han , Dong Kyu Ryu , Jin Ha Lee , Tae Gyu Chun , Yong Kee Kim , Hee Yoon Lee , Bong Yong Lee , Jeom Yong Kim , Ji Duck Kim , Kyunga Yu , Sun Young Kim
IPC分类号： A01N43/36
CPC分类号： A61K31/454 , A61K31/4015 , A61K31/4545 , C07D207/38 , C07D211/86 , C07D223/10 , C07D417/06
摘要： The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.
摘要翻译：本发明涉及具有抗癌活性的2-氧代杂环化合物及其制备方法的新用途以及包含其的药物组合物。本发明提供了用于预防和治疗包括肺癌，骨癌，胰腺癌，皮肤癌，头颈癌，皮肤或眼内黑素瘤，子宫癌，卵巢癌，直肠癌或癌症的癌症疾病的药物组合物肛门区域，胃癌，结肠癌，乳腺癌，妇科肿瘤，霍奇金病，食道癌，小肠癌，内分泌系统癌，软组织肉瘤，尿道癌，阴茎癌，前列腺癌，慢性或急性白血病，儿童实体瘤，淋巴细胞淋巴管，膀胱癌，肾或输尿管癌，或中枢神经系统肿瘤，因此可用作治疗和预防的治疗剂癌症疾病

5. 发明授权

US08324958B2 Redundancy circuits 有权
标题翻译：冗余电路
公开(公告)号：US08324958B2
公开(公告)日：2012-12-04
申请号：US12844454
申请日：2010-07-27
申请人： Ki Hoon Lee
发明人： Ki Hoon Lee
IPC分类号： H03K19/003 , H01H37/76
CPC分类号： H03K19/00392
摘要： In one embodiment, a redundancy circuit may include a comparison unit configured to record a first repair address through fuse cutting, compare a comparison address with the first repair address, and output a comparison result signal; a first fuse enable unit configured to output a first fuse enable signal for repairing the first repair address; a second fuse enable unit configured to output a second fuse enable signal for repairing a second repair address; a first determination unit configured to output a first repair determination signal in response to receipt of the first fuse enable signal and the comparison result signal; and a second determination unit configured to output a second repair determination signal in response to receipt of an inverted signal of a value of the comparison result signal corresponding to the certain bit, remaining bits, and the second fuse enable signal.
摘要翻译：在一个实施例中，冗余电路可以包括比较单元，其被配置为通过熔丝切割记录第一修复地址，将比较地址与第一修复地址进行比较，并输出比较结果信号; 第一熔丝使能单元，被配置为输出用于修复所述第一修复地址的第一熔丝使能信号; 第二熔丝使能单元，被配置为输出用于修复第二修复地址的第二熔丝使能信号; 第一确定单元，被配置为响应于接收到所述第一熔丝使能信号和所述比较结果信号而输出第一修复确定信号; 以及第二确定单元，被配置为响应于与特定比特，剩余比特和第二保险丝使能信号相对应的比较结果信号的值的反相信号而输出第二修复确定信号。

6. 发明申请

US20110219367A1 COMMUNICATION METHOD IN WIRELESS NETWORK 有权
标题翻译：无线网络中的通信方法
公开(公告)号：US20110219367A1
公开(公告)日：2011-09-08
申请号：US13063549
申请日：2009-09-11
申请人： Ki Hoon Lee
发明人： Ki Hoon Lee
IPC分类号： G06F9/44
CPC分类号： H04W8/245 , G06F8/65 , H04L67/34 , H04N21/43637 , H04N21/818 , H04W24/02
摘要： The present invention relates to a communication method for upgrading software in a wireless network. The communication method according to one aspect of the present invention relates to a communication method for upgrading software on a specific device on a wireless network, and comprises a step wherein a first message that includes information indicating versions of one or more pieces of software being used by said device is transmitted to a controller of said wireless network and a step wherein said device receives from said controller a second message that includes indication information indicating whether it is necessary to perform a software upgrade.
摘要翻译：本发明涉及一种用于升级无线网络中的软件的通信方法。根据本发明的一个方面的通信方法涉及一种用于在无线网络上的特定设备上升级软件的通信方法，并且包括以下步骤：其中包括指示正在使用的一个或多个软件的版本的信息的第一消息通过所述设备被发送到所述无线网络的控制器，并且其中所述设备从所述控制器接收包括指示是否需要执行软件升级的指示信息的第二消息的步骤。

