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1. 发明授权

US09568450B2 Measuring arrangement and method for registering an analyte concentration in a measured medium 有权
标题翻译：在测量介质中记录分析物浓度的测量布置和方法
公开(公告)号：US09568450B2
公开(公告)日：2017-02-14
申请号：US13816091
申请日：2011-08-08
申请人： Michael Hanko , Thomas Wilhelm
发明人： Michael Hanko , Thomas Wilhelm
IPC分类号： G01N27/416 , G01N27/333 , G01N27/49 , G01N27/30 , G01N27/48
CPC分类号： G01N27/416 , G01N27/30 , G01N27/302 , G01N27/333 , G01N27/4167 , G01N27/48 , G01N27/49
摘要： A measuring arrangement for registering an analyte concentration in a measured medium includes a three electrode arrangement having a working electrode, a reference electrode and a counter electrode. The working electrode includes an analyte-insensitive, redox mediator, and the reference electrode a pH-sensitive electrode. The counter electrode can be formed of an inert, electrically conductive material. The measuring arrangement can be embodied to provide a desired voltage between the working electrode and the reference electrode and to register the electrical current flowing, in such case, through the measured medium, between the counter electrode and the working electrode.
摘要翻译：用于在测量介质中记录分析物浓度的测量装置包括具有工作电极，参考电极和对电极的三电极装置。工作电极包括分析物不敏感的氧化还原介体，参比电极包括pH敏感电极。对电极可以由惰性的导电材料形成。测量装置可以实现为在工作电极和参考电极之间提供期望的电压，并且在这种情况下记录在对电极和工作电极之间流过测量介质的电流。

2. 发明授权

US09201039B2 Measuring transducer for determining a measured variable representing a content of H+and/or oh−ions in a measured medium 有权
标题翻译：测量传感器，用于确定表示测量介质中H +和/或oh-离子含量的测量变量
公开(公告)号：US09201039B2
公开(公告)日：2015-12-01
申请号：US13530459
申请日：2012-06-22
申请人： Michael Hanko , Thomas Wilhelm , Manfred Jagiella
发明人： Michael Hanko , Thomas Wilhelm , Manfred Jagiella
IPC分类号： G01N27/333 , G01N27/30 , G01N21/80 , G01N27/414
CPC分类号： G01N27/3335 , G01N21/80 , G01N27/302 , G01N27/414
摘要： A measuring transducer, which is embodied to produce and output a measurement signal dependent on the content of H+ and/or OH− ions present in a measured medium, wherein the measuring transducer has, in a region provided for contact with the measured medium, at least one polymer membrane selectively conducting H+ and/or OH− ions. The polymer membrane can comprise an H+ ion conducting polymer and/or an OH− ion conducting polymer.
摘要翻译：一种测量传感器，其被实施为产生和输出取决于测量介质中存在的H +和/或OH-离子的含量的测量信号，其中测量换能器在被提供用于与所测量的介质接触的区域中选择性地导电H +和/或OH-离子的至少一种聚合物膜。聚合物膜可以包含H +离子导电聚合物和/或OH-离子导电聚合物。

3. 发明申请

US20130217003A1 METHOD FOR DETERMINING AN ANALYTE CONTENT OF A LIQUID SAMPLE BY MEANS OF A BIOANALYZER 审中-公开
标题翻译：用生物降解剂测定液体样品分析物含量的方法
公开(公告)号：US20130217003A1
公开(公告)日：2013-08-22
申请号：US13881907
申请日：2011-08-25
申请人： Michael Hanko , Angela Eubisch , Axel Fikus
发明人： Michael Hanko , Angela Eubisch , Axel Fikus
IPC分类号： G01N33/569
CPC分类号： C25F1/00 , G01N33/52 , G01N33/54306 , G01N33/5438 , G01N33/56983
摘要： A method for automated in situ determining an analyte content of a liquid sample by means of a bioanalyzer, wherein a measurement duct has at least one substrate, comprising a repeatedly performable sequence of steps as follows: (i) preparing a sensor matrix, which has a plurality of receptors, which bind the analyte and/or a further target molecule, or bring about a chemical conversion of the analyte or of the further target molecule, leading through the measurement duct a preparation solution of at least a first chemical species, wherein a plurality of the first chemical species are bound on the substrate via the functional group binding on the substrate, wherein the other functional group of the plurality of the first chemical species bound on the substrate serves as a receptor or for subsequent binding of a receptor; (ii) leading the liquid sample, through the measurement duct, wherein analyte contained in the liquid sample or in the liquid to be measured, and/or other target molecules contained in the liquid sample or the liquid to be measured, bind, preferably selectively and specifically, on the receptors or are chemically converted by the receptors, and determining a measured variable correlated with the amount of the target molecules bound or converted by the receptors, and deriving therefrom the analyte content of the liquid sample; and (iii) regenerating, especially clearing, the at least one substrate, wherein the sensor matrix and, in given cases, molecules bound thereto, especially analyte molecules, other target molecules or other molecules, are released from the substrate and/or at least partially decomposed.
摘要翻译：一种用于通过生物分析仪自动原位测定液体样品的分析物含量的方法，其中测量管道具有至少一个底物，其包括重复执行的步骤序列如下：（i）制备传感器基质，其具有多个受体，其结合分析物和/或另外的靶分子，或者导致分析物或另外的靶分子的化学转化，通过测量管道导入至少第一化学物质的制备溶液，其中多个第一化学物质通过在基底上结合的官能团结合在基底上，其中结合在基底上的多个第一化学物质的另一官能团用作受体或用于随后的受体结合; （ii）引导液体样品通过测量管道，其中包含在液体样品中或待测量的液体中的分析物和/或液体样品或待测量液体中包含的其它靶分子优选选择性地结合并且具体地，在受体上或由受体化学转化，并且确定与受体结合或转化的靶分子的量相关的测量变量，并从其导出液体样品的分析物含量; 以及（iii）再生，特别是清除所述至少一个底物，其中所述传感器基质和在给定情况下结合到其上的分子，特别是分析物分子，其它靶分子或其它分子，从所述底物和/或至少部分分解。

4. 发明申请

US20130213821A1 METHOD FOR DETERMINING AN ANALYTE CONTENT OF A LIQUID SAMPLE BY MEANS OF A BIOANALYZER 有权
公开(公告)号：US20130213821A1
公开(公告)日：2013-08-22
申请号：US13881658
申请日：2011-08-26
申请人： Michael Hanko , Angela Eubisch , Axel Fikus
发明人： Michael Hanko , Angela Eubisch , Axel Fikus
IPC分类号： C25F1/00 , G01N33/52
CPC分类号： C25F1/00 , G01N33/52 , G01N33/54306 , G01N33/5438 , G01N33/56983
摘要： A method for automated in situ determining an analyte content of a liquid sample by means of a bioanalyzer, wherein a measurement duct has at least one substrate, comprising a repeatedly performable sequence of steps as follows: (i) preparing a sensor matrix, which has a plurality of receptors, which bind the analyte and/or a further target molecule, or bring about a chemical conversion of the analyte or of the further target molecule, leading through the measurement duct a preparation solution of at least a first chemical species, wherein a plurality of the first chemical species are bound on the substrate via the functional group binding on the substrate, wherein the other functional group of the plurality of the first chemical species bound on the substrate serves as a receptor or for subsequent binding of a receptor; (ii) leading the liquid sample, through the measurement duct, wherein analyte contained in the liquid sample or in the liquid to be measured, and/or other target molecules contained in the liquid sample or the liquid to be measured, bind, preferably selectively and specifically, on the receptors or are chemically converted by the receptors, and determining a measured variable correlated with the amount of the target molecules bound or converted by the receptors, and deriving therefrom the analyte content of the liquid sample; and (iii) regenerating, especially clearing, the at least one substrate, wherein the sensor matrix and, in given cases, molecules bound thereto, especially analyte molecules, other target molecules or other molecules, are released from the substrate and/or at least partially decomposed.