7. 发明授权

US07842606B2 Method of depositing thin film and method of manufacturing semiconductor using the same 有权
标题翻译：沉积薄膜的方法和使用其制造半导体的方法
公开(公告)号：US07842606B2
公开(公告)日：2010-11-30
申请号：US11720450
申请日：2005-11-28
申请人： Ki Hoon Lee , Young Hoon Park , Sahng Kyoo Lee , Tae Wook Seo , Ho Seung Chang
发明人： Ki Hoon Lee , Young Hoon Park , Sahng Kyoo Lee , Tae Wook Seo , Ho Seung Chang
IPC分类号： H01L21/4763 , H01L21/02
CPC分类号： G03F7/091 , H01L21/0276 , H01L21/3146 , Y10S438/952
摘要： Disclosed herein are a method of depositing a thin film and a method of manufacturing a semiconductor using the same, having high selectivity by increasing etching resistance while an extinction coefficient associated with anti-reflectivity is maintained low. The method of depositing a thin film according to the invention includes (a) depositing an carbon anti-reflective film on the bottom film of a substrate; and (b) adding a compound containing nitrogen (N), fluorine (F) or silicon (Si) to the surface or the inner portion of the carbon anti-reflective film, to deposit a thin film of a-C:N, a-C:F or a-C:Si, having high selectivity, to a thickness from 1 to 100 nm using an atomic layer deposition process. Therefore, an ultrathin film having etching resistance is formed on or in the carbon anti-reflective film and the density and compressive stress of the carbon anti-reflective film are increased, thus increasing etching selectivity.
摘要翻译：本文公开了一种沉积薄膜的方法和使用该薄膜的半导体的制造方法，通过增加抗蚀性而具有高选择性，同时将与抗反射性相关联的消光系数保持为低。根据本发明的沉积薄膜的方法包括（a）在基底的底膜上沉积碳抗反射膜; 和（b）在碳抗反射膜的表面或内部添加含有氮（N），氟（F）或硅（Si）的化合物，沉积a：N，aC：F 或aC：Si，具有高选择性，使用原子层沉积工艺，厚度为1至100nm。因此，在碳抗反射膜上或碳抗反射膜上形成具有耐腐蚀性的超薄膜，并且碳抗反射膜的密度和压缩应力增加，从而增加蚀刻选择性。

8. 发明授权

US08607222B2 Communication method for upgrading software over a wireless network 有权
标题翻译：通过无线网络升级软件的通信方法
公开(公告)号：US08607222B2
公开(公告)日：2013-12-10
申请号：US13063549
申请日：2009-09-11
申请人： Ki Hoon Lee
发明人： Ki Hoon Lee
IPC分类号： G06F9/445
CPC分类号： H04W8/245 , G06F8/65 , H04L67/34 , H04N21/43637 , H04N21/818 , H04W24/02
摘要： The present invention relates to a communication method for upgrading software in a wireless network. The communication method according to one aspect of the present invention relates to a communication method for upgrading software on a specific device on a wireless network, and comprises a step wherein a first message that includes information indicating versions of one or more pieces of software being used by said device is transmitted to a controller of said wireless network and a step wherein said device receives from said controller a second message that includes indication information indicating whether it is necessary to perform a software upgrade.
摘要翻译：本发明涉及一种用于升级无线网络中的软件的通信方法。根据本发明的一个方面的通信方法涉及一种用于在无线网络上的特定设备上升级软件的通信方法，并且包括以下步骤：其中包括指示正在使用的一个或多个软件的版本的信息的第一消息通过所述设备被发送到所述无线网络的控制器，并且其中所述设备从所述控制器接收包括指示是否需要执行软件升级的指示信息的第二消息的步骤。

9. 发明申请

US20130212044A1 SYSTEM AND MEHTOD FOR MANAGING A DISTRIBUTION NETWORK OF INVESTMENT MONEY 审中-公开
标题翻译：用于管理投资金额分配网络的系统和手段
公开(公告)号：US20130212044A1
公开(公告)日：2013-08-15
申请号：US13820752
申请日：2011-09-06
申请人： Ki Hoon Lee , Jin Heung Bae
发明人： Ki Hoon Lee , Jin Heung Bae
IPC分类号： G06Q40/06
CPC分类号： G06Q20/10 , G06Q40/06
摘要： This disclosure relates to a system and method for managing a distribution channel of investment money of a customer, which includes a plurality of modules systematically disposed in a communication pipeline of an IM managing backbone server, so that when an IM rebalancing opportunity situation occurs, a plurality of units, possessed by a customer, is guided to form a set of IM rebalancing distribution channel networks where the units are densely connected each other like a mesh, so that a customer or IM management company may not simplify but diversify rebalancing paths of IPs or IP portfolio into various patterns and therefore effectively enjoy resultant economic benefits.
摘要翻译：本公开涉及一种用于管理客户的投资资金分配渠道的系统和方法，该系统和方法包括系统地设置在IM管理骨干服务器的通信流水线中的多个模块，使得当IM重新平衡机会情况发生时，指导客户拥有的多个单位，形成一组IM重新平衡分销渠道网络，其中单元彼此密切相连，如网格，使得客户或IM管理公司可能不会简化但多样化的IP重新平衡路径或知识产权组合成各种模式，从而有效地获得经济效益。

10. 发明授权

US08493809B2 Refresh control circuit and semiconductor memory apparatus using the same 有权
标题翻译：刷新控制电路和使用其的半导体存储装置
公开(公告)号：US08493809B2
公开(公告)日：2013-07-23
申请号：US12958233
申请日：2010-12-01
申请人： Ki Hoon Lee
发明人： Ki Hoon Lee
IPC分类号： G11C11/406 , G11C8/12
CPC分类号： G11C11/40618
摘要： A refresh control circuit is capable of activating a plurality of bank selection signals in response to a refresh command signal. Each of the plurality of bank selection signals is assigned to one of a plurality of bank groups. The refresh control circuit is configured to activate the plurality of bank selection signals when a refresh cycle selection signal is deactivated, and activate a part of the plurality of bank selection signals when the refresh cycle selection signal is activated.
摘要翻译：刷新控制电路能够响应于刷新命令信号激活多个存储体选择信号。多个存储体选择信号中的每一个被分配给多个存储体组中的一个。刷新控制电路被配置为当刷新周期选择信号被去激活时激活多个存储体选择信号，并且当刷新周期选择信号被激活时激活多个存储体选择信号的一部分。

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