5. 发明授权

US10036098B2 Method for determining an analyte content of a liquid sample by means of a bioanalyzer 有权
公开(公告)号：US10036098B2
公开(公告)日：2018-07-31
申请号：US13881658
申请日：2011-08-26
申请人： Michael Hanko , Angela Eubisch , Axel Fikus
发明人： Michael Hanko , Angela Eubisch , Axel Fikus
IPC分类号： C25F1/00 , G01N33/52 , G01N33/543 , G01N33/569
CPC分类号： C25F1/00 , G01N33/52 , G01N33/54306 , G01N33/5438 , G01N33/56983
摘要： A method for automated in situ determining an analyte content of a liquid sample by means of a bioanalyzer, wherein a measurement duct has at least one substrate, comprising a repeatedly performable sequence of steps as follows: (i) preparing a sensor matrix, which has a plurality of receptors, which bind the analyte and/or a further target molecule, or bring about a chemical conversion of the analyte or of the further target molecule, leading through the measurement duct a preparation solution of at least a first chemical species, wherein a plurality of the first chemical species are bound on the substrate via the functional group binding on the substrate, wherein the other functional group of the plurality of the first chemical species bound on the substrate serves as a receptor or for subsequent binding of a receptor; (ii) leading the liquid sample, through the measurement duct, wherein analyte contained in the liquid sample or in the liquid to be measured, and/or other target molecules contained in the liquid sample or the liquid to be measured, bind, preferably selectively and specifically, on the receptors or are chemically converted by the receptors, and determining a measured variable correlated with the amount of the target molecules bound or converted by the receptors, and deriving therefrom the analyte content of the liquid sample; and (iii) regenerating, especially clearing, the at least one substrate, wherein the sensor matrix and, in given cases, molecules bound thereto, especially analyte molecules, other target molecules or other molecules, are released from the substrate and/or at least partially decomposed.

6. 发明授权

US09146138B2 Probe arrangement 有权
标题翻译：探测安排
公开(公告)号：US09146138B2
公开(公告)日：2015-09-29
申请号：US13109065
申请日：2011-05-17
申请人： Michael Hanko , René Kündscher , Torsten Pechstein
发明人： Michael Hanko , René Kündscher , Torsten Pechstein
IPC分类号： G01D11/24 , G01N27/333
CPC分类号： G01D11/245 , G01N27/333
摘要： A probe arrangement, in the case of which a probe is arranged within a tubular housing, wherein the tubular housing has at least one process window open to the process medium, and at least one functional element is secured on the probe and surrounded by the process medium. In order to suppress a taking along of the process medium during transfer of the functional element from the measured medium into a rinsing chamber, the tubular housing includes at least one treatment window open opposite the probe (3), preferably for washing, rinsing and/or calibrating the functional element, wherein the functional element is movable between the process window and the treatment window, and, during the measuring in the process medium, the at least one functional element is arranged approximately coincident with the at least one process window of the housing.
摘要翻译：探针布置，在探针布置在管状壳体内的情况下，其中管状壳体具有至少一个对加工介质开放的处理窗口，并且至少一个功能元件固定在探针上并被该工艺包围中。为了在将功能元件从测量介质转移到漂洗室中时抑制沿着处理介质的吸收，管状壳体包括与探针（3）相对开放的至少一个处理窗口，优选用于洗涤，漂洗和/ 或校准所述功能元件，其中所述功能元件可在所述处理窗口和所述处理窗口之间移动，并且在所述处理介质中的所述测量期间，所述至少一个功能元件被布置为与所述至少一个工艺窗口住房。

7. 发明授权

US09095850B2 System for treating liquids 有权
标题翻译：液体处理系统
公开(公告)号：US09095850B2
公开(公告)日：2015-08-04
申请号：US13634274
申请日：2011-03-23
申请人： Michael Hanko , Stefanie Honncher , Axel Fikus
发明人： Michael Hanko , Stefanie Honncher , Axel Fikus
IPC分类号： B01L3/00 , G01N35/10
CPC分类号： B01L3/502715 , B01L3/527 , B01L2200/027 , B01L2300/0867 , B01L2300/123 , B01L2400/0478 , B01L2400/0487 , B01L2400/0605 , B01L2400/065 , B01L2400/0655 , G01N35/1097 , Y10T137/87153
摘要： A system for treating liquids comprising: a fluidics unit having at least one functional unit; at least one liquid storage unit of the first type; at least one liquid storage unit of second type; a first liquid line; and a second liquid line, wherein a flow of liquid through the first liquid line directed from the fluidics unit to the liquid storage unit of first type is blocked, at least at times, by means of a first valve and a flow of liquid through the second liquid line in the direction from the liquid storage unit of second type to the fluidics unit is blocked, at least at times, by means of a second valve.
摘要翻译：一种用于处理液体的系统，包括：具有至少一个功能单元的流体单元; 至少一个第一类型的液体储存单元; 至少一个第二类液体储存单元; 第一条液体管线; 以及第二液体管线，其中通过从流体单元引导到第一类型的液体存储单元的通过第一液体管线的液体流至少有时通过第一阀和流过液体的流动被阻塞至少有时通过第二阀阻塞在从第二类型的液体存储单元到流体单元的方向上的第二液体管线。

8. 发明申请

US20120325659A1 MEASURING TRANSDUCER FOR DETERMINING A MEASURED VARIABLE REPRESENTING A CONTENT OF H+ AND/OR OH- IONS IN A MEASURED MEDIUM 有权
标题翻译：测量传感器，用于测量表示测量介质中H +和/或OH-离子的含量的测量变量
公开(公告)号：US20120325659A1
公开(公告)日：2012-12-27
申请号：US13530459
申请日：2012-06-22
申请人： Michael Hanko , Thomas Wilhelm , Manfred Jagiella
发明人： Michael Hanko , Thomas Wilhelm , Manfred Jagiella
IPC分类号： G01N27/333 , G01N27/414
CPC分类号： G01N27/3335 , G01N21/80 , G01N27/302 , G01N27/414
摘要： A measuring transducer, which is embodied to produce and output a measurement signal dependent on the content of W and/or OH− ions present in a measured medium, wherein the measuring transducer has, in a region provided for contact with the measured medium, at least one polymer membrane selectively conducting W and/or OH− ions. The polymer membrane can comprise an W ion conducting polymer and/or an OH− ion conducting polymer.
摘要翻译：一种测量传感器，其被实施为产生和输出取决于测量介质中存在的W和/或OH-离子的含量的测量信号，其中所述测量传感器在被提供用于与测量介质接触的区域中至少一个选择性地导电W和/或OH-离子的聚合物膜。聚合物膜可以包含W离子传导聚合物和/或OH-离子导电聚合物。

9. 发明申请

US20110033917A1 SENSOR WITH LONG-TERM STABILITY FOR BIOPROCESSES 审中-公开
标题翻译：具有长期生物稳定性的传感器
公开(公告)号：US20110033917A1
公开(公告)日：2011-02-10
申请号：US12734112
申请日：2008-10-09
申请人： Thilo Trapp , Michael Hanko , Ânnett Planitzer
发明人： Thilo Trapp , Michael Hanko , Ânnett Planitzer
IPC分类号： C12M1/34
CPC分类号： G01N33/54373 , G01N21/82
摘要： A sensor for registering a measured variable of a medium, especially in a bioprocess. The sensor includes a sensor body, wherein at least one surface section of the sensor body can be supplied with the medium, and wherein a condition of this surface section affects the measured value. The sensor is characterized by the fact that the surface section contains a substance with biocidal properties.
摘要翻译：用于记录介质的测量变量的传感器，特别是在生物过程中。传感器包括传感器体，其中传感器主体的至少一个表面部分可以被供应介质，并且其中该表面部分的状态影响测量值。传感器的特征在于表面部分含有具有杀生物性的物质。

10. 发明授权

US09091642B2 Measuring transducer for determining a measured variable representing an activity of a target ion in a measured medium 有权
标题翻译：用于确定表示测量介质中目标离子的活性的测量变量的测量传感器
公开(公告)号：US09091642B2
公开(公告)日：2015-07-28
申请号：US13566122
申请日：2012-08-03
申请人： Thomas Wilhelm , Michael Hanko , Stefan Wilke
发明人： Thomas Wilhelm , Michael Hanko , Stefan Wilke
IPC分类号： G01N27/333
CPC分类号： G01N27/333
摘要： A measuring transducer embodied to produce and output a measurement signal dependent on an activity of a target ion present in a measured medium, wherein the measuring transducer has, in a region provided for contact with the measured medium, at least one membrane conducting the target ion; wherein the measuring transducer has a first potential sensing element and a second potential sensing element, and wherein at least one section of the second potential sensing element is arranged in the interior of the membrane and the first potential sensing element is arranged in an inner electrolyte, which is separated from the measured medium by the membrane and is in contact with the membrane.
摘要翻译：一种测量传感器，其特征在于，其产生和输出取决于存在于测量介质中的目标离子的活性的测量信号，其中所述测量传感器在与测量介质接触的区域中具有至少一个导电目标离子的膜 ; 其中所述测量换能器具有第一电位感测元件和第二电位感测元件，并且其中所述第二电位感测元件的至少一个部分布置在所述膜的内部，并且所述第一电位感测元件布置在内部电解质中，其通过膜与测量的介质分离并与膜接触。

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